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Fusion gene ID: 28149 |
FusionGeneSummary for PPFIA1_RHOD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPFIA1_RHOD | Fusion gene ID: 28149 | Hgene | Tgene | Gene symbol | PPFIA1 | RHOD | Gene ID | 8500 | 29984 |
| Gene name | PTPRF interacting protein alpha 1 | ras homolog family member D | |
| Synonyms | LIP.1|LIP1|LIPRIN | ARHD|RHOHP1|RHOM|Rho | |
| Cytomap | 11q13.3 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | liprin-alpha-1LAR-interacting protein 1LIP-1Liprin-alpha1protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | rho-related GTP-binding protein RhoDRho-related protein HP1ras homolog Dras homolog gene family, member Aras homolog gene family, member D | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q13136 | O00212 | |
| Ensembl transtripts involved in fusion gene | ENST00000253925, ENST00000389547, ENST00000530548, | ENST00000308831, ENST00000533360, ENST00000532559, | |
| Fusion gene scores | * DoF score | 36 X 13 X 14=6552 | 9 X 4 X 8=288 |
| # samples | 41 | 13 | |
| ** MAII score | log2(41/6552*10)=-3.99823954213556 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/288*10)=-1.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPFIA1 [Title/Abstract] AND RHOD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-EW-A1J3-01A | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000253925 | ENST00000308831 | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
| In-frame | ENST00000253925 | ENST00000533360 | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
| 5CDS-intron | ENST00000253925 | ENST00000532559 | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
| In-frame | ENST00000389547 | ENST00000308831 | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
| In-frame | ENST00000389547 | ENST00000533360 | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
| 5CDS-intron | ENST00000389547 | ENST00000532559 | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
| intron-3CDS | ENST00000530548 | ENST00000308831 | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
| intron-3CDS | ENST00000530548 | ENST00000533360 | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
| intron-intron | ENST00000530548 | ENST00000532559 | PPFIA1 | chr11 | 70118542 | + | RHOD | chr11 | 66833367 | + |
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FusionProtFeatures for PPFIA1_RHOD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPFIA1 | RHOD |
| May regulate the disassembly of focal adhesions. Maylocalize receptor-like tyrosine phosphatases type 2A at specificsites on the plasma membrane, possibly regulating theirinteraction with the extracellular environment and theirassociation with substrates. {ECO:0000269|PubMed:7796809}. | Involved in endosome dynamics. May coordinate membranetransport with the function of the cytoskeleton. Involved in theinternalization and trafficking of activated tyrosine kinasereceptors such as PDGFRB. Participates in the reorganization ofactin cytoskeleton; the function seems to involve WHAMM andincludes regulation of filopodia formation and actin filamentbundling. Can modulate the effect of DAPK3 in reorganization ofactin cytoskeleton and focal adhesion dissolution.{ECO:0000269|PubMed:23087206, ECO:0000269|PubMed:23454120,ECO:0000269|PubMed:24102721}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 17_25 | 88 | 1597 | Compositional bias | Note=Poly-Gly |
| Hgene | PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 17_25 | 88 | 1186 | Compositional bias | Note=Poly-Gly |
| Tgene | >RHOD | chr11:70118542 | chr11:66833367 | ENST00000308831 | + | 0 | 5 | 46_54 | 44 | 211 | Motif | Effector region |
| Tgene | >RHOD | chr11:70118542 | chr11:66833367 | ENST00000308831 | + | 0 | 5 | 129_132 | 44 | 211 | Nucleotide binding | GTP |
| Tgene | >RHOD | chr11:70118542 | chr11:66833367 | ENST00000308831 | + | 0 | 5 | 71_75 | 44 | 211 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 1021_1050 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 176_214 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 249_521 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 34_141 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 623_669 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 847_871 | 88 | 1597 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 1021_1050 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 176_214 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 249_521 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 34_141 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 623_669 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 847_871 | 88 | 1186 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 1051_1120 | 88 | 1597 | Domain | SAM 3 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 878_944 | 88 | 1597 | Domain | SAM 1 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000253925 | + | 2 | 28 | 963_1027 | 88 | 1597 | Domain | SAM 2 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 1051_1120 | 88 | 1186 | Domain | SAM 3 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 878_944 | 88 | 1186 | Domain | SAM 1 |
| Hgene | >PPFIA1 | chr11:70118542 | chr11:66833367 | ENST00000389547 | + | 2 | 26 | 963_1027 | 88 | 1186 | Domain | SAM 2 |
| Tgene | RHOD | chr11:70118542 | chr11:66833367 | ENST00000308831 | + | 0 | 5 | 24_31 | 44 | 211 | Nucleotide binding | GTP |
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FusionGeneSequence for PPFIA1_RHOD |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_RHOD_ENST00000308831_chr11_66833367_+_255aa MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQSY TPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLCKD >In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_RHOD_ENST00000533360_chr11_66833367_+_163aa MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQSY >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_RHOD_ENST00000308831_chr11_66833367_+_255aa MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQSY TPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLCKD >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_RHOD_ENST00000533360_chr11_66833367_+_163aa MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQSY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_RHOD_ENST00000308831_chr11_66833367_+_765nt ATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCA GATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACG CTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGAGCTAC ACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGAT GACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAAC ATCTTTAACCGGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCATCGTCGTGGGCTGCAAGACTGACCTGTGCAAGGAC AAATCACTGGTGAACAAGCTCCGAAGAAACGGATTGGAGCCTGTGACCTACCACAGGGGCCAGGAGATGGCGAGGTCCGTGGGCGCGGTG GCCTACCTCGAGTGCTCGGCTCGGCTCCATGACAACGTCCACGCCGTCTTCCAGGAGGCCGCCGAGGTGGCCCTCAGCAGCCGCGGTCGC >In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_RHOD_ENST00000533360_chr11_66833367_+_489nt ATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCA GATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACG CTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGAGCTAC ACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGAT GACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAAC >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_RHOD_ENST00000308831_chr11_66833367_+_765nt ATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCA GATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACG CTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGAGCTAC ACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGAT GACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAAC ATCTTTAACCGGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCATCGTCGTGGGCTGCAAGACTGACCTGTGCAAGGAC AAATCACTGGTGAACAAGCTCCGAAGAAACGGATTGGAGCCTGTGACCTACCACAGGGGCCAGGAGATGGCGAGGTCCGTGGGCGCGGTG GCCTACCTCGAGTGCTCGGCTCGGCTCCATGACAACGTCCACGCCGTCTTCCAGGAGGCCGCCGAGGTGGCCCTCAGCAGCCGCGGTCGC >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_RHOD_ENST00000533360_chr11_66833367_+_489nt ATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCA GATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTGAGAGAGACTCAAGAAACG CTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACGGCACTTCCACAGAGCTAC ACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGGGACACAGCAGGGCAAGAT GACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGCCCGAACAGCTTTGACAAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_RHOD_ENST00000308831_chr11_66833367_+_1391nt GCCGCGCAGCCGGGCCCGCTCCTCCTCCGCTCCGCCAGTGTCCGGCCGCGGGCCGGCCTTAGTGACTGGGGCGGCGGGCCCCGGGGCCGC GGCGTGGGGCGGGCAGGCGGACGCCGGCCGCGGGCTGCTTTCGTCGGCTCCCAAGCTCTCCCGGAGCGAGCAGCCGCCCGCGAGCCGCCG CGGAGCCTCCTCGCCCGCTCCCGCCGGCGAGCAAGATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAG GTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACC GCCTTCTTGATACACTGAGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGC AGAGACAGCTCAACACGGCACTTCCACAGAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTG TGCACCTCCACATCTGGGACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTT GCTTCGATGTCACCAGCCCGAACAGCTTTGACAACATCTTTAACCGGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCA TCGTCGTGGGCTGCAAGACTGACCTGTGCAAGGACAAATCACTGGTGAACAAGCTCCGAAGAAACGGATTGGAGCCTGTGACCTACCACA GGGGCCAGGAGATGGCGAGGTCCGTGGGCGCGGTGGCCTACCTCGAGTGCTCGGCTCGGCTCCATGACAACGTCCACGCCGTCTTCCAGG AGGCCGCCGAGGTGGCCCTCAGCAGCCGCGGTCGCAACTTCTGGCGGCGGATTACCCAGGGCTTTTGCGTGGTGACCTGAGCGGCTCGGG GCGTCCCAGCGACGCGGGAAGGGGCAGGGCGCTGACCTGCTGCTGAGCTGGCTGGGCTGGACCCGGTCCCTAGGCTGTGACCGCCGAACT CCACTGCAACAGACGGGCGCCACCAAAGCCAGGCCCTGAGGCCTGGGAGTCCTGGACTGAGAAAGGGGGTTCCTGGGCCCACCTGCTCTG TGTAGGGCTCGTCCTGCGGTGCCCGAGAATCACTCGCTAACCCCTATGCCCGGTCCCGGACCGACATCCTGGAGCCGCCTGTGCAGCCTG ATGCCCCCTCGTGGCTGCTCCCAGGGCTGCACCTGCCAGGACCTAATGTTCTTAGGTCCCTCTGGCCAGAACCCACACCCGGCCCCTTCC >In-frame_PPFIA1_ENST00000253925_chr11_70118542_+_RHOD_ENST00000533360_chr11_66833367_+_906nt GCCGCGCAGCCGGGCCCGCTCCTCCTCCGCTCCGCCAGTGTCCGGCCGCGGGCCGGCCTTAGTGACTGGGGCGGCGGGCCCCGGGGCCGC GGCGTGGGGCGGGCAGGCGGACGCCGGCCGCGGGCTGCTTTCGTCGGCTCCCAAGCTCTCCCGGAGCGAGCAGCCGCCCGCGAGCCGCCG CGGAGCCTCCTCGCCCGCTCCCGCCGGCGAGCAAGATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAG GTGGAGGCCATGGTTCCGGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACC GCCTTCTTGATACACTGAGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGC AGAGACAGCTCAACACGGCACTTCCACAGAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTG TGCACCTCCACATCTGGGACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTT GCTTCGATGTCACCAGCCCGAACAGCTTTGACAACATCTTTAACCGGTTTCTCCCTAGGTGCTGGCTTTGCTGATTATCCATATCAGAGC TCAGGCTGGGGAGCAAGAGAGTGGTCCACTGAGAGGGCCAGAACTCTCCAGGGCTCACACATGCCCCCCACATGCCCCCTCGCCCCCCTG CAGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCATCGTCGTGGGCTGCAAGACTGACCTGTGCAAGGACAAATCACTG >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_RHOD_ENST00000308831_chr11_66833367_+_1374nt GCTCCTCCTCCGCTCCGCCAGTGTCCGGCCGCGGGCCGGCCTTAGTGACTGGGGCGGCGGGCCCCGGGGCCGCGGCGTGGGGCGGGCAGG CGGACGCCGGCCGCGGGCTGCTTTCGTCGGCTCCCAAGCTCTCCCGGAGCGAGCAGCCGCCCGCGAGCCGCCGCGGAGCCTCCTCGCCCG CTCCCGCCGGCGAGCAAGATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCC GGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTG AGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACG GCACTTCCACAGAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGG GACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGC CCGAACAGCTTTGACAACATCTTTAACCGGTGGTACCCAGAAGTGAATCATTTCTGCAAGAAGGTACCCATCATCGTCGTGGGCTGCAAG ACTGACCTGTGCAAGGACAAATCACTGGTGAACAAGCTCCGAAGAAACGGATTGGAGCCTGTGACCTACCACAGGGGCCAGGAGATGGCG AGGTCCGTGGGCGCGGTGGCCTACCTCGAGTGCTCGGCTCGGCTCCATGACAACGTCCACGCCGTCTTCCAGGAGGCCGCCGAGGTGGCC CTCAGCAGCCGCGGTCGCAACTTCTGGCGGCGGATTACCCAGGGCTTTTGCGTGGTGACCTGAGCGGCTCGGGGCGTCCCAGCGACGCGG GAAGGGGCAGGGCGCTGACCTGCTGCTGAGCTGGCTGGGCTGGACCCGGTCCCTAGGCTGTGACCGCCGAACTCCACTGCAACAGACGGG CGCCACCAAAGCCAGGCCCTGAGGCCTGGGAGTCCTGGACTGAGAAAGGGGGTTCCTGGGCCCACCTGCTCTGTGTAGGGCTCGTCCTGC GGTGCCCGAGAATCACTCGCTAACCCCTATGCCCGGTCCCGGACCGACATCCTGGAGCCGCCTGTGCAGCCTGATGCCCCCTCGTGGCTG CTCCCAGGGCTGCACCTGCCAGGACCTAATGTTCTTAGGTCCCTCTGGCCAGAACCCACACCCGGCCCCTTCCCACCTGTCATACTGGTA >In-frame_PPFIA1_ENST00000389547_chr11_70118542_+_RHOD_ENST00000533360_chr11_66833367_+_889nt GCTCCTCCTCCGCTCCGCCAGTGTCCGGCCGCGGGCCGGCCTTAGTGACTGGGGCGGCGGGCCCCGGGGCCGCGGCGTGGGGCGGGCAGG CGGACGCCGGCCGCGGGCTGCTTTCGTCGGCTCCCAAGCTCTCCCGGAGCGAGCAGCCGCCCGCGAGCCGCCGCGGAGCCTCCTCGCCCG CTCCCGCCGGCGAGCAAGATGATGTGCGAGGTGATGCCGACCATCAGCGAAGCAGAAGGCCCCCCTGGAGGAGGTGGAGGCCATGGTTCC GGCTCCCCTTCACAGCCAGATGCAGATTCACATTTTGAACAGTTGATGGTCTCCATGCTAGAAGAAAGGGACCGCCTTCTTGATACACTG AGAGAGACTCAAGAAACGCTGGCCTTAACCCAGGGGAAGTTACACGAGGTTGGTCATGAAAGAGATTCCTTGCAGAGACAGCTCAACACG GCACTTCCACAGAGCTACACCCCCACGGTGTTTGAGCGGTACATGGTCAACCTGCAAGTGAAAGGCAAACCTGTGCACCTCCACATCTGG GACACAGCAGGGCAAGATGACTATGACCGCCTGCGGCCCCTGTTCTACCCTGACGCCAGCGTCCTGCTGCTTTGCTTCGATGTCACCAGC CCGAACAGCTTTGACAACATCTTTAACCGGTTTCTCCCTAGGTGCTGGCTTTGCTGATTATCCATATCAGAGCTCAGGCTGGGGAGCAAG AGAGTGGTCCACTGAGAGGGCCAGAACTCTCCAGGGCTCACACATGCCCCCCACATGCCCCCTCGCCCCCCTGCAGTGGTACCCAGAAGT |
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FusionGenePPI for PPFIA1_RHOD |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPFIA1 | GIT1, ERC2, PPP2R5D, TNNT1, MBIP, GRIP2, PTPRF, PTPRD, PTPRS, NCOA2, PPP2CA, PPP2R1A, PPFIA1, PPFIA2, ING4, PPP2CB, CUL2, AGTPBP1, CEP70, AMOT, LATS2, YWHAB, IKBKG, PSMC4, PSMD1, PSMD13, PSMD8, SPTAN1, DROSHA, NDN, AURKB, CDKN1A, CCNH, DTNB, FAM161A, TXLNA, BRCA1, GPS2, C16orf70, CYP4X1, NTRK1, OSBP, PPFIA3, PPFIBP1, PPFIBP2, CAGE1, TUBG1, XRCC1, GBA2, CDC5L, NF2, IL17RE, LLGL2, SERPINB2, STX11, EXOC8, TTC9B, CCDC120, TRIM25 | RHOD | DIAPH2, PLXNA1, IHH, ADCK5, ADRB2, ANKFY1, SPTB, PLXNB2, DAAM1, TTC19, CETN3, TRMT61B, DIAPH1, PCBP3, C1orf198, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPFIA1_RHOD |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPFIA1_RHOD |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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