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Fusion gene ID: 28494 |
FusionGeneSummary for PPP4C_MVP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP4C_MVP | Fusion gene ID: 28494 | Hgene | Tgene | Gene symbol | PPP4C | MVP | Gene ID | 5531 | 9961 |
| Gene name | protein phosphatase 4 catalytic subunit | major vault protein | |
| Synonyms | PP-X|PP4|PP4C|PPH3|PPP4|PPX | LRP|VAULT1 | |
| Cytomap | 16p11.2 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 4 catalytic subunitprotein phosphatase 4 (formerly X), catalytic subunitprotein phosphatase X, catalytic subunit | major vault proteinlung resistance-related proteintesticular secretory protein Li 30 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P60510 | Q14764 | |
| Ensembl transtripts involved in fusion gene | ENST00000279387, ENST00000561610, | ENST00000357402, ENST00000452209, ENST00000395353, ENST00000566554, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PPP4C [Title/Abstract] AND MVP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MVP | GO:0023057 | negative regulation of signaling | 16441665 |
| Tgene | MVP | GO:0031953 | negative regulation of protein autophosphorylation | 16441665 |
| Tgene | MVP | GO:0038127 | ERBB signaling pathway | 15133037 |
| Tgene | MVP | GO:0061099 | negative regulation of protein tyrosine kinase activity | 16441665 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | TGCT | TCGA-2G-AALY-01A | PPP4C | chr16 | 30087796 | + | MVP | chr16 | 29855814 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000279387 | ENST00000357402 | PPP4C | chr16 | 30087796 | + | MVP | chr16 | 29855814 | + |
| 5CDS-intron | ENST00000279387 | ENST00000452209 | PPP4C | chr16 | 30087796 | + | MVP | chr16 | 29855814 | + |
| 5CDS-intron | ENST00000279387 | ENST00000395353 | PPP4C | chr16 | 30087796 | + | MVP | chr16 | 29855814 | + |
| 5CDS-intron | ENST00000279387 | ENST00000566554 | PPP4C | chr16 | 30087796 | + | MVP | chr16 | 29855814 | + |
| In-frame | ENST00000561610 | ENST00000357402 | PPP4C | chr16 | 30087796 | + | MVP | chr16 | 29855814 | + |
| 5CDS-intron | ENST00000561610 | ENST00000452209 | PPP4C | chr16 | 30087796 | + | MVP | chr16 | 29855814 | + |
| 5CDS-intron | ENST00000561610 | ENST00000395353 | PPP4C | chr16 | 30087796 | + | MVP | chr16 | 29855814 | + |
| 5CDS-intron | ENST00000561610 | ENST00000566554 | PPP4C | chr16 | 30087796 | + | MVP | chr16 | 29855814 | + |
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FusionProtFeatures for PPP4C_MVP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP4C | MVP |
| Protein phosphatase that is involved in many processessuch as microtubule organization at centrosomes, maturation ofspliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor(TNF)-alpha signaling, activation of c-Jun N-terminal kinaseMAPK8, regulation of histone acetylation, DNA damage checkpointsignaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation andregulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complexspecifically dephosphorylates H2AFX phosphorylated on Ser-140(gamma-H2AFX) generated during DNA replication and required forDNA double strand break repair. Dephosphorylates NDEL1 at CDK1phosphorylation sites and negatively regulates CDK1 activity ininterphase (By similarity). In response to DNA damage, catalyzesRPA2 dephosphorylation, an essential step for DNA repair since itallows the efficient RPA2-mediated recruitment of RAD51 tochromatin. {ECO:0000250, ECO:0000269|PubMed:11698396,ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:12934076,ECO:0000269|PubMed:1336397, ECO:0000269|PubMed:15805470,ECO:0000269|PubMed:18347064, ECO:0000269|PubMed:18487071,ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:18758438,ECO:0000269|PubMed:20154705}. | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involvedin signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1signaling and subsequent activation of JAK. Down-regulates SRCactivity and signaling through MAP kinases.{ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217,ECO:0000269|PubMed:16441665}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000357402 | + | 9 | 15 | 112_164 | 544 | 894 | Repeat | Note=MVP 3 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000357402 | + | 9 | 15 | 165_217 | 544 | 894 | Repeat | Note=MVP 4 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000357402 | + | 9 | 15 | 218_272 | 544 | 894 | Repeat | Note=MVP 5 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000357402 | + | 9 | 15 | 273_323 | 544 | 894 | Repeat | Note=MVP 6 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000357402 | + | 9 | 15 | 2_56 | 544 | 894 | Repeat | Note=MVP 1 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000357402 | + | 9 | 15 | 324_379 | 544 | 894 | Repeat | Note=MVP 7 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000357402 | + | 9 | 15 | 380_457 | 544 | 894 | Repeat | Note=MVP 8 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000357402 | + | 9 | 15 | 458_520 | 544 | 894 | Repeat | Note=MVP 9 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000357402 | + | 9 | 15 | 57_111 | 544 | 894 | Repeat | Note=MVP 2 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000395353 | + | 9 | 15 | 112_164 | 544 | 894 | Repeat | Note=MVP 3 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000395353 | + | 9 | 15 | 165_217 | 544 | 894 | Repeat | Note=MVP 4 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000395353 | + | 9 | 15 | 218_272 | 544 | 894 | Repeat | Note=MVP 5 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000395353 | + | 9 | 15 | 273_323 | 544 | 894 | Repeat | Note=MVP 6 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000395353 | + | 9 | 15 | 2_56 | 544 | 894 | Repeat | Note=MVP 1 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000395353 | + | 9 | 15 | 324_379 | 544 | 894 | Repeat | Note=MVP 7 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000395353 | + | 9 | 15 | 380_457 | 544 | 894 | Repeat | Note=MVP 8 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000395353 | + | 9 | 15 | 458_520 | 544 | 894 | Repeat | Note=MVP 9 |
| Tgene | MVP | chr16:30087796 | chr16:29855814 | ENST00000395353 | + | 9 | 15 | 57_111 | 544 | 894 | Repeat | Note=MVP 2 |
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FusionGeneSequence for PPP4C_MVP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPP4C_ENST00000279387_chr16_30087796_+_MVP_ENST00000357402_chr16_29855814_+_382aa MAEISDLDRQIEQLRRCELIKESEVKALCAKARHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTA VFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQK ILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVS KAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLGMGPEGQPLGRRVASGPSPGEGI >In-frame_PPP4C_ENST00000561610_chr16_30087796_+_MVP_ENST00000357402_chr16_29855814_+_382aa MAEISDLDRQIEQLRRCELIKESEVKALCAKARHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTA VFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQK ILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVS KAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLGMGPEGQPLGRRVASGPSPGEGI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPP4C_ENST00000279387_chr16_30087796_+_MVP_ENST00000357402_chr16_29855814_+_1146nt ATGGCGGAGATCAGCGACCTGGACCGGCAGATCGAGCAGCTGCGTCGCTGCGAGCTCATCAAGGAGAGCGAAGTCAAGGCCCTGTGCGCT AAGGCCAGGCACTTTGAGGTGAATGACCGGAAGGACCCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGC AAAGCCATCGCATCCCGGGTGCGGGGGGCCGTGGCCTCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCT GTCTTTGGCTTTGAGACCTCGGAAGCGAAGGGCCCCGATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGG CTGGTGGTCAGCAGTGTGGACGTGCAGTCAGTGGAGCCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATC GAGATCACCACCAACTCCCAGGAAGCGGCGGCCAAGCATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAG ATCCTGGACCAGTCAGAAGCCGAGAAAGCTCGCAAGGAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCC AAGGCGGAGGCCGAGTCCCGTGCGGAGGCAGCCCGGATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCC ATTGAAACGGAGGCTGAGCTCCAGAGGGTCCAGAAGGTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGC AAGGCTCAGCAGCTGGCTGAGGTGGAGGTGAAGAAGTTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTG GCTGGGCCTGAGATGCAGGTAAAACTGCTCCAGTCCCTGGGCCTGAAATCAACCCTCATCACCGATGGCTCCACTCCCATCAACCTCTTC AACACAGCCTTTGGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGGATA >In-frame_PPP4C_ENST00000561610_chr16_30087796_+_MVP_ENST00000357402_chr16_29855814_+_1146nt ATGGCGGAGATCAGCGACCTGGACCGGCAGATCGAGCAGCTGCGTCGCTGCGAGCTCATCAAGGAGAGCGAAGTCAAGGCCCTGTGCGCT AAGGCCAGGCACTTTGAGGTGAATGACCGGAAGGACCCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGC AAAGCCATCGCATCCCGGGTGCGGGGGGCCGTGGCCTCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCT GTCTTTGGCTTTGAGACCTCGGAAGCGAAGGGCCCCGATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGG CTGGTGGTCAGCAGTGTGGACGTGCAGTCAGTGGAGCCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATC GAGATCACCACCAACTCCCAGGAAGCGGCGGCCAAGCATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAG ATCCTGGACCAGTCAGAAGCCGAGAAAGCTCGCAAGGAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCC AAGGCGGAGGCCGAGTCCCGTGCGGAGGCAGCCCGGATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCC ATTGAAACGGAGGCTGAGCTCCAGAGGGTCCAGAAGGTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGC AAGGCTCAGCAGCTGGCTGAGGTGGAGGTGAAGAAGTTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTG GCTGGGCCTGAGATGCAGGTAAAACTGCTCCAGTCCCTGGGCCTGAAATCAACCCTCATCACCGATGGCTCCACTCCCATCAACCTCTTC AACACAGCCTTTGGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGGATA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPP4C_ENST00000279387_chr16_30087796_+_MVP_ENST00000357402_chr16_29855814_+_1359nt CGGGGCCGGAAGTAGGAGCGGCGGCGGCGGCGGCGGCGGCGGTCGAAAGCGGAGTGAAAGAGGGAGGCAGGGAGCCGGAGAGCCGGAACC GGAGTCGCAGCGGCGGAGACCCCTGTGCGGTGCGGAGGGGGCGGCGGCCCCGACTCTGACCCGCGCCGGGGGTGGGCCATGGCGGAGATC AGCGACCTGGACCGGCAGATCGAGCAGCTGCGTCGCTGCGAGCTCATCAAGGAGAGCGAAGTCAAGGCCCTGTGCGCTAAGGCCAGGCAC TTTGAGGTGAATGACCGGAAGGACCCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGCAAAGCCATCGCA TCCCGGGTGCGGGGGGCCGTGGCCTCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCTGTCTTTGGCTTT GAGACCTCGGAAGCGAAGGGCCCCGATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGGCTGGTGGTCAGC AGTGTGGACGTGCAGTCAGTGGAGCCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATCGAGATCACCACC AACTCCCAGGAAGCGGCGGCCAAGCATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAGATCCTGGACCAG TCAGAAGCCGAGAAAGCTCGCAAGGAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCCAAGGCGGAGGCC