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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28288

FusionGeneSummary for PPP1CC_CENPF

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1CC_CENPF
Fusion gene ID: 28288
HgeneTgene
Gene symbol

PPP1CC

CENPF

Gene ID

5501

1063

Gene nameprotein phosphatase 1 catalytic subunit gammacentromere protein F
SynonymsPP-1G|PP1C|PPP1GCENF|CILD31|PRO1779|STROMS|hcp-1
Cytomap

12q24.11

1q41

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase PP1-gamma catalytic subunitprotein phosphatase 1, catalytic subunit, gamma isoformprotein phosphatase 1, catalytic subunit, gamma isozymeprotein phosphatase 1C catalytic subunitserine/threonine phosphatase 1 gammacentromere protein FAH antigenCENP-F kinetochore proteincell-cycle-dependent 350K nuclear proteincentromere protein F, 350/400kDakinetochore protein CENPFmitosin
Modification date2018052220180522
UniProtAcc

P36873

P49454

Ensembl transtripts involved in fusion geneENST00000335007, ENST00000340766, 
ENST00000546933, ENST00000550991, 
ENST00000551676, ENST00000551690, 
ENST00000366955, ENST00000467765, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 2=72
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPP1CC [Title/Abstract] AND CENPF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCENPF

GO:0015031

protein transport

12974617

TgeneCENPF

GO:0045892

negative regulation of transcription, DNA-templated

15677469

TgeneCENPF

GO:0051310

metaphase plate congression

15870278


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI064871PPP1CCchr12

111158145

+CENPFchr1

214794182

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000335007ENST00000366955PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-intronENST00000335007ENST00000467765PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-3CDSENST00000340766ENST00000366955PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-intronENST00000340766ENST00000467765PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-3CDSENST00000546933ENST00000366955PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-intronENST00000546933ENST00000467765PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-3CDSENST00000550991ENST00000366955PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-intronENST00000550991ENST00000467765PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-3CDSENST00000551676ENST00000366955PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-intronENST00000551676ENST00000467765PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-3CDSENST00000551690ENST00000366955PPP1CCchr12

111158145

+CENPFchr1

214794182

+
intron-intronENST00000551690ENST00000467765PPP1CCchr12

111158145

+CENPFchr1

214794182

+

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FusionProtFeatures for PPP1CC_CENPF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1CC

P36873

CENPF

P49454

Protein phosphatase that associates with over 200regulatory proteins to form highly specific holoenzymes whichdephosphorylate hundreds of biological targets. Proteinphosphatase 1 (PP1) is essential for cell division, andparticipates in the regulation of glycogen metabolism, musclecontractility and protein synthesis. Dephosphorylates RPS6KB1.Involved in regulation of ionic conductances and long-termsynaptic plasticity. May play an important role indephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.Component of the PTW/PP1 phosphatase complex, which plays a rolein the control of chromatin structure and cell cycle progressionduring the transition from mitosis into interphase. In balancewith CSNK1D and CSNK1E, determines the circadian period length,through the regulation of the speed and rhythmicity of PER1 andPER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, therebyinactivating FOXP3 and rendering Treg cells functionally defective(PubMed:23396208). {ECO:0000269|PubMed:17936702,ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997,ECO:0000269|PubMed:23396208}. Required for kinetochore function and chromosomesegregation in mitosis. Required for kinetochore localization ofdynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasmamembrane by acting as a link between recycling vesicles and themicrotubule network though its association with STX4 and SNAP25.Acts as a potential inhibitor of pocket protein-mediated cellularprocesses during development by regulating the activity of RBproteins during cell division and proliferation. May play aregulatory or permissive role in the normal embryoniccardiomyocyte cell cycle and in promoting continued mitosis intransformed, abnormally dividing neonatal cardiomyocytes.Interaction with RB directs embryonic stem cells toward a cardiaclineage. Involved in the regulation of DNA synthesis and hencecell cycle progression, via its C-terminus. Has a potential roleregulating skeletal myogenesis and in cell differentiation inembryogenesis. Involved in dendritic cell regulation of T-cellimmunity against chlamydia. {ECO:0000269|PubMed:12974617,ECO:0000269|PubMed:17600710, ECO:0000269|PubMed:7542657,ECO:0000269|PubMed:7651420}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1CC_CENPF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1CC_CENPF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1CC_CENPF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1CC_CENPF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPP1CCC0919267ovarian neoplasm1CTD_human
TgeneCENPFC1458155Mammary Neoplasms1CTD_human