![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 28072 |
FusionGeneSummary for PPA2_TBCK |
![]() |
Fusion gene information | Fusion gene name: PPA2_TBCK | Fusion gene ID: 28072 | Hgene | Tgene | Gene symbol | PPA2 | TBCK | Gene ID | 27068 | 93627 |
Gene name | pyrophosphatase (inorganic) 2 | TBC1 domain containing kinase | |
Synonyms | HSPC124|SCFAI|SCFI|SID6-306 | HSPC302|IHPRF3|TBCKL | |
Cytomap | 4q24 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | inorganic pyrophosphatase 2, mitochondrialPPase 2pyrophosphatase SID6-306pyrophosphate phospho-hydrolase 2 | TBC domain-containing protein kinase-like protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H2U2 | Q8TEA7 | |
Ensembl transtripts involved in fusion gene | ENST00000341695, ENST00000348706, ENST00000432483, ENST00000354147, ENST00000380004, ENST00000357415, ENST00000509426, ENST00000310267, | ENST00000273980, ENST00000432496, ENST00000361687, ENST00000394706, ENST00000394708, ENST00000514689, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: PPA2 [Title/Abstract] AND TBCK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-44-5643-01A | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000341695 | ENST00000273980 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000341695 | ENST00000432496 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000341695 | ENST00000361687 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000341695 | ENST00000394706 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000341695 | ENST00000394708 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5CDS-intron | ENST00000341695 | ENST00000514689 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000348706 | ENST00000273980 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000348706 | ENST00000432496 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000348706 | ENST00000361687 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000348706 | ENST00000394706 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000348706 | ENST00000394708 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5CDS-intron | ENST00000348706 | ENST00000514689 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000432483 | ENST00000273980 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000432483 | ENST00000432496 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000432483 | ENST00000361687 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000432483 | ENST00000394706 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000432483 | ENST00000394708 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5CDS-intron | ENST00000432483 | ENST00000514689 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000354147 | ENST00000273980 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000354147 | ENST00000432496 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000354147 | ENST00000361687 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000354147 | ENST00000394706 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000354147 | ENST00000394708 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5CDS-intron | ENST00000354147 | ENST00000514689 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000380004 | ENST00000273980 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000380004 | ENST00000432496 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000380004 | ENST00000361687 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000380004 | ENST00000394706 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000380004 | ENST00000394708 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5CDS-intron | ENST00000380004 | ENST00000514689 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000357415 | ENST00000273980 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000357415 | ENST00000432496 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000357415 | ENST00000361687 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000357415 | ENST00000394706 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Frame-shift | ENST00000357415 | ENST00000394708 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5CDS-intron | ENST00000357415 | ENST00000514689 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000509426 | ENST00000273980 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000509426 | ENST00000432496 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000509426 | ENST00000361687 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000509426 | ENST00000394706 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000509426 | ENST00000394708 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-intron | ENST00000509426 | ENST00000514689 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000310267 | ENST00000273980 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000310267 | ENST00000432496 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000310267 | ENST00000361687 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000310267 | ENST00000394706 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-3CDS | ENST00000310267 | ENST00000394708 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
5UTR-intron | ENST00000310267 | ENST00000514689 | PPA2 | chr4 | 106395051 | - | TBCK | chr4 | 107016798 | - |
Top |
FusionProtFeatures for PPA2_TBCK |
![]() |
Hgene | Tgene |
PPA2 | TBCK |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for PPA2_TBCK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for PPA2_TBCK |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPA2 | VKORC1, BAG3, MTIF2, HIST1H1D, ACSF2, CLUH, ACADVL, ACSS1, GLS, PNPT1, CLPP, PCCB, NNT, ARPIN, LYRM7, NIPSNAP3A, MECR, PDPR, CAT, CD2AP, DUT, HIBCH, NEDD8, AIP, CHCHD2, EZR, FKBP14, METTL1, NAV1, PLIN3, UFM1, PPP1R11, SCPEP1, TANGO2, COMT, ZWINT, DUSP13, SYNC, NDUFAF5 | TBCK | APP, STAM, PCDHB15, PPP1R21, IL6R, TCP10L |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PPA2_TBCK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PPA2_TBCK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TBCK | C4225161 | HYPOTONIA, INFANTILE, WITH PSYCHOMOTOR RETARDATION AND CHARACTERISTIC FACIES 3 | 2 | UNIPROT |