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Fusion gene ID: 27952 |
FusionGeneSummary for POLR1B_NRXN2 |
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Fusion gene information | Fusion gene name: POLR1B_NRXN2 | Fusion gene ID: 27952 | Hgene | Tgene | Gene symbol | POLR1B | NRXN2 | Gene ID | 84172 | 9379 |
Gene name | RNA polymerase I subunit B | neurexin 2 | |
Synonyms | RPA135|RPA2|Rpo1-2 | - | |
Cytomap | 2q14.1 | 11q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA-directed RNA polymerase I subunit RPA2DNA-directed RNA polymerase I 135 kDa polypeptideDNA-directed RNA polymerase I 135kDa polypeptideRNA polymerase I subunit 2polymerase (RNA) I polypeptide B, 128kDapolymerase (RNA) I subunit B | neurexin-2-betaneurexin II | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9H9Y6 | Q9P2S2 | |
Ensembl transtripts involved in fusion gene | ENST00000263331, ENST00000541869, ENST00000409894, ENST00000537335, ENST00000417433, ENST00000498054, | ENST00000377559, ENST00000265459, ENST00000301894, ENST00000377551, ENST00000409571, ENST00000496291, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 8 X 5=320 |
# samples | 1 | 8 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: POLR1B [Title/Abstract] AND NRXN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCS | TCGA-NF-A4WX-01A | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000263331 | ENST00000377559 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
Frame-shift | ENST00000263331 | ENST00000265459 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000263331 | ENST00000301894 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000263331 | ENST00000377551 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000263331 | ENST00000409571 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000263331 | ENST00000496291 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
Frame-shift | ENST00000541869 | ENST00000377559 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
Frame-shift | ENST00000541869 | ENST00000265459 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000541869 | ENST00000301894 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000541869 | ENST00000377551 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000541869 | ENST00000409571 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000541869 | ENST00000496291 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-3CDS | ENST00000409894 | ENST00000377559 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-3CDS | ENST00000409894 | ENST00000265459 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-intron | ENST00000409894 | ENST00000301894 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-intron | ENST00000409894 | ENST00000377551 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-intron | ENST00000409894 | ENST00000409571 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-intron | ENST00000409894 | ENST00000496291 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
Frame-shift | ENST00000537335 | ENST00000377559 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
Frame-shift | ENST00000537335 | ENST00000265459 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000537335 | ENST00000301894 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000537335 | ENST00000377551 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000537335 | ENST00000409571 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000537335 | ENST00000496291 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
Frame-shift | ENST00000417433 | ENST00000377559 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
Frame-shift | ENST00000417433 | ENST00000265459 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000417433 | ENST00000301894 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000417433 | ENST00000377551 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000417433 | ENST00000409571 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
5CDS-intron | ENST00000417433 | ENST00000496291 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-3CDS | ENST00000498054 | ENST00000377559 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-3CDS | ENST00000498054 | ENST00000265459 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-intron | ENST00000498054 | ENST00000301894 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-intron | ENST00000498054 | ENST00000377551 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-intron | ENST00000498054 | ENST00000409571 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
intron-intron | ENST00000498054 | ENST00000496291 | POLR1B | chr2 | 113317151 | + | NRXN2 | chr11 | 64436076 | - |
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FusionProtFeatures for POLR1B_NRXN2 |
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Hgene | Tgene |
POLR1B | NRXN2 |
Neuronal cell surface protein that may be involved incell recognition and cell adhesion. May mediate intracellularsignaling. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for POLR1B_NRXN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for POLR1B_NRXN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
POLR1B | TAF1D, USP11, POLR1A, LZTR1, ARRB2, CAND1, POLR1D, CD3EAP, POLR1C, TSR1, DHX8, NOP56, ERBB2, ACTB, ACTA1, RRN3, MED20, HDAC6, AKT2, CCND1, RPL37, ZNF207, LDB1, GIT2, RPA3, RPA2, RPA1, ABCE1, GPN3, TWISTNB, SKAP1, LOC554223, GFOD1, EEFSEC, EIF2S3, DDX18, POLR2B, POLR3A, POLR3B, POLR2E, POLR2H, POLR2I, POLR2L, RPL11, RPL30, RPL9, RPS5, TBL3, WDR36, NTRK1, MYO1C, POLR2F, NOLC1, TCOF1, PTPN21, TRIM25 | NRXN2 | NLGN1, NLGN2, MLLT4, MAPK6, MACF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLR1B_NRXN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POLR1B_NRXN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NRXN2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | NRXN2 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |