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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27952

FusionGeneSummary for POLR1B_NRXN2

check button Fusion gene summary
Fusion gene informationFusion gene name: POLR1B_NRXN2
Fusion gene ID: 27952
HgeneTgene
Gene symbol

POLR1B

NRXN2

Gene ID

84172

9379

Gene nameRNA polymerase I subunit Bneurexin 2
SynonymsRPA135|RPA2|Rpo1-2-
Cytomap

2q14.1

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionDNA-directed RNA polymerase I subunit RPA2DNA-directed RNA polymerase I 135 kDa polypeptideDNA-directed RNA polymerase I 135kDa polypeptideRNA polymerase I subunit 2polymerase (RNA) I polypeptide B, 128kDapolymerase (RNA) I subunit Bneurexin-2-betaneurexin II
Modification date2018052320180519
UniProtAcc

Q9H9Y6

Q9P2S2

Ensembl transtripts involved in fusion geneENST00000263331, ENST00000541869, 
ENST00000409894, ENST00000537335, 
ENST00000417433, ENST00000498054, 
ENST00000377559, ENST00000265459, 
ENST00000301894, ENST00000377551, 
ENST00000409571, ENST00000496291, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 8 X 5=320
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/320*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLR1B [Title/Abstract] AND NRXN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-NF-A4WX-01APOLR1Bchr2

113317151

+NRXN2chr11

64436076

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000263331ENST00000377559POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
Frame-shiftENST00000263331ENST00000265459POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000263331ENST00000301894POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000263331ENST00000377551POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000263331ENST00000409571POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000263331ENST00000496291POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
Frame-shiftENST00000541869ENST00000377559POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
Frame-shiftENST00000541869ENST00000265459POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000541869ENST00000301894POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000541869ENST00000377551POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000541869ENST00000409571POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000541869ENST00000496291POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-3CDSENST00000409894ENST00000377559POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-3CDSENST00000409894ENST00000265459POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-intronENST00000409894ENST00000301894POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-intronENST00000409894ENST00000377551POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-intronENST00000409894ENST00000409571POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-intronENST00000409894ENST00000496291POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
Frame-shiftENST00000537335ENST00000377559POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
Frame-shiftENST00000537335ENST00000265459POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000537335ENST00000301894POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000537335ENST00000377551POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000537335ENST00000409571POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000537335ENST00000496291POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
Frame-shiftENST00000417433ENST00000377559POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
Frame-shiftENST00000417433ENST00000265459POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000417433ENST00000301894POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000417433ENST00000377551POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000417433ENST00000409571POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
5CDS-intronENST00000417433ENST00000496291POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-3CDSENST00000498054ENST00000377559POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-3CDSENST00000498054ENST00000265459POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-intronENST00000498054ENST00000301894POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-intronENST00000498054ENST00000377551POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-intronENST00000498054ENST00000409571POLR1Bchr2

113317151

+NRXN2chr11

64436076

-
intron-intronENST00000498054ENST00000496291POLR1Bchr2

113317151

+NRXN2chr11

64436076

-

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FusionProtFeatures for POLR1B_NRXN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POLR1B

Q9H9Y6

NRXN2

Q9P2S2

Neuronal cell surface protein that may be involved incell recognition and cell adhesion. May mediate intracellularsignaling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for POLR1B_NRXN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for POLR1B_NRXN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
POLR1BTAF1D, USP11, POLR1A, LZTR1, ARRB2, CAND1, POLR1D, CD3EAP, POLR1C, TSR1, DHX8, NOP56, ERBB2, ACTB, ACTA1, RRN3, MED20, HDAC6, AKT2, CCND1, RPL37, ZNF207, LDB1, GIT2, RPA3, RPA2, RPA1, ABCE1, GPN3, TWISTNB, SKAP1, LOC554223, GFOD1, EEFSEC, EIF2S3, DDX18, POLR2B, POLR3A, POLR3B, POLR2E, POLR2H, POLR2I, POLR2L, RPL11, RPL30, RPL9, RPS5, TBL3, WDR36, NTRK1, MYO1C, POLR2F, NOLC1, TCOF1, PTPN21, TRIM25NRXN2NLGN1, NLGN2, MLLT4, MAPK6, MACF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for POLR1B_NRXN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for POLR1B_NRXN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNRXN2C0036341Schizophrenia1PSYGENET
TgeneNRXN2C1510586Autism Spectrum Disorders1CTD_human