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Fusion gene ID: 28236 |
FusionGeneSummary for PPM1E_SPAG5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPM1E_SPAG5 | Fusion gene ID: 28236 | Hgene | Tgene | Gene symbol | PPM1E | SPAG5 | Gene ID | 22843 | 10615 |
| Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1E | sperm associated antigen 5 | |
| Synonyms | CaMKP-N|POPX1|PP2CH|caMKN | DEEPEST|MAP126|hMAP126 | |
| Cytomap | 17q22 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase 1Eca(2+)/calmodulin-dependent protein kinase phosphatase NcaMKP-nucleusnuclear calmodulin-dependent protein kinase phosphatasepartner of PIX 1partner of PIX-alphapartner of PIXAprotein phosphatase 1E (PP2C domain containing) | sperm-associated antigen 5astrinmitotic spindle associated protein p126mitotic spindle coiled-coil related protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q8WY54 | Q96R06 | |
| Ensembl transtripts involved in fusion gene | ENST00000308249, | ENST00000321765, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 6 X 5=120 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPM1E [Title/Abstract] AND SPAG5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPM1E | GO:0006469 | negative regulation of protein kinase activity | 11864573 |
| Hgene | PPM1E | GO:0035690 | cellular response to drug | 20801214 |
| Hgene | PPM1E | GO:0035970 | peptidyl-threonine dephosphorylation | 20801214 |
| Hgene | PPM1E | GO:0051496 | positive regulation of stress fiber assembly | 11864573 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-OL-A5RZ-01A | PPM1E | chr17 | 57043254 | + | SPAG5 | chr17 | 26913200 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000308249 | ENST00000321765 | PPM1E | chr17 | 57043254 | + | SPAG5 | chr17 | 26913200 | - |
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FusionProtFeatures for PPM1E_SPAG5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPM1E | SPAG5 |
| Protein phosphatase that inactivates multifunctional CaMkinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylatesand inactivates PAK. May play a role in the inhibition of actinfiber stress breakdown and in morphological changes driven byTNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). {ECO:0000250,ECO:0000269|PubMed:11864573}. | Essential component of the mitotic spindle required fornormal chromosome segregation and progression into anaphase(PubMed:11724960, PubMed:12356910, PubMed:27462074). Required forchromosome alignment, normal timing of sister chromatidsegregation, and maintenance of spindle pole architecture(PubMed:17664331, PubMed:27462074). In complex with SKAP, promotesstable microtubule-kinetochore attachments. May contribute to theregulation of separase activity. May regulate AURKA localizationto mitotic spindle, but not to centrosomes and CCNB1 localizationto both mitotic spindle and centrosomes (PubMed:18361916,PubMed:21402792). Involved in centriole duplication. Required forCDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization andpromotes the centrosomal localization of CDK2 (PubMed:26297806).In non-mitotic cells, upon stress induction, inhibits mammaliantarget of rapamycin complex 1 (mTORC1) association and recruitsthe mTORC1 component RPTOR to stress granules (SGs), therebypreventing mTORC1 hyperactivation-induced apoptosis(PubMed:23953116). May enhance GSK3B-mediated phosphorylation ofother substrates, such as MAPT/TAU (PubMed:18055457).{ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331,ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916,ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116,ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074,ECO:0000305|PubMed:11724960}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 7_100 | 261 | 756 | Compositional bias | Note=Glu-rich |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 31_52 | 261 | 756 | Region | Note=11 X 2 AA tandem repeats of P-E |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 31_32 | 261 | 756 | Repeat | Note=1 |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 33_34 | 261 | 756 | Repeat | Note=2 |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 35_36 | 261 | 756 | Repeat | Note=3 |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 37_38 | 261 | 756 | Repeat | Note=4 |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 39_40 | 261 | 756 | Repeat | Note=5 |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 41_42 | 261 | 756 | Repeat | Note=6 |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 43_44 | 261 | 756 | Repeat | Note=7 |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 45_46 | 261 | 756 | Repeat | Note=8%3B approximate |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 47_48 | 261 | 756 | Repeat | Note=9 |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 49_50 | 261 | 756 | Repeat | Note=10 |
| Hgene | PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 51_52 | 261 | 756 | Repeat | Note=11 |
| Tgene | >SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 545_608 | 504 | 1194 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 759_868 | 504 | 1194 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 979_1174 | 504 | 1194 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 617_789 | 504 | 1194 | Compositional bias | Note=Gln-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PPM1E | chr17:57043254 | chr17:26913200 | ENST00000308249 | + | 3 | 7 | 231_488 | 261 | 756 | Domain | PPM-type phosphatase |
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FusionGeneSequence for PPM1E_SPAG5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPM1E_ENST00000308249_chr17_57043254_+_SPAG5_ENST00000321765_chr17_26913200_-_951aa MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPESEPEPEPELVEAEAAEASVEEPGEEAATVAATEEGDQEQDPEPEEE AAVEGEEEEEGAATAAAAPGHSAVPPPPPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARATSDEVLQSDLSA HYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEQSWVLISKE LISLLHLSLLHLEEDKTTVSQESRRAETLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDL ASMREFRGLLKDAQTQLVGLHAKQEELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRV LEQVSAQLEECKGQTEQLELENSRLATDLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQA ELQQQQAVLAKEVRDLKETLEFADQENQVAHLELGQVECQLKTTLEVLRERSLQCENLKDTVENLTAKLASTIADNQEQDLEKTRQYSQK LGLLTEQLQSLTLFLQTKLKEKTEQETLLLSTACPPTQEHPLPNDRTFLGSILTAVADEEPESTPVPLLGSDKSAFTRVASMVSLQPAET PGMEESLAEMSIMTTELQSLCSLLQESKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKNEKELQEVIQQQNE KILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSNCQPMATNWIQEKVWLSQEVDKLRVMFLEMKNEKEKLMIKFQSH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPM1E_ENST00000308249_chr17_57043254_+_SPAG5_ENST00000321765_chr17_26913200_-_2853nt ATGGCCGGCTGCATCCCTGAGGAGAAAACTTACCGGCGCTTCCTGGAGCTATTCCTGGGCGAGTTTCGCGGACCGTGCGGCGGCGGCGAG CCGGAGCCGGAACCCGAACCCGAACCCGAACCCGAACCCGAGTCCGAGCCCGAGCCCGAACCTGAACTGGTAGAAGCTGAGGCGGCCGAG GCTTCGGTAGAGGAACCCGGGGAGGAGGCGGCCACGGTAGCCGCGACGGAGGAGGGGGACCAGGAGCAAGACCCGGAGCCCGAGGAGGAG GCGGCGGTTGAGGGTGAGGAGGAGGAGGAGGGCGCGGCGACGGCGGCGGCAGCCCCGGGGCACTCGGCCGTGCCGCCGCCGCCGCCCCAG CTGCCGCCTTTGCCCCCGCTCCCGCGACCGCTGTCAGAGCGCATCACCCGCGAGGAGGTGGAGGGCGAAAGCCTGGACCTGTGCCTGCAG CAGCTCTACAAATATAATTGCCCTTCCTTTTTGGCTGCTGCTTTAGCCAGAGCCACATCAGATGAAGTCCTTCAGAGTGATCTTTCTGCA CATTATATCCCAAAGGAAACGGATGGCACAGAAGGGACTGTGGAGATTGAGACAGTGAAATTGGCCCGTTCTGTCTTCAGCAAACTACAC GAGATTTGCTGCAGCTGGGTGAAAGACTTCCCCCTCCGCAGGAGACCCCAGCTTTATTATGAGACATCAATCCATGCCATCAAAAACATG CGCAGGAAAATGGAGGACAAACATGTCTGCATTCCTGACTTTAATATGCTCTTCAACCTAGAGCAATCATGGGTGCTTATCTCTAAAGAG CTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTC TGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATG GCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTA GCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAG ACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGA CAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTG CTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGG GCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAG GATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCA GAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGTTTGCAGACCAGGAGAATCAGGTTGCT CACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAACCACACTGGAAGTGCTCCGGGAGCGCAGCTTGCAGTGTGAGAACCTCAAGGAC ACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCATAGCAGATAACCAGGAGCAAGATCTGGAGAAAACACGGCAGTACTCTCAAAAG CTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTCTCTTTCTACAGACAAAACTAAAGGAGAAGACTGAACAAGAGACCCTTCTGCTG AGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGCCTAATGACAGGACCTTCCTGGGAAGCATCTTGACAGCAGTGGCAGATGAAGAG CCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACAAGAGTGCTTTCACCCGAGTAGCATCAATGGTTTCCCTTCAGCCCGCAGAGACC CCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTATGACTACTGAGCTTCAGAGTCTTTGTTCCCTGCTACAAGAGTCTAAAGAAGAA GCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGCAAGCTAGGCTGCAGGCCCAGGAAGAACAGCATCAGGAAGTCCAGAAGGCAAAA GAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCTTGCGCTACAAGAATGAAAAGGAGCTCCAGGAAGTGATACAGCAGCAGAATGAG AAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCATAAGCCTTAGAGAGGAGGTGACCCACCTTACCCGCTCACTTCGGCGTGCGGAG ACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCCAGCTGGACTCCAACTGCCAGCCTATGGCCACCAATTGGATCCAGGAGAAAGTG TGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGTTCCTGGAGATGAAAAATGAGAAGGAAAAACTCATGATCAAGTTCCAGAGCCAT AGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACAAGGAGTTAGAAAAACTAGATGACATTGTTCAGCATATTTATAAGACCCTGCTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPM1E_ENST00000308249_chr17_57043254_+_SPAG5_ENST00000321765_chr17_26913200_-_3107nt AGTGCTGATCGCTCGTGCCGGTGCGGCCGTTAACCGCCCTTGCCGGAGCCCTAGGCTCAAAAGCAGCCCCTTACCCTTCCTGGGCTTCCC CCAACCCCTTTCCCGGTCTGCCCTGGGGCATGAGCAGCGATGGCCGGCTGCATCCCTGAGGAGAAAACTTACCGGCGCTTCCTGGAGCTA TTCCTGGGCGAGTTTCGCGGACCGTGCGGCGGCGGCGAGCCGGAGCCGGAACCCGAACCCGAACCCGAACCCGAACCCGAGTCCGAGCCC GAGCCCGAACCTGAACTGGTAGAAGCTGAGGCGGCCGAGGCTTCGGTAGAGGAACCCGGGGAGGAGGCGGCCACGGTAGCCGCGACGGAG GAGGGGGACCAGGAGCAAGACCCGGAGCCCGAGGAGGAGGCGGCGGTTGAGGGTGAGGAGGAGGAGGAGGGCGCGGCGACGGCGGCGGCA GCCCCGGGGCACTCGGCCGTGCCGCCGCCGCCGCCCCAGCTGCCGCCTTTGCCCCCGCTCCCGCGACCGCTGTCAGAGCGCATCACCCGC GAGGAGGTGGAGGGCGAAAGCCTGGACCTGTGCCTGCAGCAGCTCTACAAATATAATTGCCCTTCCTTTTTGGCTGCTGCTTTAGCCAGA GCCACATCAGATGAAGTCCTTCAGAGTGATCTTTCTGCACATTATATCCCAAAGGAAACGGATGGCACAGAAGGGACTGTGGAGATTGAG