|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28078 |
FusionGeneSummary for PPARA_ATXN10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPARA_ATXN10 | Fusion gene ID: 28078 | Hgene | Tgene | Gene symbol | PPARA | ATXN10 | Gene ID | 5465 | 25814 |
| Gene name | peroxisome proliferator activated receptor alpha | ataxin 10 | |
| Synonyms | NR1C1|PPAR|PPARalpha|hPPAR | E46L|HUMEEP|SCA10 | |
| Cytomap | 22q13.31 | 22q13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peroxisome proliferator-activated receptor alphaPPAR-alphanuclear receptor subfamily 1 group C member 1peroxisome proliferative activated receptor, alphaperoxisome proliferator-activated nuclear receptor alpha variant 3 | ataxin-10brain protein E46 homologspinocerebellar ataxia type 10 protein | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | Q07869 | Q9UBB4 | |
| Ensembl transtripts involved in fusion gene | ENST00000396000, ENST00000262735, ENST00000407236, ENST00000481567, ENST00000402126, ENST00000434345, | ENST00000381061, ENST00000252934, ENST00000498009, ENST00000402380, | |
| Fusion gene scores | * DoF score | 10 X 6 X 9=540 | 7 X 5 X 7=245 |
| # samples | 11 | 8 | |
| ** MAII score | log2(11/540*10)=-2.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/245*10)=-1.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPARA [Title/Abstract] AND ATXN10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPARA | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9748239|12700342 |
| Hgene | PPARA | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 19114110 |
| Hgene | PPARA | GO:0010871 | negative regulation of receptor biosynthetic process | 12700342 |
| Hgene | PPARA | GO:0010887 | negative regulation of cholesterol storage | 19114110 |
| Hgene | PPARA | GO:0010891 | negative regulation of sequestering of triglyceride | 12700342 |
| Hgene | PPARA | GO:0045893 | positive regulation of transcription, DNA-templated | 12955147 |
| Hgene | PPARA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9748239|19955185|20837115 |
| Hgene | PPARA | GO:0050728 | negative regulation of inflammatory response | 21636785 |
| Hgene | PPARA | GO:0072363 | regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter | 19955185 |
| Hgene | PPARA | GO:0072366 | regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter | 19955185 |
| Hgene | PPARA | GO:0072369 | regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter | 19955185 |
| Hgene | PPARA | GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II | 21636785 |
| Hgene | PPARA | GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 21636785 |
| Tgene | ATXN10 | GO:0031175 | neuron projection development | 16498633 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-N7-A4Y8-01A | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000396000 | ENST00000381061 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| In-frame | ENST00000396000 | ENST00000252934 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000396000 | ENST00000498009 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000396000 | ENST00000402380 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| In-frame | ENST00000262735 | ENST00000381061 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| In-frame | ENST00000262735 | ENST00000252934 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000262735 | ENST00000498009 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000262735 | ENST00000402380 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| In-frame | ENST00000407236 | ENST00000381061 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| In-frame | ENST00000407236 | ENST00000252934 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000407236 | ENST00000498009 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000407236 | ENST00000402380 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| intron-3CDS | ENST00000481567 | ENST00000381061 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| intron-3CDS | ENST00000481567 | ENST00000252934 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| intron-intron | ENST00000481567 | ENST00000498009 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| intron-intron | ENST00000481567 | ENST00000402380 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| In-frame | ENST00000402126 | ENST00000381061 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| In-frame | ENST00000402126 | ENST00000252934 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000402126 | ENST00000498009 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000402126 | ENST00000402380 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| In-frame | ENST00000434345 | ENST00000381061 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| In-frame | ENST00000434345 | ENST00000252934 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000434345 | ENST00000498009 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
| 5CDS-intron | ENST00000434345 | ENST00000402380 | PPARA | chr22 | 46594488 | + | ATXN10 | chr22 | 46238871 | + |
Top |
FusionProtFeatures for PPARA_ATXN10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPARA | ATXN10 |
| Ligand-activated transcription factor. Key regulator oflipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activatedby oleylethanolamide, a naturally occurring lipid that regulatessatiety. Receptor for peroxisome proliferators such ashypolipidemic drugs and fatty acids. Regulates the peroxisomalbeta-oxidation pathway of fatty acids. Functions as transcriptionactivator for the ACOX1 and P450 genes. Transactivation activityrequires heterodimerization with RXRA and is antagonized by NR2C2.May be required for the propagation of clock information tometabolic pathways regulated by PER2.{ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310,ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926,ECO:0000269|PubMed:9556573}. | Necessary for the survival of cerebellar neurons.Induces neuritogenesis by activating the Ras-MAP kinase pathway.May play a role in the maintenance of a critical intracellularglycosylation level and homeostasis. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000262735 | + | 3 | 8 | 99_173 | 69 | 469 | DNA binding | Nuclear receptor |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000396000 | + | 3 | 8 | 99_173 | 69 | 469 | DNA binding | Nuclear receptor |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000402126 | + | 2 | 7 | 99_173 | 69 | 469 | DNA binding | Nuclear receptor |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000407236 | + | 3 | 8 | 99_173 | 69 | 469 | DNA binding | Nuclear receptor |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000434345 | + | 1 | 5 | 99_173 | 69 | 188 | DNA binding | Nuclear receptor |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000262735 | + | 3 | 8 | 239_466 | 69 | 469 | Domain | NR LBD |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000396000 | + | 3 | 8 | 239_466 | 69 | 469 | Domain | NR LBD |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000402126 | + | 2 | 7 | 239_466 | 69 | 469 | Domain | NR LBD |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000407236 | + | 3 | 8 | 239_466 | 69 | 469 | Domain | NR LBD |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000434345 | + | 1 | 5 | 239_466 | 69 | 188 | Domain | NR LBD |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000262735 | + | 3 | 8 | 304_433 | 69 | 469 | Region | Note=Required for heterodimerization with RXRA |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000396000 | + | 3 | 8 | 304_433 | 69 | 469 | Region | Note=Required for heterodimerization with RXRA |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000402126 | + | 2 | 7 | 304_433 | 69 | 469 | Region | Note=Required for heterodimerization with RXRA |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000407236 | + | 3 | 8 | 304_433 | 69 | 469 | Region | Note=Required for heterodimerization with RXRA |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000434345 | + | 1 | 5 | 304_433 | 69 | 188 | Region | Note=Required for heterodimerization with RXRA |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000262735 | + | 3 | 8 | 102_122 | 69 | 469 | Zinc finger | NR C4-type |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000262735 | + | 3 | 8 | 139_161 | 69 | 469 | Zinc finger | NR C4-type |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000396000 | + | 3 | 8 | 102_122 | 69 | 469 | Zinc finger | NR C4-type |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000396000 | + | 3 | 8 | 139_161 | 69 | 469 | Zinc finger | NR C4-type |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000402126 | + | 2 | 7 | 102_122 | 69 | 469 | Zinc finger | NR C4-type |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000402126 | + | 2 | 7 | 139_161 | 69 | 469 | Zinc finger | NR C4-type |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000407236 | + | 3 | 8 | 102_122 | 69 | 469 | Zinc finger | NR C4-type |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000407236 | + | 3 | 8 | 139_161 | 69 | 469 | Zinc finger | NR C4-type |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000434345 | + | 1 | 5 | 102_122 | 69 | 188 | Zinc finger | NR C4-type |
| Hgene | >PPARA | chr22:46594488 | chr22:46238871 | ENST00000434345 | + | 1 | 5 | 139_161 | 69 | 188 | Zinc finger | NR C4-type |
Top |
FusionGeneSequence for PPARA_ATXN10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PPARA_ENST00000396000_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ >In-frame_PPARA_ENST00000396000_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ >In-frame_PPARA_ENST00000262735_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ >In-frame_PPARA_ENST00000262735_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ >In-frame_PPARA_ENST00000407236_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ >In-frame_PPARA_ENST00000407236_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ >In-frame_PPARA_ENST00000402126_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ >In-frame_PPARA_ENST00000402126_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ >In-frame_PPARA_ENST00000434345_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ >In-frame_PPARA_ENST00000434345_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_133aa MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITVLTQWVIYAIRNLTEDNSQNQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PPARA_ENST00000396000_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG >In-frame_PPARA_ENST00000396000_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG >In-frame_PPARA_ENST00000262735_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG >In-frame_PPARA_ENST00000262735_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG >In-frame_PPARA_ENST00000407236_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG >In-frame_PPARA_ENST00000407236_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG >In-frame_PPARA_ENST00000402126_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG >In-frame_PPARA_ENST00000402126_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG >In-frame_PPARA_ENST00000434345_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG >In-frame_PPARA_ENST00000434345_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_399nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PPARA_ENST00000396000_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_2297nt GCGCCGCCTCCTTCGGCGTTCGCCCCACGGACCGGCAGGCGGCGGACCGCGGCCCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGAC TCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGGTAAATAGAAGGTTTAATTTACTGTTTCCAGATGGAAATA TTTAAGTGTTTTCAGTGTTTACTTCTGTTGCACTACAGACCAGTAGCTTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGT GGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGG AAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGG CTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTT GATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGAT CCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCT TCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGT ATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACG TGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGAT GTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGG CGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGT TAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAG GTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGA ATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTA CATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACT TTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATT AAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATAT TATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCT GTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATA GCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGAT TGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAG TCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCC TTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAG >In-frame_PPARA_ENST00000396000_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_2300nt GCGCCGCCTCCTTCGGCGTTCGCCCCACGGACCGGCAGGCGGCGGACCGCGGCCCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGAC TCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGGTAAATAGAAGGTTTAATTTACTGTTTCCAGATGGAAATA TTTAAGTGTTTTCAGTGTTTACTTCTGTTGCACTACAGACCAGTAGCTTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGT GGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGG AAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGG CTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTT GATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGAT CCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCT TCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGT ATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACG TGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGAT GTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGG CGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGT TAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAG GTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGA ATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTA CATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACT TTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATT AAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATAT TATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCT GTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATA GCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGAT TGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAG TCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCC TTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAG >In-frame_PPARA_ENST00000262735_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_2214nt GCGCCGCCTCCTTCGGCGTTCGCCCCACGGACCGGCAGGCGGCGGACCGCGGCCCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGAC TCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGTAGCTTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCG CGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAG AAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCT GTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACC AAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAA AGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTT TTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTT AACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGA TAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAA CTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTC TGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCAT TTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGG GAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTC AAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATT AAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAA AAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGA CTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAA AACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATA AAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGT AAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTT CTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACAC AAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCC TTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCG >In-frame_PPARA_ENST00000262735_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_2217nt GCGCCGCCTCCTTCGGCGTTCGCCCCACGGACCGGCAGGCGGCGGACCGCGGCCCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGAC TCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGTAGCTTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCG CGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAG AAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCT GTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACC AAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAA AGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTT TTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTT AACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGA TAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAA CTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTC TGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCAT TTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGG GAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTC AAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATT AAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAA AAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGA CTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAA AACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATA AAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGT AAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTT CTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACAC AAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCC TTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCG >In-frame_PPARA_ENST00000407236_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_2245nt CCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGACTCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGTTC TGGAGGCTGGGAAGTTCAAGATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTCATAGATAAGAGTAGCTTGGA GCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTA GAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTT GGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATC CGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAA GTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATA CCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGG GAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATG TAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTC TCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTA TATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCC TCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTC ACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCA GAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCT TATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTC AGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATC TATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGC TCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCAC AATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAA GCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGT ACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGT AAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGC CTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTG >In-frame_PPARA_ENST00000407236_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_2248nt CCAGGCTGAAGCTCAGGGCCCTGTCTGCTCTGTGGACTCAACAGTTTGTGGCAAGACAAGCTCAGAACTGAGAAGCTGTCACCACAGTTC TGGAGGCTGGGAAGTTCAAGATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTCATAGATAAGAGTAGCTTGGA GCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTA GAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTT GGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATC CGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAA GTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATA CCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGG GAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATG TAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTC TCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTA TATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCC TCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTC ACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCA GAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCT TATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTC AGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATC TATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGC TCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCAC AATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAA GCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGT ACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGT AAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGC CTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTG >In-frame_PPARA_ENST00000402126_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_2160nt CACAGTTCTGGAGGCTGGGAAGTTCAAGATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTCATAGATAAGAGC TTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCG ATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAA GCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATG CCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTA AAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCC AAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAA TTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCAT TAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAAC CAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATT CTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTC ACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTC TTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCA TCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAA TAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGC CACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGT TCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACA AAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTT TGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCT TCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCT AATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCA TCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATA GAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGG ATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGGGAGCCTTGTGAGAAT >In-frame_PPARA_ENST00000402126_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_2163nt CACAGTTCTGGAGGCTGGGAAGTTCAAGATCAAAGTGCCAGCAGATTCAGTGTCATGTGAGGACGTGCTTCCTGCTTCATAGATAAGAGC TTGGAGCTCGGCGGCACAACCAGCACCATCTGGTCGCGATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCG ATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAAATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAA GCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGTCCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATG CCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAAGATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTA AAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAGCTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCC AAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTTCATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAA TTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAACGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCAT TAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATAGAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAAC CAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACTTGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATT CTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTGGCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTC ACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTTCCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTC TTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGAGTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCA TCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAAGGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAA TAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAAAGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGC CACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAAGTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGT TCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACTGGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACA AAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAACATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTT TGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAAGACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCT TCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAAAAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCT AATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCTAGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCA TCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAAAGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATA GAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTTTTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGG ATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGTATGAGCTATATAATAACAAACACAAATAAATAAAAGGGAGCCTTGTGAGAAT >In-frame_PPARA_ENST00000434345_chr22_46594488_+_ATXN10_ENST00000381061_chr22_46238871_+_2032nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG CTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTT CATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAA CGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATA GAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACT TGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTG GCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTT CCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGA GTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAA GGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAA AGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAA GTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACT GGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAA CATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAA GACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAA AAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCT AGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAA AGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTT TTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGT >In-frame_PPARA_ENST00000434345_chr22_46594488_+_ATXN10_ENST00000252934_chr22_46238871_+_2035nt ATGGTGGACACGGAAAGCCCACTCTGCCCCCTCTCCCCACTCGAGGCCGGCGATCTAGAGAGCCCGTTATCTGAAGAGTTCCTGCAAGAA ATGGGAAACATCCAAGAGATTTCGCAATCCATCGGCGAGGATAGTTCTGGAAGCTTTGGCTTTACGGAATACCAGTATTTAGGAAGCTGT CCTGGCTCAGATGGCTCGGTCATCACGGTTCTGACCCAGTGGGTGATATATGCCATCCGAAACCTTACCGAAGACAACAGCCAAAACCAA GATTTGATTGCAAAGATGGAGGAACAGGGGCTGGCAGATGCATCCCTACTTAAAAAAGTGGGTTTTGAAGTTGAAAAGAAAGGCGAAAAG CTGATCCTGAAATCTACTAGAGACACCCCTAAGCCATGAATGAACTACATCCAAATACCTGAATTTTTGGAATCTGTTTCATGGATTTTT CATCTTCTACCGTATGTGAAATTGCAAGTGTTTGAAGATTTATAAGTACAAATTTGGGAACATACAAATCTTTTAGGTAGTAGAGTTTAA CGTGTATAAGCTAAAAGTGAAAGTAACTGAGTGTTCTCTTGTTTCTTTGCATTAATGTAACTGTGTGGTTTGCCTTTGTCCCCCTGGATA GAACGTGCATTTAAAGAATATATTGTACTTACTGTGACAGCAGATAATAAACCAGTCTCTTGGAGGGCACAACCCTTATTTGACAAAACT TGGATGTTGGCTTGACTGTGTTTGTCCCTTCAGATGGCAAGTCAGCATCATTCTTTATATTCCTCTTCTCATTGGGTTTTCTGAACTCTG GCAGGCGGTTGAAGTAGTTTCTCACTGTGATTAATTCTAGCAATCTCTTTTCACCCCTCTGCCTTTCCAAAACATTGACAAGACTCATTT CCAGTTAATTAATTCGAGAACCCTCCCTCTTCATTTTGGGTACTGGGCTGTCTTGTCACTGAGCCCTATCCCTTTGGAATGTGGCAGGGA GTGAGGTTGGTGAGAGAACATGTGGGCACTTAACTCTTCATGTTCCAGTTCATCCCAGAAGTAGACATCCCAGGACCCATTCTGTGTCAA GGTGAATGCCTGTGTCCTCCCCAGCTTCATGCCTCTGTCATGGGGGAAGGAATAGCTTATGTTCTGCTCTGGTGCAGTGCCGTAGATTAA AGGTACATTTCTATCTTCTTTGATTTAAAAAGCACCAGTCTCATAAAGGTGCCACTCAGTTTTAGCCATGTCTTCACTGAAATTGCAAAA GTACTTTTAGGGAGCAGGAGTTTATTTGACATCTAGTTATCTGTCTGTCTGTTCATCTATCTATCTGTCTGCTGTATGAGAGGTAGGACT GGATTAAATGACCACTGAACTCACTGAATCCAGATCATTCATATCATCAACAAAAGCTCTAGGGGGAGGTCACGTTGTGAATGCTTAAAA CATATTATTTTCTTCAACAACCATATCGCTAAACTAATATATCCAGAGATTTTGCACAATTCGTGTTGAACCTTCCAAAACAAAAATAAA GACCTGTCCAAAAGTTTTGACAAAAATACTGATTGCTCCCAAATAAAGTGCTTCTAAGCTTTGTGTAGACATAGTTTAACTGATTTGTAA AAATAGCTTAAGCATGTTGAGAATGAAGTAAAAGTTTTCCCATGTGCTGTCTAATGTACTCTGTGTAACTCTGAAGACACATCAGCTTCT AGGATTGCAGCAATCTATGAATAACATTTTTTCTCTCATTTATGACTTTCCATCAGTAAAGAAGCCATTGCAGAATTTAAAATTACACAA AGGAGTCATTCTCTCCTGGGACATAAAGAGTTAAAGCTCTGTCCTCTAAATAGAAGCCTGGCCAAAGGGAGAAAACAGTGGGAGTCCCTT TTCCCTTTTAACAAGTTTGCAATAGACACTTCTTTTTTTCCTGTCTCAATGGATGTGTGCACACCAGTGGAATCGCACAAACTTGTCGGT |
Top |
FusionGenePPI for PPARA_ATXN10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PPARA | NRBF2, STAC3, GADD45G, NCOA1, EP300, RXRG, DAP3, FABP1, MECR, RELA, NRIP1, NCOR1, PPARGC1B, AKAP13, POU1F1, HELZ2, RXRA, NCOR2, NR1H3, PPARGC1A, MED24, HSP90AA1, AIP, TRA, LPIN1, UBE2I, TNP1, CHD9, CDK3, FOXA3, PRMT1, PRMT8, SIRT1, RXRB, NCOA2, NCOA3, CEP350, GRB2, PIK3R3, BCL2, CDC34, STAT1 | ATXN10 | BSG, STYXL1, MAGED1, GSTK1, CUL3, PPP1R12A, GNB1, GNB2, FN1, MRPS16, GLS, GOLGA1, ABCA1, CA9, VCP, EGFR, SERPINH1, HSPA1A, HSPA8, CCDC8, ABCE1, HTR6, HSPB1, CEP162, CEP152, CEP128, SCLT1, CENPJ, LAMB3, MYC, UBE2A, TUBA1C, MTMR14, DUSP22, PTPRN, STOM, DLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PPARA_ATXN10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PPARA | Q07869 | DB00573 | Fenoprofen | Peroxisome proliferator-activated receptor alpha | small molecule | approved |
| Hgene | PPARA | Q07869 | DB01039 | Fenofibrate | Peroxisome proliferator-activated receptor alpha | small molecule | approved |
| Hgene | PPARA | Q07869 | DB01050 | Ibuprofen | Peroxisome proliferator-activated receptor alpha | small molecule | approved |
| Hgene | PPARA | Q07869 | DB01241 | Gemfibrozil | Peroxisome proliferator-activated receptor alpha | small molecule | approved |
| Hgene | PPARA | Q07869 | DB13873 | Fenofibric acid | Peroxisome proliferator-activated receptor alpha | small molecule | approved |
| Hgene | PPARA | Q07869 | DB00313 | Valproic Acid | Peroxisome proliferator-activated receptor alpha | small molecule | approved|investigational |
| Hgene | PPARA | Q07869 | DB00328 | Indomethacin | Peroxisome proliferator-activated receptor alpha | small molecule | approved|investigational |
| Hgene | PPARA | Q07869 | DB00412 | Rosiglitazone | Peroxisome proliferator-activated receptor alpha | small molecule | approved|investigational |
| Hgene | PPARA | Q07869 | DB00636 | Clofibrate | Peroxisome proliferator-activated receptor alpha | small molecule | approved|investigational |
| Hgene | PPARA | Q07869 | DB01132 | Pioglitazone | Peroxisome proliferator-activated receptor alpha | small molecule | approved|investigational |
| Hgene | PPARA | Q07869 | DB01393 | Bezafibrate | Peroxisome proliferator-activated receptor alpha | small molecule | approved|investigational |
| Hgene | PPARA | Q07869 | DB09064 | Ciprofibrate | Peroxisome proliferator-activated receptor alpha | small molecule | approved|investigational |
| Hgene | PPARA | Q07869 | DB01708 | Prasterone | Peroxisome proliferator-activated receptor alpha | small molecule | approved|investigational|nutraceutical |
Top |
RelatedDiseases for PPARA_ATXN10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PPARA | C0011853 | Diabetes Mellitus, Experimental | 3 | CTD_human |
| Hgene | PPARA | C0036341 | Schizophrenia | 3 | PSYGENET |
| Hgene | PPARA | C0020538 | Hypertensive disease | 2 | CTD_human |
| Hgene | PPARA | C0021655 | Insulin Resistance | 2 | CTD_human |
| Hgene | PPARA | C0010346 | Crohn Disease | 1 | CTD_human |
| Hgene | PPARA | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
| Hgene | PPARA | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | PPARA | C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | CTD_human |
| Hgene | PPARA | C0015695 | Fatty Liver | 1 | CTD_human |
| Hgene | PPARA | C0015696 | Fatty Liver, Alcoholic | 1 | CTD_human |
| Hgene | PPARA | C0018800 | Cardiomegaly | 1 | CTD_human |
| Hgene | PPARA | C0019209 | Hepatomegaly | 1 | CTD_human |
| Hgene | PPARA | C0020473 | Hyperlipidemia | 1 | CTD_human |
| Hgene | PPARA | C0020476 | Hyperlipoproteinemias | 1 | CTD_human |
| Hgene | PPARA | C0020557 | Hypertriglyceridemia | 1 | CTD_human |
| Hgene | PPARA | C0020615 | Hypoglycemia | 1 | CTD_human |
| Hgene | PPARA | C0021368 | Inflammation | 1 | CTD_human |
| Hgene | PPARA | C0022658 | Kidney Diseases | 1 | CTD_human |
| Hgene | PPARA | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
| Hgene | PPARA | C0022672 | Acute Kidney Tubular Necrosis | 1 | CTD_human |
| Hgene | PPARA | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | PPARA | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | PPARA | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | PPARA | C0026848 | Myopathy | 1 | CTD_human |
| Hgene | PPARA | C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
| Hgene | PPARA | C0028754 | Obesity | 1 | CTD_human |
| Hgene | PPARA | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | PPARA | C0033687 | Proteinuria | 1 | CTD_human |
| Hgene | PPARA | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Hgene | PPARA | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Hgene | PPARA | C0242339 | Dyslipidemias | 1 | CTD_human |
| Hgene | PPARA | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| Hgene | PPARA | C2930930 | Abdominal obesity metabolic syndrome | 1 | CTD_human |
| Hgene | PPARA | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|