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Fusion gene ID: 28050 |
FusionGeneSummary for POU2F1_ATP6V1F |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POU2F1_ATP6V1F | Fusion gene ID: 28050 | Hgene | Tgene | Gene symbol | POU2F1 | ATP6V1F | Gene ID | 5451 | 9296 |
| Gene name | POU class 2 homeobox 1 | ATPase H+ transporting V1 subunit F | |
| Synonyms | OCT1|OTF1|oct-1B | ATP6S14|VATF|Vma7 | |
| Cytomap | 1q24.2 | 7q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | POU domain, class 2, transcription factor 1NF-A1OTF-1Octamer-binding transcription factor-1oct-1octamer-binding protein 1octamer-binding transcription factor 1 | V-type proton ATPase subunit FATPase, H+ transporting, lysosomal 14kDa, V1 subunit FATPase, vacuolar, 14 kDH(+)-transporting two-sector ATPase, 14kD subunitV-ATPase 14 kDa subunitV-ATPase F subunitV-ATPase subunit Fadenosinetriphosphatase 14k chain | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P14859 | Q16864 | |
| Ensembl transtripts involved in fusion gene | ENST00000367866, ENST00000452019, ENST00000429375, ENST00000367865, ENST00000541643, ENST00000420254, ENST00000367862, | ENST00000249289, ENST00000492758, | |
| Fusion gene scores | * DoF score | 9 X 5 X 8=360 | 1 X 1 X 1=1 |
| # samples | 10 | 1 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: POU2F1 [Title/Abstract] AND ATP6V1F [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POU2F1 | GO:0045892 | negative regulation of transcription, DNA-templated | 11891224|11997177 |
| Hgene | POU2F1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15252056 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A1L2-01A | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000367866 | ENST00000249289 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| In-frame | ENST00000367866 | ENST00000492758 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| 5UTR-3CDS | ENST00000452019 | ENST00000249289 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| 5UTR-3CDS | ENST00000452019 | ENST00000492758 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| Frame-shift | ENST00000429375 | ENST00000249289 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| In-frame | ENST00000429375 | ENST00000492758 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| 3UTR-3CDS | ENST00000367865 | ENST00000249289 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| 3UTR-3CDS | ENST00000367865 | ENST00000492758 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| 5UTR-3CDS | ENST00000541643 | ENST00000249289 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| 5UTR-3CDS | ENST00000541643 | ENST00000492758 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| 5UTR-3CDS | ENST00000420254 | ENST00000249289 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| 5UTR-3CDS | ENST00000420254 | ENST00000492758 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| intron-3CDS | ENST00000367862 | ENST00000249289 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
| intron-3CDS | ENST00000367862 | ENST00000492758 | POU2F1 | chr1 | 167190195 | + | ATP6V1F | chr7 | 128505431 | + |
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FusionProtFeatures for POU2F1_ATP6V1F |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POU2F1 | ATP6V1F |
| Subunit of the peripheral V1 complex of vacuolar ATPaseessential for assembly or catalytic function. V-ATPase isresponsible for acidifying a variety of intracellular compartmentsin eukaryotic cells. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for POU2F1_ATP6V1F |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_POU2F1_ENST00000367866_chr1_167190195_+_ATP6V1F_ENST00000492758_chr7_128505431_+_87aa >In-frame_POU2F1_ENST00000429375_chr1_167190195_+_ATP6V1F_ENST00000492758_chr7_128505431_+_87aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_POU2F1_ENST00000367866_chr1_167190195_+_ATP6V1F_ENST00000492758_chr7_128505431_+_263nt ATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGCAATTTCTAAACCGGGATGACATTGGCA TCATCCTCATCAACCAGTACATCGCAGAGATGGTGCGGCATGCCCTGGACGCCCACCAGCAGTCCATCCCCGCTGTCCTGGAGATCCCCT >In-frame_POU2F1_ENST00000429375_chr1_167190195_+_ATP6V1F_ENST00000492758_chr7_128505431_+_263nt ATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGCAATTTCTAAACCGGGATGACATTGGCA TCATCCTCATCAACCAGTACATCGCAGAGATGGTGCGGCATGCCCTGGACGCCCACCAGCAGTCCATCCCCGCTGTCCTGGAGATCCCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_POU2F1_ENST00000367866_chr1_167190195_+_ATP6V1F_ENST00000492758_chr7_128505431_+_598nt GGGAGGGGGGAGGGGAGCCAGAGCGAGGGAGGGTTTATCGACCGGGCGATTTTGGTTAAAATATTCAAAATGGCGGACGGAGGAGCAGCG AGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGCAATTTCTAAACCGGGATGACATTGGCATCATCCTCATCAACCAGTACA TCGCAGAGATGGTGCGGCATGCCCTGGACGCCCACCAGCAGTCCATCCCCGCTGTCCTGGAGATCCCCTCCAAGGAGCACCCATATGACG CCGCCAAGGACTCCATCCTGCGCAGGGCCAGGGGCATGTTCACTGCCGAAGACCTGCGCTAGGGGACTCCTCATAGCCCTCAGCCCTTCC CTCGTTTCCAGGCCTCTCCCCAGGCTTGCCATCAGCCTTCTTTACTTTTTGAGCCTCTGATTTCCAATTCCCTGCTCCTTCCCACTCCAT TAAGAGGCTAGGTGAGGCGCTTCTAGGTTGCTGGGGCTCTGCTGGTTAAGGAACAGGAAGCCTGACCATCTCCCTCCACTACCTCTTCCC >In-frame_POU2F1_ENST00000429375_chr1_167190195_+_ATP6V1F_ENST00000492758_chr7_128505431_+_536nt ATTCAAAATGGCGGACGGAGGAGCAGCGAGTCAAGATGAGAGTTCAGCCGCGGCGGCAGCAGCAGCAGGCAATTTCTAAACCGGGATGAC ATTGGCATCATCCTCATCAACCAGTACATCGCAGAGATGGTGCGGCATGCCCTGGACGCCCACCAGCAGTCCATCCCCGCTGTCCTGGAG ATCCCCTCCAAGGAGCACCCATATGACGCCGCCAAGGACTCCATCCTGCGCAGGGCCAGGGGCATGTTCACTGCCGAAGACCTGCGCTAG GGGACTCCTCATAGCCCTCAGCCCTTCCCTCGTTTCCAGGCCTCTCCCCAGGCTTGCCATCAGCCTTCTTTACTTTTTGAGCCTCTGATT TCCAATTCCCTGCTCCTTCCCACTCCATTAAGAGGCTAGGTGAGGCGCTTCTAGGTTGCTGGGGCTCTGCTGGTTAAGGAACAGGAAGCC |
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FusionGenePPI for POU2F1_ATP6V1F |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| POU2F1 | GAPDH, NPAT, STIP1, NCOR2, ESR1, RXRA, RARA, THRA, AR, PGR, NR3C1, POU2AF1, MNAT1, XRCC6, XRCC5, SNAPC4, SP1, POU2F1, HCFC1, TXNRD1, VDR, TBP, TNF, RELA, BRCA1, BRD7, PRKACA, PRKDC, HDAC1, CEBPE, TLX2, HOXC9, IRF9, HOXB13, CREB1, STAT5B, PBX1, PKNOX1, HMGA1, LMNB1, CDK11B, HOXC4, APP, SPTBN1, HSPA8, PLK3, SP4, POGZ, MAGEA10, PARP1, TEAD2, FOXC1, FOXC2, FOXS1, FGB, PRR20E, TRIM25 | ATP6V1F | KIAA1377, ATP6V1D, ATP6V1E1, ATP6V1H, ATP6V1B2, ATP6V1A, SSSCA1, ZRANB2, SRXN1, ZPR1, IGBP1, UBXN7, HNRNPL, UBE2C, TTLL12, UFC1, UBE2B, UBE2D1, UBE4B, EIF2AK2, USP9X, UNK, DDB1, UBE2V1, TXN, UCHL3, ABCC1, MPV17, VDAC2, VASP, NNT, VPS26A, PICALM, CORO1B, SRSF2, DDX3X, UBR5, HYOU1, MOV10, ATP6AP2, ATP6V1C2, ATP6V1B1, AIMP1, CORO1C, NEDD8, TCTN2, TCTN3, TMEM17, TMEM216, GOLT1B, KIAA2013, ATP6V0A2, TRIM11, PLXDC2, ATP6V0D1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POU2F1_ATP6V1F |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POU2F1_ATP6V1F |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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