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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28449

FusionGeneSummary for PPP2R5A_SPATA17

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R5A_SPATA17
Fusion gene ID: 28449
HgeneTgene
Gene symbol

PPP2R5A

SPATA17

Gene ID

5525

128153

Gene nameprotein phosphatase 2 regulatory subunit B'alphaspermatogenesis associated 17
SynonymsB56A|B56alpha|PR61AIQCH|MSRG-11|MSRG11
Cytomap

1q32.3

1q41

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformPP2A B subunit isoform B'-alphaPP2A B subunit isoform B56-alphaPP2A B subunit isoform PR61-alphaPP2A B subunit isoform R5-alphaPP2A, B subunit, B' alpha isoformPP2A, B suspermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11
Modification date2018052320180519
UniProtAcc

Q15172

Q96L03

Ensembl transtripts involved in fusion geneENST00000261461, ENST00000537030, 
ENST00000498129, 
ENST00000366933, 
ENST00000471021, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 6=216
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R5A [Title/Abstract] AND SPATA17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R5A

GO:0006470

protein dephosphorylation

24157919


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTGCTTCGA-2G-AALF-01APPP2R5Achr1

212522584

+SPATA17chr1

218040364

+
TCGALDTGCTTCGA-2G-AALF-01APPP2R5Achr1

212522584

+SPATA17chr1

218040220

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000261461ENST00000366933PPP2R5Achr1

212522584

+SPATA17chr1

218040364

+
5CDS-3UTRENST00000261461ENST00000471021PPP2R5Achr1

212522584

+SPATA17chr1

218040364

+
5CDS-3UTRENST00000537030ENST00000366933PPP2R5Achr1

212522584

+SPATA17chr1

218040364

+
5CDS-3UTRENST00000537030ENST00000471021PPP2R5Achr1

212522584

+SPATA17chr1

218040364

+
intron-3UTRENST00000498129ENST00000366933PPP2R5Achr1

212522584

+SPATA17chr1

218040364

+
intron-3UTRENST00000498129ENST00000471021PPP2R5Achr1

212522584

+SPATA17chr1

218040364

+
5CDS-intronENST00000261461ENST00000366933PPP2R5Achr1

212522584

+SPATA17chr1

218040220

+
5CDS-3UTRENST00000261461ENST00000471021PPP2R5Achr1

212522584

+SPATA17chr1

218040220

+
5CDS-intronENST00000537030ENST00000366933PPP2R5Achr1

212522584

+SPATA17chr1

218040220

+
5CDS-3UTRENST00000537030ENST00000471021PPP2R5Achr1

212522584

+SPATA17chr1

218040220

+
intron-intronENST00000498129ENST00000366933PPP2R5Achr1

212522584

+SPATA17chr1

218040220

+
intron-3UTRENST00000498129ENST00000471021PPP2R5Achr1

212522584

+SPATA17chr1

218040220

+

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FusionProtFeatures for PPP2R5A_SPATA17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2R5A

Q15172

SPATA17

Q96L03

The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP2R5A_SPATA17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP2R5A_SPATA17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP2R5AAPC, BCL2, PPP2R5C, EIF2AK2, PPP2CA, PPP2R1A, PPP2R1B, AXIN1, CTLA4, MYC, CHEK2, NEK1, CBX5, ESPL1, PTTG1, PPP2R2D, DAPK1, PPP2CB, MOS, FAM43A, WNT3A, PPP2R5D, CDC20, CDC27, BUB1B, UBE2S, PRR14, TRIM25SPATA17KDM1B, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP2R5A_SPATA17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP2R5A_SPATA17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP2R5AC0013990Pathological accumulation of air in tissues1CTD_human