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Fusion gene ID: 28412 |
FusionGeneSummary for PPP2R1A_ZNF665 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2R1A_ZNF665 | Fusion gene ID: 28412 | Hgene | Tgene | Gene symbol | PPP2R1A | ZNF665 | Gene ID | 5518 | 79788 |
| Gene name | protein phosphatase 2 scaffold subunit Aalpha | zinc finger protein 665 | |
| Synonyms | MRD36|PP2A-Aalpha|PP2AA|PP2AAALPHA|PR65A | ZFP160L | |
| Cytomap | 19q13.41 | 19q13.42 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformPP2A subunit A isoform PR65-alphaPP2A subunit A isoform R1-alphamedium tumor antigen-associated 61 KDA proteinprotein phosphatase 2 (formerly 2A), regulatory subunit A (P | zinc finger protein 665 | |
| Modification date | 20180526 | 20180523 | |
| UniProtAcc | P30153 | Q9H7R5 | |
| Ensembl transtripts involved in fusion gene | ENST00000322088, ENST00000444322, ENST00000477989, ENST00000462990, ENST00000473455, | ENST00000600412, ENST00000396424, ENST00000598440, | |
| Fusion gene scores | * DoF score | 6 X 6 X 6=216 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/216*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PPP2R1A [Title/Abstract] AND ZNF665 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP2R1A | GO:0007059 | chromosome segregation | 16580887 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-19-A6J5-01A | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000322088 | ENST00000600412 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| 5CDS-5UTR | ENST00000322088 | ENST00000396424 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| 5CDS-intron | ENST00000322088 | ENST00000598440 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| 5CDS-5UTR | ENST00000444322 | ENST00000600412 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| 5CDS-5UTR | ENST00000444322 | ENST00000396424 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| 5CDS-intron | ENST00000444322 | ENST00000598440 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| intron-5UTR | ENST00000477989 | ENST00000600412 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| intron-5UTR | ENST00000477989 | ENST00000396424 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| intron-intron | ENST00000477989 | ENST00000598440 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| 5CDS-5UTR | ENST00000462990 | ENST00000600412 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| 5CDS-5UTR | ENST00000462990 | ENST00000396424 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| 5CDS-intron | ENST00000462990 | ENST00000598440 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| intron-5UTR | ENST00000473455 | ENST00000600412 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| intron-5UTR | ENST00000473455 | ENST00000396424 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
| intron-intron | ENST00000473455 | ENST00000598440 | PPP2R1A | chr19 | 52716363 | + | ZNF665 | chr19 | 53669600 | - |
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FusionProtFeatures for PPP2R1A_ZNF665 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2R1A | ZNF665 |
| The PR65 subunit of protein phosphatase 2A serves as ascaffolding molecule to coordinate the assembly of the catalyticsubunit and a variable regulatory B subunit. Upon interaction withGNA12 promotes dephosphorylation of microtubule associated proteinTAU/MAPT (PubMed:15525651). Required for proper chromosomesegregation and for centromeric localization of SGO1 in mitosis(PubMed:16580887). {ECO:0000269|PubMed:15525651,ECO:0000269|PubMed:16580887}. | May be involved in transcriptional regulation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP2R1A_ZNF665 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP2R1A_ZNF665 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPP2R1A | STK24, MCC, PPP4C, IKBKE, CTNNBIP1, ARIH2, CTTNBP2, CTTNBP2NL, STRIP1, MOB4, PDCD10, PPP2CA, PPP2R2A, STRN, STRN3, PPP2R5D, PPP2R1B, STRN4, PPP2R5C, PPP2R2D, PPME1, PPP2R5E, PPFIA1, PPP2R5A, PPP2R3B, PPFIA2, STK26, SIKE1, STK25, TRAF3IP3, PPP2CB, PPP2R2C, MLH1, PMS1, INTS1, INTS3, INTS5, INTS6, UBC, PRR14L, SGOL1, PRR14, SERTAD4, ZCCHC8, SKIV2L2, ANKLE2, FGFR1OP, RBM7, CEP350, SLMAP, S100A9, LPP, PPP2R2B, FGFR1OP2, CDK1, CDK4, HDAC1, MCM3, PRDX1, PRDX2, PARK7, RAB18, RAB7A, RAB11A, MARCH1, EEF2, RAP1A, ANAPC10, TRADD, HDAC5, PPP2R4, STUB1, MID1, MARK4, AIMP2, MAPK6, CHEK2, ELAVL1, ARRB2, SIRT7, HDAC4, SPRY2, CUL3, CUL4A, HSP90AA1, HSPA8, EEF1A1, RPSA, ANXA2, C1QBP, RPS3, GNB2L1, NPM1, RPS8, PTPN14, VCP, CAV1, NOTCH1, KLHL15, MAP3K7, SMURF1, KIAA1524, LRRK2, NFATC2, VCAM1, FN1, NOS2, ZFYVE9, SMAD3, SMAD2, ITGA4, CFTR, RAF1, AICDA, FBXW4, EGFR, PLA2G16, TAB1, AKT1, LATS2, BTF3, DNAAF5, NACA, UGGT1, TNPO3, CCDC43, CCDC6, CLCN6, CTNNA2, HSPA1A, DGKH, FECH, HSPA7, IRS4, LOC730668, PACSIN1, PEX1, POLDIP2, PPFIA3, PPP1R12B, PSIP1, RAVER1, RBMX, RPS19, SERTAD1, SRGAP2, TCEAL4, TDRD9, TFAM, ZFAND6, ESPL1, CSDC2, CUL7, OBSL1, CCDC8, DAPK1, ESR1, CSNK2B, DEC1, RORC, ZNF219, FAM122A, ZNF114, IER2, SIK2, RPS6KB2, HNRNPA1, ACADM, ATAD3B, ATP1A1, CANX, EHD1, GFPT1, GFPT2, HSD17B12, IDH3A, NFS1, PC, CLTC, CLTCL1, CYC1, EHD2, RIF1, SLC25A3, THOC6, VPS13D, RPN1, RPN2, SCD, SCD5, TMCO1, TOMM22, UQCRC2, NTRK1, AHI1, ATP6V1C1, FOXC1, FOXC2, MARK2, PPP4R1, ABI1, FAN1, SAMHD1, NABP1, VWA9, PPP2R3A, SET, PPFIBP1, DYNLL1, LIMD1, ARHGEF2, FAM13A, MTCL1, NCAPH2, PLEKHA5, CPSF3L, PPP2R3C, CDCA4, TBCCD1, ABCF3, INTS9, INTS12, INTS2, INTS4, SOGA1, FBXL16, SGOL2, TP53, FOXO3, CRY1, MACROD1, MCM2, SNW1, CDC5L, VPRBP, CDC20, NOSIP, ESRRB, CARD11, BCL10, AMBRA1, PECAM1, C1orf131, WWP2, DERL1, SYNM, DUSP19, PHLPP1, PTPDC1, FOXD4, ZNF517, ZNF331, ZNF550, NCAPD3, ARL6IP5, VAMP7, C21orf2, BBS12, DLD, DLST, HSD17B10, SDHA, SOD1, TRIM25, G3BP1, YAP1, URI1 | ZNF665 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP2R1A_ZNF665 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP2R1A_ZNF665 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPP2R1A | C4225352 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 36 | 2 | ORPHANET;UNIPROT |
| Hgene | PPP2R1A | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | PPP2R1A | C0038356 | Stomach Neoplasms | 1 | CTD_human |
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