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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28106

FusionGeneSummary for PPAT_KIF16B

check button Fusion gene summary
Fusion gene informationFusion gene name: PPAT_KIF16B
Fusion gene ID: 28106
HgeneTgene
Gene symbol

PPAT

KIF16B

Gene ID

80347

55614

Gene nameCoenzyme A synthasekinesin family member 16B
SynonymsDPCK|NBIA6|NBP|PPAT|UKR1|pOV-2C20orf23|KISC20ORF|SNX23
Cytomap

17q21.2

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionbifunctional coenzyme A synthaseCoA synthasebifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinasenucleotide binding proteinphosphopantetheine adenylyltransferase / dephosphocoenzyme A kinasekinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201a
Modification date2018052320180523
UniProtAcc

Q06203

Q96L93

Ensembl transtripts involved in fusion geneENST00000264220, ENST00000507648, 
ENST00000354981, ENST00000378003, 
ENST00000355755, ENST00000408042, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 4 X 5=120
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PPAT [Title/Abstract] AND KIF16B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPAT

GO:0015937

coenzyme A biosynthetic process

11923312


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EE-A183-06APPATchr4

57301516

-KIF16Bchr20

16509085

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000264220ENST00000354981PPATchr4

57301516

-KIF16Bchr20

16509085

-
5CDS-5UTRENST00000264220ENST00000378003PPATchr4

57301516

-KIF16Bchr20

16509085

-
5CDS-5UTRENST00000264220ENST00000355755PPATchr4

57301516

-KIF16Bchr20

16509085

-
5CDS-5UTRENST00000264220ENST00000408042PPATchr4

57301516

-KIF16Bchr20

16509085

-
intron-3CDSENST00000507648ENST00000354981PPATchr4

57301516

-KIF16Bchr20

16509085

-
intron-5UTRENST00000507648ENST00000378003PPATchr4

57301516

-KIF16Bchr20

16509085

-
intron-5UTRENST00000507648ENST00000355755PPATchr4

57301516

-KIF16Bchr20

16509085

-
intron-5UTRENST00000507648ENST00000408042PPATchr4

57301516

-KIF16Bchr20

16509085

-

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FusionProtFeatures for PPAT_KIF16B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPAT

Q06203

KIF16B

Q96L93


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPAT_KIF16B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPAT_KIF16B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPATMCM3, SMURF1, ATXN1, MMS19, EPT1, CARS, FAM114A1, GART, HSPA4, ILK, MEA1, PARVA, CARM1, RANBP3, RSU1, TROVE2, FAM96B, CIAO1, G6PD, CCZ1, HDAC3, FBXW11, ARHGAP1, IMPDH2, NPEPL1, PAK1, HPRT1, PFAS, PPP2CA, SNX2, PRPS1, PRPS2, SHMT1, TYMS, NTRK1, CRY1, NUDT5, B2MKIF16BITSN1, AURKA, GAR1, ENTHD2, MON1B, KIAA1279, ALOX5, CCZ1, SPAG9, CARM1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPAT_KIF16B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePPATQ06203DB01033MercaptopurineAmidophosphoribosyltransferasesmall moleculeapproved
HgenePPATQ06203DB01254DasatinibAmidophosphoribosyltransferasesmall moleculeapproved|investigational
HgenePPATQ06203DB00130L-GlutamineAmidophosphoribosyltransferasesmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for PPAT_KIF16B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPATC0023904Liver Neoplasms, Experimental1CTD_human
HgenePPATC0151744Myocardial Ischemia1CTD_human