	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 28320

FusionGeneSummary for PPP1R12C_RPL28

Fusion gene summary

Fusion gene information	Fusion gene name: PPP1R12C_RPL28
	Fusion gene ID: 28320
		Hgene	Tgene
	Gene symbol	PPP1R12C	RPL28
	Gene ID	54776	6158
	Gene name	protein phosphatase 1 regulatory subunit 12C	ribosomal protein L28
	Synonyms	AAVS1\|LENG3\|MBS85\|p84\|p85	L28
	Cytomap	19q13.42	19q13.42
	Type of gene	protein-coding	protein-coding
	Description	protein phosphatase 1 regulatory subunit 12Cleukocyte receptor cluster (LRC) encoded novel gene 3leukocyte receptor cluster (LRC) member 3myosin-binding subunit 85protein phosphatase 1 myosin-binding subunit of 85 kDaprotein phosphatase 1 myosin-bind	60S ribosomal protein L28large ribosomal subunit protein eL28
	Modification date	20180523	20180525
	UniProtAcc	Q9BZL4	P46779
	Ensembl transtripts involved in fusion gene	ENST00000263433, ENST00000376393, ENST00000435544,	ENST00000344063, ENST00000431533, ENST00000428193, ENST00000558815, ENST00000560583, ENST00000560055, ENST00000559463, ENST00000558131, ENST00000558752, ENST00000458349,
Fusion gene scores	* DoF score	6 X 4 X 4=96	8 X 8 X 4=256
	# samples	6	11
	** MAII score	log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/256*10)=-1.21864028647534 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPP1R12C [Title/Abstract] AND RPL28 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SKCM	TCGA-D3-A1Q4-06A	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
TCGA	LD	SKCM	TCGA-D3-A1Q4-06A	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000263433	ENST00000344063	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000431533	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000428193	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000558815	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000560583	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000560055	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000559463	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000558131	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000558752	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000458349	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-3UTR	ENST00000376393	ENST00000344063	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000376393	ENST00000431533	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000376393	ENST00000428193	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000376393	ENST00000558815	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000376393	ENST00000560583	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000376393	ENST00000560055	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000376393	ENST00000559463	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000376393	ENST00000558131	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000376393	ENST00000558752	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000376393	ENST00000458349	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-3UTR	ENST00000435544	ENST00000344063	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000435544	ENST00000431533	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000435544	ENST00000428193	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000435544	ENST00000558815	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000435544	ENST00000560583	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000435544	ENST00000560055	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000435544	ENST00000559463	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000435544	ENST00000558131	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000435544	ENST00000558752	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000435544	ENST00000458349	PPP1R12C	chr19	55623835	-	RPL28	chr19	55902922	+
5CDS-intron	ENST00000263433	ENST00000344063	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000263433	ENST00000431533	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000263433	ENST00000428193	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000263433	ENST00000558815	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000263433	ENST00000560583	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000263433	ENST00000560055	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000263433	ENST00000559463	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000263433	ENST00000558131	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000263433	ENST00000558752	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000263433	ENST00000458349	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000344063	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000431533	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000428193	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000558815	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000560583	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000560055	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000559463	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000558131	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000558752	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000376393	ENST00000458349	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000344063	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000431533	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000428193	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000558815	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000560583	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000560055	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000559463	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000558131	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000558752	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+
5CDS-intron	ENST00000435544	ENST00000458349	PPP1R12C	chr19	55623835	-	RPL28	chr19	55914311	+

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FusionProtFeatures for PPP1R12C_RPL28

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PPP1R12C Q9BZL4	RPL28 P46779
Regulates myosin phosphatase activity.{ECO:0000269\|PubMed:11399775}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for PPP1R12C_RPL28

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R12C_RPL28

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
PPP1R12C	MPRIP, IL16, PAFAH1B2, ATXN7, CACNA1A, SMAD3, NUAK1, PPP1R12C, C1orf109, RBM17, COL9A1, PPP1CB, L1TD1, JPH4	RPL28	MAGEB2, UBC, DCC, ARRB2, TDRD3, CUL2, CDK2, CUL1, COPS5, CAND1, ESR1, MAGOH, EIF4A3, PA2G4, FN1, SMAD4, UBL4A, ITGA4, PAN2, MAP2K5, FBXO6, TARDBP, GTF2I, RPL8, RPS10, RPS18, RPS19, RPS23, RPS29, RPS2, RPS3A, RPS3, GRSF1, TP53, PCSK9, CCNDBP1, BRCA1, CCDC8, RNF2, RPL23A, RPL13, RPL14, RPL19, RPL21, RPL23, RPL3, RPL34, RPL36, RPL5, RPL7, RPLP0, RPS11, RPS14, RPS15, RPS15A, RPS16, RPS25, RPL35, RPL38, RPLP1, RPLP2, RPS6, XPO1, HNRNPU, KIF11, MCM2, RC3H1, C3orf17, ZNF746, HIST1H1D, HIST1H1A, HIST1H1C, PTPRK, KLHL21, FAT4, ZDBF2, GSG2, FAT3, SIPA1L2, KIAA0020, TRO, KIAA0232, CDC42BPA, TUBB3, RPL18A, IFFO1, RRP8, CELSR2, FREM2, RBM34, AKAP11, PLCH1, RPL4, RPL26L1, PPAN-P2RY11, POLE2, GLYR1, ZNF354A, WHSC1, ZCCHC7, C1QBP, FTSJ3, POLE, ZNF644, BRIX1, RPL32, PTPRD, RPL30, RPL27, TUBA4A, DKC1, RPL18, GPR98, RPL6, ZNF184, CENPU, GPRASP2, RBM28, SDCBP, RPL7A, PEX14, ZNF865, KLHL15, RPS8, NCL, CYLD, INO80B, COX15, DNM1L, PDHA1, SOAT1, VDAC1, FOXA1, TRIM25, MTF1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for PPP1R12C_RPL28

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PPP1R12C_RPL28

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RPL28	C0043094	Weight Gain	1	CTD_human

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Fusion gene ID: 28320

FusionGeneSummary for PPP1R12C_RPL28

FusionProtFeatures for PPP1R12C_RPL28

FusionGeneSequence for PPP1R12C_RPL28

FusionGenePPI for PPP1R12C_RPL28

RelatedDrugs for PPP1R12C_RPL28

RelatedDiseases for PPP1R12C_RPL28