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Fusion gene ID: 28233 |
FusionGeneSummary for PPM1D_NUP85 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPM1D_NUP85 | Fusion gene ID: 28233 | Hgene | Tgene | Gene symbol | PPM1D | NUP85 | Gene ID | 8493 | 79902 |
| Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1D | nucleoporin 85 | |
| Synonyms | IDDGIP|PP2C-DELTA|WIP1 | FROUNT|Nup75 | |
| Cytomap | 17q23.2 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase 1Dprotein phosphatase 1D magnesium-dependent, delta isoformprotein phosphatase 2C delta isoformprotein phosphatase Wip1wild-type p53-induced phosphatase 1 | nuclear pore complex protein Nup85nucleoporin 85kDanucleoporin Nup75nucleoporin Nup85 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O15297 | Q9BW27 | |
| Ensembl transtripts involved in fusion gene | ENST00000305921, | ENST00000245544, ENST00000541827, ENST00000579324, ENST00000449421, ENST00000579298, ENST00000447371, ENST00000540768, | |
| Fusion gene scores | * DoF score | 6 X 4 X 3=72 | 8 X 7 X 5=280 |
| # samples | 5 | 10 | |
| ** MAII score | log2(5/72*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPM1D [Title/Abstract] AND NUP85 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPM1D | GO:0035970 | peptidyl-threonine dephosphorylation | 20801214 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-HT-7479-01A | PPM1D | chr17 | 58725443 | + | NUP85 | chr17 | 73221198 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000305921 | ENST00000245544 | PPM1D | chr17 | 58725443 | + | NUP85 | chr17 | 73221198 | + |
| In-frame | ENST00000305921 | ENST00000541827 | PPM1D | chr17 | 58725443 | + | NUP85 | chr17 | 73221198 | + |
| In-frame | ENST00000305921 | ENST00000579324 | PPM1D | chr17 | 58725443 | + | NUP85 | chr17 | 73221198 | + |
| 5CDS-3UTR | ENST00000305921 | ENST00000449421 | PPM1D | chr17 | 58725443 | + | NUP85 | chr17 | 73221198 | + |
| 5CDS-intron | ENST00000305921 | ENST00000579298 | PPM1D | chr17 | 58725443 | + | NUP85 | chr17 | 73221198 | + |
| 5CDS-intron | ENST00000305921 | ENST00000447371 | PPM1D | chr17 | 58725443 | + | NUP85 | chr17 | 73221198 | + |
| 5CDS-intron | ENST00000305921 | ENST00000540768 | PPM1D | chr17 | 58725443 | + | NUP85 | chr17 | 73221198 | + |
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FusionProtFeatures for PPM1D_NUP85 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPM1D | NUP85 |
| Involved in the negative regulation of p53 expression(PubMed:23242139). Required for the relief of p53-dependentcheckpoint mediated cell cycle arrest. Binds to anddephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 whichcontributes to the functional inactivation of these proteins(PubMed:15870257, PubMed:16311512). Mediates MAPK14dephosphorylation and inactivation (PubMed:21283629). Is also animportant regulator of global heterochromatin silencing andcritical in maintaining genome integrity (By similarity).{ECO:0000250|UniProtKB:Q9QZ67, ECO:0000269|PubMed:15870257,ECO:0000269|PubMed:16311512, ECO:0000269|PubMed:21283629,ECO:0000269|PubMed:23242139}. | Essential component of the nuclear pore complex (NPC)that seems to be required for NPC assembly and maintenance(PubMed:12718872). As part of the NPC Nup107-160 subcomplex playsa role in RNA export and in tethering NUP96/Nup98 and NUP153 tothe nucleus (PubMed:12718872). The Nup107-160 complex seems to berequired for spindle assembly during mitosis (PubMed:16807356).NUP85 is required for membrane clustering of CCL2-activated CCR2(PubMed:15995708). Seems to be involved in CCR2-mediatedchemotaxis of monocytes and may link activated CCR2 to thephosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusioncascade (PubMed:15995708). {ECO:0000269|PubMed:12718872,ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PPM1D | chr17:58725443 | chr17:73221198 | ENST00000305921 | + | 4 | 6 | 8_375 | 339 | 606 | Domain | PPM-type phosphatase |
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FusionGeneSequence for PPM1D_NUP85 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPM1D_ENST00000305921_chr17_58725443_+_NUP85_ENST00000245544_chr17_73221198_+_797aa MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSR CCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVII RGMKMTVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLA VARALGDLWSTDFFSGEFVVSPEPDTSVHTLDPQKHKTIILGSDGLWNMIPPQDAISMCQDQEEKKYLMVTILVLQGRLDEARQMLSKEA DASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWTHFLVT RLLYSNPTVKPIDLHYTAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLTFGSNMRE FLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWS IRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKTREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTD >In-frame_PPM1D_ENST00000305921_chr17_58725443_+_NUP85_ENST00000541827_chr17_73221198_+_797aa MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSR CCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVII RGMKMTVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLA VARALGDLWSTDFFSGEFVVSPEPDTSVHTLDPQKHKTIILGSDGLWNMIPPQDAISMCQDQEEKKYLMVTILVLQGRLDEARQMLSKEA DASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWTHFLVT RLLYSNPTVKPIDLHYTAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLTFGSNMRE FLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWS IRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKTREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTD >In-frame_PPM1D_ENST00000305921_chr17_58725443_+_NUP85_ENST00000579324_chr17_73221198_+_797aa MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSR CCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVII RGMKMTVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLA VARALGDLWSTDFFSGEFVVSPEPDTSVHTLDPQKHKTIILGSDGLWNMIPPQDAISMCQDQEEKKYLMVTILVLQGRLDEARQMLSKEA DASPASAGICRIMGDLMRTMPILSPGNTQTLTELELKWQHWHEECERYLQDSTFATSPHLESLLKIMLGDEAALLEQKELLSNWTHFLVT RLLYSNPTVKPIDLHYTAQSSLDLFLGGESSPEPLDNILLAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCKLLQSHNLTFGSNMRE FLLLEYASGLFAHPSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVRSICKILAMKAVRNNRLGSALSWS IRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGPAMMLSDRLTFLGKTREFHRMYGEKRFADAASLLLSLMTSRIAPRSFWMTLLTD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPM1D_ENST00000305921_chr17_58725443_+_NUP85_ENST00000245544_chr17_73221198_+_2391nt ATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCTTCTCCGACCAGGGCGGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGGAG CCCGAACCGACGGCTGAAGAAAAGCCCTCGCCGCGGCGGTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGC GGCGAAGTCTCGGGGAAAGGCCCAGCGGTGGCAGCCCGAGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCGGCACCTAGCCGC TGCTGCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGTGTGCGACGGGCACGGCGGGCGGGAGGCGGCACAGTTTGCCCGGGAGCACTTG TGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCTCGTCCGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGGCTTTCTCGCTTGTCAC CTTGCCATGTGGAAGAAACTGGCGGAATGGCCAAAGACTATGACGGGTCTTCCTAGCACATCAGGGACAACTGCCAGTGTGGTCATCATT CGGGGCATGAAGATGTATGTAGCTCACGTAGGTGACTCAGGGGTGGTTCTTGGAATTCAGGATGACCCGAAGGATGACTTTGTCAGAGCT GTGGAGGTGACACAGGACCATAAGCCAGAACTTCCCAAGGAAAGAGAACGAATCGAAGGACTTGGTGGGAGTGTAATGAACAAGTCTGGG GTGAATCGTGTAGTTTGGAAACGACCTCGACTCACTCACAATGGACCTGTTAGAAGGAGCACAGTTATTGACCAGATTCCTTTTCTGGCA GTAGCAAGAGCACTTGGTGATTTGTGGAGCTATGATTTCTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGACACAAGTGTCCACACT CTTGACCCTCAGAAGCACAAGTATATTATATTGGGGAGTGATGGACTTTGGAATATGATTCCACCACAAGATGCCATCTCAATGTGCCAG GACCAAGAGGAGAAAAAATACCTGATGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCC GATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACA CTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTG GAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACT CGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGC AGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAAC TGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAG TTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTG GGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGG CAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGC ATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGAT CTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAG AAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGAC GCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGA AGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCA >In-frame_PPM1D_ENST00000305921_chr17_58725443_+_NUP85_ENST00000541827_chr17_73221198_+_2391nt ATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCTTCTCCGACCAGGGCGGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGGAG CCCGAACCGACGGCTGAAGAAAAGCCCTCGCCGCGGCGGTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGC GGCGAAGTCTCGGGGAAAGGCCCAGCGGTGGCAGCCCGAGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCGGCACCTAGCCGC TGCTGCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGTGTGCGACGGGCACGGCGGGCGGGAGGCGGCACAGTTTGCCCGGGAGCACTTG TGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCTCGTCCGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGGCTTTCTCGCTTGTCAC CTTGCCATGTGGAAGAAACTGGCGGAATGGCCAAAGACTATGACGGGTCTTCCTAGCACATCAGGGACAACTGCCAGTGTGGTCATCATT CGGGGCATGAAGATGTATGTAGCTCACGTAGGTGACTCAGGGGTGGTTCTTGGAATTCAGGATGACCCGAAGGATGACTTTGTCAGAGCT GTGGAGGTGACACAGGACCATAAGCCAGAACTTCCCAAGGAAAGAGAACGAATCGAAGGACTTGGTGGGAGTGTAATGAACAAGTCTGGG GTGAATCGTGTAGTTTGGAAACGACCTCGACTCACTCACAATGGACCTGTTAGAAGGAGCACAGTTATTGACCAGATTCCTTTTCTGGCA GTAGCAAGAGCACTTGGTGATTTGTGGAGCTATGATTTCTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGACACAAGTGTCCACACT CTTGACCCTCAGAAGCACAAGTATATTATATTGGGGAGTGATGGACTTTGGAATATGATTCCACCACAAGATGCCATCTCAATGTGCCAG GACCAAGAGGAGAAAAAATACCTGATGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCC GATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACA CTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTG GAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACT CGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGC AGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAAC TGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAG TTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTG GGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGG CAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGC ATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGAT CTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAG AAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGAC GCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGA AGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCA >In-frame_PPM1D_ENST00000305921_chr17_58725443_+_NUP85_ENST00000579324_chr17_73221198_+_2391nt ATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCTTCTCCGACCAGGGCGGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGGAG CCCGAACCGACGGCTGAAGAAAAGCCCTCGCCGCGGCGGTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGC GGCGAAGTCTCGGGGAAAGGCCCAGCGGTGGCAGCCCGAGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCGGCACCTAGCCGC TGCTGCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGTGTGCGACGGGCACGGCGGGCGGGAGGCGGCACAGTTTGCCCGGGAGCACTTG TGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCTCGTCCGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGGCTTTCTCGCTTGTCAC CTTGCCATGTGGAAGAAACTGGCGGAATGGCCAAAGACTATGACGGGTCTTCCTAGCACATCAGGGACAACTGCCAGTGTGGTCATCATT CGGGGCATGAAGATGTATGTAGCTCACGTAGGTGACTCAGGGGTGGTTCTTGGAATTCAGGATGACCCGAAGGATGACTTTGTCAGAGCT GTGGAGGTGACACAGGACCATAAGCCAGAACTTCCCAAGGAAAGAGAACGAATCGAAGGACTTGGTGGGAGTGTAATGAACAAGTCTGGG GTGAATCGTGTAGTTTGGAAACGACCTCGACTCACTCACAATGGACCTGTTAGAAGGAGCACAGTTATTGACCAGATTCCTTTTCTGGCA GTAGCAAGAGCACTTGGTGATTTGTGGAGCTATGATTTCTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGACACAAGTGTCCACACT CTTGACCCTCAGAAGCACAAGTATATTATATTGGGGAGTGATGGACTTTGGAATATGATTCCACCACAAGATGCCATCTCAATGTGCCAG GACCAAGAGGAGAAAAAATACCTGATGGTGACCATCTTGGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCC GATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCATGGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACA CTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGAGGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTG GAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGCCTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACT CGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGATCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGC AGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTTTGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAAC TGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCACTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAG TTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCATCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTG GGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACCTCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGG CAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTTAGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGC ATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTCAGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGAT CTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGACCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAG AAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTTGATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGAC GCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTCAGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGA AGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCAGGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPM1D_ENST00000305921_chr17_58725443_+_NUP85_ENST00000245544_chr17_73221198_+_2702nt GGGGAAGCGCAGTGCGCAGGCGCAACTGCCTGGCTCTGCTCGCTCCGGCGCTCCGGCCCAGCTCTCGCGGACAAGTCCAGACATCGCGCG CCCCCCCTTCTCCGGGTCCGCCCCCTCCCCCTTCTCGGCGTCGTCGAAGATAAACAATAGTTGGCCGGCGAGCGCCTAGTGTGTCTCCCG CCGCCGGATTCGGCGGGCTGCGTGGGACCGGCGGGATCCCGGCCAGCCGGCCATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCTTCTC CGACCAGGGCGGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGGAGCCCGAACCGACGGCTGAAGAAAAGCCCTCGCCGCGGCG GTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGCGGCGAAGTCTCGGGGAAAGGCCCAGCGGTGGCAGCCCG AGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCGGCACCTAGCCGCTGCTGCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGT GTGCGACGGGCACGGCGGGCGGGAGGCGGCACAGTTTGCCCGGGAGCACTTGTGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCTCGTC CGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGGCTTTCTCGCTTGTCACCTTGCCATGTGGAAGAAACTGGCGGAATGGCCAAAGAC TATGACGGGTCTTCCTAGCACATCAGGGACAACTGCCAGTGTGGTCATCATTCGGGGCATGAAGATGTATGTAGCTCACGTAGGTGACTC AGGGGTGGTTCTTGGAATTCAGGATGACCCGAAGGATGACTTTGTCAGAGCTGTGGAGGTGACACAGGACCATAAGCCAGAACTTCCCAA GGAAAGAGAACGAATCGAAGGACTTGGTGGGAGTGTAATGAACAAGTCTGGGGTGAATCGTGTAGTTTGGAAACGACCTCGACTCACTCA CAATGGACCTGTTAGAAGGAGCACAGTTATTGACCAGATTCCTTTTCTGGCAGTAGCAAGAGCACTTGGTGATTTGTGGAGCTATGATTT CTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGACACAAGTGTCCACACTCTTGACCCTCAGAAGCACAAGTATATTATATTGGGGAG TGATGGACTTTGGAATATGATTCCACCACAAGATGCCATCTCAATGTGCCAGGACCAAGAGGAGAAAAAATACCTGATGGTGACCATCTT GGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCAT GGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGA GGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGC CTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGA TCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTT TGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCA CTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCA TCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACC TCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTT AGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTC AGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGA CCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTT GATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTC AGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCA GGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACT GGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAATGTATATAGATTTTTTTAAAAGAATAAATGTTGTTTTGCAAATG >In-frame_PPM1D_ENST00000305921_chr17_58725443_+_NUP85_ENST00000541827_chr17_73221198_+_2701nt GGGGAAGCGCAGTGCGCAGGCGCAACTGCCTGGCTCTGCTCGCTCCGGCGCTCCGGCCCAGCTCTCGCGGACAAGTCCAGACATCGCGCG CCCCCCCTTCTCCGGGTCCGCCCCCTCCCCCTTCTCGGCGTCGTCGAAGATAAACAATAGTTGGCCGGCGAGCGCCTAGTGTGTCTCCCG CCGCCGGATTCGGCGGGCTGCGTGGGACCGGCGGGATCCCGGCCAGCCGGCCATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCTTCTC CGACCAGGGCGGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGGAGCCCGAACCGACGGCTGAAGAAAAGCCCTCGCCGCGGCG GTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGCGGCGAAGTCTCGGGGAAAGGCCCAGCGGTGGCAGCCCG AGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCGGCACCTAGCCGCTGCTGCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGT GTGCGACGGGCACGGCGGGCGGGAGGCGGCACAGTTTGCCCGGGAGCACTTGTGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCTCGTC CGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGGCTTTCTCGCTTGTCACCTTGCCATGTGGAAGAAACTGGCGGAATGGCCAAAGAC TATGACGGGTCTTCCTAGCACATCAGGGACAACTGCCAGTGTGGTCATCATTCGGGGCATGAAGATGTATGTAGCTCACGTAGGTGACTC AGGGGTGGTTCTTGGAATTCAGGATGACCCGAAGGATGACTTTGTCAGAGCTGTGGAGGTGACACAGGACCATAAGCCAGAACTTCCCAA GGAAAGAGAACGAATCGAAGGACTTGGTGGGAGTGTAATGAACAAGTCTGGGGTGAATCGTGTAGTTTGGAAACGACCTCGACTCACTCA CAATGGACCTGTTAGAAGGAGCACAGTTATTGACCAGATTCCTTTTCTGGCAGTAGCAAGAGCACTTGGTGATTTGTGGAGCTATGATTT CTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGACACAAGTGTCCACACTCTTGACCCTCAGAAGCACAAGTATATTATATTGGGGAG TGATGGACTTTGGAATATGATTCCACCACAAGATGCCATCTCAATGTGCCAGGACCAAGAGGAGAAAAAATACCTGATGGTGACCATCTT GGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCAT GGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGA GGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGC CTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGA TCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTT TGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCA CTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCA TCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACC TCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTT AGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTC AGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGA CCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTT GATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTC AGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCA GGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACT GGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAATGTATATAGATTTTTTTAAAAGAATAAATGTTGTTTTGCAAATG >In-frame_PPM1D_ENST00000305921_chr17_58725443_+_NUP85_ENST00000579324_chr17_73221198_+_2701nt GGGGAAGCGCAGTGCGCAGGCGCAACTGCCTGGCTCTGCTCGCTCCGGCGCTCCGGCCCAGCTCTCGCGGACAAGTCCAGACATCGCGCG CCCCCCCTTCTCCGGGTCCGCCCCCTCCCCCTTCTCGGCGTCGTCGAAGATAAACAATAGTTGGCCGGCGAGCGCCTAGTGTGTCTCCCG CCGCCGGATTCGGCGGGCTGCGTGGGACCGGCGGGATCCCGGCCAGCCGGCCATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCTTCTC CGACCAGGGCGGGAGGAAGTACATGGAGGACGTTACTCAAATCGTTGTGGAGCCCGAACCGACGGCTGAAGAAAAGCCCTCGCCGCGGCG GTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGCGGCGAAGTCTCGGGGAAAGGCCCAGCGGTGGCAGCCCG AGAGGCTCGCGACCCTCTCCCGGACGCCGGGGCCTCGCCGGCACCTAGCCGCTGCTGCCGCCGCCGTTCCTCCGTGGCCTTTTTCGCCGT GTGCGACGGGCACGGCGGGCGGGAGGCGGCACAGTTTGCCCGGGAGCACTTGTGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCTCGTC CGAGCCGGCTAAGGTTTGCGCTGCCATCCGCAAAGGCTTTCTCGCTTGTCACCTTGCCATGTGGAAGAAACTGGCGGAATGGCCAAAGAC TATGACGGGTCTTCCTAGCACATCAGGGACAACTGCCAGTGTGGTCATCATTCGGGGCATGAAGATGTATGTAGCTCACGTAGGTGACTC AGGGGTGGTTCTTGGAATTCAGGATGACCCGAAGGATGACTTTGTCAGAGCTGTGGAGGTGACACAGGACCATAAGCCAGAACTTCCCAA GGAAAGAGAACGAATCGAAGGACTTGGTGGGAGTGTAATGAACAAGTCTGGGGTGAATCGTGTAGTTTGGAAACGACCTCGACTCACTCA CAATGGACCTGTTAGAAGGAGCACAGTTATTGACCAGATTCCTTTTCTGGCAGTAGCAAGAGCACTTGGTGATTTGTGGAGCTATGATTT CTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGACACAAGTGTCCACACTCTTGACCCTCAGAAGCACAAGTATATTATATTGGGGAG TGATGGACTTTGGAATATGATTCCACCACAAGATGCCATCTCAATGTGCCAGGACCAAGAGGAGAAAAAATACCTGATGGTGACCATCTT GGTGCTGCAGGGCCGGCTGGATGAGGCCCGACAGATGCTCTCCAAGGAAGCCGATGCCAGCCCCGCCTCTGCAGGCATATGCCGAATCAT GGGGGACCTGATGAGGACAATGCCCATTCTTAGTCCCGGGAACACCCAGACACTGACAGAGCTGGAGCTGAAGTGGCAGCACTGGCACGA GGAATGTGAGCGGTACCTCCAGGACAGCACATTCGCCACCAGCCCTCACCTGGAGTCTCTCTTGAAGATTATGCTGGGAGACGAAGCTGC CTTGTTAGAGCAGAAGGAACTTCTGAGTAATTGGTATCATTTCCTAGTGACTCGGCTCTTGTACTCCAATCCCACAGTAAAACCCATTGA TCTGCACTACTATGCCCAGTCCAGCCTGGACCTGTTTCTGGGAGGTGAGAGCAGCCCAGAACCCCTGGACAACATCTTGTTGGCAGCCTT TGAGTTTGACATCCATCAAGTAATCAAAGAGTGCAGCATCGCCCTGAGCAACTGGTGGTTTGTGGCCCACCTGACAGACCTGCTGGACCA CTGCAAGCTCCTCCAGTCACACAACCTCTATTTCGGTTCCAACATGAGAGAGTTCCTCCTGCTGGAGTACGCCTCGGGACTGTTTGCTCA TCCCAGCCTGTGGCAGCTGGGGGTCGATTACTTTGATTACTGCCCCGAGCTGGGCCGAGTCTCCCTGGAGCTGCACATTGAGCGGATACC TCTGAACACCGAGCAGAAAGCCCTGAAGGTGCTGCGGATCTGTGAGCAGCGGCAGATGACTGAACAAGTTCGCAGCATTTGTAAGATCTT AGCCATGAAAGCCGTCCGCAACAATCGCCTGGGTTCTGCCCTCTCTTGGAGCATCCGTGCTAAGGATGCCGCCTTTGCCACGCTCGTGTC AGACAGGTTCCTCAGGGATTACTGTGAGCGAGGCTGCTTTTCTGATTTGGATCTCATTGACAACCTGGGGCCAGCCATGATGCTCAGTGA CCGACTGACATTCCTGGGAAAGTATCGCGAGTTCCACCGTATGTACGGGGAGAAGCGTTTTGCCGACGCAGCTTCTCTCCTTCTGTCCTT GATGACGTCTCGGATTGCCCCTCGGTCTTTCTGGATGACTCTGCTGACAGACGCCTTGCCCCTTTTGGAACAGAAACAGGTGATTTTCTC AGCAGAACAGACTTATGAGTTGATGCGGTGTCTGGAGGACTTGACGTCAAGAAGACCTGTGCATGGAGAATCTGATACCGAGCAGCTCCA GGATGATGACATAGAGACCACCAAGGTGGAAATGCTGAGACTTTCTCTGGCACGAAATCTTGCTCGGGCAATTATAAGAGAAGGCTCACT GGAAGGTTCCTGAGAACTGCTTCAATGTGGTATCTTTGTATGGCAATGTATATAGATTTTTTTAAAAGAATAAATGTTGTTTTGCAAATG |
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FusionGenePPI for PPM1D_NUP85 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPM1D | CDC5L, MDM2, H2AFX, RAD21, UBC, KDM1A, BEX2, CASZ1, DIRAS3, DKK3, EPSTI1, ERRFI1, GLCE, ITIH5, LYPD3, MRC2, NAT2, OSGIN1, RHOBTB2, WHSC1L1, KPNA2, KPNA3, KPNB1, NUP153, PSMD4, RANBP2, SPAG9, CHEK2 | NUP85 | SEH1L, NUP107, NUP43, NUP37, SEC13, EEF1G, USP36, USP49, HDAC11, EGFR, FBXO6, DCTN3, GBF1, RABL6, OBSL1, EED, CCDC183, CD274, TNFSF13B, CA14, PNKD, ENPP6, TGOLN2, NUP160, NUP98, NTRK1, IFI16, PRKDC, UNC45A, FMN1, KPNB1, ZNF740, POM121, HSP90AB1, NUDC, NUP88, RANGAP1, NUP62, NUP214, RANBP2, NUP50, NUP153, B9D2, UBE2I, FOXQ1, FAF2, UXS1, VASN, CD70, SPAST, ZNF785 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | PPM1D | chr17:58725443 | chr17:73221198 | ENST00000305921 | + | 4 | 6 | 1_101 | 339 | 606 | CHEK1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPM1D_NUP85 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPM1D_NUP85 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPM1D | C0017638 | Glioma | 1 | CTD_human |
| Hgene | PPM1D | C0677866 | Brain Stem Neoplasms | 1 | CTD_human |
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