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Fusion gene ID: 28283 |
FusionGeneSummary for PPP1CB_NOP9 |
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Fusion gene information | Fusion gene name: PPP1CB_NOP9 | Fusion gene ID: 28283 | Hgene | Tgene | Gene symbol | PPP1CB | NOP9 | Gene ID | 5500 | 161424 |
Gene name | protein phosphatase 1 catalytic subunit beta | NOP9 nucleolar protein | |
Synonyms | HEL-S-80p|NSLH2|PP-1B|PP1B|PP1beta|PPP1CD | C14orf21 | |
Cytomap | 2p23.2 | 14q12 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase PP1-beta catalytic subunitepididymis secretory sperm binding protein Li 80pprotein phosphatase 1, catalytic subunit, beta isoformprotein phosphatase 1, catalytic subunit, beta isozymeprotein phosphatase 1, catalyti | nucleolar protein 9NOP9 nucleolar protein homologpumilio domain-containing protein C14orf21 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P62140 | Q86U38 | |
Ensembl transtripts involved in fusion gene | ENST00000358506, ENST00000296122, ENST00000395366, | ENST00000267425, ENST00000396802, | |
Fusion gene scores | * DoF score | 11 X 10 X 8=880 | 1 X 1 X 1=1 |
# samples | 15 | 1 | |
** MAII score | log2(15/880*10)=-2.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PPP1CB [Title/Abstract] AND NOP9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPP1CB | GO:0030155 | regulation of cell adhesion | 20354225 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE705920 | PPP1CB | chr2 | 28975914 | - | NOP9 | chr14 | 24774631 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000358506 | ENST00000267425 | PPP1CB | chr2 | 28975914 | - | NOP9 | chr14 | 24774631 | - |
intron-intron | ENST00000358506 | ENST00000396802 | PPP1CB | chr2 | 28975914 | - | NOP9 | chr14 | 24774631 | - |
intron-3UTR | ENST00000296122 | ENST00000267425 | PPP1CB | chr2 | 28975914 | - | NOP9 | chr14 | 24774631 | - |
intron-intron | ENST00000296122 | ENST00000396802 | PPP1CB | chr2 | 28975914 | - | NOP9 | chr14 | 24774631 | - |
intron-3UTR | ENST00000395366 | ENST00000267425 | PPP1CB | chr2 | 28975914 | - | NOP9 | chr14 | 24774631 | - |
intron-intron | ENST00000395366 | ENST00000396802 | PPP1CB | chr2 | 28975914 | - | NOP9 | chr14 | 24774631 | - |
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FusionProtFeatures for PPP1CB_NOP9 |
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Hgene | Tgene |
PPP1CB | NOP9 |
Protein phosphatase that associates with over 200regulatory proteins to form highly specific holoenzymes whichdephosphorylate hundreds of biological targets. Proteinphosphatase (PP1) is essential for cell division, it participatesin the regulation of glycogen metabolism, muscle contractility andprotein synthesis. Involved in regulation of ionic conductancesand long-term synaptic plasticity. Component of the PTW/PP1phosphatase complex, which plays a role in the control ofchromatin structure and cell cycle progression during thetransition from mitosis into interphase. In balance with CSNK1Dand CSNK1E, determines the circadian period length, through theregulation of the speed and rhythmicity of PER1 and PER2phosphorylation. May dephosphorylate CSNK1D and CSNK1E.Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, therebyinactivating FOXP3 and rendering Treg cells functionally defective(PubMed:23396208). {ECO:0000269|PubMed:20516061,ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP1CB_NOP9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP1CB_NOP9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP1CB_NOP9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP1CB_NOP9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NOP9 | C1458155 | Mammary Neoplasms | 1 | CTD_human |