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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 27944

FusionGeneSummary for POLN_C1orf159

check button Fusion gene summary
Fusion gene informationFusion gene name: POLN_C1orf159
Fusion gene ID: 27944
HgeneTgene
Gene symbol

POLN

C1orf159

Gene ID

353497

54991

Gene nameDNA polymerase nuchromosome 1 open reading frame 159
SynonymsPOL4P-
Cytomap

4p16.3

1p36.33

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nuuncharacterized protein C1orf159
Modification date2018052320180524
UniProtAcc

Q7Z5Q5

Q96HA4

Ensembl transtripts involved in fusion geneENST00000382865, ENST00000511885, 
ENST00000515357, 
ENST00000379339, 
ENST00000448924, ENST00000294576, 
ENST00000421241, ENST00000482816, 
ENST00000437760, ENST00000379320, 
ENST00000379319, 
Fusion gene scores* DoF score3 X 3 X 1=95 X 4 X 4=80
# samples 35
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLN [Title/Abstract] AND C1orf159 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLN

GO:0019985

translesion synthesis

20102227


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA066689POLNchr4

2243792

-C1orf159chr1

1051568

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000382865ENST00000379339POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000382865ENST00000448924POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000382865ENST00000294576POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000382865ENST00000421241POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000382865ENST00000482816POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000382865ENST00000437760POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000382865ENST00000379320POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000382865ENST00000379319POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000511885ENST00000379339POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000511885ENST00000448924POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000511885ENST00000294576POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000511885ENST00000421241POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000511885ENST00000482816POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000511885ENST00000437760POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000511885ENST00000379320POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000511885ENST00000379319POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000515357ENST00000379339POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000515357ENST00000448924POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000515357ENST00000294576POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000515357ENST00000421241POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000515357ENST00000482816POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-5UTRENST00000515357ENST00000437760POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000515357ENST00000379320POLNchr4

2243792

-C1orf159chr1

1051568

-
intron-intronENST00000515357ENST00000379319POLNchr4

2243792

-C1orf159chr1

1051568

-

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FusionProtFeatures for POLN_C1orf159


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POLN

Q7Z5Q5

C1orf159

Q96HA4

DNA polymerase with very low fidelity that catalyzesconsiderable misincorporation by inserting dTTP opposite a Gtemplate, and dGTP opposite a T template (PubMed:16787914,PubMed:17118716). Is the least accurate of the DNA polymerase Afamily (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can performaccurate translesion DNA synthesis (TLS) past a 5S-thymine glycol.Can perform efficient strand displacement past a nick or a gap andgives rise to an amount of product similar to that on non-damagedtemplate. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dTregardless of template sequence (PubMed:25775266). May play a rolein TLS during interstrand cross-link (ICL) repair(PubMed:19908865). May be involved in TLS when genomic replicationis blocked by extremely large major groove DNA lesions. Mayfunction in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linkingagents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates inFANCD2-mediated repair. Forms a complex with HELQ helicase thatparticipates in homologous recombination (HR) repair and isessential for cellular protection against DNA cross-links(PubMed:19995904). {ECO:0000269|PubMed:16787914,ECO:0000269|PubMed:17118716, ECO:0000269|PubMed:19908865,ECO:0000269|PubMed:19995904, ECO:0000269|PubMed:20102227,ECO:0000269|PubMed:25775266}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for POLN_C1orf159


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for POLN_C1orf159


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for POLN_C1orf159


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for POLN_C1orf159


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource