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Fusion gene ID: 28203 |
FusionGeneSummary for PPIG_SPATA5 |
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Fusion gene information | Fusion gene name: PPIG_SPATA5 | Fusion gene ID: 28203 | Hgene | Tgene | Gene symbol | PPIG | SPATA5 | Gene ID | 9360 | 166378 |
Gene name | peptidylprolyl isomerase G | spermatogenesis associated 5 | |
Synonyms | CARS-Cyp|CYP|SCAF10|SRCyp | AFG2|EHLMRS|SPAF | |
Cytomap | 2q31.1 | 4q28.1 | |
Type of gene | protein-coding | protein-coding | |
Description | peptidyl-prolyl cis-trans isomerase GCARS-cyclophilinCASP10Clk-associating RS-cyclophilinPPIase GSR-cyclophilinSR-cypSR-related CTD-associated factor 10cyclophilin Gpeptidyl-prolyl isomerase G (cyclophilin G)rotamase G | spermatogenesis-associated protein 5ATPase family gene 2 homologATPase family protein 2 homologspermatogenesis associated factor SPAFspermatogenesis-associated factor protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q13427 | Q8NB90 | |
Ensembl transtripts involved in fusion gene | ENST00000260970, ENST00000409714, ENST00000462903, ENST00000448752, ENST00000482772, | ENST00000274008, ENST00000422835, | |
Fusion gene scores | * DoF score | 9 X 11 X 6=594 | 3 X 3 X 2=18 |
# samples | 14 | 4 | |
** MAII score | log2(14/594*10)=-2.0850361038558 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PPIG [Title/Abstract] AND SPATA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPIG | GO:0000413 | protein peptidyl-prolyl isomerization | 20676357 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU679512 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + | ||
ChiTaRS3.1 | BU685323 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000260970 | ENST00000274008 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
5CDS-3UTR | ENST00000260970 | ENST00000422835 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
5CDS-intron | ENST00000409714 | ENST00000274008 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
5CDS-3UTR | ENST00000409714 | ENST00000422835 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
intron-intron | ENST00000462903 | ENST00000274008 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
intron-3UTR | ENST00000462903 | ENST00000422835 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
5CDS-intron | ENST00000448752 | ENST00000274008 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
5CDS-3UTR | ENST00000448752 | ENST00000422835 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
3UTR-intron | ENST00000482772 | ENST00000274008 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
3UTR-3UTR | ENST00000482772 | ENST00000422835 | PPIG | chr2 | 170492945 | - | SPATA5 | chr4 | 124023441 | + |
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FusionProtFeatures for PPIG_SPATA5 |
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Hgene | Tgene |
PPIG | SPATA5 |
PPIase that catalyzes the cis-trans isomerization ofproline imidic peptide bonds in oligopeptides and may thereforeassist protein folding (PubMed:20676357). May be implicated in thefolding, transport, and assembly of proteins. May play animportant role in the regulation of pre-mRNA splicing.{ECO:0000269|PubMed:20676357}. | May be involved in morphological and functionalmitochondrial transformations during spermatogenesis.{ECO:0000250|UniProtKB:Q3UMC0}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPIG_SPATA5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPIG_SPATA5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPIG_SPATA5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPIG_SPATA5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SPATA5 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | SPATA5 | C4225276 | EPILEPSY, HEARING LOSS, AND MENTAL RETARDATION SYNDROME | 1 | ORPHANET;UNIPROT |