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Fusion gene ID: 28429 |
FusionGeneSummary for PPP2R2A_ZDHHC2 |
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Fusion gene information | Fusion gene name: PPP2R2A_ZDHHC2 | Fusion gene ID: 28429 | Hgene | Tgene | Gene symbol | PPP2R2A | ZDHHC2 | Gene ID | 5520 | 51201 |
Gene name | protein phosphatase 2 regulatory subunit Balpha | zinc finger DHHC-type containing 2 | |
Synonyms | B55A|B55ALPHA|PR52A|PR55A|PR55alpha | DHHC2|ZNF372 | |
Cytomap | 8p21.2 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformprotein phosphatase 2, regulatory subunit B, alpha | palmitoyltransferase ZDHHC2DHHC-2reamrecreduced expression associated with metastasis proteinreduced expression in cancer proteintestis tissue sperm-binding protein Li 56ezinc finger DHHC domain-containing protein 2zinc finger protein 372zinc fin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P63151 | Q9UIJ5 | |
Ensembl transtripts involved in fusion gene | ENST00000380737, ENST00000315985, ENST00000523473, | ENST00000262096, | |
Fusion gene scores | * DoF score | 15 X 9 X 8=1080 | 5 X 5 X 4=100 |
# samples | 21 | 5 | |
** MAII score | log2(21/1080*10)=-2.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PPP2R2A [Title/Abstract] AND ZDHHC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPP2R2A | GO:0006470 | protein dephosphorylation | 1849734 |
Tgene | ZDHHC2 | GO:0018345 | protein palmitoylation | 23034182 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | OV | TCGA-25-1632-01A | PPP2R2A | chr8 | 26151256 | + | ZDHHC2 | chr8 | 17074681 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000380737 | ENST00000262096 | PPP2R2A | chr8 | 26151256 | + | ZDHHC2 | chr8 | 17074681 | + |
Frame-shift | ENST00000315985 | ENST00000262096 | PPP2R2A | chr8 | 26151256 | + | ZDHHC2 | chr8 | 17074681 | + |
3UTR-3CDS | ENST00000523473 | ENST00000262096 | PPP2R2A | chr8 | 26151256 | + | ZDHHC2 | chr8 | 17074681 | + |
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FusionProtFeatures for PPP2R2A_ZDHHC2 |
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Hgene | Tgene |
PPP2R2A | ZDHHC2 |
The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. | Palmitoyltransferase specific for GAP43 and DLG4/PSD95.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP2R2A_ZDHHC2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP2R2A_ZDHHC2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPP2R2A | FAM107A, TCEAL1, PPP2CA, PPP2R1B, EIF4EBP1, MTOR, RPS6KB1, RRN3, PPP2R1A, PPP2CB, TGFBR1, MLH1, PPP2R2D, CDCA4, SKIV2L2, CCT5, CCT8, CCT2, CCT4, CCT7, TUBA4A, CCT3, TCP1, FABP5, DSP, DSG1, CCT6A, GAPDH, HDAC5, NDRG1, ELAVL1, CUL3, PTPN14, GRK5, NOTCH1, SMURF1, GRB2, CFTR, EGFR, CDK17, CDK16, LATS2, HSPA4L, NRD1, CACNA1S, PPP3CA, THUMPD1, ABCE1, FAM122A, SERTAD4, IER2, RPS6KB2, NCAPD3, PPP2R5C, PPP2R5D, WDR4, NTRK1, AHI1, XPO1, PPME1, FOXC1, FOXC2, GC, RPS28, YARS, RBM7, RAB11FIP5, ECSIT, FBXL16, CRY2, MCM2, NOSIP, C1orf131, PTAR1, WWP2, DERL1, DUSP19, PHLPP1, PPP4C, PTPDC1, FOXD4, FAM19A3, AR, UBE2A | ZDHHC2 | MSX2, MAFB |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP2R2A_ZDHHC2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP2R2A_ZDHHC2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PPP2R2A | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |
Hgene | PPP2R2A | C1257806 | Chromosomal Instability | 1 | CTD_human |
Hgene | PPP2R2A | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
Tgene | ZDHHC2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ZDHHC2 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | ZDHHC2 | C0043094 | Weight Gain | 1 | CTD_human |