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Fusion gene ID: 28101 |
FusionGeneSummary for PPARG_CRYBA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPARG_CRYBA4 | Fusion gene ID: 28101 | Hgene | Tgene | Gene symbol | PPARG | CRYBA4 | Gene ID | 5468 | 1413 |
| Gene name | peroxisome proliferator activated receptor gamma | crystallin beta A4 | |
| Synonyms | CIMT1|GLM1|NR1C3|PPARG1|PPARG2|PPARgamma | CTRCT23|CYRBA4|MCOPCT4 | |
| Cytomap | 3p25.2 | 22q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peroxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1 | beta-crystallin A4beta crystallin A4 chain transcript PSbeta crystallin alpha 4 chainbeta-A4 crystallincrystallin, beta polypeptide A4eye lens structural protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P37231 | P53673 | |
| Ensembl transtripts involved in fusion gene | ENST00000397010, ENST00000309576, ENST00000397015, ENST00000397012, ENST00000397026, ENST00000397000, ENST00000539812, ENST00000287820, | ENST00000354760, ENST00000466315, | |
| Fusion gene scores | * DoF score | 5 X 4 X 2=40 | 3 X 3 X 3=27 |
| # samples | 8 | 3 | |
| ** MAII score | log2(8/40*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPARG [Title/Abstract] AND CRYBA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPARG | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12700342 |
| Hgene | PPARG | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 18293083 |
| Hgene | PPARG | GO:0007165 | signal transduction | 9568716 |
| Hgene | PPARG | GO:0010742 | macrophage derived foam cell differentiation | 26504087 |
| Hgene | PPARG | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 19114110 |
| Hgene | PPARG | GO:0010871 | negative regulation of receptor biosynthetic process | 12700342 |
| Hgene | PPARG | GO:0010887 | negative regulation of cholesterol storage | 19114110 |
| Hgene | PPARG | GO:0010891 | negative regulation of sequestering of triglyceride | 12700342 |
| Hgene | PPARG | GO:0016525 | negative regulation of angiogenesis | 28566713 |
| Hgene | PPARG | GO:0030224 | monocyte differentiation | 9568716 |
| Hgene | PPARG | GO:0032526 | response to retinoic acid | 16239304 |
| Hgene | PPARG | GO:0042953 | lipoprotein transport | 9568716 |
| Hgene | PPARG | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 28566713 |
| Hgene | PPARG | GO:0045713 | low-density lipoprotein particle receptor biosynthetic process | 9568716 |
| Hgene | PPARG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9568715|12700342|16239304|17611579 |
| Hgene | PPARG | GO:0048469 | cell maturation | 9568716 |
| Hgene | PPARG | GO:0048662 | negative regulation of smooth muscle cell proliferation | 20622039 |
| Hgene | PPARG | GO:0051091 | positive regulation of DNA binding transcription factor activity | 18293083 |
| Hgene | PPARG | GO:0061614 | pri-miRNA transcription by RNA polymerase II | 28566713 |
| Hgene | PPARG | GO:0071404 | cellular response to low-density lipoprotein particle stimulus | 9568716 |
| Hgene | PPARG | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | 28522568 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-HQ-A2OE-01A | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000397010 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| 5CDS-intron | ENST00000397010 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| In-frame | ENST00000309576 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| 5CDS-intron | ENST00000309576 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| In-frame | ENST00000397015 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| 5CDS-intron | ENST00000397015 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| In-frame | ENST00000397012 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| 5CDS-intron | ENST00000397012 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| In-frame | ENST00000397026 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| 5CDS-intron | ENST00000397026 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| In-frame | ENST00000397000 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| 5CDS-intron | ENST00000397000 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| In-frame | ENST00000539812 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| 5CDS-intron | ENST00000539812 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| In-frame | ENST00000287820 | ENST00000354760 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
| 5CDS-intron | ENST00000287820 | ENST00000466315 | PPARG | chr3 | 12422990 | + | CRYBA4 | chr22 | 27019198 | + |
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FusionProtFeatures for PPARG_CRYBA4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPARG | CRYBA4 |
| Crystallins are the dominant structural components ofthe vertebrate eye lens. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 139_159 | 160 | 506 | Zinc finger | NR C4-type |
| Tgene | >CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | + | 1 | 6 | 105_146 | 13 | 197 | Domain | Beta/gamma crystallin 'Greek key' 3 |
| Tgene | >CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | + | 1 | 6 | 12_51 | 13 | 197 | Domain | Beta/gamma crystallin 'Greek key' 1 |
| Tgene | >CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | + | 1 | 6 | 147_195 | 13 | 197 | Domain | Beta/gamma crystallin 'Greek key' 4 |
| Tgene | >CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | + | 1 | 6 | 52_98 | 13 | 197 | Domain | Beta/gamma crystallin 'Greek key' 2 |
| Tgene | >CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | + | 1 | 6 | 99_104 | 13 | 197 | Region | Note=Connecting peptide |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 136_210 | 160 | 506 | DNA binding | Nuclear receptor |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 136_210 | 132 | 478 | DNA binding | Nuclear receptor |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 136_210 | 132 | 478 | DNA binding | Nuclear receptor |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 136_210 | 132 | 478 | DNA binding | Nuclear receptor |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 136_210 | 132 | 478 | DNA binding | Nuclear receptor |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 238_503 | 160 | 506 | Domain | NR LBD |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 238_503 | 132 | 478 | Domain | NR LBD |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 238_503 | 132 | 478 | Domain | NR LBD |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 238_503 | 132 | 478 | Domain | NR LBD |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 238_503 | 132 | 478 | Domain | NR LBD |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 176_198 | 160 | 506 | Zinc finger | NR C4-type |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 139_159 | 132 | 478 | Zinc finger | NR C4-type |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 176_198 | 132 | 478 | Zinc finger | NR C4-type |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 139_159 | 132 | 478 | Zinc finger | NR C4-type |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 176_198 | 132 | 478 | Zinc finger | NR C4-type |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 139_159 | 132 | 478 | Zinc finger | NR C4-type |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 176_198 | 132 | 478 | Zinc finger | NR C4-type |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 139_159 | 132 | 478 | Zinc finger | NR C4-type |
| Hgene | >PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 176_198 | 132 | 478 | Zinc finger | NR C4-type |
| Tgene | CRYBA4 | chr3:12422990 | chr22:27019198 | ENST00000354760 | + | 1 | 6 | 2_11 | 13 | 197 | Region | Note=N-terminal arm |
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FusionGeneSequence for PPARG_CRYBA4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPARG_ENST00000397010_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_316aa MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC >In-frame_PPARG_ENST00000309576_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_316aa MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC >In-frame_PPARG_ENST00000397015_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_316aa MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC >In-frame_PPARG_ENST00000397012_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_316aa MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC >In-frame_PPARG_ENST00000397026_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_322aa MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPAS PPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWV GFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVH >In-frame_PPARG_ENST00000397000_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_316aa MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC >In-frame_PPARG_ENST00000539812_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_314aa MVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAGFQ GQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQ >In-frame_PPARG_ENST00000287820_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_344aa MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAEC PSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPARG_ENST00000397010_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_948nt ATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCAC TCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCA GTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAG AAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGA TTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCC GAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGC TTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTC ACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAG CTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGC TCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCT >In-frame_PPARG_ENST00000309576_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_948nt ATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCAC TCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCA GTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAG AAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGA TTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCC GAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGC TTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTC ACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAG CTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGC TCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCT >In-frame_PPARG_ENST00000397015_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_948nt ATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCAC TCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCA GTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAG AAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGA TTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCC GAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGC TTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTC ACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAG CTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGC TCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCT >In-frame_PPARG_ENST00000397012_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_948nt ATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCAC TCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCA GTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAG AAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGA TTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCC GAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGC TTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTC ACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAG CTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGC TCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCT >In-frame_PPARG_ENST00000397026_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_966nt ATGAAAGGCTTTTCAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTA ATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCA TTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCT CCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGT GGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGG CGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTG GGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCC TACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTC CTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCAC TCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACAT >In-frame_PPARG_ENST00000397000_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_948nt ATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCAC TCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCA GTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAG AAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGA TTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCC GAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGC TTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTC ACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAG CTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGC TCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCT >In-frame_PPARG_ENST00000539812_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_942nt ATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTT GATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTT GCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACT CAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCAC TATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGC CCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAA GGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCC TTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGC GATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAG TTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCC >In-frame_PPARG_ENST00000287820_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_1032nt ATGGGTGAAACTCTGGGAGATTCTCCTATTGACCCAGAAAGCGATTCCTTCACTGATACACTGTCTGCAAACATATCACAAGAAATGACC ATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTT GATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTT GCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACT CAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCAC TATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGC CCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAA GGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCC TTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGC GATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAG TTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPARG_ENST00000397010_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_1517nt AACTTACAAACGCAAGGAACTCTGAAAGTGTGCAGCACCACCGATCAGAAGAGAAAACCAAGGGACCCGAAATATGCTTTAATTAAATTT TCTTTTAAAATGTCACTGGAAAGAACATCTTGGGAAGACGGCCTGGCCGATCGCCGTGTGAAGGGCAAGCCACTCTGGCCGAGAGGGAGC CCCACACCTCGGTCTCCCCAGACCGGCCCTGGCCGGGGGCATCCCCCTAAACTTCGGATCCCTCCTCGGAAATGGGACCCTCTCTGGGCC GCCTCCCAGCGGTGGTGGCGAGGAGCAAACGACACCAGATTTGAAAGAAGCCAACACTAAACCACAAATATACAACAAGGCCATTTTCTC AAACGAGAGTCAGCCTTTAACGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTC TCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGAC ATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCT GCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGT GTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAG GGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCG TGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAAC ACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAG AACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCAC GTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTAC AAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGGA GGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAACC >In-frame_PPARG_ENST00000309576_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_1370nt CCCGCCCCCGCGCCGGGCCCGGCTCGGCCCGACCCGGCTCCGCCGCGGGCAGGCGGGGCCCAGCGCACTCGGAGCCCGAGCCCGAGCCGC AGCCGCCGCCTGGGGCGCTTGGGTCGGCCTCGAGGACACCGGAGAGGGGCGCCACGCCGCCGTGGCCGCAGATTTGAAAGAAGCCAACAC TAAACCACAAATATACAACAAGGCCATTTTCTCAAACGAGAGTCAGCCTTTAACGAAATGACCATGGTTGACACAGAGATGCCATTCTGG CCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGAC TTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTT CAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAG CCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGC AAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAG ACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGC GAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCAC CGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATG GGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTAT GTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGC AGGATCCAGCAGTGAACAGGGGTGCGGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTC TCCTTCTGCCTCCCCCTGTAACCTGTGTGAACCCAGCACCCATGTGAACTGGTCCGTGCACAGTCAGCACAAAAAACTCAAACGAATAAA >In-frame_PPARG_ENST00000397015_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_1255nt GCCGCGGGCAGGCGGGGCCCAGCGCACTCGGAGCCCGAGCCCGAGCCGCAGCCGCCGCCTGGGGCGCTTGGGTCGGCCTCGAGGACACCG GAGAGGGGCGCCACGCCGCCGTGGCCGCAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCG TGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATT ACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAG TGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTG AATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACG GCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGA GTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGG GCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCG AGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGT CCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCG GTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGC GGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTG >In-frame_PPARG_ENST00000397012_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_1506nt CTTTGTGGGCTCCTGCAAGTGCCAGGCGCTGACCACTCCTCCTGGGAGCCTAACTGAGGGGGGTAGAGGCAGCAGAGGTTAACAGAAATC TCAGGTCCCTTGGTGGAAGGTGGGTGTGTAGTCGTGGTACTTTACGCCTCGGTGTTTAGGGAGGAGCCTAAGGTAAGGAGTCAGAAACGG GGAGTAACCGAGCTGCGGCTTTTATATAAGGTCAGTGGTAGGTAAGGAAGGGGCCTTAACCTCTGCTGGTGACCAGAAGCCTGCATTTCT GCATTCTGCTTAATTCCCTTTCCTTAGATTTGAAAGAAGCCAACACTAAACCACAAATATACAACAAGGCCATTTTCTCAAACGAGAGTC AGCCTTTAACGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGA AGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCAC AAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACC TTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGA TAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCA CGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTT TGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCC CGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGG CAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGG GGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCG GGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGGAGGAGCGCATGC GTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAACCCAGCACCCATG >In-frame_PPARG_ENST00000397026_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_1534nt CCTTAACCTCTGCTGGTGACCAGAAGCCTGCATTTCTGCATTCTGCTTAATTCCCTTTCCTTAGATTTGAAAGAAGCCAACACTAAACCA CAAATATACAACAAGGCCATTTTCTCAAACGAGAGTCAGCCTTTAACGTGTTTCAGGATGATTCTTGTCTCTGGATGTCGCTGTCATGAT GGGAGAGGAATTAGTAAATTCCCAGGTCAGTTTACACTGCAGAGTGATCTTGATCTGCATGAATCAGTAAGGATGGGCTGGATAAACAAG TTGGAACCACAGTTATGAGTACCATGACATTAACTGAAACAAATGAGAAGGGATTGAAAAATCGGCGGTTAAGTGTCTTTTAAGGTCATT TCCAACAAAACTACAAAGGACCTATGAAAGGCTTTTCAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGA TCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTA CTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTG CAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCA TGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGG ATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGA AAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGG ATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGA CAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATG AAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATC ACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAA CAGGGGTGCGGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCC