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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28113

FusionGeneSummary for PPDPF_HNRNPD

check button Fusion gene summary
Fusion gene informationFusion gene name: PPDPF_HNRNPD
Fusion gene ID: 28113
HgeneTgene
Gene symbol

PPDPF

HNRNPD

Gene ID

79144

3184

Gene namepancreatic progenitor cell differentiation and proliferation factorheterogeneous nuclear ribonucleoprotein D
SynonymsC20orf149|dJ697K14.9|exdpfAUF1|AUF1A|HNRPD|P37|hnRNPD0
Cytomap

20q13.33

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionpancreatic progenitor cell differentiation and proliferation factorexocrine differentiation and proliferation factorpancreatic progenitor cell differentiation and proliferation factor homologheterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0
Modification date2018052320180523
UniProtAcc

Q9H3Y8

Q14103

Ensembl transtripts involved in fusion geneENST00000370179, ENST00000370177, 
ENST00000473620, 		ENST00000313899, 
ENST00000353341, ENST00000543098, 
ENST00000352301, ENST00000508119, 
ENST00000541060, 
Fusion gene scores* DoF score10 X 10 X 1=10010 X 10 X 3=300
# samples 1212
** MAII scorelog2(12/100*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/300*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPDPF [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF805251PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
ChiTaRS3.1BF805263PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000370179ENST00000313899PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
Frame-shiftENST00000370179ENST00000353341PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
Frame-shiftENST00000370179ENST00000543098PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
Frame-shiftENST00000370179ENST00000352301PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
5CDS-5UTRENST00000370179ENST00000508119PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
5CDS-5UTRENST00000370179ENST00000541060PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
Frame-shiftENST00000370177ENST00000313899PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
Frame-shiftENST00000370177ENST00000353341PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
Frame-shiftENST00000370177ENST00000543098PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
Frame-shiftENST00000370177ENST00000352301PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
5CDS-5UTRENST00000370177ENST00000508119PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
5CDS-5UTRENST00000370177ENST00000541060PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
3UTR-3CDSENST00000473620ENST00000313899PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
3UTR-3CDSENST00000473620ENST00000353341PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
3UTR-3CDSENST00000473620ENST00000543098PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
3UTR-3CDSENST00000473620ENST00000352301PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
3UTR-5UTRENST00000473620ENST00000508119PPDPFchr20

62152884

-HNRNPDchr4

83278003

+
3UTR-5UTRENST00000473620ENST00000541060PPDPFchr20

62152884

-HNRNPDchr4

83278003

+

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FusionProtFeatures for PPDPF_HNRNPD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPDPF

Q9H3Y8

HNRNPD

Q14103

Probable regulator of exocrine pancreas development.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPDPF_HNRNPD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPDPF_HNRNPD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPDPF_HNRNPD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHNRNPDQ14103DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein D0small moleculeapproved|investigational

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RelatedDiseases for PPDPF_HNRNPD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource