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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27970

FusionGeneSummary for POLR2E_POLR2E

check button Fusion gene summary
Fusion gene informationFusion gene name: POLR2E_POLR2E
Fusion gene ID: 27970
HgeneTgene
Gene symbol

POLR2E

POLR2E

Gene ID

5434

5434

Gene nameRNA polymerase II subunit ERNA polymerase II subunit E
SynonymsRPABC1|RPB5|XAP4|hRPB25|hsRPB5RPABC1|RPB5|XAP4|hRPB25|hsRPB5
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionDNA-directed RNA polymerases I, II, and III subunit RPABC1DNA directed RNA polymerase II 23 kda polypeptideDNA-directed RNA polymerase II 23 kDa polypeptideDNA-directed RNA polymerase II subunit EDNA-directed RNA polymerase subunit RPABC1RNA polymeraDNA-directed RNA polymerases I, II, and III subunit RPABC1DNA directed RNA polymerase II 23 kda polypeptideDNA-directed RNA polymerase II 23 kDa polypeptideDNA-directed RNA polymerase II subunit EDNA-directed RNA polymerase subunit RPABC1RNA polymera
Modification date2018052320180523
UniProtAcc

P19388

P19388

Ensembl transtripts involved in fusion geneENST00000586746, ENST00000215587, 
ENST00000585838, 		ENST00000586746, 
ENST00000215587, ENST00000585838, 
Fusion gene scores* DoF score2 X 3 X 2=124 X 5 X 3=60
# samples 35
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLR2E [Title/Abstract] AND POLR2E [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLR2E

GO:0006366

transcription by RNA polymerase II

9852112

TgenePOLR2E

GO:0006366

transcription by RNA polymerase II

9852112


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ362075POLR2Echr19

1093828

+POLR2Echr19

1093992

-
ChiTaRS3.1CB215068POLR2Echr19

1093926

+POLR2Echr19

1091875

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000586746ENST00000586746POLR2Echr19

1093828

+POLR2Echr19

1093992

-
intron-3CDSENST00000586746ENST00000215587POLR2Echr19

1093828

+POLR2Echr19

1093992

-
intron-intronENST00000586746ENST00000585838POLR2Echr19

1093828

+POLR2Echr19

1093992

-
intron-3CDSENST00000215587ENST00000586746POLR2Echr19

1093828

+POLR2Echr19

1093992

-
intron-3CDSENST00000215587ENST00000215587POLR2Echr19

1093828

+POLR2Echr19

1093992

-
intron-intronENST00000215587ENST00000585838POLR2Echr19

1093828

+POLR2Echr19

1093992

-
intron-3CDSENST00000585838ENST00000586746POLR2Echr19

1093828

+POLR2Echr19

1093992

-
intron-3CDSENST00000585838ENST00000215587POLR2Echr19

1093828

+POLR2Echr19

1093992

-
intron-intronENST00000585838ENST00000585838POLR2Echr19

1093828

+POLR2Echr19

1093992

-
intron-3CDSENST00000586746ENST00000586746POLR2Echr19

1093926

+POLR2Echr19

1091875

-
intron-3CDSENST00000586746ENST00000215587POLR2Echr19

1093926

+POLR2Echr19

1091875

-
intron-5UTRENST00000586746ENST00000585838POLR2Echr19

1093926

+POLR2Echr19

1091875

-
intron-3CDSENST00000215587ENST00000586746POLR2Echr19

1093926

+POLR2Echr19

1091875

-
intron-3CDSENST00000215587ENST00000215587POLR2Echr19

1093926

+POLR2Echr19

1091875

-
intron-5UTRENST00000215587ENST00000585838POLR2Echr19

1093926

+POLR2Echr19

1091875

-
intron-3CDSENST00000585838ENST00000586746POLR2Echr19

1093926

+POLR2Echr19

1091875

-
intron-3CDSENST00000585838ENST00000215587POLR2Echr19

1093926

+POLR2Echr19

1091875

-
intron-5UTRENST00000585838ENST00000585838POLR2Echr19

1093926

+POLR2Echr19

1091875

-

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FusionProtFeatures for POLR2E_POLR2E


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POLR2E

P19388

POLR2E

P19388

DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Common component of RNA polymerases I, II and IIIwhich synthesize ribosomal RNA precursors, mRNA precursors andmany functional non-coding RNAs, and small RNAs, such as 5S rRNAand tRNAs, respectively. Pol II is the central component of thebasal RNA polymerase II transcription machinery. Pols are composedof mobile elements that move relative to each other. In Pol II,POLR2E/RPB5 is part of the lower jaw surrounding the central largecleft and thought to grab the incoming DNA template. Seems to bethe major component in this process (By similarity). {ECO:0000250,ECO:0000269|PubMed:9852112}. DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Common component of RNA polymerases I, II and IIIwhich synthesize ribosomal RNA precursors, mRNA precursors andmany functional non-coding RNAs, and small RNAs, such as 5S rRNAand tRNAs, respectively. Pol II is the central component of thebasal RNA polymerase II transcription machinery. Pols are composedof mobile elements that move relative to each other. In Pol II,POLR2E/RPB5 is part of the lower jaw surrounding the central largecleft and thought to grab the incoming DNA template. Seems to bethe major component in this process (By similarity). {ECO:0000250,ECO:0000269|PubMed:9852112}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for POLR2E_POLR2E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for POLR2E_POLR2E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for POLR2E_POLR2E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for POLR2E_POLR2E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource