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Fusion gene ID: 28105 |
FusionGeneSummary for PPAT_IGFBP7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPAT_IGFBP7 | Fusion gene ID: 28105 | Hgene | Tgene | Gene symbol | PPAT | IGFBP7 | Gene ID | 80347 | 3490 |
| Gene name | Coenzyme A synthase | insulin like growth factor binding protein 7 | |
| Synonyms | DPCK|NBIA6|NBP|PPAT|UKR1|pOV-2 | AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF | |
| Cytomap | 17q21.2 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bifunctional coenzyme A synthaseCoA synthasebifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinasenucleotide binding proteinphosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase | insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q06203 | Q16270 | |
| Ensembl transtripts involved in fusion gene | ENST00000264220, ENST00000507648, | ENST00000295666, ENST00000537922, ENST00000512512, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 3=48 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPAT [Title/Abstract] AND IGFBP7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPAT | GO:0015937 | coenzyme A biosynthetic process | 11923312 |
| Tgene | IGFBP7 | GO:0007155 | cell adhesion | 8117260 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PAAD | TCGA-HZ-A4BH-01A | PPAT | chr4 | 57267496 | - | IGFBP7 | chr4 | 57907099 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264220 | ENST00000295666 | PPAT | chr4 | 57267496 | - | IGFBP7 | chr4 | 57907099 | - |
| In-frame | ENST00000264220 | ENST00000537922 | PPAT | chr4 | 57267496 | - | IGFBP7 | chr4 | 57907099 | - |
| 5CDS-5UTR | ENST00000264220 | ENST00000512512 | PPAT | chr4 | 57267496 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000507648 | ENST00000295666 | PPAT | chr4 | 57267496 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-3CDS | ENST00000507648 | ENST00000537922 | PPAT | chr4 | 57267496 | - | IGFBP7 | chr4 | 57907099 | - |
| intron-5UTR | ENST00000507648 | ENST00000512512 | PPAT | chr4 | 57267496 | - | IGFBP7 | chr4 | 57907099 | - |
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FusionProtFeatures for PPAT_IGFBP7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPAT | IGFBP7 |
| Binds IGF-I and IGF-II with a relatively low affinity.Stimulates prostacyclin (PGI2) production. Stimulates celladhesion. {ECO:0000269|PubMed:8117260,ECO:0000269|PubMed:8939990}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPAT | chr4:57267496 | chr4:57907099 | ENST00000264220 | - | 7 | 11 | 12_261 | 295 | 518 | Domain | Glutamine amidotransferase type-2 |
| Tgene | >IGFBP7 | chr4:57267496 | chr4:57907099 | ENST00000295666 | - | 0 | 5 | 160_264 | 158 | 283 | Domain | Note=Ig-like C2-type |
| Tgene | >IGFBP7 | chr4:57267496 | chr4:57907099 | ENST00000537922 | - | 0 | 4 | 160_264 | 158 | 280 | Domain | Note=Ig-like C2-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | IGFBP7 | chr4:57267496 | chr4:57907099 | ENST00000295666 | - | 0 | 5 | 105_158 | 158 | 283 | Domain | Kazal-like |
| Tgene | IGFBP7 | chr4:57267496 | chr4:57907099 | ENST00000295666 | - | 0 | 5 | 28_106 | 158 | 283 | Domain | IGFBP N-terminal |
| Tgene | IGFBP7 | chr4:57267496 | chr4:57907099 | ENST00000537922 | - | 0 | 4 | 105_158 | 158 | 280 | Domain | Kazal-like |
| Tgene | IGFBP7 | chr4:57267496 | chr4:57907099 | ENST00000537922 | - | 0 | 4 | 28_106 | 158 | 280 | Domain | IGFBP N-terminal |
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FusionGeneSequence for PPAT_IGFBP7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPAT_ENST00000264220_chr4_57267496_-_IGFBP7_ENST00000295666_chr4_57907099_-_420aa MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIG HTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEA PTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLPGEIVEISRHNVQTLDIIS RSEGNPVAFCIFEYVYFARPDSMFEGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGG >In-frame_PPAT_ENST00000264220_chr4_57267496_-_IGFBP7_ENST00000537922_chr4_57907099_-_417aa MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIG HTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEA PTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLPGEIVEISRHNVQTLDIIS RSEGNPVAFCIFEYVYFARPDSMFEGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPAT_ENST00000264220_chr4_57267496_-_IGFBP7_ENST00000295666_chr4_57907099_-_1260nt ATGGAGCTGGAGGAGTTGGGGATCCGAGAGGAATGTGGCGTGTTCGGGTGCATCGCCTCAGGAGAGTGGCCCACGCAGCTGGATGTACCG CATGTGATCACTCTGGGACTCGTGGGGCTGCAGCACCGGGGTCAGGAGAGTGCTGGTATTGTGACTAGTGATGGGAGTTCGGTGCCAACA TTCAAATCACACAAGGGAATGGGTCTTGTAAATCACGTCTTTACTGAAGACAATTTGAAAAAATTATATGTTTCAAATCTTGGAATTGGA CACACCAGGTATGCCACCACAGGAAAATGTGAACTAGAAAATTGTCAGCCCTTCGTTGTTGAAACACTTCATGGGAAGATAGCTGTGGCA CATAATGGCGAATTGGTAAATGCTGCTCGATTAAGGAAAAAGCTTCTGCGTCATGGTATTGGTCTGTCTACAAGTTCTGATAGTGAAATG ATTACCCAGTTACTGGCGTATACCCCTCCTCAGGAACAAGATGACACCCCAGACTGGGTAGCCAGGATTAAAAACTTGATGAAGGAAGCA CCCACAGCATACTCCCTGCTTATAATGCACAGAGATGTTATTTATGCAGTACGAGATCCTTATGGAAATCGTCCCTTATGCATTGGTCGT CTTATTCCAGTGTCTGATATAAATGACAAAGAGAAAAAAACATCAGAAACAGAAGGATGGGTGGTGTCTTCAGAATCTTGTAGCTTCTTA TCTATTGGTGCAAGATATTACCGTGAAGTCTTGCCTGGAGAAATTGTGGAAATATCCAGACACAATGTCCAAACTCTTGATATTATATCA AGGTCTGAAGGAAACCCAGTGGCTTTTTGTATCTTTGAATATGTTTATTTTGCAAGACCAGACAGTATGTTCGAAGGTCCTTCCATAGTG ACGCCCCCCAAGGACATCTGGAATGTCACTGGTGCCCAGGTGTACTTGAGCTGTGAGGTCATCGGAATCCCGACACCTGTCCTCATCTGG AACAAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAACTCCTGCCTGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGC CCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGGTATCTCCTCTAAGTAAGGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCC CAAGGACAGGCTTCAGCATCAGCAAAAATTACAGTGGTTGATGCCTTACATGAAATACCAGTGAAAAAAGGTGAAGGTGCCGAGCTATAA >In-frame_PPAT_ENST00000264220_chr4_57267496_-_IGFBP7_ENST00000537922_chr4_57907099_-_1251nt ATGGAGCTGGAGGAGTTGGGGATCCGAGAGGAATGTGGCGTGTTCGGGTGCATCGCCTCAGGAGAGTGGCCCACGCAGCTGGATGTACCG CATGTGATCACTCTGGGACTCGTGGGGCTGCAGCACCGGGGTCAGGAGAGTGCTGGTATTGTGACTAGTGATGGGAGTTCGGTGCCAACA TTCAAATCACACAAGGGAATGGGTCTTGTAAATCACGTCTTTACTGAAGACAATTTGAAAAAATTATATGTTTCAAATCTTGGAATTGGA CACACCAGGTATGCCACCACAGGAAAATGTGAACTAGAAAATTGTCAGCCCTTCGTTGTTGAAACACTTCATGGGAAGATAGCTGTGGCA CATAATGGCGAATTGGTAAATGCTGCTCGATTAAGGAAAAAGCTTCTGCGTCATGGTATTGGTCTGTCTACAAGTTCTGATAGTGAAATG ATTACCCAGTTACTGGCGTATACCCCTCCTCAGGAACAAGATGACACCCCAGACTGGGTAGCCAGGATTAAAAACTTGATGAAGGAAGCA