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Fusion gene ID: 27944 |
FusionGeneSummary for POLN_C1orf159 |
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Fusion gene information | Fusion gene name: POLN_C1orf159 | Fusion gene ID: 27944 | Hgene | Tgene | Gene symbol | POLN | C1orf159 | Gene ID | 353497 | 54991 |
Gene name | DNA polymerase nu | chromosome 1 open reading frame 159 | |
Synonyms | POL4P | - | |
Cytomap | 4p16.3 | 1p36.33 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu | uncharacterized protein C1orf159 | |
Modification date | 20180523 | 20180524 | |
UniProtAcc | Q7Z5Q5 | Q96HA4 | |
Ensembl transtripts involved in fusion gene | ENST00000382865, ENST00000511885, ENST00000515357, | ENST00000379339, ENST00000448924, ENST00000294576, ENST00000421241, ENST00000482816, ENST00000437760, ENST00000379320, ENST00000379319, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 5 X 4 X 4=80 |
# samples | 3 | 5 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: POLN [Title/Abstract] AND C1orf159 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | POLN | GO:0019985 | translesion synthesis | 20102227 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA066689 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000382865 | ENST00000379339 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000382865 | ENST00000448924 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000382865 | ENST00000294576 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000382865 | ENST00000421241 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000382865 | ENST00000482816 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000382865 | ENST00000437760 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000382865 | ENST00000379320 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000382865 | ENST00000379319 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000511885 | ENST00000379339 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000511885 | ENST00000448924 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000511885 | ENST00000294576 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000511885 | ENST00000421241 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000511885 | ENST00000482816 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000511885 | ENST00000437760 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000511885 | ENST00000379320 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000511885 | ENST00000379319 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000515357 | ENST00000379339 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000515357 | ENST00000448924 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000515357 | ENST00000294576 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000515357 | ENST00000421241 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000515357 | ENST00000482816 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-5UTR | ENST00000515357 | ENST00000437760 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000515357 | ENST00000379320 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
intron-intron | ENST00000515357 | ENST00000379319 | POLN | chr4 | 2243792 | - | C1orf159 | chr1 | 1051568 | - |
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FusionProtFeatures for POLN_C1orf159 |
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Hgene | Tgene |
POLN | C1orf159 |
DNA polymerase with very low fidelity that catalyzesconsiderable misincorporation by inserting dTTP opposite a Gtemplate, and dGTP opposite a T template (PubMed:16787914,PubMed:17118716). Is the least accurate of the DNA polymerase Afamily (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can performaccurate translesion DNA synthesis (TLS) past a 5S-thymine glycol.Can perform efficient strand displacement past a nick or a gap andgives rise to an amount of product similar to that on non-damagedtemplate. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dTregardless of template sequence (PubMed:25775266). May play a rolein TLS during interstrand cross-link (ICL) repair(PubMed:19908865). May be involved in TLS when genomic replicationis blocked by extremely large major groove DNA lesions. Mayfunction in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linkingagents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates inFANCD2-mediated repair. Forms a complex with HELQ helicase thatparticipates in homologous recombination (HR) repair and isessential for cellular protection against DNA cross-links(PubMed:19995904). {ECO:0000269|PubMed:16787914,ECO:0000269|PubMed:17118716, ECO:0000269|PubMed:19908865,ECO:0000269|PubMed:19995904, ECO:0000269|PubMed:20102227,ECO:0000269|PubMed:25775266}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for POLN_C1orf159 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for POLN_C1orf159 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLN_C1orf159 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for POLN_C1orf159 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |