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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28435

FusionGeneSummary for PPP2R2C_TENM2

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R2C_TENM2
Fusion gene ID: 28435
HgeneTgene
Gene symbol

PPP2R2C

TENM2

Gene ID

5522

57451

Gene nameprotein phosphatase 2 regulatory subunit Bgammateneurin transmembrane protein 2
SynonymsB55-GAMMA|B55gamma|IMYPNO|IMYPNO1|PR52|PR55GODZ2|TEN-M2|TNM2|ten-2
Cytomap

4p16.1

5q34

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 2, regulatory subunit B, gammaPP2A, subunit B, B-gamma isoformPP2A, subunit B, B55-gamma isoformPP2A, subunit B, PR55-gamma isoformPP2A, subunit B, R2-gamma isoformgamma isoform of regulatory subunit B55, protein phosphatase 2photeneurin-2neurestin alphaodd Oz/ten-m homolog 2odz, odd Oz/ten-m homolog 2protein Odd Oz/ten-m homolog 2tenascin-M2
Modification date2018052720180523
UniProtAcc

Q9Y2T4

Q9NT68

Ensembl transtripts involved in fusion geneENST00000506140, ENST00000515571, 
ENST00000382599, ENST00000507294, 
ENST00000314348, ENST00000335585, 
ENST00000518659, ENST00000545108, 
ENST00000520393, ENST00000519204, 
ENST00000520394, ENST00000403607, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 2=32
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP2R2C [Title/Abstract] AND TENM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF363040PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000506140ENST00000518659PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000506140ENST00000545108PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000506140ENST00000520393PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000506140ENST00000519204PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000506140ENST00000520394PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000506140ENST00000403607PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000515571ENST00000518659PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000515571ENST00000545108PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000515571ENST00000520393PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000515571ENST00000519204PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000515571ENST00000520394PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000515571ENST00000403607PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000382599ENST00000518659PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000382599ENST00000545108PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000382599ENST00000520393PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000382599ENST00000519204PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000382599ENST00000520394PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000382599ENST00000403607PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000507294ENST00000518659PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000507294ENST00000545108PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000507294ENST00000520393PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000507294ENST00000519204PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000507294ENST00000520394PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000507294ENST00000403607PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000314348ENST00000518659PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000314348ENST00000545108PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000314348ENST00000520393PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000314348ENST00000519204PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000314348ENST00000520394PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000314348ENST00000403607PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000335585ENST00000518659PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-3CDSENST00000335585ENST00000545108PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000335585ENST00000520393PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000335585ENST00000519204PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000335585ENST00000520394PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+
intron-intronENST00000335585ENST00000403607PPP2R2Cchr4

6407684

-TENM2chr5

166802418

+

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FusionProtFeatures for PPP2R2C_TENM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2R2C

Q9Y2T4

TENM2

Q9NT68

The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. Involved in neural development, regulating theestablishment of proper connectivity within the nervous system.Promotes the formation of filopodia and enlarged growth cone inneuronal cells. Induces homophilic cell-cell adhesion (Bysimilarity). May function as a cellular signal transducer.{ECO:0000250, ECO:0000269|PubMed:21724987}. Isoform 2: Acts as a ligand of the ADGRL1 receptor.Mediates axon guidance and heterophilic cell-cell adhesion.{ECO:0000269|PubMed:21724987}. Ten-2 intracellular domain: Induces gene transcriptioninhibition. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP2R2C_TENM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP2R2C_TENM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP2R2C_TENM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP2R2C_TENM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP2R2CC0005586Bipolar Disorder2PSYGENET
HgenePPP2R2CC0013990Pathological accumulation of air in tissues1CTD_human
TgeneTENM2C0236969Substance-Related Disorders1CTD_human