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Fusion gene ID: 27965 |
FusionGeneSummary for POLR2B_IGF2BP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLR2B_IGF2BP3 | Fusion gene ID: 27965 | Hgene | Tgene | Gene symbol | POLR2B | IGF2BP3 | Gene ID | 5431 | 10643 |
| Gene name | RNA polymerase II subunit B | insulin like growth factor 2 mRNA binding protein 3 | |
| Synonyms | POL2RB|RPB2|hRPB140 | CT98|IMP-3|IMP3|KOC|KOC1|VICKZ3 | |
| Cytomap | 4q12 | 7p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-directed RNA polymerase II subunit RPB2DNA-directed RNA polymerase II 140 kDa polypeptideDNA-directed RNA polymerase II subunit BRNA polymerase II second largest subunitRNA polymerase II subunit 2RNA polymerase II subunit B2polymerase (RNA) II ( | insulin-like growth factor 2 mRNA-binding protein 3IGF-II mRNA-binding protein 3IGF2 mRNA-binding protein 3KH domain containing protein overexpressed in cancerVICKZ family member 3cancer/testis antigen 98 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P30876 | O00425 | |
| Ensembl transtripts involved in fusion gene | ENST00000381227, ENST00000431623, ENST00000441246, ENST00000314595, ENST00000510355, | ENST00000258729, ENST00000491719, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 3 X 3=27 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: POLR2B [Title/Abstract] AND IGF2BP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POLR2B | GO:0006366 | transcription by RNA polymerase II | 9852112 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | W81478 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000381227 | ENST00000258729 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| 5CDS-intron | ENST00000381227 | ENST00000491719 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| 5CDS-intron | ENST00000431623 | ENST00000258729 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| 5CDS-intron | ENST00000431623 | ENST00000491719 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| 5CDS-intron | ENST00000441246 | ENST00000258729 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| 5CDS-intron | ENST00000441246 | ENST00000491719 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| 5CDS-intron | ENST00000314595 | ENST00000258729 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| 5CDS-intron | ENST00000314595 | ENST00000491719 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| intron-intron | ENST00000510355 | ENST00000258729 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
| intron-intron | ENST00000510355 | ENST00000491719 | POLR2B | chr4 | 57897082 | + | IGF2BP3 | chr7 | 23419096 | + |
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FusionProtFeatures for POLR2B_IGF2BP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLR2B | IGF2BP3 |
| DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Second largest component of RNA polymerase II whichsynthesizes mRNA precursors and many functional non-coding RNAs.Proposed to contribute to the polymerase catalytic activity andforms the polymerase active center together with the largestsubunit. Pol II is the central component of the basal RNApolymerase II transcription machinery. It is composed of mobileelements that move relative to each other. RPB2 is part of thecore element with the central large cleft, the clamp element thatmoves to open and close the cleft and the jaws that are thought tograb the incoming DNA template (By similarity). {ECO:0000250,ECO:0000269|PubMed:9852112}. | RNA-binding factor that may recruit target transcriptsto cytoplasmic protein-RNA complexes (mRNPs). This transcript'caging' into mRNPs allows mRNA transport and transient storage.It also modulates the rate and location at which targettranscripts encounter the translational apparatus and shields themfrom endonuclease attacks or microRNA-mediated degradation. Bindsto the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes celladhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of theinsulin-like growth factor 2 (IGF2) mRNAs.{ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for POLR2B_IGF2BP3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for POLR2B_IGF2BP3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLR2B_IGF2BP3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POLR2B_IGF2BP3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | IGF2BP3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | IGF2BP3 | C0031149 | Peritoneal Neoplasms | 1 | CTD_human |
| Tgene | IGF2BP3 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
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