ACAGTGAAATTGGCCCGTTCTGTCTTCAGCAAACTACACGAGATTTGCTGCAGCTGGGTGAAAGACTTCCCCCTCCGCAGGAGACCCCAG CTTTATTATGAGACATCAATCCATGCCATCAAAAACATGCGCAGGAAAATGGAGGACAAACATGTCTGCATTCCTGACTTTAATATGCTC TTCAACCTAGAGCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACT ACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTC AAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCA CACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTG GTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTG GATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGT GATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAA CTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAG AGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAA TGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAA GAGACCTTGGAGTTTGCAGACCAGGAGAATCAGGTTGCTCACCTGGAGCTGGGTCAGGTTGAGTGTCAATTGAAAACCACACTGGAAGTG CTCCGGGAGCGCAGCTTGCAGTGTGAGAACCTCAAGGACACTGTAGAGAACCTAACGGCTAAACTGGCCAGCACCATAGCAGATAACCAG GAGCAAGATCTGGAGAAAACACGGCAGTACTCTCAAAAGCTAGGGCTGCTGACTGAGCAACTACAGAGCCTGACTCTCTTTCTACAGACA AAACTAAAGGAGAAGACTGAACAAGAGACCCTTCTGCTGAGTACAGCCTGTCCTCCCACCCAGGAACACCCTCTGCCTAATGACAGGACC TTCCTGGGAAGCATCTTGACAGCAGTGGCAGATGAAGAGCCAGAATCAACTCCTGTGCCCTTGCTTGGAAGTGACAAGAGTGCTTTCACC CGAGTAGCATCAATGGTTTCCCTTCAGCCCGCAGAGACCCCAGGCATGGAGGAGAGCCTGGCAGAAATGAGTATTATGACTACTGAGCTT CAGAGTCTTTGTTCCCTGCTACAAGAGTCTAAAGAAGAAGCCATCAGGACTCTGCAGCGAAAAATTTGTGAGCTGCAAGCTAGGCTGCAG GCCCAGGAAGAACAGCATCAGGAAGTCCAGAAGGCAAAAGAAGCAGACATAGAGAAGCTGAACCAGGCCTTGTGCTTGCGCTACAAGAAT GAAAAGGAGCTCCAGGAAGTGATACAGCAGCAGAATGAGAAGATCCTAGAACAGATAGACAAGAGTGGCGAGCTCATAAGCCTTAGAGAG GAGGTGACCCACCTTACCCGCTCACTTCGGCGTGCGGAGACAGAGACCAAAGTGCTCCAGGAGGCCCTGGCAGGCCAGCTGGACTCCAAC TGCCAGCCTATGGCCACCAATTGGATCCAGGAGAAAGTGTGGCTCTCTCAGGAGGTGGACAAACTGAGAGTGATGTTCCTGGAGATGAAA AATGAGAAGGAAAAACTCATGATCAAGTTCCAGAGCCATAGAAATATCCTAGAGGAGAACCTTCGGCGCTCTGACAAGGAGTTAGAAAAA CTAGATGACATTGTTCAGCATATTTATAAGACCCTGCTCTCTATTCCAGAGGTGGTGAGGGGATGCAAAGAACTACAGGGATTGCTGGAA TTTCTGAGCTAAGAAACTGAAAGCCAGAATCTGCTTCACCTCTTTTTACCTGCAATACCCCCTTACCCCAATACCAAGACCAACTGGCAT |
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FusionGenePPI for PPM1E_SPAG5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPM1E | ARHGEF7, DISC1, TNIK, PRKAA2, PRKAA1, NDUFAF5, PRMT2, NTRK1, COX4I1, DNAJA3, HLA-C, MAD2L1, NDUFA4, SLC25A5, SLFN11, SSR4, STX17, TARDBP, UQCRC2, TRO, PSMG4, PSMG3, BRCA2, FAM83H, FAM192A, PSME3, SERPINB4, ICMT | SPAG5 | SNAPIN, CDK1, CEBPD, ATN1, HECW2, ARNT2, FMR1, IQCE, BARD1, DCX, POLR2L, SMARCE1, EIF4E2, FBXO28, ORC6, AMOTL2, CCHCR1, CHCHD3, C1orf109, RBM41, LGALS14, TSHZ3, SH2D4A, TTC23, ZC2HC1C, CCDC33, LINGO1, HAUS1, SNAP47, ZMAT2, CDC20B, ZFC3H1, KANSL1, GOLGA8EP, GOLGA8F, CEP170, SRGAP3, DTNBP1, IFT57, C17orf59, CCDC67, KIAA0753, CCDC14, MED4, RPGRIP1L, OFD1, SPICE1, CEP44, DCTN1, ZNF385C, ZFYVE26, ENKD1, ZGPAT, DYNLL1, MAPRE1, MID1, MID2, NLGN3, RINT1, COPS7B, RIC8A, SYCE3, TSPYL1, CCDC89, MED21, RHPN1, BFSP2, EMILIN1, CCDC22, TSKS, KIAA1467, COG6, PLK1, SLC9C1, TUBA3C, MED1, NEURL4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | SPAG5 | chr17:57043254 | chr17:26913200 | ENST00000321765 | - | 4 | 24 | 482_850 | 504 | 1194 | KNSTRN |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPM1E_SPAG5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPM1E_SPAG5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPM1E | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | SPAG5 | C0000786 | Spontaneous abortion | 1 | CTD_human |
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