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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28062

FusionGeneSummary for POU6F2_AOAH

check button Fusion gene summary
Fusion gene informationFusion gene name: POU6F2_AOAH
Fusion gene ID: 28062
HgeneTgene
Gene symbol

POU6F2

AOAH

Gene ID

11281

313

Gene namePOU class 6 homeobox 2acyloxyacyl hydrolase
SynonymsRPF-1|WT5|WTSL-
Cytomap

7p14.1

7p14.2

Type of geneprotein-codingprotein-coding
DescriptionPOU domain, class 6, transcription factor 2Wilms tumor suppressor locusretina-derived POU-domain factor-1acyloxyacyl hydrolaseacyloxyacyl hydrolase (neutrophil)
Modification date2018040320180523
UniProtAcc

P78424

P28039

Ensembl transtripts involved in fusion geneENST00000403058, ENST00000518318, 
ENST00000517348, ENST00000559001, 
ENST00000464276, 		ENST00000535891, 
ENST00000258749, ENST00000431169, 
ENST00000538464, ENST00000491444, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 6 X 4=144
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POU6F2 [Title/Abstract] AND AOAH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAOAH

GO:0006631

fatty acid metabolic process

1883828|29343645

TgeneAOAH

GO:0009104

lipopolysaccharide catabolic process

1883828|29343645


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-26-A7UX-01BPOU6F2chr7

39503983

+AOAHchr7

36571950

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000403058ENST00000535891POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000403058ENST00000258749POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000403058ENST00000431169POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000403058ENST00000538464POU6F2chr7

39503983

+AOAHchr7

36571950

-
5CDS-5UTRENST00000403058ENST00000491444POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000518318ENST00000535891POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000518318ENST00000258749POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000518318ENST00000431169POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000518318ENST00000538464POU6F2chr7

39503983

+AOAHchr7

36571950

-
5CDS-5UTRENST00000518318ENST00000491444POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-3CDSENST00000517348ENST00000535891POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-3CDSENST00000517348ENST00000258749POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-3CDSENST00000517348ENST00000431169POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-3CDSENST00000517348ENST00000538464POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-5UTRENST00000517348ENST00000491444POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000559001ENST00000535891POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000559001ENST00000258749POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000559001ENST00000431169POU6F2chr7

39503983

+AOAHchr7

36571950

-
Frame-shiftENST00000559001ENST00000538464POU6F2chr7

39503983

+AOAHchr7

36571950

-
5CDS-5UTRENST00000559001ENST00000491444POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-3CDSENST00000464276ENST00000535891POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-3CDSENST00000464276ENST00000258749POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-3CDSENST00000464276ENST00000431169POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-3CDSENST00000464276ENST00000538464POU6F2chr7

39503983

+AOAHchr7

36571950

-
intron-5UTRENST00000464276ENST00000491444POU6F2chr7

39503983

+AOAHchr7

36571950

-

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FusionProtFeatures for POU6F2_AOAH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POU6F2

P78424

AOAH

P28039

Probable transcription factor likely to be involved inearly steps in the differentiation of amacrine and ganglion cells.Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1does not bind DNA. Removes the secondary (acyloxyacyl-linked) fatty acylchains from the lipid A region of bacterial lipopolysaccharides(PubMed:1883828, PubMed:8089145, PubMed:29343645). By breakingdown LPS, terminates the host response to bacterial infection andprevents prolonged and damaging inflammatory responses (Bysimilarity). In peritoneal macrophages, seems to be important forrecovery from a state of immune tolerance following infection byGram-negative bacteria (By similarity).{ECO:0000250|UniProtKB:O35298, ECO:0000269|PubMed:1883828,ECO:0000269|PubMed:29343645, ECO:0000269|PubMed:8089145}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for POU6F2_AOAH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for POU6F2_AOAH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
POU6F2AOAH


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for POU6F2_AOAH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for POU6F2_AOAH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePOU6F2C0004352Autistic Disorder1CTD_human
HgenePOU6F2C1832099Wilms tumor and radial bilateral aplasia1CTD_human;UNIPROT
TgeneAOAHC0236733Amphetamine-Related Disorders1CTD_human