TGTAACCTGTGTGAACCCAGCACCCATGTGAACTGGTCCGTGCACAGTCAGCACAAAAAACTCAAACGAATAAAAAAGAGAAAGTCTGGT >In-frame_PPARG_ENST00000397000_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_1201nt GAAGCCAACACTAAACCACAAATATACAACAAGGCCATTTTCTCAAACGAGAGTCAGCCTTTAACGAAATGACCATGGTTGACACAGAGA TGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCA CTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATG ACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGC CTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTT GTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGC TTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTC TGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCT GTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCC TCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAG GATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGC AGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGT GGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAACCCAGCACCCATGTGAACTGGTCCGTGCACAGTCAGCACAAAAAACTC >In-frame_PPARG_ENST00000539812_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_1201nt GAAGCCAACACTAAACCACAAATATACAACAAGGCCATTTTCTCAAACGAGAGTCAGCCTTTAACGAAATGACCATGGTTGACACAGAGA TGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCA CTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATG ACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGC CTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTT GTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCAGGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGC TTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGCGTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTC TGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAACACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCT GTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGAGAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCC TCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCACGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAG GATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTACAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGC AGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGGAGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGT GGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAACCCAGCACCCATGTGAACTGGTCCGTGCACAGTCAGCACAAAAAACTC >In-frame_PPARG_ENST00000287820_chr3_12422990_+_CRYBA4_ENST00000354760_chr22_27019198_+_1338nt ACTCATGGGTGTATTCACAAATTCTGTTACTTCAAGTCTTTTTCTTTTAACGGATTGATCTTTTGCTAGATAGAGACAAAATATCAGTGT GAATTACAGCAAACCCCTATTCCATGCTGTTATGGGTGAAACTCTGGGAGATTCTCCTATTGACCCAGAAAGCGATTCCTTCACTGATAC ACTGTCTGCAAACATATCACAAGAAATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTGGATCT CTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTTGACTTCTCCAGCATTTCTACTCCACATTACGAAGA CATTCCATTCACAAGAACAGATCCAGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTGGAGCC TGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCG TGTCTGTGGAGATAAAGCTTCTGGATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGATGGTGGTGTGGGATGAGGACGGCTTCCA GGGCCGGCGGCACGAGTTCACGGCCGAGTGCCCCAGCGTGCTGGAGCTTGGCTTCGAGACTGTGCGATCTTTGAAAGTGCTGAGTGGAGC GTGGGTGGGCTTTGAGCATGCTGGCTTCCAAGGGCAGCAGTACATTCTGGAACGAGGCGAATATCCAAGCTGGGATGCCTGGGGCGGCAA CACGGCCTACCCCGCCGAGAGGCTCACCTCCTTCCGGCCTGCGGCCTGTGCTAACCACCGTGACTCGAGGCTGACAATCTTCGAGCAAGA GAACTTCCTGGGCAAGAAAGGAGAGCTGAGCGATGACTATCCTTCCCTCCAGGCCATGGGATGGGAAGGCAATGAAGTAGGGTCCTTCCA CGTCCACTCTGGGGCCTGGGTTTGCTCCCAGTTTCCGGGCTACCGAGGATTTCAGTATGTGCTGGAATGCGATCACCATTCCGGTGACTA CAAACATTTCCGGGAGTGGGGCTCTCATGCCCCGACCTTCCAGGTGCAGAGCATCCGCAGGATCCAGCAGTGAACAGGGGTGCGGCACGG AGGAGCGCATGCGTGCTTATCTGCAATGGAGGCGCTCTGGAGGCTGTGGTGTGTTCTCTCCTTCTGCCTCCCCCTGTAACCTGTGTGAAC |
Top |
FusionGenePPI for PPARG_CRYBA4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPARG | NCOA4, GADD45G, DNTTIP2, PPARGC1A, HDAC3, HDAC4, RB1, EP300, EDF1, FABP1, NR0B2, SVIL, NRIP1, POU1F1, CREBBP, RXRA, MED24, MSX2, PML, ZBTB5, NR2E3, MAFF, ZBTB20, ZBTB3, ZNF496, ZBTB9, ZSCAN1, PIAS1, NCOR1, NCOR2, HMGA1, SP1, TFAP2A, CEBPB, MED1, ZNHIT3, TRIP4, JMJD1C, NFKBIB, SERPINH1, NCOA1, TRIM24, NCOA2, NCOA3, GRIP1, KAT5, LRIF1, HDAC1, MECP2, EZH2, NCOA6, NR0B1, COPS5, FHOD1, KIF1A, RXRB, ROBO4, KLF4, KDM4C, TNP1, KCTD13, RAD54L2, ANP32A, APP, RELA, UBC, CDC34, JAZF1, MED14, BCAS2, NEDD4, SMARCD3, SMARCA4, CDK5, MIF4GD, USP7, ALOX15B, SMAD2, ZFYVE9, NR3C1, MUC1, NSD1, PAXIP1, ASH2L, RBBP5, PRKAA1, PRKAA2, CTNNB1, SFPQ, NR4A1, NR4A2, JUN, NFE2L3, PHB2, STAT5A, VDR, RXRG, MAP2K1, CAV1, SMAD3, PDIA2, PPM1B, XRCC6, XRCC5, MAPK1, RANBP3, XPO1, JUND, LMO4, RFX5, CIITA, TCF4, NFKB1, PPARG, PRKCA, PIN1, STAT6, IKBKB, KAT2A, KIF11, CEP350, UBE2I, KLF5, IGFBP3, EGFR, MDM2, YWHAB, YWHAG, PPARGC1B, STAT1, STUB1, FLYWCH2 | CRYBA4 | CEP76, EML5, DDB2, RBP4, UBB, CUL4B, TJP1, FOXF2, APAF1, RICTOR, DISC1, PPOX, CUL4A, MKS1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000287820 | + | 3 | 7 | 205_280 | 160 | 506 | FAM120B |
| Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000309576 | + | 4 | 8 | 205_280 | 132 | 478 | FAM120B |
| Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397010 | + | 4 | 8 | 205_280 | 132 | 478 | FAM120B |
| Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397012 | + | 4 | 8 | 205_280 | 132 | 478 | FAM120B |
| Hgene | PPARG | chr3:12422990 | chr22:27019198 | ENST00000397015 | + | 3 | 7 | 205_280 | 132 | 478 | FAM120B |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPARG_CRYBA4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PPARG | P37231 | DB00244 | Mesalazine | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
| Hgene | PPARG | P37231 | DB00573 | Fenoprofen | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
| Hgene | PPARG | P37231 | DB00795 | Sulfasalazine | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
| Hgene | PPARG | P37231 | DB01039 | Fenofibrate | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
| Hgene | PPARG | P37231 | DB01050 | Ibuprofen | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
| Hgene | PPARG | P37231 | DB13873 | Fenofibric acid | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
| Hgene | PPARG | P37231 | DB00313 | Valproic Acid | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB00328 | Indomethacin | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB00412 | Rosiglitazone | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB00731 | Nateglinide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB00912 | Repaglinide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB00966 | Telmisartan | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB01014 | Balsalazide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB01067 | Glipizide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB01118 | Amiodarone | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB01132 | Pioglitazone | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB01252 | Mitiglinide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB01393 | Bezafibrate | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB08604 | Triclosan | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
| Hgene | PPARG | P37231 | DB09213 | Dexibuprofen | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Top |
RelatedDiseases for PPARG_CRYBA4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPARG | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 5 | CTD_human |
| Hgene | PPARG | C0011853 | Diabetes Mellitus, Experimental | 3 | CTD_human |
| Hgene | PPARG | C0020538 | Hypertensive disease | 3 | CTD_human;HPO |
| Hgene | PPARG | C0021655 | Insulin Resistance | 3 | CTD_human;HPO |
| Hgene | PPARG | C0035126 | Reperfusion Injury | 3 | CTD_human |
| Hgene | PPARG | C2609414 | Acute kidney injury | 3 | CTD_human |
| Hgene | PPARG | C0002395 | Alzheimer's Disease | 2 | CTD_human |
| Hgene | PPARG | C0021368 | Inflammation | 2 | CTD_human |
| Hgene | PPARG | C0022116 | Ischemia | 2 | CTD_human |
| Hgene | PPARG | C0028754 | Obesity | 2 | CTD_human;HPO;UNIPROT |
| Hgene | PPARG | C0030297 | Pancreatic Neoplasm | 2 | CTD_human |
| Hgene | PPARG | C0038356 | Stomach Neoplasms | 2 | CTD_human |
| Hgene | PPARG | C1720861 | Familial Partial Lipodystrophy, Type 3 | 2 | ORPHANET;UNIPROT |
| Hgene | PPARG | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | PPARG | C0004153 | Atherosclerosis | 1 | CTD_human |
| Hgene | PPARG | C0004763 | Barrett Esophagus | 1 | CTD_human |
| Hgene | PPARG | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | PPARG | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | PPARG | C0010346 | Crohn Disease | 1 | CTD_human |
| Hgene | PPARG | C0011849 | Diabetes Mellitus | 1 | CTD_human;HPO |
| Hgene | PPARG | C0017658 | Glomerulonephritis | 1 | CTD_human |
| Hgene | PPARG | C0018801 | Heart failure | 1 | CTD_human |
| Hgene | PPARG | C0023794 | Lipoidosis | 1 | CTD_human |
| Hgene | PPARG | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | PPARG | C0025202 | melanoma | 1 | CTD_human |
| Hgene | PPARG | C0025517 | Metabolic Diseases | 1 | CTD_human |
| Hgene | PPARG | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Hgene | PPARG | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | PPARG | C0033860 | Psoriasis | 1 | CTD_human |
| Hgene | PPARG | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | PPARG | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| Hgene | PPARG | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
| Hgene | PPARG | C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | CTD_human |
| Hgene | PPARG | C0221406 | Pituitary-dependent Cushing's disease | 1 | CTD_human |
| Hgene | PPARG | C0236811 | Chronobiology Disorders | 1 | CTD_human |
| Hgene | PPARG | C0242339 | Dyslipidemias | 1 | CTD_human |
| Hgene | PPARG | C0242488 | Acute Lung Injury | 1 | CTD_human |
| Hgene | PPARG | C0271694 | Familial partial lipodystrophy | 1 | CTD_human |
| Hgene | PPARG | C0282548 | Leukostasis | 1 | CTD_human |
| Hgene | PPARG | C0525045 | Mood Disorders | 1 | PSYGENET |
| Hgene | PPARG | C2239176 | Liver carcinoma | 1 | CTD_human |
| Hgene | PPARG | C2931367 | Thyroid cancer, follicular | 1 | CTD_human |
| Tgene | CRYBA4 | C3808012 | CATARACT 23 | 1 | CTD_human;UNIPROT |
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