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Fusion gene ID: 28265 |
FusionGeneSummary for PPM1K_PFN3 |
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Fusion gene information | Fusion gene name: PPM1K_PFN3 | Fusion gene ID: 28265 | Hgene | Tgene | Gene symbol | PPM1K | PFN3 | Gene ID | 152926 | 345456 |
Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1K | profilin 3 | |
Synonyms | BDP|MSUDMV|PP2Ckappa|PP2Cm|PTMP|UG0882E07 | - | |
Cytomap | 4q22.1 | 5q35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein phosphatase 1K, mitochondrialPP2C domain-containing protein phosphatase 1KPP2C-kappaPP2C-type mitochondrial phosphoprotein phosphatasebranched-chain I+/--ketoacid dehydrogenase phosphatasebranched-chain alpha-ketoacid dehydrogenase phosphatas | profilin-3profilin III | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8N3J5 | P60673 | |
Ensembl transtripts involved in fusion gene | ENST00000608933, ENST00000295908, ENST00000508256, ENST00000506423, ENST00000315194, ENST00000514204, | ENST00000358571, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: PPM1K [Title/Abstract] AND PFN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BX279877 | PPM1K | chr4 | 89205795 | + | PFN3 | chr5 | 176827456 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000608933 | ENST00000358571 | PPM1K | chr4 | 89205795 | + | PFN3 | chr5 | 176827456 | - |
intron-3CDS | ENST00000295908 | ENST00000358571 | PPM1K | chr4 | 89205795 | + | PFN3 | chr5 | 176827456 | - |
intron-3CDS | ENST00000508256 | ENST00000358571 | PPM1K | chr4 | 89205795 | + | PFN3 | chr5 | 176827456 | - |
intron-3CDS | ENST00000506423 | ENST00000358571 | PPM1K | chr4 | 89205795 | + | PFN3 | chr5 | 176827456 | - |
intron-3CDS | ENST00000315194 | ENST00000358571 | PPM1K | chr4 | 89205795 | + | PFN3 | chr5 | 176827456 | - |
intron-3CDS | ENST00000514204 | ENST00000358571 | PPM1K | chr4 | 89205795 | + | PFN3 | chr5 | 176827456 | - |
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FusionProtFeatures for PPM1K_PFN3 |
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Hgene | Tgene |
PPM1K | PFN3 |
Binds to actin and affects the structure of thecytoskeleton. Slightly reduces actin polymerization. Binds topoly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P),phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) andphosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved inspermatogenesis. {ECO:0000269|PubMed:19419568}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPM1K_PFN3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPM1K_PFN3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPM1K_PFN3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPM1K_PFN3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |