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Fusion gene ID: 28236 |
FusionGeneSummary for PPM1E_SPAG5 |
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Fusion gene information | Fusion gene name: PPM1E_SPAG5 | Fusion gene ID: 28236 | Hgene | Tgene | Gene symbol | PPM1E | SPAG5 | Gene ID | 22843 | 10615 |
Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1E | sperm associated antigen 5 | |
Synonyms | CaMKP-N|POPX1|PP2CH|caMKN | DEEPEST|MAP126|hMAP126 | |
Cytomap | 17q22 | 17q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein phosphatase 1Eca(2+)/calmodulin-dependent protein kinase phosphatase NcaMKP-nucleusnuclear calmodulin-dependent protein kinase phosphatasepartner of PIX 1partner of PIX-alphapartner of PIXAprotein phosphatase 1E (PP2C domain containing) | sperm-associated antigen 5astrinmitotic spindle associated protein p126mitotic spindle coiled-coil related protein | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q8WY54 | Q96R06 | |
Ensembl transtripts involved in fusion gene | ENST00000308249, | ENST00000321765, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 6 X 5=120 |
# samples | 3 | 7 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PPM1E [Title/Abstract] AND SPAG5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPM1E | GO:0006469 | negative regulation of protein kinase activity | 11864573 |
Hgene | PPM1E | GO:0035690 | cellular response to drug | 20801214 |
Hgene | PPM1E | GO:0035970 | peptidyl-threonine dephosphorylation | 20801214 |
Hgene | PPM1E | GO:0051496 | positive regulation of stress fiber assembly | 11864573 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-OL-A5RZ-01A | PPM1E | chr17 | 57043254 | + | SPAG5 | chr17 | 26913200 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000308249 | ENST00000321765 | PPM1E | chr17 | 57043254 | + | SPAG5 | chr17 | 26913200 | - |
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FusionProtFeatures for PPM1E_SPAG5 |
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Hgene | Tgene |
PPM1E | SPAG5 |
Protein phosphatase that inactivates multifunctional CaMkinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylatesand inactivates PAK. May play a role in the inhibition of actinfiber stress breakdown and in morphological changes driven byTNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). {ECO:0000250,ECO:0000269|PubMed:11864573}. | Essential component of the mitotic spindle required fornormal chromosome segregation and progression into anaphase(PubMed:11724960, PubMed:12356910, PubMed:27462074). Required forchromosome alignment, normal timing of sister chromatidsegregation, and maintenance of spindle pole architecture(PubMed:17664331, PubMed:27462074). In complex with SKAP, promotesstable microtubule-kinetochore attachments. May contribute to theregulation of separase activity. May regulate AURKA localizationto mitotic spindle, but not to centrosomes and CCNB1 localizationto both mitotic spindle and centrosomes (PubMed:18361916,PubMed:21402792). Involved in centriole duplication. Required forCDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization andpromotes the centrosomal localization of CDK2 (PubMed:26297806).In non-mitotic cells, upon stress induction, inhibits mammaliantarget of rapamycin complex 1 (mTORC1) association and recruitsthe mTORC1 component RPTOR to stress granules (SGs), therebypreventing mTORC1 hyperactivation-induced apoptosis(PubMed:23953116). May enhance GSK3B-mediated phosphorylation ofother substrates, such as MAPT/TAU (PubMed:18055457).{ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331,ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916,ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116,ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074,ECO:0000305|PubMed:11724960}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 7_100 | 261 | 756 | Compositional bias | Note=Glu-rich |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 31_52 | 261 | 756 | Region | Note=11 X 2 AA tandem repeats of P-E |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 31_32 | 261 | 756 | Repeat | Note=1 |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 33_34 | 261 | 756 | Repeat | Note=2 |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 35_36 | 261 | 756 | Repeat | Note=3 |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 37_38 | 261 | 756 | Repeat | Note=4 |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 39_40 | 261 | 756 | Repeat | Note=5 |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 41_42 | 261 | 756 | Repeat | Note=6 |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 43_44 | 261 | 756 | Repeat | Note=7 |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 45_46 | 261 | 756 | Repeat | Note=8%3B approximate |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 47_48 | 261 | 756 | Repeat | Note=9 |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 49_50 | 261 | 756 | Repeat | Note=10 |
Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 51_52 | 261 | 756 | Repeat | Note=11 |
Tgene | >SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 545_608 | 504 | 1194 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 759_868 | 504 | 1194 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 979_1174 | 504 | 1194 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 617_789 | 504 | 1194 | Compositional bias | Note=Gln-rich |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 231_488 | 261 | 756 | Domain | PPM-type phosphatase |
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FusionGeneSequence for PPM1E_SPAG5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_PPM1E_ENST00000308249_chr17_57043254_+_SPAG5_ENST00000321765_chr17_26913200_-_951aa MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEE AAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSA HYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEQSWVLISKE LISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDL ASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRV LEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQA ELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQK LGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAET PGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNE KILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSH |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_PPM1E_ENST00000308249_chr17_57043254_+_SPAG5_ENST00000321765_chr17_26913200_-_2853nt ATGGCCGGCTGCATCCCTGAGGAGAAAACTTACCGGCGCTTCCTGGAGCTATTCCTGGGCGAGTTTCGCGGACCGTGCGGCGGCGGCGAG CCGGAGCCGGAACCCGAACCCGAACCCGAACCCGAACCCGAGTCCGAGCCCGAGCCCGAACCTGAACTGGTAGAAGCTGAGGCGGCCGAG GCTTCGGTAGAGGAACCCGGGGAGGAGGCGGCCACGGTAGCCGCGACGGAGGAGGGGGACCAGGAGCAAGACCCGGAGCCCGAGGAGGAG GCGGCGGTTGAGGGTGAGGAGGAGGAGGAGGGCGCGGCGACGGCGGCGGCAGCCCCGGGGCACTCGGCCGTGCCGCCGCCGCCGCCCCAG CTGCCGCCTTTGCCCCCGCTCCCGCGACCGCTGTCAGAGCGCATCACCCGCGAGGAGGTGGAGGGCGAAAGCCTGGACCTGTGCCTGCAG CAGCTCTACAAATATAATTGCCCTTCCTTTTTGGCTGCTGCTTTAGCCAGAGCCACATCAGATGAAGTCCTTCAGAGTGATCTTTCTGCA CATTATATCCCAAAGGAAACGGATGGCACAGAAGGGACTGTGGAGATTGAGACAGTGAAATTGGCCCGTTCTGTCTTCAGCAAACTACAC GAGATTTGCTGCAGCTGGGTGAAAGACTTCCCCCTCCGCAGGAGACCCCAGCTTTATTATGAGACATCAATCCATGCCATCAAAAACATG CGCAGGAAAATGGAGGACAAACATGTCTGCATTCCTGACTTTAATATGCTCTTCAACCTAGAGCAATCATGGGTGCTTATCTCTAAAGAG CTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTC TGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATG GCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTA GCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAG ACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGA CAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTG CTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGG GCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAG GATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCA GAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGTTTGCAGACCAGGAGAATCAGGTTGCT CACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAACCACACTGGAAGTGCTCCGGGAGCGCAGCTTGCAGTGTGAGAACCTCAAGGAC ACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCATAGCAGATAACCAGGAGCAAGATCTGGAGAAAACACGGCAGTACTCTCAAAAG CTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTCTCTTTCTACAGACAAAACTAAAGGAGAAGACTGAACAAGAGACCCTTCTGCTG AGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGCCTAATGACAGGACCTTCCTGGGAAGCATCTTGACAGCAGTGGCAGATGAAGAG CCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACAAGAGTGCTTTCACCCGAGTAGCATCAATGGTTTCCCTTCAGCCCGCAGAGACC CCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTATGACTACTGAGCTTCAGAGTCTTTGTTCCCTGCTACAAGAGTCTAAAGAAGAA GCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGCAAGCTAGGCTGCAGGCCCAGGAAGAACAGCATCAGGAAGTCCAGAAGGCAAAA GAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCTTGCGCTACAAGAATGAAAAGGAGCTCCAGGAAGTGATACAGCAGCAGAATGAG AAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCATAAGCCTTAGAGAGGAGGTGACCCACCTTACCCGCTCACTTCGGCGTGCGGAG ACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCCAGCTGGACTCCAACTGCCAGCCTATGGCCACCAATTGGATCCAGGAGAAAGTG TGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGTTCCTGGAGATGAAAAATGAGAAGGAAAAACTCATGATCAAGTTCCAGAGCCAT AGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACAAGGAGTTAGAAAAACTAGATGACATTGTTCAGCATATTTATAAGACCCTGCTC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_PPM1E_ENST00000308249_chr17_57043254_+_SPAG5_ENST00000321765_chr17_26913200_-_3107nt AGTGCTGATCGCTCGTGCCGGTGCGGCCGTTAACCGCCCTTGCCGGAGCCCTAGGCTCAAAAGCAGCCCCTTACCCTTCCTGGGCTTCCC CCAACCCCTTTCCCGGTCTGCCCTGGGGCATGAGCAGCGATGGCCGGCTGCATCCCTGAGGAGAAAACTTACCGGCGCTTCCTGGAGCTA TTCCTGGGCGAGTTTCGCGGACCGTGCGGCGGCGGCGAGCCGGAGCCGGAACCCGAACCCGAACCCGAACCCGAACCCGAGTCCGAGCCC GAGCCCGAACCTGAACTGGTAGAAGCTGAGGCGGCCGAGGCTTCGGTAGAGGAACCCGGGGAGGAGGCGGCCACGGTAGCCGCGACGGAG GAGGGGGACCAGGAGCAAGACCCGGAGCCCGAGGAGGAGGCGGCGGTTGAGGGTGAGGAGGAGGAGGAGGGCGCGGCGACGGCGGCGGCA GCCCCGGGGCACTCGGCCGTGCCGCCGCCGCCGCCCCAGCTGCCGCCTTTGCCCCCGCTCCCGCGACCGCTGTCAGAGCGCATCACCCGC GAGGAGGTGGAGGGCGAAAGCCTGGACCTGTGCCTGCAGCAGCTCTACAAATATAATTGCCCTTCCTTTTTGGCTGCTGCTTTAGCCAGA GCCACATCAGATGAAGTCCTTCAGAGTGATCTTTCTGCACATTATATCCCAAAGGAAACGGATGGCACAGAAGGGACTGTGGAGATTGAG ACAGTGAAATTGGCCCGTTCTGTCTTCAGCAAACTACACGAGATTTGCTGCAGCTGGGTGAAAGACTTCCCCCTCCGCAGGAGACCCCAG CTTTATTATGAGACATCAATCCATGCCATCAAAAACATGCGCAGGAAAATGGAGGACAAACATGTCTGCATTCCTGACTTTAATATGCTC TTCAACCTAGAGCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACT ACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTC AAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCA CACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTG GTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTG GATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGT GATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAA CTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAG AGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAA TGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAA GAGACCTTGGAGTTTGCAGACCAGGAGAATCAGGTTGCTCACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAACCACACTGGAAGTG CTCCGGGAGCGCAGCTTGCAGTGTGAGAACCTCAAGGACACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCATAGCAGATAACCAG GAGCAAGATCTGGAGAAAACACGGCAGTACTCTCAAAAGCTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTCTCTTTCTACAGACA AAACTAAAGGAGAAGACTGAACAAGAGACCCTTCTGCTGAGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGCCTAATGACAGGACC TTCCTGGGAAGCATCTTGACAGCAGTGGCAGATGAAGAGCCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACAAGAGTGCTTTCACC CGAGTAGCATCAATGGTTTCCCTTCAGCCCGCAGAGACCCCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTATGACTACTGAGCTT CAGAGTCTTTGTTCCCTGCTACAAGAGTCTAAAGAAGAAGCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGCAAGCTAGGCTGCAG GCCCAGGAAGAACAGCATCAGGAAGTCCAGAAGGCAAAAGAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCTTGCGCTACAAGAAT GAAAAGGAGCTCCAGGAAGTGATACAGCAGCAGAATGAGAAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCATAAGCCTTAGAGAG GAGGTGACCCACCTTACCCGCTCACTTCGGCGTGCGGAGACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCCAGCTGGACTCCAAC TGCCAGCCTATGGCCACCAATTGGATCCAGGAGAAAGTGTGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGTTCCTGGAGATGAAA AATGAGAAGGAAAAACTCATGATCAAGTTCCAGAGCCATAGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACAAGGAGTTAGAAAAA CTAGATGACATTGTTCAGCATATTTATAAGACCCTGCTCTCTATTCCAGAGGTGGTGAGGGGATGCAAAGAACTACAGGGATTGCTGGAA TTTCTGAGCTAAGAAACTGAAAGCCAGAATCTGCTTCACCTCTTTTTACCTGCAATACCCCCTTACCCCAATACCAAGACCAACTGGCAT |
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FusionGenePPI for PPM1E_SPAG5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPM1E | ARHGEF7, DISC1, TNIK, PRKAA2, PRKAA1, NDUFAF5, PRMT2, NTRK1, COX4I1, DNAJA3, HLA-C, MAD2L1, NDUFA4, SLC25A5, SLFN11, SSR4, STX17, TARDBP, UQCRC2, TRO, PSMG4, PSMG3, BRCA2, FAM83H, FAM192A, PSME3, SERPINB4, ICMT | SPAG5 | SNAPIN, CDK1, CEBPD, ATN1, HECW2, ARNT2, FMR1, IQCE, BARD1, DCX, POLR2L, SMARCE1, EIF4E2, FBXO28, ORC6, AMOTL2, CCHCR1, CHCHD3, C1orf109, RBM41, LGALS14, TSHZ3, SH2D4A, TTC23, ZC2HC1C, CCDC33, LINGO1, HAUS1, SNAP47, ZMAT2, CDC20B, ZFC3H1, KANSL1, GOLGA8EP, GOLGA8F, CEP170, SRGAP3, DTNBP1, IFT57, C17orf59, CCDC67, KIAA0753, CCDC14, MED4, RPGRIP1L, OFD1, SPICE1, CEP44, DCTN1, ZNF385C, ZFYVE26, ENKD1, ZGPAT, DYNLL1, MAPRE1, MID1, MID2, NLGN3, RINT1, COPS7B, RIC8A, SYCE3, TSPYL1, CCDC89, MED21, RHPN1, BFSP2, EMILIN1, CCDC22, TSKS, KIAA1467, COG6, PLK1, SLC9C1, TUBA3C, MED1, NEURL4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 482_850 | 504 | 1194 | KNSTRN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPM1E_SPAG5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPM1E_SPAG5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PPM1E | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | SPAG5 | C0000786 | Spontaneous abortion | 1 | CTD_human |