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Fusion gene ID: 27963 |
FusionGeneSummary for POLR2B_CEP135 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLR2B_CEP135 | Fusion gene ID: 27963 | Hgene | Tgene | Gene symbol | POLR2B | CEP135 | Gene ID | 5431 | 9662 |
| Gene name | RNA polymerase II subunit B | centrosomal protein 135 | |
| Synonyms | POL2RB|RPB2|hRPB140 | CEP4|KIAA0635|MCPH8 | |
| Cytomap | 4q12 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-directed RNA polymerase II subunit RPB2DNA-directed RNA polymerase II 140 kDa polypeptideDNA-directed RNA polymerase II subunit BRNA polymerase II second largest subunitRNA polymerase II subunit 2RNA polymerase II subunit B2polymerase (RNA) II ( | centrosomal protein of 135 kDacentrosomal protein 135kDacentrosomal protein 4centrosome protein cep135 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P30876 | Q66GS9 | |
| Ensembl transtripts involved in fusion gene | ENST00000381227, ENST00000431623, ENST00000441246, ENST00000314595, ENST00000510355, | ENST00000257287, ENST00000422247, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: POLR2B [Title/Abstract] AND CEP135 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POLR2B | GO:0006366 | transcription by RNA polymerase II | 9852112 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-S9-A89Z-01A | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000381227 | ENST00000257287 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| 5CDS-intron | ENST00000381227 | ENST00000422247 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| In-frame | ENST00000431623 | ENST00000257287 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| 5CDS-intron | ENST00000431623 | ENST00000422247 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| In-frame | ENST00000441246 | ENST00000257287 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| 5CDS-intron | ENST00000441246 | ENST00000422247 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| In-frame | ENST00000314595 | ENST00000257287 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| 5CDS-intron | ENST00000314595 | ENST00000422247 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| intron-3CDS | ENST00000510355 | ENST00000257287 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
| intron-intron | ENST00000510355 | ENST00000422247 | POLR2B | chr4 | 57861575 | + | CEP135 | chr4 | 56851447 | + |
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FusionProtFeatures for POLR2B_CEP135 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLR2B | CEP135 |
| DNA-dependent RNA polymerase catalyzes the transcriptionof DNA into RNA using the four ribonucleoside triphosphates assubstrates. Second largest component of RNA polymerase II whichsynthesizes mRNA precursors and many functional non-coding RNAs.Proposed to contribute to the polymerase catalytic activity andforms the polymerase active center together with the largestsubunit. Pol II is the central component of the basal RNApolymerase II transcription machinery. It is composed of mobileelements that move relative to each other. RPB2 is part of thecore element with the central large cleft, the clamp element thatmoves to open and close the cleft and the jaws that are thought tograb the incoming DNA template (By similarity). {ECO:0000250,ECO:0000269|PubMed:9852112}. | Involved in early centrioleassembly/duplication/biogenesis/formation/. Required for centrioleelongation. Required for the recruitment of CEP295 to the proximalend of new-born centrioles at the centriolar microtubule wallduring early S phase in a PLK4-dependent manner.{ECO:0000269|PubMed:27185865}. Centrosomal protein involved in centriole biogenesis.Acts as a scaffolding protein during early centriole biogenesis.Required for the targeting of centriole satellite proteins tocentrosomes such as of PCM1, SSX2IP and CEP290 and recruitment ofWRAP73 to centrioles. Also required for centriole-centriolecohesion during interphase by acting as a platform protein forCEP250 at the centriole. Required for the recruitment of CEP295 tothe proximal end of new-born centrioles at the centriolarmicrotubule wall during early S phase in a PLK4-dependent manner.Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early Sphase in a PLK4-dependent manner (PubMed:27185865).{ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18851962,ECO:0000269|PubMed:26675238, ECO:0000269|PubMed:27185865}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CEP135 | chr4:57861575 | chr4:56851447 | ENST00000257287 | + | 12 | 26 | 1069_1116 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP135 | chr4:57861575 | chr4:56851447 | ENST00000422247 | + | 0 | 6 | 1069_1116 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP135 | chr4:57861575 | chr4:56851447 | ENST00000422247 | + | 0 | 6 | 195_420 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP135 | chr4:57861575 | chr4:56851447 | ENST00000422247 | + | 0 | 6 | 447_1039 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP135 | chr4:57861575 | chr4:56851447 | ENST00000422247 | + | 0 | 6 | 71_152 | -78 | 250 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >POLR2B | chr4:57861575 | chr4:56851447 | ENST00000314595 | + | 6 | 25 | 1119_1140 | 245 | 1175 | Zinc finger | Note=C4-type |
