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Fusion gene ID: 27966 |
FusionGeneSummary for POLR2B_REST |
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Fusion gene information | Fusion gene name: POLR2B_REST | Fusion gene ID: 27966 | Hgene | Tgene | Gene symbol | POLR2B | REST | Gene ID | 5431 | 5978 |
Gene name | RNA polymerase II subunit B | RE1 silencing transcription factor | |
Synonyms | POL2RB|RPB2|hRPB140 | GINGF5|HGF5|NRSF|WT6|XBR | |
Cytomap | 4q12 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA-directed RNA polymerase II subunit RPB2DNA-directed RNA polymerase II 140 kDa polypeptideDNA-directed RNA polymerase II subunit BRNA polymerase II second largest subunitRNA polymerase II subunit 2RNA polymerase II subunit B2polymerase (RNA) II ( | RE1-silencing transcription factorneural-restrictive silencer factorneuron restrictive silencer factorrepressor binding to the X2 box | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P30876 | Q13127 | |
Ensembl transtripts involved in fusion gene | ENST00000381227, ENST00000431623, ENST00000441246, ENST00000314595, ENST00000510355, | ENST00000309042, ENST00000514063, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 2 X 2 X 2=8 |
# samples | 6 | 2 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: POLR2B [Title/Abstract] AND REST [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | POLR2B | GO:0006366 | transcription by RNA polymerase II | 9852112 |
Tgene | REST | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8568247|21284946 |
Tgene | REST | GO:0043922 | negative regulation by host of viral transcription | 17555596 |
Tgene | REST | GO:0045892 | negative regulation of transcription, DNA-templated | 7697725|10449787|10734093|17984088|19342457 |
Tgene | REST | GO:0045893 | positive regulation of transcription, DNA-templated | 17984088 |
Tgene | REST | GO:0070933 | histone H4 deacetylation | 17555596 |
Tgene | REST | GO:0071385 | cellular response to glucocorticoid stimulus | 17984088 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-CN-6013-01A | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000381227 | ENST00000309042 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
5CDS-intron | ENST00000381227 | ENST00000514063 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
intron-intron | ENST00000431623 | ENST00000309042 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
intron-intron | ENST00000431623 | ENST00000514063 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
5CDS-intron | ENST00000441246 | ENST00000309042 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
5CDS-intron | ENST00000441246 | ENST00000514063 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
5CDS-intron | ENST00000314595 | ENST00000309042 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
5CDS-intron | ENST00000314595 | ENST00000514063 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
intron-intron | ENST00000510355 | ENST00000309042 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
intron-intron | ENST00000510355 | ENST00000514063 | POLR2B | chr4 | 57857064 | + | REST | chr4 | 57832822 | + |
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FusionProtFeatures for POLR2B_REST |
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Hgene | Tgene |
POLR2B | REST |
DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Second largest component of RNA polymerase II whichsynthesizes mRNA precursors and many functional non-coding RNAs.Proposed to contribute to the polymerase catalytic activity andforms the polymerase active center together with the largestsubunit. Pol II is the central component of the basal RNApolymerase II transcription machinery. It is composed of mobileelements that move relative to each other. RPB2 is part of thecore element with the central large cleft, the clamp element thatmoves to open and close the cleft and the jaws that are thought tograb the incoming DNA template (By similarity). {ECO:0000250,ECO:0000269|PubMed:9852112}. | Transcriptional repressor which binds neuron-restrictivesilencer element (NRSE) and represses neuronal gene transcriptionin non-neuronal cells. Restricts the expression of neuronal genesby associating with two distinct corepressors, mSin3 and CoREST,which in turn recruit histone deacetylase to the promoters ofREST-regulated genes. Mediates repression by recruiting the BHCcomplex at RE1/NRSE sites which acts by deacetylating anddemethylating specific sites on histones, thereby acting as achromatin modifier. Transcriptional repression by REST-CDYL viathe recruitment of histone methyltransferase EHMT2 may beimportant in transformation suppression.{ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:19061646,ECO:0000269|PubMed:26551668, ECO:0000269|PubMed:7697725,ECO:0000269|PubMed:7871435, ECO:0000269|PubMed:8568247}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for POLR2B_REST |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for POLR2B_REST |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
POLR2B | MED10, MED9, MED29, MED19, MED28, MED26, POLR2C, POLR2E, POLR2L, POLR2H, POLR2K, BTF3, RECQL5, RPAP2, RPAP3, GTF2F2, POLR2G, POLR2J, RPAP1, RUVBL2, GPN1, GTF2F1, TCEA1, KDM1A, AIRE, POLR2A, LZTR1, IKBKG, ZSCAN1, CTDP1, INTS3, INTS5, INTS6, INTS1, ZC3H13, WDR82, TADA2A, MYC, SUB1, POLR2D, CALM1, SHFM1, INTS10, PIDD1, CUL3, CUL5, CAND1, CCNH, CDK7, MEN1, POLR2I, TUBA4A, TUBB4B, DCTN1, ATP6V1B2, POLR3F, BARD1, MDC1, VCP, HDAC11, CDK20, FBXO6, HECW2, ITCH, NEDD4, WWOX, RABEP2, ILK, XRN2, ESR1, SRC, PSMB9, TCEB3, OBSL1, SUZ12, RNF2, SNAR-B2, RPRD1B, GPN2, POLR2M, EEF1A1, EEFSEC, POLR1A, POLR1B, SUPT5H, POLR2F, POLR3A, RPS5, TUBB, NTRK1, IFI16, MED4, XPO1, DNAJC7, CTR9, CEP170P1, BRD2, NELFA, RNGTT, LMO2, GPN3, PIH1D1, ASB6, CPNE2, NCL, AAR2, INO80B, RUVBL1, URI1, WDR92, ZNHIT2, TRIM25, G3BP1 | REST | RCOR1, KDM5C, RNF2, NCOR1, HDAC2, HDAC1, CDYL, SMARCA4, HDAC5, HDAC4, SMARCE1, SMARCC2, SP1, TBP, GTF2B, SIN3B, SIN3A, SUB1, GRIA2, TERF2, BTRC, FBXW11, FBXW2, FBXW4, FBXW5, FBXW8, FBXW7, EIF4A3, EHMT2, CSNK1E, UBC, PLK1, TEX14, SCYL1, PIN1, MAPK1, CTDSP1, AURKA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLR2B_REST |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POLR2B_REST |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | REST | C0015923 | Fetal Alcohol Syndrome | 1 | PSYGENET |
Tgene | REST | C0027708 | Nephroblastoma | 1 | CTD_human;HPO;ORPHANET |
Tgene | REST | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | REST | C0036572 | Seizures | 1 | CTD_human |
Tgene | REST | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | REST | C3891301 | WILMS TUMOR, SUSCEPTIBILITY TO | 1 | UNIPROT |