GAGTCCCGTGCGGAGGCAGCCCGGATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCCATTGAAACGGAG GCTGAGCTCCAGAGGGTCCAGAAGGTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGCAAGGCTCAGCAG CTGGCTGAGGTGGAGGTGAAGAAGTTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTGGCTGGGCCTGAG ATGCAGGTAAAACTGCTCCAGTCCCTGGGCCTGAAATCAACCCTCATCACCGATGGCTCCACTCCCATCAACCTCTTCAACACAGCCTTT GGGCTGCTGGGGATGGGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGGATATCCCCCCAGTCT GCTCAGGCCCCTCAAGCTCCTGGAGACAACCACGTGGTGCCTGTACTGCGCTAACTCCTGATTAATACAATGGAAGTTTCTGGGCATTTA >In-frame_PPP4C_ENST00000561610_chr16_30087796_+_MVP_ENST00000357402_chr16_29855814_+_1344nt GTGGGGGAGCCGGGCCGGCTCTAGAATCGAGTTGTCCGCTCCGAGCCCCGGACGGACACTGATCCGCGGGCTCGTCTTGGCCTTTCCCAG GAGACCCCTGTGCGGTGCGGAGGGGGCGGCGGCCCCGACTCTGACCCGCGCCGGGGGTGGGCCATGGCGGAGATCAGCGACCTGGACCGG CAGATCGAGCAGCTGCGTCGCTGCGAGCTCATCAAGGAGAGCGAAGTCAAGGCCCTGTGCGCTAAGGCCAGGCACTTTGAGGTGAATGAC CGGAAGGACCCCCAAGAGACGGCCAAGCTCTTTTCAGTGCCAGACTTTGTAGGTGATGCCTGCAAAGCCATCGCATCCCGGGTGCGGGGG GCCGTGGCCTCTGTCACTTTCGATGACTTCCATAAGAACTCAGCCCGCATCATTCGCACTGCTGTCTTTGGCTTTGAGACCTCGGAAGCG AAGGGCCCCGATGGCATGGCCCTGCCCAGGCCCCGGGACCAGGCTGTCTTCCCCCAAAACGGGCTGGTGGTCAGCAGTGTGGACGTGCAG TCAGTGGAGCCTGTGGATCAGAGGACCCGGGACGCCCTGCAACGCAGCGTCCAGCTGGCCATCGAGATCACCACCAACTCCCAGGAAGCG GCGGCCAAGCATGAGGCTCAGAGACTGGAGCAGGAAGCCCGCGGCCGGCTTGAGCGGCAGAAGATCCTGGACCAGTCAGAAGCCGAGAAA GCTCGCAAGGAACTTTTGGAGCTGGAGGCTCTGAGCATGGCCGTGGAGAGCACCGGGACTGCCAAGGCGGAGGCCGAGTCCCGTGCGGAG GCAGCCCGGATTGAGGGAGAAGGGTCCGTGCTGCAGGCCAAGCTAAAAGCACAGGCCTTGGCCATTGAAACGGAGGCTGAGCTCCAGAGG GTCCAGAAGGTCCGAGAGCTGGAACTGGTCTATGCCCGGGCCCAGCTGGAGCTGGAGGTGAGCAAGGCTCAGCAGCTGGCTGAGGTGGAG GTGAAGAAGTTCAAGCAGATGACAGAGGCCATAGGCCCCAGCACCATCAGGGACCTTGCTGTGGCTGGGCCTGAGATGCAGGTAAAACTG CTCCAGTCCCTGGGCCTGAAATCAACCCTCATCACCGATGGCTCCACTCCCATCAACCTCTTCAACACAGCCTTTGGGCTGCTGGGGATG GGGCCCGAGGGTCAGCCCCTGGGCAGAAGGGTGGCCAGTGGGCCCAGCCCTGGGGAGGGGATATCCCCCCAGTCTGCTCAGGCCCCTCAA |
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FusionGenePPI for PPP4C_MVP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPP4C | REL, SMEK1, TIPRL, SMEK2, PPP4R1, PPP2R1A, PPP2CB, PPP4R2, CCDC6, BAG6, GEMIN4, SMN1, DHX38, CCT2, TCP1, CCT5, CCT3, CCT6A, CCT4, IGBP1, CCT7, PPP4R4, PPP2R5D, CCT8, RELA, TP53, JUN, NFKB1, TRAF6, TLR4, MAP4K1, SRRM2, HDAC3, PPP2R2B, PPP2R2D, PPP2R4, GLYATL3, PLOD3, CCT6P1, WDR81, SLC25A31, TRMT1L, ATAD3A, EEF1A1, PPME1, ATAD3B, TUBA3C, TK1, ELAVL1, TRIM28, CUL3, CAND1, IKBKG, LCMT1, DYNLT1, XPO1, PPP2CA, UBXN10, BCAS2, CDC5L, CLASP2, PPP2R2A, PRPF19, SUPT5H, RNGTT | MVP | PARP4, ESR1, PTEN, SIRT7, SLC2A4, RFWD2, TEP1, DHX9, CHMP4B, NNT, EPHX2, HP, KPNA2, CYTB, PLSCR1, GIT2, MVP, CKAP4, POT1, BAG3, HSP90AB1, NCBP1, VAT1, PSAP, BZRAP1, DISC1, DLX2, ADAMTSL4, AES, BANP, C1orf94, CALCOCO2, CAMK2B, CCDC36, FAM154A, FAM46C, GOLGA2, KCTD9, KPNA3, MDFI, MEOX1, MEOX2, MID2, MKL1, NOTCH2NL, OBFC1, PIH1D2, PSTPIP1, RAB3IP, RBPMS, REL, RHOXF2, RIMBP3, RNF111, SERTAD1, SKIL, TCF4, TFCP2, TP53, TRAF2, TRIM27, TRIM42, TRIP13, TRIP6, VAC14, ZBTB32, ZMIZ2, DDX19B, KRAS, CLTC, LGALS3BP, PTPN1, STAT5B, TGM2, GTSE1, SKI, MCM2, NF2, SNW1, CDC5L, U2AF2, GOPC, RCOR3, HSPA8, UBC, CYLD, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP4C_MVP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP4C_MVP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MVP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | MVP | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
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