![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 28106 |
FusionGeneSummary for PPAT_KIF16B |
![]() |
Fusion gene information | Fusion gene name: PPAT_KIF16B | Fusion gene ID: 28106 | Hgene | Tgene | Gene symbol | PPAT | KIF16B | Gene ID | 80347 | 55614 |
Gene name | Coenzyme A synthase | kinesin family member 16B | |
Synonyms | DPCK|NBIA6|NBP|PPAT|UKR1|pOV-2 | C20orf23|KISC20ORF|SNX23 | |
Cytomap | 17q21.2 | 20p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | bifunctional coenzyme A synthaseCoA synthasebifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinasenucleotide binding proteinphosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase | kinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201a | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q06203 | Q96L93 | |
Ensembl transtripts involved in fusion gene | ENST00000264220, ENST00000507648, | ENST00000354981, ENST00000378003, ENST00000355755, ENST00000408042, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 4 X 5=120 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: PPAT [Title/Abstract] AND KIF16B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | PPAT | GO:0015937 | coenzyme A biosynthetic process | 11923312 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-EE-A183-06A | PPAT | chr4 | 57301516 | - | KIF16B | chr20 | 16509085 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264220 | ENST00000354981 | PPAT | chr4 | 57301516 | - | KIF16B | chr20 | 16509085 | - |
5CDS-5UTR | ENST00000264220 | ENST00000378003 | PPAT | chr4 | 57301516 | - | KIF16B | chr20 | 16509085 | - |
5CDS-5UTR | ENST00000264220 | ENST00000355755 | PPAT | chr4 | 57301516 | - | KIF16B | chr20 | 16509085 | - |
5CDS-5UTR | ENST00000264220 | ENST00000408042 | PPAT | chr4 | 57301516 | - | KIF16B | chr20 | 16509085 | - |
intron-3CDS | ENST00000507648 | ENST00000354981 | PPAT | chr4 | 57301516 | - | KIF16B | chr20 | 16509085 | - |
intron-5UTR | ENST00000507648 | ENST00000378003 | PPAT | chr4 | 57301516 | - | KIF16B | chr20 | 16509085 | - |
intron-5UTR | ENST00000507648 | ENST00000355755 | PPAT | chr4 | 57301516 | - | KIF16B | chr20 | 16509085 | - |
intron-5UTR | ENST00000507648 | ENST00000408042 | PPAT | chr4 | 57301516 | - | KIF16B | chr20 | 16509085 | - |
Top |
FusionProtFeatures for PPAT_KIF16B |
![]() |
Hgene | Tgene |
PPAT | KIF16B |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PPAT_KIF16B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PPAT_KIF16B |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPAT | MCM3, SMURF1, ATXN1, MMS19, EPT1, CARS, FAM114A1, GART, HSPA4, ILK, MEA1, PARVA, CARM1, RANBP3, RSU1, TROVE2, FAM96B, CIAO1, G6PD, CCZ1, HDAC3, FBXW11, ARHGAP1, IMPDH2, NPEPL1, PAK1, HPRT1, PFAS, PPP2CA, SNX2, PRPS1, PRPS2, SHMT1, TYMS, NTRK1, CRY1, NUDT5, B2M | KIF16B | ITSN1, AURKA, GAR1, ENTHD2, MON1B, KIAA1279, ALOX5, CCZ1, SPAG9, CARM1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PPAT_KIF16B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | PPAT | Q06203 | DB01033 | Mercaptopurine | Amidophosphoribosyltransferase | small molecule | approved |
Hgene | PPAT | Q06203 | DB01254 | Dasatinib | Amidophosphoribosyltransferase | small molecule | approved|investigational |
Hgene | PPAT | Q06203 | DB00130 | L-Glutamine | Amidophosphoribosyltransferase | small molecule | approved|investigational|nutraceutical |
Top |
RelatedDiseases for PPAT_KIF16B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | PPAT | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Hgene | PPAT | C0151744 | Myocardial Ischemia | 1 | CTD_human |