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Fusion gene ID: 28396 |
FusionGeneSummary for PPP2CA_CDKL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP2CA_CDKL3 | Fusion gene ID: 28396 | Hgene | Tgene | Gene symbol | PPP2CA | CDKL3 | Gene ID | 5515 | 51265 |
| Gene name | protein phosphatase 2 catalytic subunit alpha | cyclin dependent kinase like 3 | |
| Synonyms | PP2Ac|PP2CA|PP2Calpha|RP-C | NKIAMRE | |
| Cytomap | 5q31.1 | 5q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformPP2A-alphaprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformprotein phosphatase 2, catalytic subunit, alpha isozymereplication protein Cserine/threonine protein | cyclin-dependent kinase-like 3serine-threonine protein kinase NKIAMRE | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P67775 | Q8IVW4 | |
| Ensembl transtripts involved in fusion gene | ENST00000481195, ENST00000231504, | ENST00000609654, ENST00000609383, ENST00000536186, ENST00000435240, ENST00000265334, ENST00000523054, ENST00000521118, ENST00000523832, ENST00000521755, ENST00000435211, ENST00000522501, | |
| Fusion gene scores | * DoF score | 9 X 6 X 6=324 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PPP2CA [Title/Abstract] AND CDKL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AO-A0JD-01A | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000481195 | ENST00000609654 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| In-frame | ENST00000481195 | ENST00000609383 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| In-frame | ENST00000481195 | ENST00000536186 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| In-frame | ENST00000481195 | ENST00000435240 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| In-frame | ENST00000481195 | ENST00000265334 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| In-frame | ENST00000481195 | ENST00000523054 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| In-frame | ENST00000481195 | ENST00000521118 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5CDS-intron | ENST00000481195 | ENST00000523832 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5CDS-intron | ENST00000481195 | ENST00000521755 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5CDS-intron | ENST00000481195 | ENST00000435211 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5CDS-intron | ENST00000481195 | ENST00000522501 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-3CDS | ENST00000231504 | ENST00000609654 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-3CDS | ENST00000231504 | ENST00000609383 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-3CDS | ENST00000231504 | ENST00000536186 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-3CDS | ENST00000231504 | ENST00000435240 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-3CDS | ENST00000231504 | ENST00000265334 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-3CDS | ENST00000231504 | ENST00000523054 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-3CDS | ENST00000231504 | ENST00000521118 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-intron | ENST00000231504 | ENST00000523832 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-intron | ENST00000231504 | ENST00000521755 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-intron | ENST00000231504 | ENST00000435211 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
| 5UTR-intron | ENST00000231504 | ENST00000522501 | PPP2CA | chr5 | 133561451 | - | CDKL3 | chr5 | 133640258 | - |
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FusionProtFeatures for PPP2CA_CDKL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP2CA | CDKL3 |
| PP2A is the major phosphatase for microtubule-associatedproteins (MAPs). PP2A can modulate the activity of phosphorylase Bkinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2kinase. Cooperates with SGO2 to protect centromeric cohesin fromseparase-mediated cleavage in oocytes specifically during meiosisI (By similarity). Can dephosphorylate SV40 large T antigen andp53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.{ECO:0000250, ECO:0000269|PubMed:10801873,ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:9920888}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CDKL3 | chr5:133561451 | chr5:133640258 | ENST00000435211 | - | 0 | 9 | 4_286 | -40 | 456 | Domain | Protein kinase |
| Tgene | >CDKL3 | chr5:133561451 | chr5:133640258 | ENST00000523832 | - | 0 | 8 | 4_286 | 0 | 456 | Domain | Protein kinase |
| Tgene | >CDKL3 | chr5:133561451 | chr5:133640258 | ENST00000435211 | - | 0 | 9 | 44_50 | -40 | 456 | Motif | Note=[NKR]KIAxRE |
| Tgene | >CDKL3 | chr5:133561451 | chr5:133640258 | ENST00000523832 | - | 0 | 8 | 44_50 | 0 | 456 | Motif | Note=[NKR]KIAxRE |
| Tgene | >CDKL3 | chr5:133561451 | chr5:133640258 | ENST00000435211 | - | 0 | 9 | 10_18 | -40 | 456 | Nucleotide binding | ATP |
| Tgene | >CDKL3 | chr5:133561451 | chr5:133640258 | ENST00000523832 | - | 0 | 8 | 10_18 | 0 | 456 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CDKL3 | chr5:133561451 | chr5:133640258 | ENST00000265334 | - | 9 | 13 | 4_286 | 486 | 593 | Domain | Protein kinase |
| Tgene | CDKL3 | chr5:133561451 | chr5:133640258 | ENST00000265334 | - | 9 | 13 | 44_50 | 486 | 593 | Motif | Note=[NKR]KIAxRE |
| Tgene | CDKL3 | chr5:133561451 | chr5:133640258 | ENST00000265334 | - | 9 | 13 | 10_18 | 486 | 593 | Nucleotide binding | ATP |
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FusionGeneSequence for PPP2CA_CDKL3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP2CA_CDKL3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPP2CA | TRIP13, TBCD, ARL2, TLX1, ISYNA1, MRPS26, PTN, CSNK1A1, PPM1B, CDK2, CDK6, ETF1, RELA, CCNG2, PPP2R5C, PXN, PPP2R3B, PPP2R3A, PPP2R2A, BEST1, CTTNBP2, CTTNBP2NL, STRIP1, MOB4, PDCD10, PPP2R1A, STRN, STRN3, PPP2R5D, PPP2R1B, STRN4, PPP2R2D, PPME1, PPP2R5E, PPFIA1, IGBP1, CCT2, CCT8, CCT3, TCP1, CCT5, CCT6A, CCT7, PPFIA3, PPP2R5A, CCT4, PPFIA2, FGFR1OP, PPP2R5B, STK26, SIKE1, STK24, STK25, TRAF3IP3, PPP2R2C, PRKCD, BCL2, SGK1, SPRY2, PMS2, RBL2, HDAC7, HDAC4, HDAC5, MID1, INTS1, INTS6, PRKDC, TERF1, IRAK1, PRR14L, SGOL1, PRR14, TUBA8, ANKLE2, CEP350, SLMAP, KPNB1, PPP2R2B, PPP2R4, FGFR1OP2, PRKAA1, RALA, AXIN1, MYC, MAPK3, AKT1, CHEK2, TWIST1, PABPC1, CUL3, CUL5, CUL1, MAP3K3, CHUK, IKBKB, IKBKG, VCP, CAV1, PSMC6, NUBP2, CLNS1A, PIN1, DDTL, PIR, PSMD1, SOD1, PSMD3, AURKB, BRCA1, ECT2, MDC1, PAXIP1, CBX5, NOTCH1, KLHL15, SMURF1, VCAM1, FN1, ITGA4, CFTR, RAF1, CTDP1, ID1, NPM1, POLA1, BAG3, CDKN2C, MYH9, XRN1, NRD1, AHCYL1, ARPC4, HNRNPH1, NIF3L1, PFDN1, SSB, TNPO1, TNPO3, RPA3, RPA2, RPA1, ZNF346, HTT, ESPL1, ZFP36, SETBP1, VAC14, EP300, DAPK1, UNC5B, PYGM, CSNK2B, DEC1, RORC, FOXS1, LCMT1, SERTAD4, GRN, SGOL2, KNG1, ZNF114, FOXD4L6, LACC1, SIK2, CAMK1, RPS6KB2, TIPRL, UNK, FNBP1, PPAT, PPP2CB, NTRK1, RAC1, PIM1, AHI1, FECH, NPTX1, PCM1, PPP4R1, PPP4C, RP9, CCDC6, CEP131, PKN3, ATP6V1D, CPSF3L, INTS10, INTS9, INTS12, STRIP2, INTS2, INTS5, INTS4, USP7, ESR1, CDC20, CDC27, NOSIP, ESRRB, CARD11, BCL10, AMBRA1, KISS1R, AR, DUSP19, ARHGEF2, ENSA, FAM122A, FAM122B, FBXL16, TBC1D4, TTC33, UNG, WDR61, PTPDC1, FOXD4, TBCCD1, CDCA4, NCAPD3, FAM19A3, ZNF331, RFWD2, LRRC56, WNT7A, ZNF550, ZNF517, EEF1A1, ZNF785, ZFC3H1, ZNF764, TINAG, KLHDC8A, WDR86, PAK1, VHL, AKT3, AKT2, BRCA2, TRIM25, CCND2, CEBPA, URI1, TRIM28 | CDKL3 | APP, GGA1, SNRNP70, TTF2, CDK6, SRPK1, GOLGA2, MDFI, TRIM27, ZBTB14, FXR2, MTUS2, LZTS2, ATG4A, PIH1D3, CCDC155, KRTAP10-9, ZBTB8A, STAMBP, KRAS, HSPA8 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP2CA_CDKL3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP2CA_CDKL3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPP2CA | C0004096 | Asthma | 1 | CTD_human |
| Hgene | PPP2CA | C0018799 | Heart Diseases | 1 | CTD_human |
| Hgene | PPP2CA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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