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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28404

FusionGeneSummary for PPP2CB_DLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP2CB_DLC1
Fusion gene ID: 28404
HgeneTgene
Gene symbol

PPP2CB

DLC1

Gene ID

5516

10395

Gene nameprotein phosphatase 2 catalytic subunit betaDLC1 Rho GTPase activating protein
SynonymsPP2Abeta|PP2CBARHGAP7|HP|STARD12|p122-RhoGAP
Cytomap

8p12

8p22

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2A catalytic subunit beta isoformPP2A-betaprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta isoformprotein phosphatase 2, catalytic subunit, beta isorho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia
Modification date2018052220180519
UniProtAcc

P62714

Q96QB1

Ensembl transtripts involved in fusion geneENST00000520500, ENST00000221138, 
ENST00000518564, 
ENST00000276297, 
ENST00000358919, ENST00000512044, 
ENST00000316609, ENST00000511869, 
ENST00000510318, ENST00000520226, 
Fusion gene scores* DoF score4 X 3 X 5=608 X 7 X 4=224
# samples 58
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP2CB [Title/Abstract] AND DLC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDLC1

GO:0006915

apoptotic process

17292327

TgeneDLC1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

TgeneDLC1

GO:0008285

negative regulation of cell proliferation

12545165|17932950

TgeneDLC1

GO:0030336

negative regulation of cell migration

17932950|19158340

TgeneDLC1

GO:0035307

positive regulation of protein dephosphorylation

17292327

TgeneDLC1

GO:0051497

negative regulation of stress fiber assembly

17932950

TgeneDLC1

GO:0051895

negative regulation of focal adhesion assembly

19158340

TgeneDLC1

GO:1900119

positive regulation of execution phase of apoptosis

17888903


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-2Y-A9H8-01APPP2CBchr8

30669836

-DLC1chr8

12973166

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000520500ENST00000276297PPP2CBchr8

30669836

-DLC1chr8

12973166

-
intron-3CDSENST00000520500ENST00000358919PPP2CBchr8

30669836

-DLC1chr8

12973166

-
intron-3CDSENST00000520500ENST00000512044PPP2CBchr8

30669836

-DLC1chr8

12973166

-
intron-intronENST00000520500ENST00000316609PPP2CBchr8

30669836

-DLC1chr8

12973166

-
intron-intronENST00000520500ENST00000511869PPP2CBchr8

30669836

-DLC1chr8

12973166

-
intron-intronENST00000520500ENST00000510318PPP2CBchr8

30669836

-DLC1chr8

12973166

-
intron-5UTRENST00000520500ENST00000520226PPP2CBchr8

30669836

-DLC1chr8

12973166

-
Frame-shitENST00000221138ENST00000276297PPP2CBchr8

30669836

-DLC1chr8

12973166

-
Frame-shitENST00000221138ENST00000358919PPP2CBchr8

30669836

-DLC1chr8

12973166

-
Frame-shitENST00000221138ENST00000512044PPP2CBchr8

30669836

-DLC1chr8

12973166

-
5CDS-intronENST00000221138ENST00000316609PPP2CBchr8

30669836

-DLC1chr8

12973166

-
5CDS-intronENST00000221138ENST00000511869PPP2CBchr8

30669836

-DLC1chr8

12973166

-
5CDS-intronENST00000221138ENST00000510318PPP2CBchr8

30669836

-DLC1chr8

12973166

-
5CDS-5UTRENST00000221138ENST00000520226PPP2CBchr8

30669836

-DLC1chr8

12973166

-
Frame-shitENST00000518564ENST00000276297PPP2CBchr8

30669836

-DLC1chr8

12973166

-
Frame-shitENST00000518564ENST00000358919PPP2CBchr8

30669836

-DLC1chr8

12973166

-
Frame-shitENST00000518564ENST00000512044PPP2CBchr8

30669836

-DLC1chr8

12973166

-
5CDS-intronENST00000518564ENST00000316609PPP2CBchr8

30669836

-DLC1chr8

12973166

-
5CDS-intronENST00000518564ENST00000511869PPP2CBchr8

30669836

-DLC1chr8

12973166

-
5CDS-intronENST00000518564ENST00000510318PPP2CBchr8

30669836

-DLC1chr8

12973166

-
5CDS-5UTRENST00000518564ENST00000520226PPP2CBchr8

30669836

-DLC1chr8

12973166

-

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FusionProtFeatures for PPP2CB_DLC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP2CB

P62714

DLC1

Q96QB1

PP2A can modulate the activity of phosphorylase B kinasecasein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.{ECO:0000269|PubMed:2555176}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP2CB_DLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP2CB_DLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP2CBSTK24, PPP4C, ARL2, TLX1, RELA, PPP2R1A, STRN, STRIP1, STRN4, STRN3, TCP1, CCT2, CCT6A, CTTNBP2NL, MOB4, CCT3, CCT5, IGBP1, PPP2R2A, CCT8, CCT7, CCT4, FGFR1OP, PPP2R5D, CTTNBP2, TIPRL, PPP2R1B, INTS1, INTS6, INTS3, INTS5, TERF1, ACTBL2, PRR14L, SGOL1, MYLPF, SIKE1, PRR14, PPME1, ANKLE2, PFDN6, PPFIA1, SLMAP, VBP1, PPP2R5E, PPP2R5C, PFDN5, PFDN2, PPP2R2B, PPP2R2D, MYH10, ADARB1, HDAC5, MARK4, ZNF775, ZFP28, DOCK7, C22orf39, TCTEX1D2, RPLP1, PLXNA3, ACP5, CBX5, NOTCH1, VCP, ITGA4, MAK, TAB1, GSTA1, HK3, RAF1, TAB2, TRMT61B, CDK17, CDK18, CDK16, AARSD1, ATG7, NIF3L1, NSUN2, ELAC2, WDR12, TTC1, ASB5, STK25, STK26, SNAI2, ZFP36, BHLHE41, CEP350, STRIP2, CCDC6, TBCCD1, NDUFAF1, PPP4R1, PPP2R5A, FECH, PPP2R3C, PPP2R3B, FGFR1OP2, FOXC1, ZNF444, SERTAD4, HMGCS1, PPP2CA, IFI16, MARK3, SET, PPFIA3, MAP7, MAP4K4, PDCD10, CEP131, DECR2, PKN3, PLEKHA5, CPSF3L, CEP72, INTS9, INTS12, SMEK2, INTS2, INTS4, TMEM41B, CCDC61, FOXO3, CRY1, CRY2, ESR1, CDC20, NOSIP, ESRRB, ARHGEF2, CAMSAP3, ENSA, FAM122A, FAM122B, FBXL16, IK, PPP2R4, TBC1D4, TTC33, WDR61, FOXD4, TRIM25, URI1DLC1WWC1, S100A10, TENC1, CAV1, CUL1, CUL2, CUL3, CUL4A, DDB1, FBXW5, AKT1, RPS6KA1, WWC2, WWC3, FBXW7, LACC1, FEM1B, C17orf75, PTEN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP2CB_DLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP2CB_DLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDLC1C0038356Stomach Neoplasms1CTD_human;HPO
TgeneDLC1C0919267ovarian neoplasm1CTD_human