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Fusion gene ID: 28404 |
FusionGeneSummary for PPP2CB_DLC1 |
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Fusion gene information | Fusion gene name: PPP2CB_DLC1 | Fusion gene ID: 28404 | Hgene | Tgene | Gene symbol | PPP2CB | DLC1 | Gene ID | 5516 | 10395 |
Gene name | protein phosphatase 2 catalytic subunit beta | DLC1 Rho GTPase activating protein | |
Synonyms | PP2Abeta|PP2CB | ARHGAP7|HP|STARD12|p122-RhoGAP | |
Cytomap | 8p12 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 2A catalytic subunit beta isoformPP2A-betaprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta iso | rho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P62714 | Q96QB1 | |
Ensembl transtripts involved in fusion gene | ENST00000520500, ENST00000221138, ENST00000518564, | ENST00000276297, ENST00000358919, ENST00000512044, ENST00000316609, ENST00000511869, ENST00000510318, ENST00000520226, | |
Fusion gene scores | * DoF score | 4 X 3 X 5=60 | 8 X 7 X 4=224 |
# samples | 5 | 8 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PPP2CB [Title/Abstract] AND DLC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DLC1 | GO:0006915 | apoptotic process | 17292327 |
Tgene | DLC1 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 17888903 |
Tgene | DLC1 | GO:0008285 | negative regulation of cell proliferation | 12545165|17932950 |
Tgene | DLC1 | GO:0030336 | negative regulation of cell migration | 17932950|19158340 |
Tgene | DLC1 | GO:0035307 | positive regulation of protein dephosphorylation | 17292327 |
Tgene | DLC1 | GO:0051497 | negative regulation of stress fiber assembly | 17932950 |
Tgene | DLC1 | GO:0051895 | negative regulation of focal adhesion assembly | 19158340 |
Tgene | DLC1 | GO:1900119 | positive regulation of execution phase of apoptosis | 17888903 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-2Y-A9H8-01A | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000520500 | ENST00000276297 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
intron-3CDS | ENST00000520500 | ENST00000358919 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
intron-3CDS | ENST00000520500 | ENST00000512044 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
intron-intron | ENST00000520500 | ENST00000316609 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
intron-intron | ENST00000520500 | ENST00000511869 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
intron-intron | ENST00000520500 | ENST00000510318 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
intron-5UTR | ENST00000520500 | ENST00000520226 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
Frame-shift | ENST00000221138 | ENST00000276297 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
Frame-shift | ENST00000221138 | ENST00000358919 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
Frame-shift | ENST00000221138 | ENST00000512044 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
5CDS-intron | ENST00000221138 | ENST00000316609 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
5CDS-intron | ENST00000221138 | ENST00000511869 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
5CDS-intron | ENST00000221138 | ENST00000510318 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
5CDS-5UTR | ENST00000221138 | ENST00000520226 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
Frame-shift | ENST00000518564 | ENST00000276297 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
Frame-shift | ENST00000518564 | ENST00000358919 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
Frame-shift | ENST00000518564 | ENST00000512044 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
5CDS-intron | ENST00000518564 | ENST00000316609 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
5CDS-intron | ENST00000518564 | ENST00000511869 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
5CDS-intron | ENST00000518564 | ENST00000510318 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
5CDS-5UTR | ENST00000518564 | ENST00000520226 | PPP2CB | chr8 | 30669836 | - | DLC1 | chr8 | 12973166 | - |
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FusionProtFeatures for PPP2CB_DLC1 |
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Hgene | Tgene |
PPP2CB | DLC1 |
PP2A can modulate the activity of phosphorylase B kinasecasein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.{ECO:0000269|PubMed:2555176}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP2CB_DLC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP2CB_DLC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPP2CB | STK24, PPP4C, ARL2, TLX1, RELA, PPP2R1A, STRN, STRIP1, STRN4, STRN3, TCP1, CCT2, CCT6A, CTTNBP2NL, MOB4, CCT3, CCT5, IGBP1, PPP2R2A, CCT8, CCT7, CCT4, FGFR1OP, PPP2R5D, CTTNBP2, TIPRL, PPP2R1B, INTS1, INTS6, INTS3, INTS5, TERF1, ACTBL2, PRR14L, SGOL1, MYLPF, SIKE1, PRR14, PPME1, ANKLE2, PFDN6, PPFIA1, SLMAP, VBP1, PPP2R5E, PPP2R5C, PFDN5, PFDN2, PPP2R2B, PPP2R2D, MYH10, ADARB1, HDAC5, MARK4, ZNF775, ZFP28, DOCK7, C22orf39, TCTEX1D2, RPLP1, PLXNA3, ACP5, CBX5, NOTCH1, VCP, ITGA4, MAK, TAB1, GSTA1, HK3, RAF1, TAB2, TRMT61B, CDK17, CDK18, CDK16, AARSD1, ATG7, NIF3L1, NSUN2, ELAC2, WDR12, TTC1, ASB5, STK25, STK26, SNAI2, ZFP36, BHLHE41, CEP350, STRIP2, CCDC6, TBCCD1, NDUFAF1, PPP4R1, PPP2R5A, FECH, PPP2R3C, PPP2R3B, FGFR1OP2, FOXC1, ZNF444, SERTAD4, HMGCS1, PPP2CA, IFI16, MARK3, SET, PPFIA3, MAP7, MAP4K4, PDCD10, CEP131, DECR2, PKN3, PLEKHA5, CPSF3L, CEP72, INTS9, INTS12, SMEK2, INTS2, INTS4, TMEM41B, CCDC61, FOXO3, CRY1, CRY2, ESR1, CDC20, NOSIP, ESRRB, ARHGEF2, CAMSAP3, ENSA, FAM122A, FAM122B, FBXL16, IK, PPP2R4, TBC1D4, TTC33, WDR61, FOXD4, TRIM25, URI1 | DLC1 | WWC1, S100A10, TENC1, CAV1, CUL1, CUL2, CUL3, CUL4A, DDB1, FBXW5, AKT1, RPS6KA1, WWC2, WWC3, FBXW7, LACC1, FEM1B, C17orf75, PTEN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP2CB_DLC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP2CB_DLC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DLC1 | C0038356 | Stomach Neoplasms | 1 | CTD_human;HPO |
Tgene | DLC1 | C0919267 | ovarian neoplasm | 1 | CTD_human |