	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 28468

FusionGeneSummary for PPP3CA_BRD2

Fusion gene summary

Fusion gene information	Fusion gene name: PPP3CA_BRD2
	Fusion gene ID: 28468
		Hgene	Tgene
	Gene symbol	PPP3CA	BRD2
	Gene ID	5530	6046
	Gene name	protein phosphatase 3 catalytic subunit alpha	bromodomain containing 2
	Synonyms	CALN\|CALNA\|CALNA1\|CCN1\|CNA1\|IECEE\|IECEE1\|PPP2B	BRD2-IT1\|D6S113E\|FSH\|FSRG1\|NAT\|O27.1.1\|RING3\|RNF3
	Cytomap	4q24	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 (	bromodomain-containing protein 2BRD2 intronic transcript 1female sterile homeotic-related gene 1really interesting new gene 3 protein
	Modification date	20180523	20180519
	UniProtAcc	Q08209	P25440
	Ensembl transtripts involved in fusion gene	ENST00000512215, ENST00000394854, ENST00000323055, ENST00000394853, ENST00000507176, ENST00000523694, ENST00000510292,	ENST00000374825, ENST00000496118, ENST00000580234, ENST00000374831, ENST00000395289, ENST00000443797, ENST00000395287, ENST00000449085, ENST00000438194, ENST00000466744, ENST00000383108, ENST00000547895, ENST00000549843, ENST00000442863, ENST00000552513, ENST00000442219, ENST00000498329, ENST00000488549, ENST00000425201, ENST00000399529, ENST00000399528, ENST00000550142, ENST00000548837, ENST00000399527, ENST00000549236, ENST00000482105, ENST00000414731, ENST00000449118, ENST00000550598, ENST00000479973, ENST00000546777, ENST00000450320, ENST00000547286, ENST00000552587, ENST00000549126, ENST00000553146, ENST00000448067, ENST00000436979, ENST00000466208,
Fusion gene scores	* DoF score	11 X 7 X 5=385	7 X 9 X 2=126
	# samples	9	10
	** MAII score	log2(9/385*10)=-2.09686153925259 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/126*10)=-0.333423733725192 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPP3CA [Title/Abstract] AND BRD2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP3CA	GO:0006470	protein dephosphorylation	18815128\|19154138
Hgene	PPP3CA	GO:0033173	calcineurin-NFAT signaling cascade	19154138\|22688515
Hgene	PPP3CA	GO:0035690	cellular response to drug	11005320
Hgene	PPP3CA	GO:0045944	positive regulation of transcription by RNA polymerase II	22688515
Hgene	PPP3CA	GO:0051592	response to calcium ion	18815128
Tgene	BRD2	GO:0006357	regulation of transcription by RNA polymerase II	18406326

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	PRAD	TCGA-CH-5790-01A	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000512215	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000512215	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000394854	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000394854	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000323055	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000323055	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
Frame-shift	ENST00000394853	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
5CDS-intron	ENST00000394853	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000507176	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000507176	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000523694	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000523694	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-3CDS	ENST00000510292	ENST00000374825	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000496118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000580234	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000374831	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000395289	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000443797	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000395287	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000449085	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000438194	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000466744	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000383108	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000547895	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000549843	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000442863	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000552513	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000442219	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000498329	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000488549	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000425201	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000399529	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000399528	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000550142	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000548837	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000399527	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000549236	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000482105	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000414731	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000449118	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000550598	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000479973	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000546777	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000450320	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000547286	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000552587	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000549126	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000553146	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000448067	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000436979	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+
intron-intron	ENST00000510292	ENST00000466208	PPP3CA	chr4	101945485	-	BRD2	chr6	32944339	+

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FusionProtFeatures for PPP3CA_BRD2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PPP3CA Q08209	BRD2 P25440
Calcium-dependent, calmodulin-stimulated proteinphosphatase which plays an essential role in the transduction ofintracellular Ca(2+)-mediated signals (PubMed:15671020,PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of thesubstrates contain a PxIxIT motif and/or a LxVP motif(PubMed:17498738, PubMed:17502104, PubMed:23468591,PubMed:27974827, PubMed:22343722). In response to increased Ca(2+)levels, dephosphorylates and activates phosphatase SSH1 whichresults in cofilin dephosphorylation (PubMed:15671020). Inresponse to increased Ca(2+) levels following mitochondrialdepolarization, dephosphorylates DNM1L inducing DNM1Ltranslocation to the mitochondrion (PubMed:18838687).Dephosphorylates heat shock protein HSPB1 (By similarity).Dephosphorylates and activates transcription factor NFATC1(PubMed:19154138). In response to increased Ca(2+) levels,regulates NFAT-mediated transcription probably bydephosphorylating NFAT and promoting its nuclear translocation(PubMed:26248042). Dephosphorylates and inactivates transcriptionfactor ELK1 (PubMed:19154138). Dephosphorylates DARPP32(PubMed:19154138). {ECO:0000250\|UniProtKB:P48452,ECO:0000269\|PubMed:15671020, ECO:0000269\|PubMed:17498738,ECO:0000269\|PubMed:17502104, ECO:0000269\|PubMed:18838687,ECO:0000269\|PubMed:19154138, ECO:0000269\|PubMed:22343722,ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26248042,ECO:0000269\|PubMed:27974827}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for PPP3CA_BRD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP3CA_BRD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
PPP3CA	C16orf74, PPIA, RCAN1, ADRB2, RCAN2, AKAP5, BCL2, CABIN1, MYOZ2, MYOZ1, IRF2, GRB2, AKT1, PHLPP2, PTEN, PSMA6, PDE4D, KCNIP3, TRAF3, PPP3R1, MRI1, RHOC, MAPK7, HNRNPH1, P3H1, SETSIP, MAT2B, NASP, NRD1, PDIA6, PFDN5, PPP2R2A, TNPO3, TNPO1, TSN, VBP1, XPO5, MARCH7, CEP76, TP53, VCP, JUN, FAM122A, RASSF2, PDHB, RCAN3, NFATC4, SIK3, ARFIP1, C6orf211, PSMD9, CRTC2, LBH, NCAPG, TUBA1B, DEFA1, TMEM200A, SMPD3, NFATC1, KLRG2, AATK, FGFR4, RYK, PTK7	BRD2	E2F2, E2F1, BRD2, HIST1H4A, TBP, TERF2, HIST2H2BE, BRD4, ELAVL1, BRD7, CSNK2A2, OBSL1, FAM90A1, DENND2D, RUVBL2, HIST1H2BG, HIST1H3A, BAG1, CSNK2A1, CSNK2B, EPB41L1, POLR2B, BRPF1, TAGLN2, COX5A, FARP1, TADA3, WHSC1L1, PWWP2B, CDC5L, CDC14B, BRD3, PIP4K2A, CAMKV, PES1, EPB41L5, MDK, INO80B, AR, ERG, SPOP

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for PPP3CA_BRD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PPP3CA_BRD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PPP3CA	C0019202	Hepatolenticular Degeneration	1	CTD_human
Hgene	PPP3CA	C0030305	Pancreatitis	1	CTD_human
Hgene	PPP3CA	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	PPP3CA	C0039584	Testicular Diseases	1	CTD_human
Hgene	PPP3CA	C0149721	Left Ventricular Hypertrophy	1	CTD_human
Hgene	PPP3CA	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
Tgene	BRD2	C0017636	Glioblastoma	1	CTD_human
Tgene	BRD2	C0025149	Medulloblastoma	1	CTD_human

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Fusion gene ID: 28468

FusionGeneSummary for PPP3CA_BRD2

FusionProtFeatures for PPP3CA_BRD2

FusionGeneSequence for PPP3CA_BRD2

FusionGenePPI for PPP3CA_BRD2

RelatedDrugs for PPP3CA_BRD2

RelatedDiseases for PPP3CA_BRD2