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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28425

FusionGeneSummary for PPP2R2A_PPP2R2A

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2R2A_PPP2R2A
Fusion gene ID: 28425
HgeneTgene
Gene symbol

PPP2R2A

PPP2R2A

Gene ID

5520

5520

Gene nameprotein phosphatase 2 regulatory subunit Balphaprotein phosphatase 2 regulatory subunit Balpha
SynonymsB55A|B55ALPHA|PR52A|PR55A|PR55alphaB55A|B55ALPHA|PR52A|PR55A|PR55alpha
Cytomap

8p21.2

8p21.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformprotein phosphatase 2, regulatory subunit B, alphaserine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformprotein phosphatase 2, regulatory subunit B, alpha
Modification date2018052320180523
UniProtAcc

P63151

P63151

Ensembl transtripts involved in fusion geneENST00000380737, ENST00000315985, 
ENST00000523473, 		ENST00000380737, 
ENST00000315985, ENST00000523473, 
Fusion gene scores* DoF score15 X 9 X 8=10806 X 8 X 4=192
# samples 219
** MAII scorelog2(21/1080*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2R2A [Title/Abstract] AND PPP2R2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP2R2A

GO:0006470

protein dephosphorylation

1849734

TgenePPP2R2A

GO:0006470

protein dephosphorylation

1849734


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW879061PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
ChiTaRS3.1AW879127PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
ChiTaRS3.1AL050206PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
ChiTaRS3.1AL041184PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000380737ENST00000380737PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
3UTR-3UTRENST00000380737ENST00000315985PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
3UTR-intronENST00000380737ENST00000523473PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
3UTR-3UTRENST00000315985ENST00000380737PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
3UTR-3UTRENST00000315985ENST00000315985PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
3UTR-intronENST00000315985ENST00000523473PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
intron-3UTRENST00000523473ENST00000380737PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
intron-3UTRENST00000523473ENST00000315985PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
intron-intronENST00000523473ENST00000523473PPP2R2Achr8

26228218

+PPP2R2Achr8

26228107

-
3UTR-3UTRENST00000380737ENST00000380737PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
3UTR-intronENST00000380737ENST00000315985PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
3UTR-intronENST00000380737ENST00000523473PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
intron-3UTRENST00000315985ENST00000380737PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
intron-intronENST00000315985ENST00000315985PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
intron-intronENST00000315985ENST00000523473PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
intron-3UTRENST00000523473ENST00000380737PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
intron-intronENST00000523473ENST00000315985PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
intron-intronENST00000523473ENST00000523473PPP2R2Achr8

26228891

-PPP2R2Achr8

26228929

+
intron-intronENST00000380737ENST00000380737PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-
intron-intronENST00000380737ENST00000315985PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-
intron-intronENST00000380737ENST00000523473PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-
intron-intronENST00000315985ENST00000380737PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-
intron-intronENST00000315985ENST00000315985PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-
intron-intronENST00000315985ENST00000523473PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-
intron-intronENST00000523473ENST00000380737PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-
intron-intronENST00000523473ENST00000315985PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-
intron-intronENST00000523473ENST00000523473PPP2R2Achr8

25282682

+PPP2R2Achr8

25282518

-

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FusionProtFeatures for PPP2R2A_PPP2R2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2R2A

P63151

PPP2R2A

P63151

The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment. The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP2R2A_PPP2R2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP2R2A_PPP2R2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP2R2A_PPP2R2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP2R2A_PPP2R2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP2R2AC0013990Pathological accumulation of air in tissues1CTD_human
HgenePPP2R2AC1257806Chromosomal Instability1CTD_human
HgenePPP2R2AC1449861Micronuclei, Chromosome-Defective1CTD_human
TgenePPP2R2AC0013990Pathological accumulation of air in tissues1CTD_human
TgenePPP2R2AC1257806Chromosomal Instability1CTD_human
TgenePPP2R2AC1449861Micronuclei, Chromosome-Defective1CTD_human