FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 28058

FusionGeneSummary for POU2F1_ZFYVE28

check button Fusion gene summary
Fusion gene informationFusion gene name: POU2F1_ZFYVE28
Fusion gene ID: 28058
HgeneTgene
Gene symbol

POU2F1

ZFYVE28

Gene ID

5451

57732

Gene namePOU class 2 homeobox 1zinc finger FYVE-type containing 28
SynonymsOCT1|OTF1|oct-1BLST2|LYST2
Cytomap

1q24.2

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionPOU domain, class 2, transcription factor 1NF-A1OTF-1Octamer-binding transcription factor-1oct-1octamer-binding protein 1octamer-binding transcription factor 1lateral signaling target protein 2 homologhLst2zinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28
Modification date2018051920180523
UniProtAcc

P14859

Q9HCC9

Ensembl transtripts involved in fusion geneENST00000367866, ENST00000452019, 
ENST00000429375, ENST00000367865, 
ENST00000541643, ENST00000420254, 
ENST00000367862, 		ENST00000290974, 
ENST00000511071, ENST00000515312, 
ENST00000515169, ENST00000509171, 
ENST00000503000, ENST00000508471, 
ENST00000505421, 
Fusion gene scores* DoF score9 X 5 X 8=3608 X 6 X 7=336
# samples 108
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POU2F1 [Title/Abstract] AND ZFYVE28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOU2F1

GO:0045892

negative regulation of transcription, DNA-templated

11891224|11997177

HgenePOU2F1

GO:0045944

positive regulation of transcription by RNA polymerase II

15252056


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVTHYMTCGA-ZB-A969-01APOU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
TCGALDTHYMTCGA-ZB-A969-01APOU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000367866ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000367866ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000367866ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000367866ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000367866ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000367866ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5CDS-intronENST00000367866ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5CDS-intronENST00000367866ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000452019ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000452019ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000452019ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000452019ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000452019ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000452019ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-intronENST00000452019ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-intronENST00000452019ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000429375ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000429375ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000429375ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000429375ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000429375ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000429375ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5CDS-intronENST00000429375ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5CDS-intronENST00000429375ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
3UTR-3CDSENST00000367865ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
3UTR-3CDSENST00000367865ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
3UTR-3CDSENST00000367865ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
3UTR-3CDSENST00000367865ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
3UTR-3CDSENST00000367865ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
3UTR-3CDSENST00000367865ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
3UTR-intronENST00000367865ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
3UTR-intronENST00000367865ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000541643ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000541643ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000541643ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000541643ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000541643ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000541643ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-intronENST00000541643ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-intronENST00000541643ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000420254ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000420254ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000420254ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000420254ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000420254ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-3CDSENST00000420254ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-intronENST00000420254ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
5UTR-intronENST00000420254ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
intron-3CDSENST00000367862ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
intron-3CDSENST00000367862ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
intron-3CDSENST00000367862ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
intron-3CDSENST00000367862ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
intron-3CDSENST00000367862ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
intron-3CDSENST00000367862ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
intron-intronENST00000367862ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
intron-intronENST00000367862ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2339223

-
Frame-shiftENST00000367866ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
Frame-shiftENST00000367866ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
Frame-shiftENST00000367866ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000367866ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000367866ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000367866ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000367866ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000367866ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-3CDSENST00000452019ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-3CDSENST00000452019ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-3CDSENST00000452019ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000452019ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000452019ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000452019ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000452019ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000452019ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
Frame-shiftENST00000429375ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
Frame-shiftENST00000429375ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
Frame-shiftENST00000429375ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000429375ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000429375ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000429375ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000429375ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5CDS-intronENST00000429375ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
3UTR-3CDSENST00000367865ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
3UTR-3CDSENST00000367865ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
3UTR-3CDSENST00000367865ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
3UTR-intronENST00000367865ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
3UTR-intronENST00000367865ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
3UTR-intronENST00000367865ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
3UTR-intronENST00000367865ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
3UTR-intronENST00000367865ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-3CDSENST00000541643ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-3CDSENST00000541643ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-3CDSENST00000541643ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000541643ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000541643ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000541643ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000541643ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000541643ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-3CDSENST00000420254ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-3CDSENST00000420254ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-3CDSENST00000420254ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000420254ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000420254ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000420254ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000420254ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
5UTR-intronENST00000420254ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
intron-3CDSENST00000367862ENST00000290974POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
intron-3CDSENST00000367862ENST00000511071POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
intron-3CDSENST00000367862ENST00000515312POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
intron-intronENST00000367862ENST00000515169POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
intron-intronENST00000367862ENST00000509171POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
intron-intronENST00000367862ENST00000503000POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
intron-intronENST00000367862ENST00000508471POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-
intron-intronENST00000367862ENST00000505421POU2F1chr1

167190195

+ZFYVE28chr4

2321998

-

Top

FusionProtFeatures for POU2F1_ZFYVE28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POU2F1

P14859

ZFYVE28

Q9HCC9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for POU2F1_ZFYVE28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for POU2F1_ZFYVE28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
POU2F1GAPDH, NPAT, STIP1, NCOR2, ESR1, RXRA, RARA, THRA, AR, PGR, NR3C1, POU2AF1, MNAT1, XRCC6, XRCC5, SNAPC4, SP1, POU2F1, HCFC1, TXNRD1, VDR, TBP, TNF, RELA, BRCA1, BRD7, PRKACA, PRKDC, HDAC1, CEBPE, TLX2, HOXC9, IRF9, HOXB13, CREB1, STAT5B, PBX1, PKNOX1, HMGA1, LMNB1, CDK11B, HOXC4, APP, SPTBN1, HSPA8, PLK3, SP4, POGZ, MAGEA10, PARP1, TEAD2, FOXC1, FOXC2, FOXS1, FGB, PRR20E, TRIM25ZFYVE28EGF, RAB5A, RAB4A, RAB7A, EGFR, PRNP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for POU2F1_ZFYVE28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for POU2F1_ZFYVE28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource