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Fusion gene ID: 28487 |
FusionGeneSummary for PPP3CC_PSD3 |
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Fusion gene information | Fusion gene name: PPP3CC_PSD3 | Fusion gene ID: 28487 | Hgene | Tgene | Gene symbol | PPP3CC | PSD3 | Gene ID | 5533 | 23362 |
Gene name | protein phosphatase 3 catalytic subunit gamma | pleckstrin and Sec7 domain containing 3 | |
Synonyms | CALNA3|CNA3|PP2Bgamma | EFA6D|EFA6R|HCA67 | |
Cytomap | 8p21.3 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 2B catalytic subunit gamma isoformCAM-PRP catalytic subunitcalcineurin, testis-specific catalytic subunitcalmodulin-dependent calcineurin A subunit gamma isoformprotein phosphatase 2B, catalytic subunit, gamma isof | PH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucle | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P48454 | Q9NYI0 | |
Ensembl transtripts involved in fusion gene | ENST00000518852, ENST00000240139, ENST00000289963, ENST00000397775, | ENST00000327040, ENST00000440756, ENST00000286485, ENST00000428502, ENST00000523619, ENST00000520789, | |
Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 4 X 4 X 2=32 |
# samples | 10 | 4 | |
** MAII score | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PPP3CC [Title/Abstract] AND PSD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPP3CC | GO:0006470 | protein dephosphorylation | 19154138 |
Hgene | PPP3CC | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF512520 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000518852 | ENST00000327040 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000518852 | ENST00000440756 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000518852 | ENST00000286485 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000518852 | ENST00000428502 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000518852 | ENST00000523619 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000518852 | ENST00000520789 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000240139 | ENST00000327040 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000240139 | ENST00000440756 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000240139 | ENST00000286485 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000240139 | ENST00000428502 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000240139 | ENST00000523619 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000240139 | ENST00000520789 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000289963 | ENST00000327040 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000289963 | ENST00000440756 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000289963 | ENST00000286485 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000289963 | ENST00000428502 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000289963 | ENST00000523619 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000289963 | ENST00000520789 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000397775 | ENST00000327040 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000397775 | ENST00000440756 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000397775 | ENST00000286485 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000397775 | ENST00000428502 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000397775 | ENST00000523619 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
5CDS-intron | ENST00000397775 | ENST00000520789 | PPP3CC | chr8 | 22298971 | + | PSD3 | chr8 | 18662415 | - |
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FusionProtFeatures for PPP3CC_PSD3 |
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Hgene | Tgene |
PPP3CC | PSD3 |
Calcium-dependent, calmodulin-stimulated proteinphosphatase which plays an essential role in the transduction ofintracellular Ca(2+)-mediated signals. Dephosphorylates andactivates transcription factor NFATC1. Dephosphorylates andinactivates transcription factor ELK1. Dephosphorylates DARPP32.{ECO:0000269|PubMed:19154138}. | Guanine nucleotide exchange factor for ARF6.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP3CC_PSD3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP3CC_PSD3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP3CC_PSD3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP3CC_PSD3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PPP3CC | C0036341 | Schizophrenia | 4 | PSYGENET |
Hgene | PPP3CC | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | PPP3CC | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | PPP3CC | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | PPP3CC | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | PPP3CC | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | PSD3 | C0017638 | Glioma | 1 | CTD_human |
Tgene | PSD3 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | PSD3 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |