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Fusion gene ID: 28000 |
FusionGeneSummary for POLR3E_ERGIC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLR3E_ERGIC3 | Fusion gene ID: 28000 | Hgene | Tgene | Gene symbol | POLR3E | ERGIC3 | Gene ID | 55718 | 51614 |
| Gene name | RNA polymerase III subunit E | ERGIC and golgi 3 | |
| Synonyms | RPC5|SIN | C20orf47|C2orf47|CGI-54|Erv46|NY-BR-84|PRO0989|SDBCAG84|dJ477O4.2 | |
| Cytomap | 16p12.2 | 20q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-directed RNA polymerase III subunit RPC5DNA-directed RNA polymerase III 80 kDa polypeptideRNA polymerase III 80 kDa subunit RPC5RNA polymerase III subunit C5polymerase (RNA) III (DNA directed) polypeptide E (80kD)polymerase (RNA) III subunit E | endoplasmic reticulum-Golgi intermediate compartment protein 3endoplasmic reticulum-localized protein ERp43serologically defined breast cancer antigen 84serologically defined breast cancer antigen NY-BR-84 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NVU0 | Q9Y282 | |
| Ensembl transtripts involved in fusion gene | ENST00000299853, ENST00000564209, ENST00000418581, ENST00000359210, ENST00000564256, | ENST00000348547, ENST00000357394, ENST00000279052, ENST00000447986, ENST00000482338, | |
| Fusion gene scores | * DoF score | 3 X 5 X 4=60 | 6 X 6 X 3=108 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POLR3E [Title/Abstract] AND ERGIC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AF116614 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000299853 | ENST00000348547 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000299853 | ENST00000357394 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000299853 | ENST00000279052 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000299853 | ENST00000447986 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-intron | ENST00000299853 | ENST00000482338 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000564209 | ENST00000348547 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000564209 | ENST00000357394 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000564209 | ENST00000279052 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000564209 | ENST00000447986 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-intron | ENST00000564209 | ENST00000482338 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000418581 | ENST00000348547 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000418581 | ENST00000357394 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000418581 | ENST00000279052 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000418581 | ENST00000447986 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-intron | ENST00000418581 | ENST00000482338 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000359210 | ENST00000348547 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000359210 | ENST00000357394 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000359210 | ENST00000279052 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000359210 | ENST00000447986 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-intron | ENST00000359210 | ENST00000482338 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000564256 | ENST00000348547 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000564256 | ENST00000357394 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000564256 | ENST00000279052 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-3CDS | ENST00000564256 | ENST00000447986 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
| intron-intron | ENST00000564256 | ENST00000482338 | POLR3E | chr16 | 22331976 | - | ERGIC3 | chr20 | 34129877 | + |
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FusionProtFeatures for POLR3E_ERGIC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLR3E | ERGIC3 |
| DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Specific peripheric component of RNA polymerase IIIwhich synthesizes small RNAs, such as 5S rRNA and tRNAs. Essentialfor efficient transcription from both the type 2 VAI and type 3 U6RNA polymerase III promoters. Plays a key role in sensing andlimiting infection by intracellular bacteria and DNA viruses. Actsas nuclear and cytosolic DNA sensor involved in innate immuneresponse. Can sense non-self dsDNA that serves as template fortranscription into dsRNA. The non-self RNA polymerase IIItranscripts, such as Epstein-Barr virus-encoded RNAs (EBERs)induce type I interferon and NF- Kappa-B through the RIG-I pathway(By similarity). {ECO:0000250, ECO:0000269|PubMed:19609254,ECO:0000269|PubMed:19631370}. | Possible role in transport between endoplasmic reticulumand Golgi. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for POLR3E_ERGIC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for POLR3E_ERGIC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLR3E_ERGIC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POLR3E_ERGIC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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