CCCACAGCATACTCCCTGCTTATAATGCACAGAGATGTTATTTATGCAGTACGAGATCCTTATGGAAATCGTCCCTTATGCATTGGTCGT CTTATTCCAGTGTCTGATATAAATGACAAAGAGAAAAAAACATCAGAAACAGAAGGATGGGTGGTGTCTTCAGAATCTTGTAGCTTCTTA TCTATTGGTGCAAGATATTACCGTGAAGTCTTGCCTGGAGAAATTGTGGAAATATCCAGACACAATGTCCAAACTCTTGATATTATATCA AGGTCTGAAGGAAACCCAGTGGCTTTTTGTATCTTTGAATATGTTTATTTTGCAAGACCAGACAGTATGTTCGAAGGTCCTTCCATAGTG ACGCCCCCCAAGGACATCTGGAATGTCACTGGTGCCCAGGTGTACTTGAGCTGTGAGGTCATCGGAATCCCGACACCTGTCCTCATCTGG AACAAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAACTCCTGCCTGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGC CCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGGTATCTCCTCTAAGTAAGGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPAT_ENST00000264220_chr4_57267496_-_IGFBP7_ENST00000295666_chr4_57907099_-_1942nt AGTAGCTGGGGCCACCCTCGGGAAGGAAGAGCCTGTCGCGAGCGCGAGCTTCTGAGCTCGACGGGCCGAGCTGGCAGCTGGTTGGTGCTT ACACCTTGGCCGCAGCGGCAGGTCCTTCCACGTGCTTTCGGCGGCGACATGGAGCTGGAGGAGTTGGGGATCCGAGAGGAATGTGGCGTG TTCGGGTGCATCGCCTCAGGAGAGTGGCCCACGCAGCTGGATGTACCGCATGTGATCACTCTGGGACTCGTGGGGCTGCAGCACCGGGGT CAGGAGAGTGCTGGTATTGTGACTAGTGATGGGAGTTCGGTGCCAACATTCAAATCACACAAGGGAATGGGTCTTGTAAATCACGTCTTT ACTGAAGACAATTTGAAAAAATTATATGTTTCAAATCTTGGAATTGGACACACCAGGTATGCCACCACAGGAAAATGTGAACTAGAAAAT TGTCAGCCCTTCGTTGTTGAAACACTTCATGGGAAGATAGCTGTGGCACATAATGGCGAATTGGTAAATGCTGCTCGATTAAGGAAAAAG CTTCTGCGTCATGGTATTGGTCTGTCTACAAGTTCTGATAGTGAAATGATTACCCAGTTACTGGCGTATACCCCTCCTCAGGAACAAGAT GACACCCCAGACTGGGTAGCCAGGATTAAAAACTTGATGAAGGAAGCACCCACAGCATACTCCCTGCTTATAATGCACAGAGATGTTATT TATGCAGTACGAGATCCTTATGGAAATCGTCCCTTATGCATTGGTCGTCTTATTCCAGTGTCTGATATAAATGACAAAGAGAAAAAAACA TCAGAAACAGAAGGATGGGTGGTGTCTTCAGAATCTTGTAGCTTCTTATCTATTGGTGCAAGATATTACCGTGAAGTCTTGCCTGGAGAA ATTGTGGAAATATCCAGACACAATGTCCAAACTCTTGATATTATATCAAGGTCTGAAGGAAACCCAGTGGCTTTTTGTATCTTTGAATAT GTTTATTTTGCAAGACCAGACAGTATGTTCGAAGGTCCTTCCATAGTGACGCCCCCCAAGGACATCTGGAATGTCACTGGTGCCCAGGTG TACTTGAGCTGTGAGGTCATCGGAATCCCGACACCTGTCCTCATCTGGAACAAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAA CTCCTGCCTGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGGTATCTCCT CTAAGTAAGGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAGTGGTTGAT GCCTTACATGAAATACCAGTGAAAAAAGGTGAAGGTGCCGAGCTATAAACCTCCAGAATATTATTAGTCTGCATGGTTAAAAGTAGTCAT GGATAACTACATTACCTGTTCTTGCCTAATAAGTTTCTTTTAATCCAATCCACTAACACTTTAGTTATATTCACTGGTTTTACACAGAGA AATACAAAATAAAGATCACACATCAAGACTATCTACAAAAATTTATTATATATTTACAGAAGAAAAGCATGCATATCATTAAACAAATAA AATACTTTTTATCACAACACAGTACATATTTGTCATTTTTAAAAAGCCACACAATAGAAACAAGACACCAAGATATTTAATTATCTTGTT GACTCCTGTAAAATAGCTAAACACTCATCATTCGCGGTGCAATACTCATAGACATAAGTTCCTGAAACAATAGTTTGCATGCGTAAGGCA TTCGCACCAAAGAAATCTGAAAAGAAAAAACAAATGGTAATTAGCAGAATTGTATTGAAGTGACCCCACTTCTCTACCCCAGAAAAAGAC >In-frame_PPAT_ENST00000264220_chr4_57267496_-_IGFBP7_ENST00000537922_chr4_57907099_-_1766nt AGTAGCTGGGGCCACCCTCGGGAAGGAAGAGCCTGTCGCGAGCGCGAGCTTCTGAGCTCGACGGGCCGAGCTGGCAGCTGGTTGGTGCTT ACACCTTGGCCGCAGCGGCAGGTCCTTCCACGTGCTTTCGGCGGCGACATGGAGCTGGAGGAGTTGGGGATCCGAGAGGAATGTGGCGTG TTCGGGTGCATCGCCTCAGGAGAGTGGCCCACGCAGCTGGATGTACCGCATGTGATCACTCTGGGACTCGTGGGGCTGCAGCACCGGGGT CAGGAGAGTGCTGGTATTGTGACTAGTGATGGGAGTTCGGTGCCAACATTCAAATCACACAAGGGAATGGGTCTTGTAAATCACGTCTTT ACTGAAGACAATTTGAAAAAATTATATGTTTCAAATCTTGGAATTGGACACACCAGGTATGCCACCACAGGAAAATGTGAACTAGAAAAT TGTCAGCCCTTCGTTGTTGAAACACTTCATGGGAAGATAGCTGTGGCACATAATGGCGAATTGGTAAATGCTGCTCGATTAAGGAAAAAG CTTCTGCGTCATGGTATTGGTCTGTCTACAAGTTCTGATAGTGAAATGATTACCCAGTTACTGGCGTATACCCCTCCTCAGGAACAAGAT GACACCCCAGACTGGGTAGCCAGGATTAAAAACTTGATGAAGGAAGCACCCACAGCATACTCCCTGCTTATAATGCACAGAGATGTTATT TATGCAGTACGAGATCCTTATGGAAATCGTCCCTTATGCATTGGTCGTCTTATTCCAGTGTCTGATATAAATGACAAAGAGAAAAAAACA TCAGAAACAGAAGGATGGGTGGTGTCTTCAGAATCTTGTAGCTTCTTATCTATTGGTGCAAGATATTACCGTGAAGTCTTGCCTGGAGAA ATTGTGGAAATATCCAGACACAATGTCCAAACTCTTGATATTATATCAAGGTCTGAAGGAAACCCAGTGGCTTTTTGTATCTTTGAATAT GTTTATTTTGCAAGACCAGACAGTATGTTCGAAGGTCCTTCCATAGTGACGCCCCCCAAGGACATCTGGAATGTCACTGGTGCCCAGGTG TACTTGAGCTGTGAGGTCATCGGAATCCCGACACCTGTCCTCATCTGGAACAAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAA CTCCTGCCTGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGGTATCTCCT CTAAGTAAGGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAGTGGTTGAT GCCTTACATGAAATACCAGTGAAAAAAGGTACACAATAAATCTCACAGCCATTTAAAAATGACTAGTACATTTGCTTTAAAAAGAACAGA ACTAAGTATGAAAGTATCAGACGTAGCTATTGATGAAATTCTGTAGTTAGCAACCCATAAGGGCATTAAGTATGCCATTAAAATGTACAG CATGAGACTCCAAAAGATTATCTGGATGGGTGACTGAACATCGTTATTATGACTTAGATGCTTTTACCTTATCTAACATGTAAGAGTCAA AATCAAACTTGCCTGGAATGGCTTCTATTTCCCATAGCTTTCTACCTATCTACTTGGCATTTTCCCTTTGTGTTGTGACTATTAAATTCC |
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FusionGenePPI for PPAT_IGFBP7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPAT | MCM3, SMURF1, ATXN1, MMS19, EPT1, CARS, FAM114A1, GART, HSPA4, ILK, MEA1, PARVA, CARM1, RANBP3, RSU1, TROVE2, FAM96B, CIAO1, G6PD, CCZ1, HDAC3, FBXW11, ARHGAP1, IMPDH2, NPEPL1, PAK1, HPRT1, PFAS, PPP2CA, SNX2, PRPS1, PRPS2, SHMT1, TYMS, NTRK1, CRY1, NUDT5, B2M | IGFBP7 | IGF1, IGF2, CHMP3, VEGFA, INS, DSTN, RTN4, HNF1A, RBBP8, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPAT_IGFBP7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PPAT | Q06203 | DB01033 | Mercaptopurine | Amidophosphoribosyltransferase | small molecule | approved |
| Hgene | PPAT | Q06203 | DB01254 | Dasatinib | Amidophosphoribosyltransferase | small molecule | approved|investigational |
| Hgene | PPAT | Q06203 | DB00130 | L-Glutamine | Amidophosphoribosyltransferase | small molecule | approved|investigational|nutraceutical |
| Tgene | IGFBP7 | Q16270 | DB00071 | Insulin Pork | Insulin-like growth factor-binding protein 7 | biotech | approved |
| Tgene | IGFBP7 | Q16270 | DB00030 | Insulin Human | Insulin-like growth factor-binding protein 7 | biotech | approved|investigational |
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RelatedDiseases for PPAT_IGFBP7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPAT | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| Hgene | PPAT | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | IGFBP7 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | IGFBP7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | IGFBP7 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | IGFBP7 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | IGFBP7 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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