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Fusion gene ID: 28476 |
FusionGeneSummary for PPP3CA_RASGEF1B |
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Fusion gene information | Fusion gene name: PPP3CA_RASGEF1B | Fusion gene ID: 28476 | Hgene | Tgene | Gene symbol | PPP3CA | RASGEF1B | Gene ID | 5530 | 153020 |
Gene name | protein phosphatase 3 catalytic subunit alpha | RasGEF domain family member 1B | |
Synonyms | CALN|CALNA|CALNA1|CCN1|CNA1|IECEE|IECEE1|PPP2B | GPIG4 | |
Cytomap | 4q24 | 4q21.21 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 ( | ras-GEF domain-containing family member 1BGPI gamma-4 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q08209 | Q0VAM2 | |
Ensembl transtripts involved in fusion gene | ENST00000512215, ENST00000394854, ENST00000323055, ENST00000394853, ENST00000507176, ENST00000523694, ENST00000510292, | ENST00000509081, ENST00000264400, ENST00000335927, ENST00000436139, ENST00000514889, | |
Fusion gene scores | * DoF score | 11 X 7 X 5=385 | 6 X 4 X 5=120 |
# samples | 9 | 6 | |
** MAII score | log2(9/385*10)=-2.09686153925259 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PPP3CA [Title/Abstract] AND RASGEF1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPP3CA | GO:0006470 | protein dephosphorylation | 18815128|19154138 |
Hgene | PPP3CA | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138|22688515 |
Hgene | PPP3CA | GO:0035690 | cellular response to drug | 11005320 |
Hgene | PPP3CA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
Hgene | PPP3CA | GO:0051592 | response to calcium ion | 18815128 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-05-4390-01A | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000512215 | ENST00000509081 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000512215 | ENST00000264400 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000512215 | ENST00000335927 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000512215 | ENST00000436139 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000512215 | ENST00000514889 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394854 | ENST00000509081 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394854 | ENST00000264400 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394854 | ENST00000335927 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394854 | ENST00000436139 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394854 | ENST00000514889 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000323055 | ENST00000509081 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000323055 | ENST00000264400 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000323055 | ENST00000335927 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000323055 | ENST00000436139 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000323055 | ENST00000514889 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394853 | ENST00000509081 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394853 | ENST00000264400 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394853 | ENST00000335927 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394853 | ENST00000436139 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000394853 | ENST00000514889 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000507176 | ENST00000509081 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000507176 | ENST00000264400 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000507176 | ENST00000335927 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000507176 | ENST00000436139 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000507176 | ENST00000514889 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000523694 | ENST00000509081 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000523694 | ENST00000264400 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000523694 | ENST00000335927 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000523694 | ENST00000436139 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5CDS-intron | ENST00000523694 | ENST00000514889 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000510292 | ENST00000509081 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000510292 | ENST00000264400 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000510292 | ENST00000335927 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000510292 | ENST00000436139 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000510292 | ENST00000514889 | PPP3CA | chr4 | 102030111 | - | RASGEF1B | chr4 | 82524076 | - |
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FusionProtFeatures for PPP3CA_RASGEF1B |
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Hgene | Tgene |
PPP3CA | RASGEF1B |
Calcium-dependent, calmodulin-stimulated proteinphosphatase which plays an essential role in the transduction ofintracellular Ca(2+)-mediated signals (PubMed:15671020,PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of thesubstrates contain a PxIxIT motif and/or a LxVP motif(PubMed:17498738, PubMed:17502104, PubMed:23468591,PubMed:27974827, PubMed:22343722). In response to increased Ca(2+)levels, dephosphorylates and activates phosphatase SSH1 whichresults in cofilin dephosphorylation (PubMed:15671020). Inresponse to increased Ca(2+) levels following mitochondrialdepolarization, dephosphorylates DNM1L inducing DNM1Ltranslocation to the mitochondrion (PubMed:18838687).Dephosphorylates heat shock protein HSPB1 (By similarity).Dephosphorylates and activates transcription factor NFATC1(PubMed:19154138). In response to increased Ca(2+) levels,regulates NFAT-mediated transcription probably bydephosphorylating NFAT and promoting its nuclear translocation(PubMed:26248042). Dephosphorylates and inactivates transcriptionfactor ELK1 (PubMed:19154138). Dephosphorylates DARPP32(PubMed:19154138). {ECO:0000250|UniProtKB:P48452,ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738,ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687,ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722,ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042,ECO:0000269|PubMed:27974827}. | Guanine nucleotide exchange factor (GEF) withspecificity for RAP2A, it doesn't seems to activate other Rasfamily proteins (in vitro). {ECO:0000269|PubMed:19645719,ECO:0000269|PubMed:23894443}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP3CA_RASGEF1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP3CA_RASGEF1B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPP3CA | C16orf74, PPIA, RCAN1, ADRB2, RCAN2, AKAP5, BCL2, CABIN1, MYOZ2, MYOZ1, IRF2, GRB2, AKT1, PHLPP2, PTEN, PSMA6, PDE4D, KCNIP3, TRAF3, PPP3R1, MRI1, RHOC, MAPK7, HNRNPH1, P3H1, SETSIP, MAT2B, NASP, NRD1, PDIA6, PFDN5, PPP2R2A, TNPO3, TNPO1, TSN, VBP1, XPO5, MARCH7, CEP76, TP53, VCP, JUN, FAM122A, RASSF2, PDHB, RCAN3, NFATC4, SIK3, ARFIP1, C6orf211, PSMD9, CRTC2, LBH, NCAPG, TUBA1B, DEFA1, TMEM200A, SMPD3, NFATC1, KLRG2, AATK, FGFR4, RYK, PTK7 | RASGEF1B | EGFR, COL1A1, GAPDHS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP3CA_RASGEF1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP3CA_RASGEF1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PPP3CA | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
Hgene | PPP3CA | C0030305 | Pancreatitis | 1 | CTD_human |
Hgene | PPP3CA | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | PPP3CA | C0039584 | Testicular Diseases | 1 | CTD_human |
Hgene | PPP3CA | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
Hgene | PPP3CA | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | RASGEF1B | C3495559 | Juvenile arthritis | 1 | CTD_human |