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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28441

FusionGeneSummary for PPP2R3C_NFKBIA

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R3C_NFKBIA
Fusion gene ID: 28441
HgeneTgene
Gene symbol

PPP2R3C

NFKBIA

Gene ID

55012

4792

Gene nameprotein phosphatase 2 regulatory subunit B''gammaNFKB inhibitor alpha
SynonymsC14orf10|G4-1|G5prIKBA|MAD-3|NFKBI
Cytomap

14q13.2

14q13.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gammaprotein phosphatase 2 (formerly 2A), regulatory subunit B''protein phosphatase 2, regulatory subunit B'', gammaprotein phosphatase subunit G5PRrhabdomyosarcoma antigen MU-RMS-NF-kappa-B inhibitor alphaI-kappa-B-alphaIkappaBalphaikB-alphamajor histocompatibility complex enhancer-binding protein MAD3nuclear factor of kappa light chain gene enhancer in B-cellsnuclear factor of kappa light polypeptide gene enhancer in B-cell
Modification date2018052320180522
UniProtAcc

Q969Q6

P25963

Ensembl transtripts involved in fusion geneENST00000261475, ENST00000555644, 
ENST00000216797, ENST00000557140, 
ENST00000557389, ENST00000557100, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP2R3C [Title/Abstract] AND NFKBIA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFKBIA

GO:0007249

I-kappaB kinase/NF-kappaB signaling

25038658

TgeneNFKBIA

GO:0032088

negative regulation of NF-kappaB transcription factor activity

11931770

TgeneNFKBIA

GO:0033209

tumor necrosis factor-mediated signaling pathway

25038658

TgeneNFKBIA

GO:0042994

cytoplasmic sequestering of transcription factor

1493333

TgeneNFKBIA

GO:0045944

positive regulation of transcription by RNA polymerase II

19245366

TgeneNFKBIA

GO:0050729

positive regulation of inflammatory response

25038658


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A07U-01APPP2R3Cchr14

35557157

-NFKBIAchr14

35871266

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000261475ENST00000216797PPP2R3Cchr14

35557157

-NFKBIAchr14

35871266

-
Frame-shiftENST00000261475ENST00000557140PPP2R3Cchr14

35557157

-NFKBIAchr14

35871266

-
Frame-shiftENST00000261475ENST00000557389PPP2R3Cchr14

35557157

-NFKBIAchr14

35871266

-
5CDS-intronENST00000261475ENST00000557100PPP2R3Cchr14

35557157

-NFKBIAchr14

35871266

-
intron-3CDSENST00000555644ENST00000216797PPP2R3Cchr14

35557157

-NFKBIAchr14

35871266

-
intron-3CDSENST00000555644ENST00000557140PPP2R3Cchr14

35557157

-NFKBIAchr14

35871266

-
intron-3CDSENST00000555644ENST00000557389PPP2R3Cchr14

35557157

-NFKBIAchr14

35871266

-
intron-intronENST00000555644ENST00000557100PPP2R3Cchr14

35557157

-NFKBIAchr14

35871266

-

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FusionProtFeatures for PPP2R3C_NFKBIA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2R3C

Q969Q6

NFKBIA

P25963

Inhibits the activity of dimeric NF-kappa-B/RELcomplexes by trapping REL dimers in the cytoplasm through maskingof their nuclear localization signals. On cellular stimulation byimmune and proinflammatory responses, becomes phosphorylatedpromoting ubiquitination and degradation, enabling the dimericRELA to translocate to the nucleus and activate transcription.{ECO:0000269|PubMed:7479976}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP2R3C_NFKBIA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP2R3C_NFKBIA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP2R3CIKBKB, POLR1C, RTN3, CCDC33, CMTM5, PPP2CB, FGFR1OP, HSPB1, CEP128, CEP19, DYNC1H1, ITGB4, MYBL2, PCM1, LGMN, OFD1, KIAA0753, CEP350, CEP131, PPP2R1A, CCDC132, CEP72, DYNC2H1, CCDC77, NCBP2-AS2, MTNR1ANFKBIAPOM121, SUMO4, COMMD1, NCOR2, PIR, BARD1, RELA, MED19, CHUK, PTPN13, FBXW11, BTRC, TP53, VCP, NFKB1, HNRNPA1, DYNLL1, PIK3R1, IKBKB, RPS6KA1, G3BP2, REL, CAPN1, MAP3K14, IKBKAP, LYL1, HOXB7, UBE2D1, AURKA, RELB, PSMA2, HDAC3, ABL1, NCOR1, HDAC1, HDAC2, HDAC4, HDAC5, RPS3, CUL1, SKP1, SLC25A4, RASA1, CLU, MALT1, BCL10, CSNK1A1, IKBKG, CDC34, CSNK2B, HNRNPU, MAPK14, NFKBIB, TRE17, COPS2, FBXW8, PSMA4, UBE2D3, UBE2D2, UBE2L3, RWDD3, ERC1, PIN1, RPS6KA3, ITPK1, MAP3K1, DNAJA3, SOCS3, ZBTB7A, IKBKE, TBK1, ATF4, ZNF212, IKZF4, ARRB1, ARRB2, PSMA1, STAT1, PRKCA, GPS1, COPS3, POLR2C, CD7, ST7, TNF, UFD1L, NPLOC4, MTOR, NEDD9, UBE2I, MAP3K7, SPECC1L, SPDL1, NFKB2, POLR2A, DCAF6, PPP1R9A, AIDA, POLR2J, NME2P1, ANKRD27, POLRMT, YES1, SRC, SCRN2, CTU2, OGDHL, OTUB1, HIF1AN, TLDC1, PRTFDC1, UBFD1, TBC1D24, RHOA, TCEA1, DENR, BIRC2, TBCE, GNG5, CUEDC1, C6orf211, CHAC2, MAVS, XPO1, CENPF, COL7A1, ATXN3, NFKBIE, AVL9, MED31, ARHGAP39, RNF183, RNF121, AKT1, MCTS1, GNPNAT1, PLS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP2R3C_NFKBIA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNFKBIAP25963DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphasmall moleculeapproved|vet_approved

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RelatedDiseases for PPP2R3C_NFKBIA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNFKBIAC0007786Brain Ischemia1CTD_human
TgeneNFKBIAC0019829Hodgkin Disease1CTD_human
TgeneNFKBIAC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNFKBIAC0030297Pancreatic Neoplasm1CTD_human
TgeneNFKBIAC0033860Psoriasis1CTD_human
TgeneNFKBIAC0151744Myocardial Ischemia1CTD_human
TgeneNFKBIAC1458155Mammary Neoplasms1CTD_human
TgeneNFKBIAC2239176Liver carcinoma1CTD_human
TgeneNFKBIAC2677481Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant1CTD_human;UNIPROT