![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 28462 |
FusionGeneSummary for PPP2R5E_MBIP |
![]() |
Fusion gene information | Fusion gene name: PPP2R5E_MBIP | Fusion gene ID: 28462 | Hgene | Tgene | Gene symbol | PPP2R5E | MBIP | Gene ID | 5529 | 51562 |
Gene name | protein phosphatase 2 regulatory subunit B'epsilon | MAP3K12 binding inhibitory protein 1 | |
Synonyms | B56E|B56epsilon | - | |
Cytomap | 14q23.2 | 14q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoformPP2A, B subunit, B' epsilonPP2A, B subunit, B56 epsilonPP2A, B subunit, PR61 epsilonPP2A, B subunit, R5 epsilonepsilon isoform of regulatory subunit B56, protein phospha | MAP3K12-binding inhibitory protein 1MAPK upstream kinase-binding inhibitory proteinMUK-binding inhibitory protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q16537 | Q9NS73 | |
Ensembl transtripts involved in fusion gene | ENST00000337537, ENST00000555899, ENST00000422769, ENST00000553266, | ENST00000416007, ENST00000318473, ENST00000359527, ENST00000603913, | |
Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PPP2R5E [Title/Abstract] AND MBIP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MBIP | GO:0043966 | histone H3 acetylation | 18838386 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-GJ-A9DB-01A | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000337537 | ENST00000416007 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
Frame-shift | ENST00000337537 | ENST00000318473 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
Frame-shift | ENST00000337537 | ENST00000359527 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
5CDS-intron | ENST00000337537 | ENST00000603913 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
Frame-shift | ENST00000555899 | ENST00000416007 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
Frame-shift | ENST00000555899 | ENST00000318473 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
Frame-shift | ENST00000555899 | ENST00000359527 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
5CDS-intron | ENST00000555899 | ENST00000603913 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
intron-3CDS | ENST00000422769 | ENST00000416007 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
intron-3CDS | ENST00000422769 | ENST00000318473 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
intron-3CDS | ENST00000422769 | ENST00000359527 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
intron-intron | ENST00000422769 | ENST00000603913 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
5UTR-3CDS | ENST00000553266 | ENST00000416007 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
5UTR-3CDS | ENST00000553266 | ENST00000318473 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
5UTR-3CDS | ENST00000553266 | ENST00000359527 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
5UTR-intron | ENST00000553266 | ENST00000603913 | PPP2R5E | chr14 | 64006247 | - | MBIP | chr14 | 36784121 | - |
Top |
FusionProtFeatures for PPP2R5E_MBIP |
![]() |
Hgene | Tgene |
PPP2R5E | MBIP |
The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. | Inhibits the MAP3K12 activity to induce the activationof the JNK/SAPK pathway. Component of the ATAC complex, a complexwith histone acetyltransferase activity on histones H3 and H4.{ECO:0000269|PubMed:19103755}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PPP2R5E_MBIP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PPP2R5E_MBIP |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPP2R5E | PPP2CA, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, ELAVL1, NOD2, APP, CBX5, SMAD9, EGFR, AARS, TRMT10A, TERF2IP, SAE1, TPD52L2, ZDHHC17, CLOCK, CRY1, CSNK1E, CSNK2B, DEC1, BHLHE41, FBXW11, RORC, CRY2, PPP2R5E, PPP1CA, VTI1B, MOS, DNASE2B, FAM43A, WNT3A, DCLRE1C, CDK17, CCNG1, API5, IK, PPP2R5C, MARK2, SAMHD1, CDC20, NANOG, ZNF785, PRR14, ZFPL1, DCAF11, CRIP1, KLF15, GJB7, ZNF517, LPAR4, VSIG1, TMEM206, C1QL4, CCNG2, RPS27, C19orf57, TRIM25 | MBIP | CEP63, MBIP, NDEL1, RAP1GDS1, WDR5, DGCR6L, VTA1, CCDC85B, EPB41L3, PPFIA1, MCM7, PLEKHF2, COPS4, CSRP2BP, FXR2, NINL, LMO3, MAP3K12, CALM1, YEATS2, DR1, KAT2B, KAT2A, TADA2A, TADA3, CCDC101, PIK3R3, LIMS1, EXOC8, RAPGEF1, MYD88, LMNB1, MAPK6, HECW2, DGCR6, CCNC, LMO2, BFSP2, STX11, POLR1C, DIP2A, VPS28, MIS18A, MOAP1, DRC7, ING5, TGIF2LY, KLC3, TXLNB, TXLNA, PSME3, ZNF131, TP53RK, IQGAP3, ZZZ3, CRTAP, PHLDB3, STXBP4, P3H1, RNF40, GMCL1, CTR9, CCDC85C, FAM199X, KLHL26, RFWD3, TPRKB, CARD8, PSMC3, MED23, EWSR1, IKZF5, FAM92A1, SPERT, BRMS1, CDH19, MYF6, NCAPH2, TUBA4A, CCBL1, OSGEP, SMARCB1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PPP2R5E_MBIP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PPP2R5E_MBIP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PPP2R5E | C1257806 | Chromosomal Instability | 1 | CTD_human |
Hgene | PPP2R5E | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |