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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28283

FusionGeneSummary for PPP1CB_NOP9

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP1CB_NOP9
Fusion gene ID: 28283
HgeneTgene
Gene symbol

PPP1CB

NOP9

Gene ID

5500

161424

Gene nameprotein phosphatase 1 catalytic subunit betaNOP9 nucleolar protein
SynonymsHEL-S-80p|NSLH2|PP-1B|PP1B|PP1beta|PPP1CDC14orf21
Cytomap

2p23.2

14q12

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase PP1-beta catalytic subunitepididymis secretory sperm binding protein Li 80pprotein phosphatase 1, catalytic subunit, beta isoformprotein phosphatase 1, catalytic subunit, beta isozymeprotein phosphatase 1, catalytinucleolar protein 9NOP9 nucleolar protein homologpumilio domain-containing protein C14orf21
Modification date2018052220180519
UniProtAcc

P62140

Q86U38

Ensembl transtripts involved in fusion geneENST00000358506, ENST00000296122, 
ENST00000395366, 
ENST00000267425, 
ENST00000396802, 
Fusion gene scores* DoF score11 X 10 X 8=8801 X 1 X 1=1
# samples 151
** MAII scorelog2(15/880*10)=-2.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PPP1CB [Title/Abstract] AND NOP9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP1CB

GO:0030155

regulation of cell adhesion

20354225


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE705920PPP1CBchr2

28975914

-NOP9chr14

24774631

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000358506ENST00000267425PPP1CBchr2

28975914

-NOP9chr14

24774631

-
intron-intronENST00000358506ENST00000396802PPP1CBchr2

28975914

-NOP9chr14

24774631

-
intron-3UTRENST00000296122ENST00000267425PPP1CBchr2

28975914

-NOP9chr14

24774631

-
intron-intronENST00000296122ENST00000396802PPP1CBchr2

28975914

-NOP9chr14

24774631

-
intron-3UTRENST00000395366ENST00000267425PPP1CBchr2

28975914

-NOP9chr14

24774631

-
intron-intronENST00000395366ENST00000396802PPP1CBchr2

28975914

-NOP9chr14

24774631

-

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FusionProtFeatures for PPP1CB_NOP9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP1CB

P62140

NOP9

Q86U38

Protein phosphatase that associates with over 200regulatory proteins to form highly specific holoenzymes whichdephosphorylate hundreds of biological targets. Proteinphosphatase (PP1) is essential for cell division, it participatesin the regulation of glycogen metabolism, muscle contractility andprotein synthesis. Involved in regulation of ionic conductancesand long-term synaptic plasticity. Component of the PTW/PP1phosphatase complex, which plays a role in the control ofchromatin structure and cell cycle progression during thetransition from mitosis into interphase. In balance with CSNK1Dand CSNK1E, determines the circadian period length, through theregulation of the speed and rhythmicity of PER1 and PER2phosphorylation. May dephosphorylate CSNK1D and CSNK1E.Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, therebyinactivating FOXP3 and rendering Treg cells functionally defective(PubMed:23396208). {ECO:0000269|PubMed:20516061,ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP1CB_NOP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP1CB_NOP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP1CB_NOP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP1CB_NOP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNOP9C1458155Mammary Neoplasms1CTD_human