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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28291

FusionGeneSummary for PPP1R10_MUS81

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1R10_MUS81
Fusion gene ID: 28291
HgeneTgene
Gene symbol

PPP1R10

MUS81

Gene ID

5514

80198

Gene nameprotein phosphatase 1 regulatory subunit 10MUS81 structure-specific endonuclease subunit
SynonymsCAT53|FB19|PNUTS|PP1R10|R111|p99SLX3
Cytomap

6p21.33

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 1 regulatory subunit 10HLA-C associated transcript 53MHC class I region proline-rich protein CAT53PP1-binding protein of 114 kDaphosphatase 1 nuclear targeting subunitprotein phosphatase 1, regulatory (inhibitor) crossover junction endonuclease MUS81MUS81 endonuclease homologSLX3 structure-specific endonuclease subunit homolog
Modification date2018051920180523
UniProtAcc

Q96QC0

Q96NY9

Ensembl transtripts involved in fusion geneENST00000376511, ENST00000484449, 
ENST00000420949, ENST00000549281, 
ENST00000468706, ENST00000449113, 
ENST00000547333, ENST00000475926, 
ENST00000426299, ENST00000551493, 
ENST00000494003, ENST00000383586, 
ENST00000548899, ENST00000478528, 
ENST00000424446, ENST00000552146, 
ENST00000488513, ENST00000429597, 
ENST00000549865, ENST00000482076, 
ENST00000533035, ENST00000308110, 
ENST00000525006, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 3 X 3=27
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP1R10 [Title/Abstract] AND MUS81 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1R10

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

23426265


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-W3-A825-06APPP1R10chr6

30584255

-MUS81chr11

65628146

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000376511ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-5UTRENST00000376511ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-intronENST00000376511ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-intronENST00000484449ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-5UTRENST00000484449ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
5UTR-intronENST00000484449ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000420949ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000420949ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000420949ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000549281ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000549281ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000549281ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000468706ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000468706ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000468706ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000449113ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000449113ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000449113ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000547333ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000547333ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000547333ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000475926ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000475926ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000475926ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000426299ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000426299ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000426299ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000551493ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000551493ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000551493ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000494003ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000494003ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000494003ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000383586ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000383586ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000383586ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000548899ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000548899ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000548899ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000478528ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000478528ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000478528ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000424446ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000424446ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000424446ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000552146ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000552146ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000552146ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000488513ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000488513ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000488513ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000429597ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000429597ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000429597ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000549865ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000549865ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000549865ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000482076ENST00000533035PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-5UTRENST00000482076ENST00000308110PPP1R10chr6

30584255

-MUS81chr11

65628146

+
intron-intronENST00000482076ENST00000525006PPP1R10chr6

30584255

-MUS81chr11

65628146

+

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FusionProtFeatures for PPP1R10_MUS81


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1R10

Q96QC0

MUS81

Q96NY9

Scaffold protein which mediates the formation of thePTW/PP1 phosphatase complex by providing a binding platform toeach component of the complex. The PTW/PP1 phosphatase complexplays a role in the control of chromatin structure and cell cycleprogression during the transition from mitosis into interphase.Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA andPPP1CC phosphatase activities. Has inhibitory activity on PPP1CAonly when phosphorylated. Binds to mRNA, single-stranded DNA(ssDNA), poly(A) and poly(G) homopolymers (By similarity).{ECO:0000250, ECO:0000269|PubMed:9450550}. Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNAstructures with a 5'-end at the branch nick. Typical substratesinclude 3'-flap structures, replication forks and nicked Hollidayjunctions. May be required in mitosis for the processing ofstalled or collapsed replication forks.{ECO:0000269|PubMed:11741546, ECO:0000269|PubMed:12374758,ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304,ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:15805243,ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19595721,ECO:0000269|PubMed:19596235}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1R10_MUS81


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1R10_MUS81


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP1R10PPP1CA, WDR82, PPP1CB, PPP1CC, TOX4, PPP1R10, HSPA4, ISG15, LSM5, ABCF2, PRKACA, HNRNPK, MMS19, MPG, RPA1, RPA2, RPA3, HUWE1, OBSL1, RSPH9, FNDC4, ZFP41, PPP1R13B, PPP1R3A, NTRK1, APP, PTEN, MED23, XRCC3, CTR9, TERF2IP, CAPN13, MMP26, FAM19A3, FMNL1, KCTD17, PPP1R7, G3BP1MUS81EME1, CHEK2, TERT, TERF2, SLX4, SLX1B, EME2, WEE1, SLX1A, FBXL5, PLK1, SUMO2, UHRF1, CREBBP, ZNF496, ATXN7L1, ZNF181, BRD9, LTK, TMEM209, ZNF17, ZNF358, FANCD2, CCT7, PLEK2, TRAF6, CDK5RAP2, POLD2, SREK1, TIMELESS, POLR2L, DNAJB9, RPS3, KPNA6, TFB1M, TRIM24, RAMP1, BRAF, STIL, ZNF142, RFC1, IDH2, DDX23, GTPBP8, MDFI, WRN, SAMD4B, DUS3L, INO80, ALMS1, SNW1, PIGB, VCP, POLR3K, XIAP, ELK4, RFTN1, BLOC1S1, SFPQ, KIAA2026, VWCE, MBP, PCNXL2, SF3A2, HIST1H2BG, HERC2, HNRNPU, NPM1, RPL10, SORT1, ERCC1, ERCC4, DIS3, VPRBP, DDB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1R10_MUS81


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1R10_MUS81


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource