FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 28462

FusionGeneSummary for PPP2R5E_MBIP

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R5E_MBIP
Fusion gene ID: 28462
HgeneTgene
Gene symbol

PPP2R5E

MBIP

Gene ID

5529

51562

Gene nameprotein phosphatase 2 regulatory subunit B'epsilonMAP3K12 binding inhibitory protein 1
SynonymsB56E|B56epsilon-
Cytomap

14q23.2

14q13.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoformPP2A, B subunit, B' epsilonPP2A, B subunit, B56 epsilonPP2A, B subunit, PR61 epsilonPP2A, B subunit, R5 epsilonepsilon isoform of regulatory subunit B56, protein phosphaMAP3K12-binding inhibitory protein 1MAPK upstream kinase-binding inhibitory proteinMUK-binding inhibitory protein
Modification date2018052320180523
UniProtAcc

Q16537

Q9NS73

Ensembl transtripts involved in fusion geneENST00000337537, ENST00000555899, 
ENST00000422769, ENST00000553266, 
ENST00000416007, ENST00000318473, 
ENST00000359527, ENST00000603913, 
Fusion gene scores* DoF score7 X 5 X 5=1751 X 1 X 1=1
# samples 71
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PPP2R5E [Title/Abstract] AND MBIP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMBIP

GO:0043966

histone H3 acetylation

18838386


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-GJ-A9DB-01APPP2R5Echr14

64006247

-MBIPchr14

36784121

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000337537ENST00000416007PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
Frame-shiftENST00000337537ENST00000318473PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
Frame-shiftENST00000337537ENST00000359527PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
5CDS-intronENST00000337537ENST00000603913PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
Frame-shiftENST00000555899ENST00000416007PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
Frame-shiftENST00000555899ENST00000318473PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
Frame-shiftENST00000555899ENST00000359527PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
5CDS-intronENST00000555899ENST00000603913PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
intron-3CDSENST00000422769ENST00000416007PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
intron-3CDSENST00000422769ENST00000318473PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
intron-3CDSENST00000422769ENST00000359527PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
intron-intronENST00000422769ENST00000603913PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
5UTR-3CDSENST00000553266ENST00000416007PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
5UTR-3CDSENST00000553266ENST00000318473PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
5UTR-3CDSENST00000553266ENST00000359527PPP2R5Echr14

64006247

-MBIPchr14

36784121

-
5UTR-intronENST00000553266ENST00000603913PPP2R5Echr14

64006247

-MBIPchr14

36784121

-

Top

FusionProtFeatures for PPP2R5E_MBIP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2R5E

Q16537

MBIP

Q9NS73

The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. Inhibits the MAP3K12 activity to induce the activationof the JNK/SAPK pathway. Component of the ATAC complex, a complexwith histone acetyltransferase activity on histones H3 and H4.{ECO:0000269|PubMed:19103755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PPP2R5E_MBIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PPP2R5E_MBIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP2R5EPPP2CA, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, ELAVL1, NOD2, APP, CBX5, SMAD9, EGFR, AARS, TRMT10A, TERF2IP, SAE1, TPD52L2, ZDHHC17, CLOCK, CRY1, CSNK1E, CSNK2B, DEC1, BHLHE41, FBXW11, RORC, CRY2, PPP2R5E, PPP1CA, VTI1B, MOS, DNASE2B, FAM43A, WNT3A, DCLRE1C, CDK17, CCNG1, API5, IK, PPP2R5C, MARK2, SAMHD1, CDC20, NANOG, ZNF785, PRR14, ZFPL1, DCAF11, CRIP1, KLF15, GJB7, ZNF517, LPAR4, VSIG1, TMEM206, C1QL4, CCNG2, RPS27, C19orf57, TRIM25MBIPCEP63, MBIP, NDEL1, RAP1GDS1, WDR5, DGCR6L, VTA1, CCDC85B, EPB41L3, PPFIA1, MCM7, PLEKHF2, COPS4, CSRP2BP, FXR2, NINL, LMO3, MAP3K12, CALM1, YEATS2, DR1, KAT2B, KAT2A, TADA2A, TADA3, CCDC101, PIK3R3, LIMS1, EXOC8, RAPGEF1, MYD88, LMNB1, MAPK6, HECW2, DGCR6, CCNC, LMO2, BFSP2, STX11, POLR1C, DIP2A, VPS28, MIS18A, MOAP1, DRC7, ING5, TGIF2LY, KLC3, TXLNB, TXLNA, PSME3, ZNF131, TP53RK, IQGAP3, ZZZ3, CRTAP, PHLDB3, STXBP4, P3H1, RNF40, GMCL1, CTR9, CCDC85C, FAM199X, KLHL26, RFWD3, TPRKB, CARD8, PSMC3, MED23, EWSR1, IKZF5, FAM92A1, SPERT, BRMS1, CDH19, MYF6, NCAPH2, TUBA4A, CCBL1, OSGEP, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PPP2R5E_MBIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PPP2R5E_MBIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP2R5EC1257806Chromosomal Instability1CTD_human
HgenePPP2R5EC1449861Micronuclei, Chromosome-Defective1CTD_human