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Fusion gene ID: 27994 |
FusionGeneSummary for POLR3B_PDS5B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLR3B_PDS5B | Fusion gene ID: 27994 | Hgene | Tgene | Gene symbol | POLR3B | PDS5B | Gene ID | 55703 | 23047 |
| Gene name | RNA polymerase III subunit B | PDS5 cohesin associated factor B | |
| Synonyms | C128|HLD8|INMAP|RPC2 | APRIN|AS3|CG008 | |
| Cytomap | 12q23.3 | 13q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-directed RNA polymerase III subunit RPC2DNA-directed RNA polymerase III 127.6 kDa polypeptideDNA-directed RNA polymerase III subunit BRNA polymerase III subunit C2interphase nucleus and mitotic apparatus associated proteinpolymerase (RNA) III (DN | sister chromatid cohesion protein PDS5 homolog Bandrogen induced inhibitor of proliferationandrogen-induced proliferation inhibitorandrogen-induced prostate proliferative shutoff-associated protein AS3androgen-induced shutoff 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NW08 | Q9NTI5 | |
| Ensembl transtripts involved in fusion gene | ENST00000228347, ENST00000539066, ENST00000549195, | ENST00000315596, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 3 X 3 X 3=27 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: POLR3B [Title/Abstract] AND PDS5B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PDS5B | GO:0008285 | negative regulation of cell proliferation | 10963680 |
| Tgene | PDS5B | GO:0042127 | regulation of cell proliferation | 10963680 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HC-7817-01B | POLR3B | chr12 | 106751729 | + | PDS5B | chr13 | 33315218 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000228347 | ENST00000315596 | POLR3B | chr12 | 106751729 | + | PDS5B | chr13 | 33315218 | + |
| intron-3CDS | ENST00000539066 | ENST00000315596 | POLR3B | chr12 | 106751729 | + | PDS5B | chr13 | 33315218 | + |
| intron-3CDS | ENST00000549195 | ENST00000315596 | POLR3B | chr12 | 106751729 | + | PDS5B | chr13 | 33315218 | + |
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FusionProtFeatures for POLR3B_PDS5B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLR3B | PDS5B |
| DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Second largest core component of RNA polymerase IIIwhich synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposedto contribute to the polymerase catalytic activity and forms thepolymerase active center together with the largest subunit. PolIII is composed of mobile elements and RPC2 is part of the coreelement with the central large cleft and probably a clamp elementthat moves to open and close the cleft (By similarity). Plays akey role in sensing and limiting infection by intracellularbacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensorinvolved in innate immune response. Can sense non-self dsDNA thatserves as template for transcription into dsRNA. The non-self RNApolymerase III transcripts, such as Epstein-Barr virus-encodedRNAs (EBERs) induce type I interferon and NF- Kappa-B through theRIG-I pathway. {ECO:0000250, ECO:0000269|PubMed:19609254,ECO:0000269|PubMed:19631370}. | Regulator of sister chromatid cohesion in mitosis whichmay stabilize cohesin complex association with chromatin. Maycouple sister chromatid cohesion during mitosis to DNAreplication. Cohesion ensures that chromosome partitioning isaccurate in both meiotic and mitotic cells and plays an importantrole in DNA repair. Plays a role in androgen-induced proliferativearrest in prostate cells. {ECO:0000269|PubMed:10963680,ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19696148}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PDS5B | chr12:106751729 | chr13:33315218 | ENST00000315596 | + | 20 | 35 | 1249_1261 | 802 | 1448 | DNA binding | A.T hook 1 |
| Tgene | >PDS5B | chr12:106751729 | chr13:33315218 | ENST00000315596 | + | 20 | 35 | 1287_1299 | 802 | 1448 | DNA binding | A.T hook 2 |
| Tgene | >PDS5B | chr12:106751729 | chr13:33315218 | ENST00000315596 | + | 20 | 35 | 1372_1384 | 802 | 1448 | DNA binding | A.T hook 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >POLR3B | chr12:106751729 | chr13:33315218 | ENST00000228347 | + | 1 | 28 | 1080_1095 | 24 | 1134 | Zinc finger | Note=C4-type |
| Hgene | >POLR3B | chr12:106751729 | chr13:33315218 | ENST00000539066 | + | 1 | 28 | 1080_1095 | -81 | 1076 | Zinc finger | Note=C4-type |
| Tgene | PDS5B | chr12:106751729 | chr13:33315218 | ENST00000315596 | + | 20 | 35 | 383_419 | 802 | 1448 | Repeat | HEAT |
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FusionGeneSequence for POLR3B_PDS5B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_POLR3B_ENST00000228347_chr12_106751729_+_PDS5B_ENST00000315596_chr13_33315218_+_670aa MDVLAEEFGNLTPEQLAAPIPTVELPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMKNNHSKSGTSTLRLLTTILHSDGDLTEQG KISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALAINDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHA RQCLVKNINVRREYLKQHAAVSEKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIK QTKDAQGPDDAKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFFTPGKPKTTNVLGAVNKPL SSAGKQSQTKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMSSPLPGKKSDKRDDSDLVRSELEKPRGRKKTPVTEQEEK LGMDDLTKLVQEQKPKGSQRSRKRGHTASESDEQQWPEEKRLKEDILENEDEQNSPPKKGKRGRPPKPLGGGTPKEEPTMKTSKKGSKKK SGPPAPEEEEEEERQSGNTEQKSKSKQHRVSRRAQQRAESPESSAIESTQSTPQKGRGRPSKTPSPSQPKKNVRVGRSKQAATKENDSSE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_POLR3B_ENST00000228347_chr12_106751729_+_PDS5B_ENST00000315596_chr13_33315218_+_2010nt ATGGACGTGCTAGCGGAGGAGTTTGGGAACCTGACTCCGGAGCAGCTGGCGGCGCCGATCCCGACTGTAGAGCTTCCAGGGAAAAAGACA ACTAAACTTTGGGTTCCAGATGAAGAAGTATCTCCTGAGACAATGGTCAAAATTCAGGCTATTAAAATGATGGTTCGATGGCTACTTGGA ATGAAAAATAATCACAGTAAATCAGGAACTTCTACCTTAAGATTGCTAACAACAATATTGCATAGTGATGGAGACTTGACAGAACAGGGG AAAATTAGTAAACCAGATATGTCACGTCTGAGACTTGCTGCTGGGAGTGCTATTGTGAAGCTGGCACAAGAACCCTGTTACCATGAAATC ATCACATTAGAACAATATCAGCTATGTGCATTAGCTATCAACGATGAATGCTATCAAGTAAGACAAGTGTTTGCCCAGAAACTTCACAAA GGCCTTTCCCGTTTACGGCTTCCACTTGAGTATATGGCAATCTGTGCCCTTTGTGCAAAAGATCCTGTAAAGGAGAGAAGAGCTCATGCT AGGCAATGTTTGGTGAAAAATATAAATGTAAGGCGGGAGTATCTGAAGCAGCATGCAGCTGTTAGTGAAAAATTATTGTCTCTTCTACCA GAGTATGTTGTTCCATATACAATTCACCTTTTGGCACATGACCCAGATTATGTCAAAGTACAGGATATTGAACAACTTAAAGATGTTAAA GAATGTCTTTGGTTTGTTCTGGAAATATTAATGGCTAAAAATGAAAATAACAGTCACGCTTTTATCAGAAAGATGGTAGAAAATATTAAA CAAACAAAAGATGCCCAAGGACCAGATGATGCAAAAATGAATGAAAAACTGTACACTGTGTGTGATGTTGCCATGAATATCATCATGTCA AAGAGTACTACATACAGTTTGGAATCTCCTAAAGACCCGGTACTACCAGCTCGTTTCTTCACTCAACCTGACAAGAATTTCAGTAACACC AAAAATTATCTGCCTCCTGAAATGAAATCATTTTTCACTCCTGGAAAACCTAAAACAACCAATGTTCTAGGAGCTGTTAACAAGCCACTT TCATCAGCAGGCAAGCAATCTCAGACCAAATCATCACGAATGGAAACTGTAAGCAATGCAAGCAGCAGCTCAAATCCAAGCTCTCCTGGA AGAATAAAGGGGAGGCTTGATAGTTCTGAAATGGATCACAGTGAAAATGAAGATTACACAATGTCTTCACCTTTGCCGGGGAAAAAAAGT GACAAGAGAGACGACTCTGATCTTGTAAGGTCTGAATTGGAGAAGCCTAGAGGCAGGAAAAAAACGCCCGTCACAGAACAGGAGGAGAAA TTAGGTATGGATGACTTGACTAAGTTGGTACAGGAACAGAAACCTAAAGGCAGTCAGCGAAGTCGGAAAAGAGGCCATACGGCTTCAGAA TCTGATGAACAGCAGTGGCCTGAGGAAAAGAGGCTCAAAGAAGATATATTAGAAAATGAAGATGAACAGAATAGTCCGCCAAAAAAGGGT AAAAGAGGCCGACCACCAAAACCTCTTGGTGGAGGTACACCAAAAGAAGAGCCAACAATGAAAACTTCTAAAAAAGGAAGCAAAAAAAAA TCTGGACCTCCAGCACCAGAGGAGGAGGAAGAAGAAGAAAGACAAAGTGGAAATACGGAACAGAAGTCCAAAAGCAAACAGCACCGAGTG TCAAGGAGAGCACAGCAGAGAGCAGAATCTCCTGAATCTAGTGCAATTGAATCCACACAGTCCACACCACAGAAAGGACGAGGAAGACCA TCAAAAACGCCATCACCATCACAACCAAAAAAAAATGTCCGTGTAGGACGCTCCAAACAAGCAGCTACTAAGGAAAATGATTCAAGTGAA GAAGTAGATGTGTTTCAGGGTAGCTCTCCTGTCGATGATATTCCACAGGAAGAAACAGAGGAGGAGGAAGTTTCTACAGTAAATGTACGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_POLR3B_ENST00000228347_chr12_106751729_+_PDS5B_ENST00000315596_chr13_33315218_+_5199nt ACCAGAGGGCGTACTTTCCTTACTCGGCCTCGGCCACATCCGGGTTCCACCGCAGATTCGGGCAGGGAGCGGGCGGAACCTTTCTACCGC GTCTCTAGCTAACACGCACGGCGGGGACAGTTTAGGCCTCCGCGCACCGTTCGCCGGGAGTCTTGCAGTTTGCTTGGTGCAGGGAAGGCG GGCGCGGAGGTTCTATCTGTTTCTTCCTCCTTCGTGAGCAGCATGGACGTGCTAGCGGAGGAGTTTGGGAACCTGACTCCGGAGCAGCTG GCGGCGCCGATCCCGACTGTAGAGCTTCCAGGGAAAAAGACAACTAAACTTTGGGTTCCAGATGAAGAAGTATCTCCTGAGACAATGGTC AAAATTCAGGCTATTAAAATGATGGTTCGATGGCTACTTGGAATGAAAAATAATCACAGTAAATCAGGAACTTCTACCTTAAGATTGCTA ACAACAATATTGCATAGTGATGGAGACTTGACAGAACAGGGGAAAATTAGTAAACCAGATATGTCACGTCTGAGACTTGCTGCTGGGAGT GCTATTGTGAAGCTGGCACAAGAACCCTGTTACCATGAAATCATCACATTAGAACAATATCAGCTATGTGCATTAGCTATCAACGATGAA TGCTATCAAGTAAGACAAGTGTTTGCCCAGAAACTTCACAAAGGCCTTTCCCGTTTACGGCTTCCACTTGAGTATATGGCAATCTGTGCC CTTTGTGCAAAAGATCCTGTAAAGGAGAGAAGAGCTCATGCTAGGCAATGTTTGGTGAAAAATATAAATGTAAGGCGGGAGTATCTGAAG CAGCATGCAGCTGTTAGTGAAAAATTATTGTCTCTTCTACCAGAGTATGTTGTTCCATATACAATTCACCTTTTGGCACATGACCCAGAT TATGTCAAAGTACAGGATATTGAACAACTTAAAGATGTTAAAGAATGTCTTTGGTTTGTTCTGGAAATATTAATGGCTAAAAATGAAAAT AACAGTCACGCTTTTATCAGAAAGATGGTAGAAAATATTAAACAAACAAAAGATGCCCAAGGACCAGATGATGCAAAAATGAATGAAAAA CTGTACACTGTGTGTGATGTTGCCATGAATATCATCATGTCAAAGAGTACTACATACAGTTTGGAATCTCCTAAAGACCCGGTACTACCA GCTCGTTTCTTCACTCAACCTGACAAGAATTTCAGTAACACCAAAAATTATCTGCCTCCTGAAATGAAATCATTTTTCACTCCTGGAAAA CCTAAAACAACCAATGTTCTAGGAGCTGTTAACAAGCCACTTTCATCAGCAGGCAAGCAATCTCAGACCAAATCATCACGAATGGAAACT GTAAGCAATGCAAGCAGCAGCTCAAATCCAAGCTCTCCTGGAAGAATAAAGGGGAGGCTTGATAGTTCTGAAATGGATCACAGTGAAAAT GAAGATTACACAATGTCTTCACCTTTGCCGGGGAAAAAAAGTGACAAGAGAGACGACTCTGATCTTGTAAGGTCTGAATTGGAGAAGCCT AGAGGCAGGAAAAAAACGCCCGTCACAGAACAGGAGGAGAAATTAGGTATGGATGACTTGACTAAGTTGGTACAGGAACAGAAACCTAAA GGCAGTCAGCGAAGTCGGAAAAGAGGCCATACGGCTTCAGAATCTGATGAACAGCAGTGGCCTGAGGAAAAGAGGCTCAAAGAAGATATA TTAGAAAATGAAGATGAACAGAATAGTCCGCCAAAAAAGGGTAAAAGAGGCCGACCACCAAAACCTCTTGGTGGAGGTACACCAAAAGAA GAGCCAACAATGAAAACTTCTAAAAAAGGAAGCAAAAAAAAATCTGGACCTCCAGCACCAGAGGAGGAGGAAGAAGAAGAAAGACAAAGT GGAAATACGGAACAGAAGTCCAAAAGCAAACAGCACCGAGTGTCAAGGAGAGCACAGCAGAGAGCAGAATCTCCTGAATCTAGTGCAATT GAATCCACACAGTCCACACCACAGAAAGGACGAGGAAGACCATCAAAAACGCCATCACCATCACAACCAAAAAAAAATGTCCGTGTAGGA CGCTCCAAACAAGCAGCTACTAAGGAAAATGATTCAAGTGAAGAAGTAGATGTGTTTCAGGGTAGCTCTCCTGTCGATGATATTCCACAG GAAGAAACAGAGGAGGAGGAAGTTTCTACAGTAAATGTACGGCGGCGAAGTGCTAAAAGGGAACGGCGATGAACAAATGTAATTAATAAC TTTCTCTGTGAAAGCTTTGGAAAAATCTTTTTTTTTTTTTTTGGTCAAGCTTGAGGCTGAATAAAGCCTTTGATGCACAAAATGGGACTG CTGAAGAGTGGACAGTTGGACCTTACTTTGGTGACCCCATACATTTGTGGTCACATGCTTTAGCCATACACATGGTAACATTGACTATGG AGTCTTGTGAAAGTGTAATGTGCGATGGCTATGTAGACATAAAGAAGAAACTTGTAAATATCTTTTTTCTTTTTTTTAATGTTTCTGATT TCTGAAGTGCTTGTATAGCTTTTATCTGCGGCTTTAAACTGACAGTACCCGACTGTTTATTGGATCTATTGATTTGAAAAGAATTTGTTA GGATAGATCTTAAGCAGTAATCTGTCAGTGTTTGTATTTGTATTCTCTGCAATTTTACTGTGAAAAAAAATTTGTTTTCAACAATTGGTG TCATTTTCTTGATGTCACTATTTGTTGGAGAGTTAAATGGTCTCTTCCCTTTGTGTATCTTACCTAGTGTTTACTCCTGGGCACCCTTAA TCTTCAGAGGTGCTAAATTGTCTGCCATTACACCAGAAGGATGCCTCTGATAGGAGGACAACCATGCAAATTGTGAAATAGTCCTGAAGT TCTTGGATTACTTTACACCTCAGTATTGATTTGTCCCAGAATTTTCTGGCCTTTCATGGCAATGAAAATTTTAAGAAGAAAGATTTAAAG TATTTTAATTTTAAAGAGTGTGTTATAAAATAATGTACTGAATTCTTTATCCCATTTTATCATCCTTTCAGTTTTTATTAATCTACTGTA TCAATAAAATTCTGTAATTTGAATGAGTTTTTAATAGTCTAGAATGTTATTGTGTATAGATATTTCCTCTTGAACGTTATGTTCAGAAAA TGCAAATTACACTATAATATAAAACCTGATATATACACATTAGAAATATTCCAGTTCTCCGTAACAGTGTAAAGTTAATCAGAAAGAAAA AATTTTATTGATGCAGTGTGTCTTTATAAAGCTGTTCTTGAAAGCCAAGTGTTTTGTATTTTATAGTGAGTTGCATGTTTTTGAAAAAAA GTGCTGAAAATGGGATGTGCTGTTTTCTGTAAATTCATATTTAGCCATAGTATATGATAGATTGCCCCATAACATAGTTTTTCATCAAGA GTTTATTATTGTACTTTATTTTGGAGCCAAAAAATTGATTCTGGGGGGTGGGGGCAGCGTAGAAGTGGTATATCCAAGTATATCAGCTAC TGTAGTTGTCACAGTCTTGTGAACTTTGAATGAAATTCCACTTTGTCCAGATTGGGAGAAGTGGAAATTTATTTGGATTTAGAGCAGGTC TTTTTTTTTCTTCATTGTAATCTGCAAAATGTAGAAATAAATTACTTAAGGCAGTATCCTTTATACAGTTGTATAAACTGTATTTTGAAC CAAAACATATAGGTTACTACTTAATGCTTACCTAATTTCATTTTAGTATTTTAGGTGCTGTTATGTTTTTTCATGGTTAACACCAGAGGG GAAAAAATCATATTCTAACTTATTAAATTTATCACATTGAATAGTGGAACATTTTCATATGATACACCATTATGTTTAAGATATATTTCC AAGATTGGTTATAATAGATGGGGCATATAATAAAGAAGCTACTATTTTGGAAAATGACATTTTACTATTTGCCAATGTATATTGCAATTG ATGTGATTATTTTTCTTTTAAAGATTTGTTTGTGTTTATGAAACAGCCATTTATTTTTTAAAAAGTGTTTTGAATTGTGTCTTAATCTCT CCATATTCAACTATTCTTCATTTACAACAATAGTGACACCAGTAATTATGAGAGGCTGTCATATATCAAAGCAGCTCAGGTGGGATCAAC ATACATTGGTTTTGAAATGTTTCCTTAGCTCGGTTCTCCCAAACACATAATTTCTGTTTCAGCAGTACAAAGGCATGTTTTAAAATCTAT AACATAAAGAATAAGGAATAGCTTTGTATTTTTGTCATTGATTAAATTGCACCAGAAATGTTTATGGAAATATTAAGAACATTTTATAAA ACATACGAAAAAGTGATTGTGAAGGATTTTTATTTGCATGATTATAGTTAAGCAAATTTCATTTCACATTTTTGTAATGCTGTACAGCAG TTCACAAAAAAATGTTCATTGTAGATTTTGTTATGTTCAATGCCAATGAGTCTGTAATTTTACGACCTGTCTGTTCTTTTTTTGGGTGGA TTACGATGTAAATTTTTCTTTTCTTTCTTTCTTTTTTTTTTTTTTTGTGTAGAAAAATAGGTGCAATAATGATCAAAGTTTTGATGTCTT GAGTCTCCATCTTAGGGGATTATCTTACGTTTAAGCTTAACATTTCATGTAGTAAGATTTGGAGAGCCACATACTTTACAGTAAAATTAA GTGTGTATAAAACATTAATTGCTAACAATTGTTAGCAAACTATTTCAGTGATAATGTTCATTTTGAAAATATGTACTGTATAACATTAAG AAAATATTTAACTCCCTGTAACAAGTTCCATTATGAAAATCTTATTCCTCAGTGAGGTTATCTTGCTGCACTCTGTAGCAAATTTGTTTA ATCTACATTATAATAAAATTTCTTGCTGCAGTGCAACAGGAGGCTTTTTCAGTGATCTTCACTGTATATGTAAATTACAAATGTGGCTGT AAAACTTATTCCAGGTATTAAAGGTTAAATTGCTTTCTATATCTTCTTATAACTTGTAAGTCTGATTTTTAAGATTTCCTTTTGTCCACT TGTAAGAATGTCAGGAATTTAAGAATTTGTTTAAATTAGGCATATCTCTGCCATCACATAGTATTATGTCACCATAATGAACAATTGCTA |
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FusionGenePPI for POLR3B_PDS5B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| POLR3B | POLR3D, RAE1, POLR3H, GPN1, RPAP2, RPAP1, POLR3A, POLR2H, POLR1C, CRCP, POLR1D, TSR1, MOV10, NXF1, MAF1, GPN3, PIH1D1, PPP1CC, PPP1CA, SKAP1, EEF1A1, IPO9, MRPL17, NOB1, POLR1A, POLR1B, POLR2A, POLR2E, POLR3C, POLR3E, LOC101060521, POLR3F, POLR3G, POLR3K, RPL30, RRS1, SMARCA5, NTRK1, KRAS, GSK3A, POLR2F, MATR3, DSN1, POLR3GL, UXT, P4HA2, APOBEC3D, URI1 | PDS5B | CDCA5, STAG1, STAG2, SMC3, SMC1A, WFDC5, PDS5A, RAD21, WAPAL, SIRT7, NSMCE2, APP, LAMP2, OBSL1, EED, RNF2, BSG, CD274, SEPT12, LYPD3, SLC30A4, TGOLN2, SCN2B, BRCA2, RAD51, PALB2, CDC45, PCNA, NTRK1, CEP164, GYPB, VIPR2, CHRM4, APLNR, ANK1, SLC15A1, CD70, KIAA1467, SCN3B, HTR2C, MAS1, P2RX5, LPAR4, TRIM25, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLR3B_PDS5B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POLR3B_PDS5B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | POLR3B | C3280644 | LEUKODYSTROPHY, HYPOMYELINATING, 8, WITH OR WITHOUT OLIGODONTIA AND/OR HYPOGONADOTROPIC HYPOGONADISM | 3 | UNIPROT |
| Hgene | POLR3B | C3714756 | Intellectual Disability | 1 | CTD_human |
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