![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 28449 |
FusionGeneSummary for PPP2R5A_SPATA17 |
![]() |
Fusion gene information | Fusion gene name: PPP2R5A_SPATA17 | Fusion gene ID: 28449 | Hgene | Tgene | Gene symbol | PPP2R5A | SPATA17 | Gene ID | 5525 | 128153 |
Gene name | protein phosphatase 2 regulatory subunit B'alpha | spermatogenesis associated 17 | |
Synonyms | B56A|B56alpha|PR61A | IQCH|MSRG-11|MSRG11 | |
Cytomap | 1q32.3 | 1q41 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformPP2A B subunit isoform B'-alphaPP2A B subunit isoform B56-alphaPP2A B subunit isoform PR61-alphaPP2A B subunit isoform R5-alphaPP2A, B subunit, B' alpha isoformPP2A, B su | spermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q15172 | Q96L03 | |
Ensembl transtripts involved in fusion gene | ENST00000261461, ENST00000537030, ENST00000498129, | ENST00000366933, ENST00000471021, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 6=216 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PPP2R5A [Title/Abstract] AND SPATA17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPP2R5A | GO:0006470 | protein dephosphorylation | 24157919 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | TGCT | TCGA-2G-AALF-01A | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040364 | + |
TCGA | LD | TGCT | TCGA-2G-AALF-01A | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040220 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000261461 | ENST00000366933 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040364 | + |
5CDS-3UTR | ENST00000261461 | ENST00000471021 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040364 | + |
5CDS-3UTR | ENST00000537030 | ENST00000366933 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040364 | + |
5CDS-3UTR | ENST00000537030 | ENST00000471021 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040364 | + |
intron-3UTR | ENST00000498129 | ENST00000366933 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040364 | + |
intron-3UTR | ENST00000498129 | ENST00000471021 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040364 | + |
5CDS-intron | ENST00000261461 | ENST00000366933 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040220 | + |
5CDS-3UTR | ENST00000261461 | ENST00000471021 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040220 | + |
5CDS-intron | ENST00000537030 | ENST00000366933 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040220 | + |
5CDS-3UTR | ENST00000537030 | ENST00000471021 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040220 | + |
intron-intron | ENST00000498129 | ENST00000366933 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040220 | + |
intron-3UTR | ENST00000498129 | ENST00000471021 | PPP2R5A | chr1 | 212522584 | + | SPATA17 | chr1 | 218040220 | + |
Top |
FusionProtFeatures for PPP2R5A_SPATA17 |
![]() |
Hgene | Tgene |
PPP2R5A | SPATA17 |
The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PPP2R5A_SPATA17 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PPP2R5A_SPATA17 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPP2R5A | APC, BCL2, PPP2R5C, EIF2AK2, PPP2CA, PPP2R1A, PPP2R1B, AXIN1, CTLA4, MYC, CHEK2, NEK1, CBX5, ESPL1, PTTG1, PPP2R2D, DAPK1, PPP2CB, MOS, FAM43A, WNT3A, PPP2R5D, CDC20, CDC27, BUB1B, UBE2S, PRR14, TRIM25 | SPATA17 | KDM1B, KRAS |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PPP2R5A_SPATA17 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PPP2R5A_SPATA17 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PPP2R5A | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |