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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28483

FusionGeneSummary for PPP3CC_DLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP3CC_DLC1
Fusion gene ID: 28483
HgeneTgene
Gene symbol

PPP3CC

DLC1

Gene ID

5533

10395

Gene nameprotein phosphatase 3 catalytic subunit gammaDLC1 Rho GTPase activating protein
SynonymsCALNA3|CNA3|PP2BgammaARHGAP7|HP|STARD12|p122-RhoGAP
Cytomap

8p21.3

8p22

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2B catalytic subunit gamma isoformCAM-PRP catalytic subunitcalcineurin, testis-specific catalytic subunitcalmodulin-dependent calcineurin A subunit gamma isoformprotein phosphatase 2B, catalytic subunit, gamma isofrho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia
Modification date2018052320180519
UniProtAcc

P48454

Q96QB1

Ensembl transtripts involved in fusion geneENST00000518852, ENST00000240139, 
ENST00000289963, ENST00000397775, 
ENST00000276297, ENST00000358919, 
ENST00000512044, ENST00000316609, 
ENST00000511869, ENST00000510318, 
ENST00000520226, 
Fusion gene scores* DoF score7 X 5 X 6=2108 X 7 X 4=224
# samples 108
** MAII scorelog2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP3CC [Title/Abstract] AND DLC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP3CC

GO:0006470

protein dephosphorylation

19154138

HgenePPP3CC

GO:0033173

calcineurin-NFAT signaling cascade

19154138

TgeneDLC1

GO:0006915

apoptotic process

17292327

TgeneDLC1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

TgeneDLC1

GO:0008285

negative regulation of cell proliferation

12545165|17932950

TgeneDLC1

GO:0030336

negative regulation of cell migration

17932950|19158340

TgeneDLC1

GO:0035307

positive regulation of protein dephosphorylation

17292327

TgeneDLC1

GO:0051497

negative regulation of stress fiber assembly

17932950

TgeneDLC1

GO:0051895

negative regulation of focal adhesion assembly

19158340

TgeneDLC1

GO:1900119

positive regulation of execution phase of apoptosis

17888903


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF358436PPP3CCchr8

22392911

+DLC1chr8

12959874

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000518852ENST00000276297PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000518852ENST00000358919PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000518852ENST00000512044PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000518852ENST00000316609PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000518852ENST00000511869PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000518852ENST00000510318PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000518852ENST00000520226PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000240139ENST00000276297PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000240139ENST00000358919PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000240139ENST00000512044PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000240139ENST00000316609PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000240139ENST00000511869PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000240139ENST00000510318PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000240139ENST00000520226PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000289963ENST00000276297PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000289963ENST00000358919PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000289963ENST00000512044PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000289963ENST00000316609PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000289963ENST00000511869PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000289963ENST00000510318PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000289963ENST00000520226PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000397775ENST00000276297PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000397775ENST00000358919PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000397775ENST00000512044PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000397775ENST00000316609PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000397775ENST00000511869PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000397775ENST00000510318PPP3CCchr8

22392911

+DLC1chr8

12959874

-
intron-intronENST00000397775ENST00000520226PPP3CCchr8

22392911

+DLC1chr8

12959874

-

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FusionProtFeatures for PPP3CC_DLC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP3CC

P48454

DLC1

Q96QB1

Calcium-dependent, calmodulin-stimulated proteinphosphatase which plays an essential role in the transduction ofintracellular Ca(2+)-mediated signals. Dephosphorylates andactivates transcription factor NFATC1. Dephosphorylates andinactivates transcription factor ELK1. Dephosphorylates DARPP32.{ECO:0000269|PubMed:19154138}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP3CC_DLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP3CC_DLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP3CC_DLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP3CC_DLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP3CCC0036341Schizophrenia4PSYGENET
HgenePPP3CCC0005586Bipolar Disorder1PSYGENET
HgenePPP3CCC0011570Mental Depression1PSYGENET
HgenePPP3CCC0011581Depressive disorder1PSYGENET
HgenePPP3CCC0033975Psychotic Disorders1PSYGENET
HgenePPP3CCC0349204Nonorganic psychosis1PSYGENET
TgeneDLC1C0038356Stomach Neoplasms1CTD_human;HPO
TgeneDLC1C0919267ovarian neoplasm1CTD_human