| Hgene | >POLR2B | chr4:57861575 | chr4:56851447 | ENST00000381227 | + | 7 | 26 | 1119_1140 | 245 | 1175 | Zinc finger | Note=C4-type |
| Tgene | CEP135 | chr4:57861575 | chr4:56851447 | ENST00000257287 | + | 12 | 26 | 195_420 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP135 | chr4:57861575 | chr4:56851447 | ENST00000257287 | + | 12 | 26 | 447_1039 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP135 | chr4:57861575 | chr4:56851447 | ENST00000257287 | + | 12 | 26 | 71_152 | 593 | 1782 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for POLR2B_CEP135 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_POLR2B_ENST00000381227_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_793aa MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQ IYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQHIEEVSLFGKSELEKTIEHLTCVNH QLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKI DELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQ LDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHN RAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLR ELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLS >In-frame_POLR2B_ENST00000431623_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_718aa MLDCNQPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNG LTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQHIEEVSLFGK SELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGE LESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKE TLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKE KENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQ EDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHE >In-frame_POLR2B_ENST00000441246_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_786aa MQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPT HWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFII NGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQHIEEVSLFGKSELEKTIEHLTCVNHQLESEKY ELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKM TSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKE LDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEV KAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLD SGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQ >In-frame_POLR2B_ENST00000314595_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_793aa MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQ IYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQHIEEVSLFGKSELEKTIEHLTCVNH QLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKI DELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQ LDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHN RAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLR ELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_POLR2B_ENST00000381227_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_2379nt ATGTACGACGCGGATGAGGATATGCAATATGATGAGGATGATGATGAAATCACCCCGGATTTGTGGCAAGAAGCATGCTGGATTGTAATC AGTTCCTATTTTGACGAGAAAGGCTTGGTTAGACAACAGCTGGATTCTTTTGATGAGTTTATTCAGATGTCTGTTCAAAGAATTGTGGAA GACGCTCCTCCTATAGACCTACAGGCTGAAGCTCAGCATGCTAGTGGAGAAGTTGAAGAACCGCCACGATATTTGCTGAAGTTTGAACAA ATTTATCTTTCCAAGCCTACCCATTGGGAAAGAGATGGTGCTCCTTCACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTAT TCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCATTAAAGAAGGTGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGA AAAATTCCAATTATGTTGCGGTCAACTTACTGCCTTTTGAATGGCTTGACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGAT CCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGGTTCTGATTGCCCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAA AAGGATTCTAAATATGCCTACACAGGAGAGTGTAGATCATGTCTTGAGAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTG GCAAGAGGAGGACAGCATATTGAAGAAGTGAGTCTTTTTGGAAAATCAGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCAT CAGCTTGAAAGCGAAAAATATGAATTAAAGTCTAAAGTGTTAATAATGAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAA GCTCAAAAATTTAGCCATGTGGCTGGTGACTCATCTCATCAGAAAACAGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGG TCAGTTGATGACTATCAGCACCGACTTTCCATAAAAAGAGGTGAACTTGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATA GATGAACTAAACCTTAAGATGACTTCACAGGATGAGGAGGCTCATGTAATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTT CTCCAGGAGACTGTAGATGAGAAGACAGAAAAGATTGCAAATTTGCAAGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAG ATAATGATCTCAGAGTGTGAATCATCTGTGAACCAGCTGAAAGAAACATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAG CTTGATGCAGCTCACAAAGAACTCGATGAAGTAGGAAGATCTAGAGAAATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCT ACAATGGCAAGAGAAAATCAAGAAATCTCATTGGAATTGGAAGCAGCAGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATAC ATAACAGAGGTGTCACGATGGGAGAGCTTAATGGCTGCCAAGGAAAAAGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAAC CGTGCTGAAGACTGGGAGGTCAAAGCCCATCAAGCTGAGGGAGAAAGCAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGG AGACATCTTCGAGAAAGAGTGGAGCTATTAGAAAAAGAAATTCAAGAGCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCA ATGGCAAAAGCCATGTCTCGATTAGAAGAAGAGCTGAGACATCAAGAAGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGA GAACTTTGCATTAAACTTGATTCAGGCAAAGATATTATGACCCAGCAATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAA TTAGAAAATGTAAAGTCAGAGTCAGACCTACTGAAAAAACAACTTTCAAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCT ACAAACAGAGATAAAGAATTTCATTCTCACTTAACCTCCCACGAGAAGGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCT GAAAGCAAATTAACTAGTCAAAGCCGGGAAAACACCATGCTTCGAGCTAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGG CAGATCTCAACTGAAAGATACGAACGAGAACGAGCAATCCAAGAGATGCGTCGACATGGTCTTGCTACACCACCCCTTAGTTCCACTCTG >In-frame_POLR2B_ENST00000431623_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_2154nt ATGCTGGATTGTAATCAGCCACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGAAAGAGATGGTGCTCCT TCACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCATTAAAGAA GGTGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTACTGCCTTTTGAATGGC TTGACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGGTTCTGATT GCCCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGAGTGTAGATCATGTCTT GAGAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATTGAAGAAGTGAGTCTTTTTGGAAAA TCAGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATATGAATTAAAGTCTAAAGTGTTAATA ATGAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTGGCTGGTGACTCATCTCATCAGAAA ACAGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCACCGACTTTCCATAAAAAGAGGTGAA CTTGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATGACTTCACAGGATGAGGAGGCTCAT GTAATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAGAAGACAGAAAAGATTGCAAATTTG CAAGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAATCATCTGTGAACCAGCTGAAAGAA ACATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAACTCGATGAAGTAGGAAGATCTAGA GAAATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAAGAAATCTCATTGGAATTGGAAGCA GCAGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGGGAGAGCTTAATGGCTGCCAAGGAA AAAGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTCAAAGCCCATCAAGCTGAGGGAGAA AGCAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTGGAGCTATTAGAAAAAGAAATTCAA GAGCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGATTAGAAGAAGAGCTGAGACATCAA GAAGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGATTCAGGCAAAGATATTATGACCCAG CAATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAGTCAGACCTACTGAAAAAACAACTT TCAAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTTCATTCTCACTTAACCTCCCACGAG AAGGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAAAGCCGGGAAAACACCATGCTTCGA GCTAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATACGAACGAGAACGAGCAATCCAAGAG >In-frame_POLR2B_ENST00000441246_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_2358nt ATGCAATATGATGAGGATGATGATGAAATCACCCCGGATTTGTGGCAAGAAGCATGCTGGATTGTAATCAGTTCCTATTTTGACGAGAAA GGCTTGGTTAGACAACAGCTGGATTCTTTTGATGAGTTTATTCAGATGTCTGTTCAAAGAATTGTGGAAGACGCTCCTCCTATAGACCTA CAGGCTGAAGCTCAGCATGCTAGTGGAGAAGTTGAAGAACCGCCACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACC CATTGGGAAAGAGATGGTGCTCCTTCACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGAT ATAACAAAAACAGTCATTAAAGAAGGTGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGG TCAACTTACTGCCTTTTGAATGGCTTGACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATT AATGGATCAGAAAAGGTTCTGATTGCCCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTAC ACAGGAGAGTGTAGATCATGTCTTGAGAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATT GAAGAAGTGAGTCTTTTTGGAAAATCAGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATAT GAATTAAAGTCTAAAGTGTTAATAATGAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTG GCTGGTGACTCATCTCATCAGAAAACAGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCAC CGACTTTCCATAAAAAGAGGTGAACTTGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATG ACTTCACAGGATGAGGAGGCTCATGTAATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAG AAGACAGAAAAGATTGCAAATTTGCAAGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAA TCATCTGTGAACCAGCTGAAAGAAACATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAA CTCGATGAAGTAGGAAGATCTAGAGAAATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAA GAAATCTCATTGGAATTGGAAGCAGCAGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGG GAGAGCTTAATGGCTGCCAAGGAAAAAGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTC AAAGCCCATCAAGCTGAGGGAGAAAGCAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTG GAGCTATTAGAAAAAGAAATTCAAGAGCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGA TTAGAAGAAGAGCTGAGACATCAAGAAGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGAT TCAGGCAAAGATATTATGACCCAGCAATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAG TCAGACCTACTGAAAAAACAACTTTCAAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTT CATTCTCACTTAACCTCCCACGAGAAGGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAA AGCCGGGAAAACACCATGCTTCGAGCTAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATAC GAACGAGAACGAGCAATCCAAGAGATGCGTCGACATGGTCTTGCTACACCACCCCTTAGTTCCACTCTGAGGTCTCCTTCACATTCTCCT >In-frame_POLR2B_ENST00000314595_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_2379nt ATGTACGACGCGGATGAGGATATGCAATATGATGAGGATGATGATGAAATCACCCCGGATTTGTGGCAAGAAGCATGCTGGATTGTAATC AGTTCCTATTTTGACGAGAAAGGCTTGGTTAGACAACAGCTGGATTCTTTTGATGAGTTTATTCAGATGTCTGTTCAAAGAATTGTGGAA GACGCTCCTCCTATAGACCTACAGGCTGAAGCTCAGCATGCTAGTGGAGAAGTTGAAGAACCGCCACGATATTTGCTGAAGTTTGAACAA ATTTATCTTTCCAAGCCTACCCATTGGGAAAGAGATGGTGCTCCTTCACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTAT TCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCATTAAAGAAGGTGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGA AAAATTCCAATTATGTTGCGGTCAACTTACTGCCTTTTGAATGGCTTGACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGAT CCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGGTTCTGATTGCCCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAA AAGGATTCTAAATATGCCTACACAGGAGAGTGTAGATCATGTCTTGAGAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTG GCAAGAGGAGGACAGCATATTGAAGAAGTGAGTCTTTTTGGAAAATCAGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCAT CAGCTTGAAAGCGAAAAATATGAATTAAAGTCTAAAGTGTTAATAATGAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAA GCTCAAAAATTTAGCCATGTGGCTGGTGACTCATCTCATCAGAAAACAGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGG TCAGTTGATGACTATCAGCACCGACTTTCCATAAAAAGAGGTGAACTTGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATA GATGAACTAAACCTTAAGATGACTTCACAGGATGAGGAGGCTCATGTAATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTT CTCCAGGAGACTGTAGATGAGAAGACAGAAAAGATTGCAAATTTGCAAGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAG ATAATGATCTCAGAGTGTGAATCATCTGTGAACCAGCTGAAAGAAACATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAG CTTGATGCAGCTCACAAAGAACTCGATGAAGTAGGAAGATCTAGAGAAATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCT ACAATGGCAAGAGAAAATCAAGAAATCTCATTGGAATTGGAAGCAGCAGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATAC ATAACAGAGGTGTCACGATGGGAGAGCTTAATGGCTGCCAAGGAAAAAGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAAC CGTGCTGAAGACTGGGAGGTCAAAGCCCATCAAGCTGAGGGAGAAAGCAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGG AGACATCTTCGAGAAAGAGTGGAGCTATTAGAAAAAGAAATTCAAGAGCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCA ATGGCAAAAGCCATGTCTCGATTAGAAGAAGAGCTGAGACATCAAGAAGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGA GAACTTTGCATTAAACTTGATTCAGGCAAAGATATTATGACCCAGCAATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAA TTAGAAAATGTAAAGTCAGAGTCAGACCTACTGAAAAAACAACTTTCAAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCT ACAAACAGAGATAAAGAATTTCATTCTCACTTAACCTCCCACGAGAAGGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCT GAAAGCAAATTAACTAGTCAAAGCCGGGAAAACACCATGCTTCGAGCTAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGG CAGATCTCAACTGAAAGATACGAACGAGAACGAGCAATCCAAGAGATGCGTCGACATGGTCTTGCTACACCACCCCTTAGTTCCACTCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_POLR2B_ENST00000381227_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_4807nt ACTGAGAACCTACTTAAAGCTATGGCAAAGGCACTGGAGGATTGAGCTAGGTGGGCAGAAAAGAGCAGTGTCGTTATTTGTGCAACAACA TTGAAAAACAAGCAGAAATAAAACATTGACGGAACGGATACGACCGCAGATTGCGGGAGCTGTCCTCTCAATCAGCCCGGCAGCGGCGGC CCACAATTTACGCGTGTGCAACCCTAACCCCGGCCCAAGCTTGACCTACAATTTGCGCAGGCGCAGATCCTAACTTTGGCGTCCCTGTGG GCGGCCTTTGGTGTGAGACGCGTGGTATTCTGGGAACGTCGGAGACGGAAGTTACTTCGTCTTTAGCTCCTGGCGCTGCTGGCTTCTGGG CGGTTTTTGTCTTTTGATTTCAAGAGTTAGGAGCTCGAGAACCGTTTGGCAATATGTACGACGCGGATGAGGATATGCAATATGATGAGG ATGATGATGAAATCACCCCGGATTTGTGGCAAGAAGCATGCTGGATTGTAATCAGTTCCTATTTTGACGAGAAAGGCTTGGTTAGACAAC AGCTGGATTCTTTTGATGAGTTTATTCAGATGTCTGTTCAAAGAATTGTGGAAGACGCTCCTCCTATAGACCTACAGGCTGAAGCTCAGC ATGCTAGTGGAGAAGTTGAAGAACCGCCACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGAAAGAGATG GTGCTCCTTCACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCA TTAAAGAAGGTGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTACTGCCTTT TGAATGGCTTGACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGG TTCTGATTGCCCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGAGTGTAGAT CATGTCTTGAGAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATTGAAGAAGTGAGTCTTT TTGGAAAATCAGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATATGAATTAAAGTCTAAAG TGTTAATAATGAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTGGCTGGTGACTCATCTC ATCAGAAAACAGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCACCGACTTTCCATAAAAA GAGGTGAACTTGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATGACTTCACAGGATGAGG AGGCTCATGTAATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAGAAGACAGAAAAGATTG CAAATTTGCAAGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAATCATCTGTGAACCAGC TGAAAGAAACATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAACTCGATGAAGTAGGAA GATCTAGAGAAATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAAGAAATCTCATTGGAAT TGGAAGCAGCAGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGGGAGAGCTTAATGGCTG CCAAGGAAAAAGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTCAAAGCCCATCAAGCTG AGGGAGAAAGCAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTGGAGCTATTAGAAAAAG AAATTCAAGAGCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGATTAGAAGAAGAGCTGA GACATCAAGAAGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGATTCAGGCAAAGATATTA TGACCCAGCAATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAGTCAGACCTACTGAAAA AACAACTTTCAAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTTCATTCTCACTTAACCT CCCACGAGAAGGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAAAGCCGGGAAAACACCA TGCTTCGAGCTAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATACGAACGAGAACGAGCAA TCCAAGAGATGCGTCGACATGGTCTTGCTACACCACCCCTTAGTTCCACTCTGAGGTCTCCTTCACATTCTCCTGAACATAGAAATGTGT AATTATCAGAAAGAATAATGGCTTTCAATGAGTTCCTATGTGGATTTTTAAAAGAACAGAACAGTAATGAAATATTTGAAGTACTTGTTG CTGAAAATCATGAACATGGACACAAATTCTACCTCTGTCAACTTTTATTTAAATCAGTGAATATGTTAAAAAGTTTGGTTTAAAAGAACT ATATCTATATGTATATTTTCATATATATGACAGAACAAGAATATGTATTAATAGTGCCTAATGTATCTATATTTTTATTATTCATGAATT AAATTACTAAAAGTATGTTTATACTGTGAATTAATATAATGTATTCACATTATTCTTTAATAATCTGTTTATTAATAAGCCATGATATGT GTATGTAAATATTCTTACAGTACTTGTTTTTAGTTGTCATGCCTATGTTTAGACCATATCTTAATGTATTCACAAAGAATTATCAACTTT GATGCTATGCTGTCATGCTTAACTTTTTCTTCTTAAAATTATTCATAGATCTACTGTCTGTTGTCAAGGGGAATATATTCAGGTCTAGTC TTCTTATAATAGCAGAGGTCTTGGTAAAATAACTACCATATATAACGTGTTATTGCCATCTAGAAGAACTATGATGAGAAAGATACATTT ATATATTATGTAAAATGTTAACTATCATCATATGGACTCTATGTAACACAAATTCAAAAGCAAACTAAAAGCTATATGCAGAGTTTTGTA TAAAACAATAGAACAGAAATTTGGGACATTTTTCTAGGAAATAAAATTCCTCGGTGTATTAATCTAAGGTTTCAAAGTATAAAAGTATAT GGGGTAGGCCGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGTGGATTTCCTAAGGTCAGGAGTTTGAGA CCAGCCTGAGCAATGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTATCTGGGCTTGGTGGCGGGCACCTGTAATCCCAGCCACT TGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGGCTGCGGTGAGCCAAGATCATGCCATTGCACTCCAGCCTGGGTGAC AGAGTAACACTCTGTCTCAGAAAAAAAAAAAAAGAAAAATATATGGGGTAAATACAGTAAAACGTTTTGTTAAATTCCAATATACATTCA GTGATACCACTCTTTTTCTTCTAAGCCTGTGTGTTATAATTTACCAGTTCCCCAAAATGCCATTTTTAACGCCGAACTGTGTAATATACA TGGAAAACAGCTTTTTACAATTAATTTTCAAAGTTGTAATTTTAAAGAATTTGGGTGTATACCTATGTTAATGAAACAACAGAAGTACAA AAAAGAATATCAGATACAAAAATCAATCGTGAAGAAAATCTGTTCTTAATATATTTCATTATGATTGAAAAACATAAAAACTAACATAGG AAAGTGAATGATCAGTTACTTATGATATATTTTGTTTCCTCTTGTGGTTTAATAAAGTGAAGTGTGTGTGTGTGTGTGTGTGTGTATACC TGGGGGTGGGCAGTGCTCTTTTTCTAAAACTAATATGGCTTATATATCTGAATTATGCCCTTTTTAGTGTGTATTAGGATGTGGGCTGGT TTGCTTTTCTACCACCTTTGTAATTTTATGTATCCCATCTCCTTTGTGTGAATTCATATATTATAGCAAAATACAAGAGACATGGGACTG TTTGCAATACCATATGGAAATCTTTTAATAAATATATGTAAATAAAATAAAAAATATTTGTCTCCACCTTTTCCCCAAAAGCAACAGCAA GACATATTTTGTTAGATATTTTATTTTTAATGTTTTCTATAATTTAAAAATGTATAGCCTGCCAAATGTTGTTTTCATAACCATGATATT GTTTTGAAAAAATTTTATCTTAAAATACTGAATGTTCTGACCTTTTATAGATGTTTTTGATTTTGTTTTAAATAATTTTAAATTATGGAG >In-frame_POLR2B_ENST00000431623_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_4365nt GTGGTATTCTGGGAACGTCGGAGACGGAAGTTACTTCGTCTTTAGCTCCTGGCGCTGCTGGCTTCTGGGCGGTTTTTGTCTTTTGATTTC AAGAGTTAGGAGCTCGAGAACCGTTTGGCAATATGTACGACGCGGATGAGGATATGCAATATGATGAGGATGATGATGAAATCACCCCGG ATTTGTGGCAAGAAGCATGCTGGATTGTAATCAGCCACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGA AAGAGATGGTGCTCCTTCACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGATATAACAAA AACAGTCATTAAAGAAGGTGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTA CTGCCTTTTGAATGGCTTGACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATTAATGGATC AGAAAAGGTTCTGATTGCCCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGA GTGTAGATCATGTCTTGAGAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATTGAAGAAGT GAGTCTTTTTGGAAAATCAGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATATGAATTAAA GTCTAAAGTGTTAATAATGAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTGGCTGGTGA CTCATCTCATCAGAAAACAGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCACCGACTTTC CATAAAAAGAGGTGAACTTGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATGACTTCACA GGATGAGGAGGCTCATGTAATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAGAAGACAGA AAAGATTGCAAATTTGCAAGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAATCATCTGT GAACCAGCTGAAAGAAACATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAACTCGATGA AGTAGGAAGATCTAGAGAAATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAAGAAATCTC ATTGGAATTGGAAGCAGCAGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGGGAGAGCTT AATGGCTGCCAAGGAAAAAGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTCAAAGCCCA TCAAGCTGAGGGAGAAAGCAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTGGAGCTATT AGAAAAAGAAATTCAAGAGCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGATTAGAAGA AGAGCTGAGACATCAAGAAGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGATTCAGGCAA AGATATTATGACCCAGCAATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAGTCAGACCT ACTGAAAAAACAACTTTCAAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTTCATTCTCA CTTAACCTCCCACGAGAAGGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAAAGCCGGGA AAACACCATGCTTCGAGCTAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATACGAACGAGA ACGAGCAATCCAAGAGATGCGTCGACATGGTCTTGCTACACCACCCCTTAGTTCCACTCTGAGGTCTCCTTCACATTCTCCTGAACATAG AAATGTGTAATTATCAGAAAGAATAATGGCTTTCAATGAGTTCCTATGTGGATTTTTAAAAGAACAGAACAGTAATGAAATATTTGAAGT ACTTGTTGCTGAAAATCATGAACATGGACACAAATTCTACCTCTGTCAACTTTTATTTAAATCAGTGAATATGTTAAAAAGTTTGGTTTA AAAGAACTATATCTATATGTATATTTTCATATATATGACAGAACAAGAATATGTATTAATAGTGCCTAATGTATCTATATTTTTATTATT CATGAATTAAATTACTAAAAGTATGTTTATACTGTGAATTAATATAATGTATTCACATTATTCTTTAATAATCTGTTTATTAATAAGCCA TGATATGTGTATGTAAATATTCTTACAGTACTTGTTTTTAGTTGTCATGCCTATGTTTAGACCATATCTTAATGTATTCACAAAGAATTA TCAACTTTGATGCTATGCTGTCATGCTTAACTTTTTCTTCTTAAAATTATTCATAGATCTACTGTCTGTTGTCAAGGGGAATATATTCAG GTCTAGTCTTCTTATAATAGCAGAGGTCTTGGTAAAATAACTACCATATATAACGTGTTATTGCCATCTAGAAGAACTATGATGAGAAAG ATACATTTATATATTATGTAAAATGTTAACTATCATCATATGGACTCTATGTAACACAAATTCAAAAGCAAACTAAAAGCTATATGCAGA GTTTTGTATAAAACAATAGAACAGAAATTTGGGACATTTTTCTAGGAAATAAAATTCCTCGGTGTATTAATCTAAGGTTTCAAAGTATAA AAGTATATGGGGTAGGCCGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGTGGATTTCCTAAGGTCAGGA GTTTGAGACCAGCCTGAGCAATGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTATCTGGGCTTGGTGGCGGGCACCTGTAATCC CAGCCACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGGCTGCGGTGAGCCAAGATCATGCCATTGCACTCCAGCC TGGGTGACAGAGTAACACTCTGTCTCAGAAAAAAAAAAAAAGAAAAATATATGGGGTAAATACAGTAAAACGTTTTGTTAAATTCCAATA TACATTCAGTGATACCACTCTTTTTCTTCTAAGCCTGTGTGTTATAATTTACCAGTTCCCCAAAATGCCATTTTTAACGCCGAACTGTGT AATATACATGGAAAACAGCTTTTTACAATTAATTTTCAAAGTTGTAATTTTAAAGAATTTGGGTGTATACCTATGTTAATGAAACAACAG AAGTACAAAAAAGAATATCAGATACAAAAATCAATCGTGAAGAAAATCTGTTCTTAATATATTTCATTATGATTGAAAAACATAAAAACT AACATAGGAAAGTGAATGATCAGTTACTTATGATATATTTTGTTTCCTCTTGTGGTTTAATAAAGTGAAGTGTGTGTGTGTGTGTGTGTG TGTATACCTGGGGGTGGGCAGTGCTCTTTTTCTAAAACTAATATGGCTTATATATCTGAATTATGCCCTTTTTAGTGTGTATTAGGATGT GGGCTGGTTTGCTTTTCTACCACCTTTGTAATTTTATGTATCCCATCTCCTTTGTGTGAATTCATATATTATAGCAAAATACAAGAGACA TGGGACTGTTTGCAATACCATATGGAAATCTTTTAATAAATATATGTAAATAAAATAAAAAATATTTGTCTCCACCTTTTCCCCAAAAGC AACAGCAAGACATATTTTGTTAGATATTTTATTTTTAATGTTTTCTATAATTTAAAAATGTATAGCCTGCCAAATGTTGTTTTCATAACC ATGATATTGTTTTGAAAAAATTTTATCTTAAAATACTGAATGTTCTGACCTTTTATAGATGTTTTTGATTTTGTTTTAAATAATTTTAAA >In-frame_POLR2B_ENST00000441246_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_4689nt ATTCTGGGAACGTCGGAGACGGAAGTTACTTCGTCTTTAGCTCCTGGCGCTGCTGGCTTCTGGGCGGTTTTTGTCTTTTGATTTCAAGAG TTAGGAGCTCGAGAACCGTTTGGCAATATGTACGACGCGGATGAGGGCTGGAGTGCAGTGGCGCGATCTCAGCTCCTGCGAGGAGGCGGA CCGCCCATTCCGTGCCCGGTAGCCGCGAGGGACCGGTGGTAGCCGCGAGGGACGGGCGGCGGGCTCGGTGCTGTGGCGAGGCGGGGATGG CACTCCCCCCCGCCGCCCCGTGGGGCGGCCCCGACTTTCGGGCGATATGCAATATGATGAGGATGATGATGAAATCACCCCGGATTTGTG GCAAGAAGCATGCTGGATTGTAATCAGTTCCTATTTTGACGAGAAAGGCTTGGTTAGACAACAGCTGGATTCTTTTGATGAGTTTATTCA GATGTCTGTTCAAAGAATTGTGGAAGACGCTCCTCCTATAGACCTACAGGCTGAAGCTCAGCATGCTAGTGGAGAAGTTGAAGAACCGCC ACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGAAAGAGATGGTGCTCCTTCACCAATGATGCCCAATGA AGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCATTAAAGAAGGTGAAGAACAACTTCAGAC TCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTACTGCCTTTTGAATGGCTTGACAGATCGTGATCTTTG TGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGGTTCTGATTGCCCAAGAGAAAATGGCAAC AAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGAGTGTAGATCATGTCTTGAGAATTCTTCCCGACCCAC CAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATTGAAGAAGTGAGTCTTTTTGGAAAATCAGAATTAGAGAAAACTAT TGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATATGAATTAAAGTCTAAAGTGTTAATAATGAAAGAAACAATAGAGTC GTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTGGCTGGTGACTCATCTCATCAGAAAACAGAGGTGAACTCACTTAG GATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCACCGACTTTCCATAAAAAGAGGTGAACTTGAATCAGCCCAAGCACA AATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATGACTTCACAGGATGAGGAGGCTCATGTAATGAAAAAGACCATTGG TGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAGAAGACAGAAAAGATTGCAAATTTGCAAGAAAACCTAGCTAATAA AGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAATCATCTGTGAACCAGCTGAAAGAAACATTGGTTAATCGAGATCG TGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAACTCGATGAAGTAGGAAGATCTAGAGAAATCGCTTTTAAGGAAAA CAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAAGAAATCTCATTGGAATTGGAAGCAGCAGTGCAAGAAAAAGAAGA AATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGGGAGAGCTTAATGGCTGCCAAGGAAAAAGAAAATCAAGATTTGTT AGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTCAAAGCCCATCAAGCTGAGGGAGAAAGCAGCTCAGTTCGACTGGA ACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTGGAGCTATTAGAAAAAGAAATTCAAGAGCACATAAATGCCCATCA TGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGATTAGAAGAAGAGCTGAGACATCAAGAAGATGAGAAAGCAACAGT ATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGATTCAGGCAAAGATATTATGACCCAGCAATTGAATTCGAAAAACCT TGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAGTCAGACCTACTGAAAAAACAACTTTCAAATGAGAGACATACAGT TAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTTCATTCTCACTTAACCTCCCACGAGAAGGATACAGAAATCCAGCT ACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAAAGCCGGGAAAACACCATGCTTCGAGCTAAAGTGGCACAGTTACA AACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATACGAACGAGAACGAGCAATCCAAGAGATGCGTCGACATGGTCTTGC TACACCACCCCTTAGTTCCACTCTGAGGTCTCCTTCACATTCTCCTGAACATAGAAATGTGTAATTATCAGAAAGAATAATGGCTTTCAA TGAGTTCCTATGTGGATTTTTAAAAGAACAGAACAGTAATGAAATATTTGAAGTACTTGTTGCTGAAAATCATGAACATGGACACAAATT CTACCTCTGTCAACTTTTATTTAAATCAGTGAATATGTTAAAAAGTTTGGTTTAAAAGAACTATATCTATATGTATATTTTCATATATAT GACAGAACAAGAATATGTATTAATAGTGCCTAATGTATCTATATTTTTATTATTCATGAATTAAATTACTAAAAGTATGTTTATACTGTG AATTAATATAATGTATTCACATTATTCTTTAATAATCTGTTTATTAATAAGCCATGATATGTGTATGTAAATATTCTTACAGTACTTGTT TTTAGTTGTCATGCCTATGTTTAGACCATATCTTAATGTATTCACAAAGAATTATCAACTTTGATGCTATGCTGTCATGCTTAACTTTTT CTTCTTAAAATTATTCATAGATCTACTGTCTGTTGTCAAGGGGAATATATTCAGGTCTAGTCTTCTTATAATAGCAGAGGTCTTGGTAAA ATAACTACCATATATAACGTGTTATTGCCATCTAGAAGAACTATGATGAGAAAGATACATTTATATATTATGTAAAATGTTAACTATCAT CATATGGACTCTATGTAACACAAATTCAAAAGCAAACTAAAAGCTATATGCAGAGTTTTGTATAAAACAATAGAACAGAAATTTGGGACA TTTTTCTAGGAAATAAAATTCCTCGGTGTATTAATCTAAGGTTTCAAAGTATAAAAGTATATGGGGTAGGCCGGGTGCAGTGGCTCACGC CTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGTGGATTTCCTAAGGTCAGGAGTTTGAGACCAGCCTGAGCAATGTGGTGAAACCCCA TCTCTACTAAAAATACAAAAATTATCTGGGCTTGGTGGCGGGCACCTGTAATCCCAGCCACTTGGGAGGCTGAGGCAGGAGAATTGCTTG AACCCGGGAGGTGGAGGCTGCGGTGAGCCAAGATCATGCCATTGCACTCCAGCCTGGGTGACAGAGTAACACTCTGTCTCAGAAAAAAAA AAAAAGAAAAATATATGGGGTAAATACAGTAAAACGTTTTGTTAAATTCCAATATACATTCAGTGATACCACTCTTTTTCTTCTAAGCCT GTGTGTTATAATTTACCAGTTCCCCAAAATGCCATTTTTAACGCCGAACTGTGTAATATACATGGAAAACAGCTTTTTACAATTAATTTT CAAAGTTGTAATTTTAAAGAATTTGGGTGTATACCTATGTTAATGAAACAACAGAAGTACAAAAAAGAATATCAGATACAAAAATCAATC GTGAAGAAAATCTGTTCTTAATATATTTCATTATGATTGAAAAACATAAAAACTAACATAGGAAAGTGAATGATCAGTTACTTATGATAT ATTTTGTTTCCTCTTGTGGTTTAATAAAGTGAAGTGTGTGTGTGTGTGTGTGTGTGTATACCTGGGGGTGGGCAGTGCTCTTTTTCTAAA ACTAATATGGCTTATATATCTGAATTATGCCCTTTTTAGTGTGTATTAGGATGTGGGCTGGTTTGCTTTTCTACCACCTTTGTAATTTTA TGTATCCCATCTCCTTTGTGTGAATTCATATATTATAGCAAAATACAAGAGACATGGGACTGTTTGCAATACCATATGGAAATCTTTTAA TAAATATATGTAAATAAAATAAAAAATATTTGTCTCCACCTTTTCCCCAAAAGCAACAGCAAGACATATTTTGTTAGATATTTTATTTTT AATGTTTTCTATAATTTAAAAATGTATAGCCTGCCAAATGTTGTTTTCATAACCATGATATTGTTTTGAAAAAATTTTATCTTAAAATAC TGAATGTTCTGACCTTTTATAGATGTTTTTGATTTTGTTTTAAATAATTTTAAATTATGGAGCTTGACCTAGATTTGCCAATAAACTTTC >In-frame_POLR2B_ENST00000314595_chr4_57861575_+_CEP135_ENST00000257287_chr4_56851447_+_4437nt CTTTTGATTTCAAGAGTTAGGAGCTCGAGAACCGTTTGGCAATATGTACGACGCGGATGAGGATATGCAATATGATGAGGATGATGATGA AATCACCCCGGATTTGTGGCAAGAAGCATGCTGGATTGTAATCAGTTCCTATTTTGACGAGAAAGGCTTGGTTAGACAACAGCTGGATTC TTTTGATGAGTTTATTCAGATGTCTGTTCAAAGAATTGTGGAAGACGCTCCTCCTATAGACCTACAGGCTGAAGCTCAGCATGCTAGTGG AGAAGTTGAAGAACCGCCACGATATTTGCTGAAGTTTGAACAAATTTATCTTTCCAAGCCTACCCATTGGGAAAGAGATGGTGCTCCTTC ACCAATGATGCCCAATGAAGCTAGATTAAGGAATCTCACGTATTCTGCTCCGCTTTATGTTGATATAACAAAAACAGTCATTAAAGAAGG TGAAGAACAACTTCAGACTCAGCATCAGAAAACTTTTATAGGAAAAATTCCAATTATGTTGCGGTCAACTTACTGCCTTTTGAATGGCTT GACAGATCGTGATCTTTGTGAGTTAAATGAATGCCCTTTGGATCCTGGTGGCTATTTCATTATTAATGGATCAGAAAAGGTTCTGATTGC CCAAGAGAAAATGGCAACAAACACAGTTTATGTGTTTGCCAAAAAGGATTCTAAATATGCCTACACAGGAGAGTGTAGATCATGTCTTGA GAATTCTTCCCGACCCACCAGTACTATATGGGTTAGCATGCTGGCAAGAGGAGGACAGCATATTGAAGAAGTGAGTCTTTTTGGAAAATC AGAATTAGAGAAAACTATTGAACATTTGACATGTGTTAATCATCAGCTTGAAAGCGAAAAATATGAATTAAAGTCTAAAGTGTTAATAAT GAAAGAAACAATAGAGTCGTTAGAGAACAAATTAAAAGTCCAAGCTCAAAAATTTAGCCATGTGGCTGGTGACTCATCTCATCAGAAAAC AGAGGTGAACTCACTTAGGATAGTGAATGAGCAGCTACAGCGGTCAGTTGATGACTATCAGCACCGACTTTCCATAAAAAGAGGTGAACT TGAATCAGCCCAAGCACAAATTAAAATACTGGAGGAAAAGATAGATGAACTAAACCTTAAGATGACTTCACAGGATGAGGAGGCTCATGT AATGAAAAAGACCATTGGTGTTATTGATAAAGAAAAAGACTTTCTCCAGGAGACTGTAGATGAGAAGACAGAAAAGATTGCAAATTTGCA AGAAAACCTAGCTAATAAAGAAAAAGCTGTTGCTCAAATGAAGATAATGATCTCAGAGTGTGAATCATCTGTGAACCAGCTGAAAGAAAC ATTGGTTAATCGAGATCGTGAGATAAACAGCCTCCGGCGCCAGCTTGATGCAGCTCACAAAGAACTCGATGAAGTAGGAAGATCTAGAGA AATCGCTTTTAAGGAAAACAGAAGACTGCAAGATGACCTGGCTACAATGGCAAGAGAAAATCAAGAAATCTCATTGGAATTGGAAGCAGC AGTGCAAGAAAAAGAAGAAATGAAGAGCAGAGTTCATAAATACATAACAGAGGTGTCACGATGGGAGAGCTTAATGGCTGCCAAGGAAAA AGAAAATCAAGATTTGTTAGATAGATTTCAGATGCTTCATAACCGTGCTGAAGACTGGGAGGTCAAAGCCCATCAAGCTGAGGGAGAAAG CAGCTCAGTTCGACTGGAACTTCTTTCTATTGACACTGAGAGGAGACATCTTCGAGAAAGAGTGGAGCTATTAGAAAAAGAAATTCAAGA GCACATAAATGCCCATCATGCTTATGAATCTCAGATCTCATCAATGGCAAAAGCCATGTCTCGATTAGAAGAAGAGCTGAGACATCAAGA AGATGAGAAAGCAACAGTATTAAATGACTTGTCATCTCTTAGAGAACTTTGCATTAAACTTGATTCAGGCAAAGATATTATGACCCAGCA ATTGAATTCGAAAAACCTTGAGTTTGAGAGGGTTGTGGTGGAATTAGAAAATGTAAAGTCAGAGTCAGACCTACTGAAAAAACAACTTTC AAATGAGAGACATACAGTTAAAAACCTCGAATCATTGTTGGCTACAAACAGAGATAAAGAATTTCATTCTCACTTAACCTCCCACGAGAA GGATACAGAAATCCAGCTACTTAAGGAGAAGTTAACCCTTTCTGAAAGCAAATTAACTAGTCAAAGCCGGGAAAACACCATGCTTCGAGC TAAAGTGGCACAGTTACAAACAGATTATGATGCTCTGAAAAGGCAGATCTCAACTGAAAGATACGAACGAGAACGAGCAATCCAAGAGAT GCGTCGACATGGTCTTGCTACACCACCCCTTAGTTCCACTCTGAGGTCTCCTTCACATTCTCCTGAACATAGAAATGTGTAATTATCAGA AAGAATAATGGCTTTCAATGAGTTCCTATGTGGATTTTTAAAAGAACAGAACAGTAATGAAATATTTGAAGTACTTGTTGCTGAAAATCA TGAACATGGACACAAATTCTACCTCTGTCAACTTTTATTTAAATCAGTGAATATGTTAAAAAGTTTGGTTTAAAAGAACTATATCTATAT GTATATTTTCATATATATGACAGAACAAGAATATGTATTAATAGTGCCTAATGTATCTATATTTTTATTATTCATGAATTAAATTACTAA AAGTATGTTTATACTGTGAATTAATATAATGTATTCACATTATTCTTTAATAATCTGTTTATTAATAAGCCATGATATGTGTATGTAAAT ATTCTTACAGTACTTGTTTTTAGTTGTCATGCCTATGTTTAGACCATATCTTAATGTATTCACAAAGAATTATCAACTTTGATGCTATGC TGTCATGCTTAACTTTTTCTTCTTAAAATTATTCATAGATCTACTGTCTGTTGTCAAGGGGAATATATTCAGGTCTAGTCTTCTTATAAT AGCAGAGGTCTTGGTAAAATAACTACCATATATAACGTGTTATTGCCATCTAGAAGAACTATGATGAGAAAGATACATTTATATATTATG TAAAATGTTAACTATCATCATATGGACTCTATGTAACACAAATTCAAAAGCAAACTAAAAGCTATATGCAGAGTTTTGTATAAAACAATA GAACAGAAATTTGGGACATTTTTCTAGGAAATAAAATTCCTCGGTGTATTAATCTAAGGTTTCAAAGTATAAAAGTATATGGGGTAGGCC GGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGAGTGGATTTCCTAAGGTCAGGAGTTTGAGACCAGCCTGAG CAATGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTATCTGGGCTTGGTGGCGGGCACCTGTAATCCCAGCCACTTGGGAGGCTG AGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGGCTGCGGTGAGCCAAGATCATGCCATTGCACTCCAGCCTGGGTGACAGAGTAACAC TCTGTCTCAGAAAAAAAAAAAAAGAAAAATATATGGGGTAAATACAGTAAAACGTTTTGTTAAATTCCAATATACATTCAGTGATACCAC TCTTTTTCTTCTAAGCCTGTGTGTTATAATTTACCAGTTCCCCAAAATGCCATTTTTAACGCCGAACTGTGTAATATACATGGAAAACAG CTTTTTACAATTAATTTTCAAAGTTGTAATTTTAAAGAATTTGGGTGTATACCTATGTTAATGAAACAACAGAAGTACAAAAAAGAATAT CAGATACAAAAATCAATCGTGAAGAAAATCTGTTCTTAATATATTTCATTATGATTGAAAAACATAAAAACTAACATAGGAAAGTGAATG ATCAGTTACTTATGATATATTTTGTTTCCTCTTGTGGTTTAATAAAGTGAAGTGTGTGTGTGTGTGTGTGTGTGTATACCTGGGGGTGGG CAGTGCTCTTTTTCTAAAACTAATATGGCTTATATATCTGAATTATGCCCTTTTTAGTGTGTATTAGGATGTGGGCTGGTTTGCTTTTCT ACCACCTTTGTAATTTTATGTATCCCATCTCCTTTGTGTGAATTCATATATTATAGCAAAATACAAGAGACATGGGACTGTTTGCAATAC CATATGGAAATCTTTTAATAAATATATGTAAATAAAATAAAAAATATTTGTCTCCACCTTTTCCCCAAAAGCAACAGCAAGACATATTTT GTTAGATATTTTATTTTTAATGTTTTCTATAATTTAAAAATGTATAGCCTGCCAAATGTTGTTTTCATAACCATGATATTGTTTTGAAAA AATTTTATCTTAAAATACTGAATGTTCTGACCTTTTATAGATGTTTTTGATTTTGTTTTAAATAATTTTAAATTATGGAGCTTGACCTAG |
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FusionGenePPI for POLR2B_CEP135 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| POLR2B | MED10, MED9, MED29, MED19, MED28, MED26, POLR2C, POLR2E, POLR2L, POLR2H, POLR2K, BTF3, RECQL5, RPAP2, RPAP3, GTF2F2, POLR2G, POLR2J, RPAP1, RUVBL2, GPN1, GTF2F1, TCEA1, KDM1A, AIRE, POLR2A, LZTR1, IKBKG, ZSCAN1, CTDP1, INTS3, INTS5, INTS6, INTS1, ZC3H13, WDR82, TADA2A, MYC, SUB1, POLR2D, CALM1, SHFM1, INTS10, PIDD1, CUL3, CUL5, CAND1, CCNH, CDK7, MEN1, POLR2I, TUBA4A, TUBB4B, DCTN1, ATP6V1B2, POLR3F, BARD1, MDC1, VCP, HDAC11, CDK20, FBXO6, HECW2, ITCH, NEDD4, WWOX, RABEP2, ILK, XRN2, ESR1, SRC, PSMB9, TCEB3, OBSL1, SUZ12, RNF2, SNAR-B2, RPRD1B, GPN2, POLR2M, EEF1A1, EEFSEC, POLR1A, POLR1B, SUPT5H, POLR2F, POLR3A, RPS5, TUBB, NTRK1, IFI16, MED4, XPO1, DNAJC7, CTR9, CEP170P1, BRD2, NELFA, RNGTT, LMO2, GPN3, PIH1D1, ASB6, CPNE2, NCL, AAR2, INO80B, RUVBL1, URI1, WDR92, ZNHIT2, TRIM25, G3BP1 | CEP135 | WRAP73, STK24, NCOA5, SMAD9, CBX6, CARD9, C17orf59, MED4, CEP128, CEP162, XKR4, AIMP1, MAPRE1, SPATA5, SREK1, SREK1IP1, ZMAT2, SPICE1, ADSL, ALDH3A2, ALMS1, ARHGAP21, ATP6V1B1, CEP131, PROSER3, C2CD3, CAMSAP1, CC2D1A, CCDC138, CCDC14, CCDC18, CCDC66, CCDC77, CCP110, CDK4, CEP120, CEP152, CEP170, CEP192, CEP350, CEP44, CEP55, CEP72, CEP85, CEP95, CEP97, COMMD3-BMI1, CSNK1A1, CSPP1, CTNND1, CTSV, CYLD, DHX35, DLG5, DVL1, DVL2, DVL3, ECH1, ERC1, FAM83B, FAM83H, FGFR1OP, FOPNL, GEN1, GLUD2, GPATCH1, GRIP1, GTPBP1, GYS1, HAUS1, HAUS3, HAUS4, HAUS6, HAUS7, HAUS8, IBTK, IFT74, ISOC1, KEAP1, KIAA0753, KIAA1671, KIF14, KIF7, LMO7, ERVK3-1, LRRC49, LUZP1, LZTS2, MAGED1, MAP7D3, MCTS1, MIIP, MPHOSPH9, MTPN, NAV1, NBR1, NCKAP5L, NDE1, NDEL1, NEDD1, NME7, NUP155, OFD1, PAFAH1B1, PCM1, PIBF1, PLEKHG1, PLK1, PRKCI, PRRC2B, RAB8A, RCOR1, RTTN, SDCCAG3, SEC23IP, SIPA1L1, SIPA1L2, SIPA1L3, SPATA2, SPATA24, SPATA2L, SQSTM1, SRP72, SRPK1, SSX2IP, SYNM, TBC1D19, TBK1, TCHP, TEX9, TJP1, TJP2, TMEM160, TMEM209, TNIP1, TNRC6A, TNRC6B, TP53, TP53BP2, TPGS1, TRIP6, TTK, TXLNA, TXLNG, USP54, TBC1D31, WDR83, XRN1, YTHDF1, YWHAH, ODF2, LZTS3, GOLGB1, PLD1, TRIM27, TTLL5, MIB1, KIAA1328, ELMO2, CEP290, CEP295, WDR90, HNRNPCL1, CCDC61, CDC14A, TXLNB, MIS18A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLR2B_CEP135 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POLR2B_CEP135 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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