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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28312

FusionGeneSummary for PPP1R12B_LRRN2

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R12B_LRRN2
Fusion gene ID: 28312
HgeneTgene
Gene symbol

PPP1R12B

LRRN2

Gene ID

4660

10446

Gene nameprotein phosphatase 1 regulatory subunit 12Bleucine rich repeat neuronal 2
SynonymsMYPT2|PP1bp55FIGLER7|GAC1|LRANK1|LRRN5
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 12Bmyosin phosphatase target subunit 2myosin phosphatase-targeting subunit 2protein phosphatase 1, regulatory (inhibitor) subunit 12Bleucine-rich repeat neuronal protein 2fibronectin type III, immunoglobulin and leucine rich repeat domain 7glioma amplified on chromosome 1 proteinleucine rich and ankyrin repeats 1leucine rich repeat neuronal 5leucine-rich repeat neuronal protein 5
Modification date2018052320180523
UniProtAcc

O60237

O75325

Ensembl transtripts involved in fusion geneENST00000608999, ENST00000336894, 
ENST00000480184, ENST00000356764, 
ENST00000290419, ENST00000391959, 
ENST00000367270, 		ENST00000367176, 
ENST00000367177, ENST00000496057, 
ENST00000367175, 
Fusion gene scores* DoF score8 X 6 X 4=1924 X 1 X 4=16
# samples 94
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP1R12B [Title/Abstract] AND LRRN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-69-7979-01APPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000608999ENST00000367176PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000608999ENST00000367177PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000608999ENST00000496057PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000608999ENST00000367175PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000336894ENST00000367176PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000336894ENST00000367177PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000336894ENST00000496057PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000336894ENST00000367175PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000480184ENST00000367176PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000480184ENST00000367177PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000480184ENST00000496057PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000480184ENST00000367175PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000356764ENST00000367176PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000356764ENST00000367177PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000356764ENST00000496057PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
5CDS-5UTRENST00000356764ENST00000367175PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000290419ENST00000367176PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000290419ENST00000367177PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000290419ENST00000496057PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000290419ENST00000367175PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000391959ENST00000367176PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000391959ENST00000367177PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000391959ENST00000496057PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000391959ENST00000367175PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000367270ENST00000367176PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000367270ENST00000367177PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000367270ENST00000496057PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-
intron-5UTRENST00000367270ENST00000367175PPP1R12Bchr1

202318270

+LRRN2chr1

204589346

-

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FusionProtFeatures for PPP1R12B_LRRN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R12B

O60237

LRRN2

O75325


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R12B_LRRN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R12B_LRRN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP1R12BIL16, HSPA8, PRKG1, PPP1CB, COPS6, PAN2, NUAK1, PPP2R1A, FKBP6, SKP1, PIK3R3, CD14, MYH9, IQGAP1, SYNPO, ANLN, MYO19, MYO18ALRRN2NEUROD4, XIAP, BIRC2, TRIM13, ETNK1, LRIG3, FBXO11, ST7L, TRAF2, FGFR1, USP22, GYLTL1B, DNAJC18, ATP1A3, ATF6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1R12B_LRRN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1R12B_LRRN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource