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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2796

FusionGeneSummary for ARNT_CRISPLD2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARNT_CRISPLD2
Fusion gene ID: 2796
HgeneTgene
Gene symbol

ARNT

CRISPLD2

Gene ID

375056

83716

Gene nameMIA SH3 domain ER export factor 3cysteine rich secretory protein LCCL domain containing 2
SynonymsARNT|D320|TANGO|TANGO1|UNQ6077CRISP11|LCRISP2|LGL1
Cytomap

1q41

16q24.1

Type of geneprotein-codingprotein-coding
Descriptiontransport and Golgi organization protein 1 homologC219-reactive peptideMIA family member 3, ER export factormelanoma inhibitory activity family, member 3melanoma inhibitory activity protein 3transport and Golgi organization protein 1cysteine-rich secretory protein LCCL domain-containing 2CRISP-11LCCL domain-containing cysteine-rich secretory protein 2cysteine-rich secretory protein 11late gestation lung 1testis secretory sperm-binding protein Li 207atrypsin inhibitor
Modification date2018052320180523
UniProtAcc

P27540

Q9H0B8

Ensembl transtripts involved in fusion geneENST00000358595, ENST00000354396, 
ENST00000515192, ENST00000505755, 
ENST00000468970, 
ENST00000262424, 
ENST00000567845, ENST00000566431, 
ENST00000564567, ENST00000569090, 
Fusion gene scores* DoF score6 X 6 X 3=1082 X 2 X 2=8
# samples 62
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ARNT [Title/Abstract] AND CRISPLD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARNT

GO:0002687

positive regulation of leukocyte migration

17726152

HgeneARNT

GO:0007162

negative regulation of cell adhesion

17726152

HgeneARNT

GO:0030336

negative regulation of cell migration

17044017

HgeneARNT

GO:0042060

wound healing

17044017


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM991829ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000358595ENST00000262424ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000358595ENST00000567845ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000358595ENST00000566431ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000358595ENST00000564567ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000358595ENST00000569090ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-3UTRENST00000354396ENST00000262424ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000354396ENST00000567845ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000354396ENST00000566431ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000354396ENST00000564567ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000354396ENST00000569090ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-3UTRENST00000515192ENST00000262424ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000515192ENST00000567845ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000515192ENST00000566431ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000515192ENST00000564567ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000515192ENST00000569090ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-3UTRENST00000505755ENST00000262424ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000505755ENST00000567845ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000505755ENST00000566431ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000505755ENST00000564567ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000505755ENST00000569090ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-3UTRENST00000468970ENST00000262424ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000468970ENST00000567845ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000468970ENST00000566431ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000468970ENST00000564567ARNTchr1

150783004

+CRISPLD2chr16

84941953

-
intron-intronENST00000468970ENST00000569090ARNTchr1

150783004

+CRISPLD2chr16

84941953

-

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FusionProtFeatures for ARNT_CRISPLD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARNT

P27540

CRISPLD2

Q9H0B8

Required for activity of the Ah (dioxin) receptor. Thisprotein is required for the ligand-binding subunit to translocatefrom the cytosol to the nucleus after ligand binding. The complexthen initiates transcription of genes involved in the activationof PAH procarcinogens. The heterodimer binds to core DNA sequence5'-TACGTG-3' within the hypoxia response element (HRE) of targetgene promoters and functions as a transcriptional regulator of theadaptive response to hypoxia (By similarity). The heterodimerARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxinresponse element (DRE) of target gene promoters and activatestheir transcription (PubMed:28396409).{ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409}. Promotes matrix assembly. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARNT_CRISPLD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARNT_CRISPLD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARNT_CRISPLD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARNT_CRISPLD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARNTC0000786Spontaneous abortion1CTD_human
HgeneARNTC0009404Colorectal Neoplasms1CTD_human
HgeneARNTC0014175Endometriosis1CTD_human
HgeneARNTC0023890Liver Cirrhosis1CTD_human
HgeneARNTC0025202melanoma1CTD_human
HgeneARNTC0027659Neoplasms, Experimental1CTD_human
HgeneARNTC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneARNTC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCRISPLD2C0023895Liver diseases1CTD_human
TgeneCRISPLD2C0024115Lung diseases1CTD_human
TgeneCRISPLD2C0235032Neurotoxicity Syndromes1CTD_human