FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27922

FusionGeneSummary for POLDIP3_MED15

check button Fusion gene summary
Fusion gene informationFusion gene name: POLDIP3_MED15
Fusion gene ID: 27922
HgeneTgene
Gene symbol

POLDIP3

MED15

Gene ID

84271

51586

Gene nameDNA polymerase delta interacting protein 3mediator complex subunit 15
SynonymsPDIP3|PDIP46|SKARARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7
Cytomap

22q13.2

22q11.21

Type of geneprotein-codingprotein-coding
Descriptionpolymerase delta-interacting protein 346 kDa DNA polymerase delta interaction proteinRNA-binding protein P46S6K1 Aly/REF-like targetpolymerase (DNA) delta interacting protein 3polymerase (DNA-directed), delta interacting protein 3mediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible ge
Modification date2018052220180523
UniProtAcc

Q9BY77

Q96RN5

Ensembl transtripts involved in fusion geneENST00000348657, ENST00000252115, 
ENST00000339677, ENST00000451060, 
ENST00000491021, 		ENST00000425759, 
ENST00000292733, ENST00000542773, 
ENST00000263205, ENST00000406969, 
ENST00000382974, ENST00000541476, 
ENST00000478831, 
Fusion gene scores* DoF score6 X 6 X 5=18013 X 9 X 7=819
# samples 715
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/819*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLDIP3 [Title/Abstract] AND MED15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePOLDIP3

GO:0016973

poly(A)+ mRNA export from nucleus

22928037


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A4F4-06APOLDIP3chr22

42998776

-MED15chr22

20905723

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000348657ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000348657ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000348657ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000252115ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000252115ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000252115ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000339677ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
In-frameENST00000339677ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5CDS-intronENST00000339677ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-3CDSENST00000451060ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-3CDSENST00000451060ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000451060ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-3CDSENST00000491021ENST00000425759POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-3CDSENST00000491021ENST00000292733POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000542773POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000263205POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000406969POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000382974POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000541476POLDIP3chr22

42998776

-MED15chr22

20905723

+
5UTR-intronENST00000491021ENST00000478831POLDIP3chr22

42998776

-MED15chr22

20905723

+

Top

FusionProtFeatures for POLDIP3_MED15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POLDIP3

Q9BY77

MED15

Q96RN5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118161_17452789Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118178_19352789Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118205_21852789Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118226_23952789Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118243_26252789Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118266_51552789Compositional biasNote=Pro-rich
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118360_36752789Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118449_45652789Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118602_61152789Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117161_17452749Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117178_19352749Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117205_21852749Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117226_23952749Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117243_26252749Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117266_51552749Compositional biasNote=Pro-rich
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117360_36752749Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117449_45652749Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117602_61152749Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116161_17452678Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116178_19352678Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116205_21852678Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116226_23952678Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116243_26252678Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116266_51552678Compositional biasNote=Pro-rich
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116360_36752678Compositional biasNote=Poly-Gln
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116449_45652678Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116602_61152678Compositional biasNote=Poly-Pro
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+118547_56452789MotifNuclear localization signal
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+117547_56452749MotifNuclear localization signal
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+116547_56452678MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLDIP3chr22:42998776chr22:20905723ENST00000252115-29280_351150422DomainRRM
HgenePOLDIP3chr22:42998776chr22:20905723ENST00000348657-28280_351150393DomainRRM


Top

FusionGeneSequence for POLDIP3_MED15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_POLDIP3_ENST00000348657_chr22_42998776_-_MED15_ENST00000425759_chr22_20905723_+_776aa
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSAQL
QLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQ
LQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQA
LPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSS
QPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKI
DKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFV
PAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQS

>In-frame_POLDIP3_ENST00000348657_chr22_42998776_-_MED15_ENST00000292733_chr22_20905723_+_847aa
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSDPM
NALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQ
QQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQ
ALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPM
VVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLP
SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDI
LTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTR
KRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSV

>In-frame_POLDIP3_ENST00000252115_chr22_42998776_-_MED15_ENST00000425759_chr22_20905723_+_776aa
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSAQL
QLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQ
LQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQA
LPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSS
QPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKI
DKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFV
PAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQS

>In-frame_POLDIP3_ENST00000252115_chr22_42998776_-_MED15_ENST00000292733_chr22_20905723_+_847aa
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSDPM
NALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQ
QQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQ
ALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPM
VVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLP
SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDI
LTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTR
KRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSV

>In-frame_POLDIP3_ENST00000339677_chr22_42998776_-_MED15_ENST00000425759_chr22_20905723_+_776aa
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSAQL
QLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQ
LQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQA
LPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSS
QPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKI
DKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFV
PAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQS

>In-frame_POLDIP3_ENST00000339677_chr22_42998776_-_MED15_ENST00000292733_chr22_20905723_+_847aa
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKIGLSDARLKLGVKDAREKLLQKDARFRIKGK
VQDAREMLNSRKQQTTVPQKPRQVADAREKISLKRSSPAAFINPPIGTVTPALKLTKTIQDEYLSLVARLIIHFRDIHNKKSQASVSDPM
NALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQ
QQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQ
ALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPM
VVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLP
SPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDI
LTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTR
KRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_POLDIP3_ENST00000348657_chr22_42998776_-_MED15_ENST00000425759_chr22_20905723_+_2328nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGCCCAGCTG
CAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAG
CAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAG
CAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAG
CTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCA
CCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCA
CAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCT
CTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTG
CAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTG
TCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCA
CAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTG
ACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGC
TCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATC
GACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAG
ACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAA
CAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTT
CCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGC
ATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACT
GTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGC
CCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTC

>In-frame_POLDIP3_ENST00000348657_chr22_42998776_-_MED15_ENST00000292733_chr22_20905723_+_2541nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATG
AATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGG
ATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCT
GTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAG
CAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCA
GTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAG
CAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
GCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAG
ATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCG
CAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATG
GTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGA
GTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCC
CAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCC
AGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCT
GTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTAC
ATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATT
CTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCC
ACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCT
GTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGG
AAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAAC
CTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAG
CTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTG
CACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAG

>In-frame_POLDIP3_ENST00000252115_chr22_42998776_-_MED15_ENST00000425759_chr22_20905723_+_2328nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGCCCAGCTG
CAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAG
CAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAG
CAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAG
CTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCA
CCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCA
CAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCT
CTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTG
CAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTG
TCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCA
CAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTG
ACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGC
TCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATC
GACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAG
ACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAA
CAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTT
CCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGC
ATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACT
GTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGC
CCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTC

>In-frame_POLDIP3_ENST00000252115_chr22_42998776_-_MED15_ENST00000292733_chr22_20905723_+_2541nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATG
AATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGG
ATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCT
GTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAG
CAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCA
GTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAG
CAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
GCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAG
ATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCG
CAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATG
GTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGA
GTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCC
CAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCC
AGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCT
GTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTAC
ATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATT
CTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCC
ACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCT
GTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGG
AAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAAC
CTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAG
CTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTG
CACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAG

>In-frame_POLDIP3_ENST00000339677_chr22_42998776_-_MED15_ENST00000425759_chr22_20905723_+_2328nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGCCCAGCTG
CAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAG
CAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAG
CAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAG
CTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCA
CCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCA
CAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCT
CTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTG
CAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTG
TCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCA
CAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTG
ACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGC
TCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATC
GACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAG
ACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAA
CAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTT
CCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGC
ATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACT
GTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGC
CCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTC

>In-frame_POLDIP3_ENST00000339677_chr22_42998776_-_MED15_ENST00000292733_chr22_20905723_+_2541nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATG
AATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGG
ATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCT
GTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAG
CAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCA
GTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAG
CAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
GCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAG
ATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCG
CAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATG
GTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGA
GTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCC
CAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCC
AGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCT
GTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTAC
ATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATT
CTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCC
ACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCT
GTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGG
AAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAAC
CTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAG
CTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTG
CACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_POLDIP3_ENST00000348657_chr22_42998776_-_MED15_ENST00000425759_chr22_20905723_+_3329nt
TTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTTGCTCGGCGGAGCAAGATGGCGGACATCTCCC
TGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTCCGATCTCGAGTTGGGA
TCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATTGGCCTCTCAGATGCCC
GGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAAGTGCAGGATGCCAGAG
AGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAGATCAGCTTGAAGAGGA
GTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAGGACGAATACCTTTCTC
TCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGCCCAGCTGCAGCTCCAGCAGGTGG
CGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGT
TCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGC
ATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAAC
AGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCAC
AGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTC
CAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGT
TGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAG
CAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGG
GCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACG
TCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCAC
AGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGG
AGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACA
GAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTG
AGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCC
AGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCA
TTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCC
AGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCA
AGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACC
GGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGG
TCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAGGGATGGCCCGCAGCCT
CATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTT
TATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTT
GGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTCACCGTGGCCTGTCCACGG
TCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCACCCCTACTCGTTCCTATAG
AACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGA
GCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGCTGGCTCCCCGCCACCA
GCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATCCTGCTGCCGGCACCCCTG
TGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAGCACCACACACTGAGCA
CCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGGGCACCGGCCAGCACCCTC

>In-frame_POLDIP3_ENST00000348657_chr22_42998776_-_MED15_ENST00000292733_chr22_20905723_+_3543nt
TTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTTGCTCGGCGGAGCAAGATGGCGGACATCTCCC
TGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTCCGATCTCGAGTTGGGA
TCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATTGGCCTCTCAGATGCCC
GGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAAGTGCAGGATGCCAGAG
AGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAGATCAGCTTGAAGAGGA
GTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAGGACGAATACCTTTCTC
TCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATGAATGCACTCCAGAGCC
TGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGGATGGGTAGCCTTGGTG
CCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCTGTCGTGTCTACGGCAA
CTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTAC
AGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGC
AGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGC
TGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGC
CACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGC
ACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGG
TGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCC
CAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGA
GCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGC
CCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGC
CCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTG
TCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCC
GCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGA
AGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCC
CGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCC
TGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGG
ATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACT
GCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTG
ACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCT
CCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCG
CCTAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTA
GAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGAT
AGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGAT
CCTCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGT
GTGTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTT
TGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGC
TGGCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCA
GGGGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAG
GACCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGT
TGCCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAAT

>In-frame_POLDIP3_ENST00000252115_chr22_42998776_-_MED15_ENST00000425759_chr22_20905723_+_3360nt
GCGAGAGTTGGTCCGCGGACGCCGGAAGTAGTTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTT
GCTCGGCGGAGCAAGATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCG
GGAGTTGGAGGTGTCCGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGAT
GCCCGGCAGAAGATTGGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTT
CGAATCAAAGGGAAAGTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCT
GATGCCCGGGAGAAGATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTC
ACCAAAACCATCCAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCC
GTCAGTGCCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAG
CAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAG
CAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTG
CAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCA
CCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCAC
CACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTG
TCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCA
GTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGC
AGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCC
GGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCC
TCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTC
ATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGC
ATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAG
CGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCG
GTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTG
TACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGAT
GATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGC
AGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGAC
TATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCC
AGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCC
TAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGA
GAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAG
GCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCC
TCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGT
GTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTG
GGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTG
GCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGG
GGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGA
CCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTG
CCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAATAA

>In-frame_POLDIP3_ENST00000252115_chr22_42998776_-_MED15_ENST00000292733_chr22_20905723_+_3574nt
GCGAGAGTTGGTCCGCGGACGCCGGAAGTAGTTCGTCGCTCCCTAGCGGCCGAAGGGGCGGGCTCGCGGGGTCTCGACTGCTTTCGGCTT
GCTCGGCGGAGCAAGATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCG
GGAGTTGGAGGTGTCCGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGAT
GCCCGGCAGAAGATTGGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTT
CGAATCAAAGGGAAAGTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCT
GATGCCCGGGAGAAGATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTC
ACCAAAACCATCCAGGACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCC
GTCAGTGATCCTATGAATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGA
CAGTCTCTGGGCGGGATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCC
CCTCACAGCATGGCTGTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAG
CAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAG
CAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAAT
CAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAG
CAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCC
CAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAA
CTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTT
GTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAG
ATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCG
ATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCC
AGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGA
CCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAG
CAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAG
AGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAAT
GACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCC
AACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCA
GTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCC
AAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGT
GTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCC
TTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCC
CAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCC
TGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAA
ACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCC
ATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGG
GTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTA
AAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTC
CAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTC
CTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCC
CACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGG
GCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTA

>In-frame_POLDIP3_ENST00000339677_chr22_42998776_-_MED15_ENST00000425759_chr22_20905723_+_3255nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGCCCAGCTG
CAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAGCAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAG
CAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCAGTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAG
CAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAGCAGCAGCAACAGCAGCTGCAGCGAATAGCACAG
CTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGCTTTGCAGGCCCAGCCACCAATTCAGCAGCCA
CCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAGATGCATCACACACAGCACCACCAGCCGCCACCA
CAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCGCAGACCCAGCCTTTGGTGTCACAGGCGCAAGCT
CTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATGGTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTG
CAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGAGTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTG
TCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCCCAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCA
CAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCCAGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTG
ACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCTGTGAACCCCAGCTCTGTCATGAGCCCAGCTGGC
TCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTACATCGAGCCCCTGCGCCGCATGATCAACAAGATC
GACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATTCTGACAGACCCCTCGAAGCGGTGTCCCCTGAAG
ACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCCACTCCCCCACCGCCCCCGGTGCCACCGACCAAA
CAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCTGTCTTCAACCATTCCCTGTACCGCACATTCGTT
CCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGGAAGCGCAGGCTTGAGGATGATGAGCGGCAGAGC
ATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAACCTGGACCCTTCTCACTGCAGCAACAATGGCACT
GTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAGCTCAGTGTGCCCGCTGACTATCCTGCCCAAAGC
CCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTGCACCGCTGCATGACCTCCAGGCTGCTGCAGCTC
CCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAGGCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAG
GGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTAGGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGG
TTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACCTGTACAGAACTGGGATAGGCGCAGTGGAGCGGG
TTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCCAGGAGCCAGATGCGATCCTCAGGCTGCTCTCAC
CGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGTTGTTAGAGCGTCTCGTGTGTGCTAGACGCACCC
CTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGATTCTCTGGTCACAGTTTTGGGTTCAGGCTATGCT
GCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGCCTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGC
TGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTGGGGCACCCAGGGAGCAGGGGCGTCAGGGATCCT
GCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGAAGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAG
CACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGGGAGCGCCTCCCTATGTTGCCTGCCACTCTGGGC
ACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCACCATCTGTGATTATAATAAATTTATTATTCCTGT

>In-frame_POLDIP3_ENST00000339677_chr22_42998776_-_MED15_ENST00000292733_chr22_20905723_+_3469nt
ATGGCGGACATCTCCCTGGACGAACTCATCAGGAAGCGCGGGGCGGCGGCGAAAGGACGGCTTAATGCCAGACCGGGAGTTGGAGGTGTC
CGATCTCGAGTTGGGATCCAGCAAGGCCTTCTCAGCCAGTCAACACGCACAGCCACCTTCCAGCAGAGATTTGATGCCCGGCAGAAGATT
GGCCTCTCAGATGCCCGGCTCAAACTGGGAGTCAAGGATGCCCGGGAGAAGCTTTTGCAGAAAGATGCCCGATTTCGAATCAAAGGGAAA
GTGCAGGATGCCAGAGAGATGTTGAACTCTCGCAAGCAGCAGACCACGGTGCCCCAGAAGCCCCGCCAGGTTGCTGATGCCCGGGAGAAG
ATCAGCTTGAAGAGGAGTTCCCCTGCTGCCTTCATAAACCCACCCATTGGGACAGTGACCCCTGCTCTGAAGCTCACCAAAACCATCCAG
GACGAATACCTTTCTCTCGTGGCCAGGCTCATTATCCATTTTCGAGACATTCATAACAAGAAATCTCAAGCTTCCGTCAGTGATCCTATG
AATGCACTCCAGAGCCTGACTGGCGGACCTGCTGCGGGAGCCGCTGGAATTGGCATGCCTCCTCGGGGCCCGGGACAGTCTCTGGGCGGG
ATGGGTAGCCTTGGTGCCATGGGACAGCCAATGTCTCTCTCAGGGCAGCCGCCTCCTGGGACCTCGGGGATGGCCCCTCACAGCATGGCT
GTCGTGTCTACGGCAACTCCACAGACCCAGCTGCAGCTCCAGCAGGTGGCGCTGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGCAGCAG
CAGCAGGCGGCGCTACAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGTTCCAGGCTCAGCAGAGTGCCATGCAGCAGCAGTTCCAAGCA
GTAGTGCAGCAGCAGCAGCAGCTCCAGCAGCAGCAGCAGCAGCAGCAGCATCTAATTAAATTGCATCATCAAAATCAGCAACAGATACAG
CAGCAGCAACAGCAGCTGCAGCGAATAGCACAGCTGCAGCTCCAACAACAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAG
GCTTTGCAGGCCCAGCCACCAATTCAGCAGCCACCGATGCAGCAGCCACAGCCTCCGCCCTCCCAGGCTCTGCCCCAGCAGCTGCAGCAG
ATGCATCACACACAGCACCACCAGCCGCCACCACAGCCCCAGCAGCCTCCAGTTGCTCAGAACCAACCATCACAACTCCCGCCACAGTCG
CAGACCCAGCCTTTGGTGTCACAGGCGCAAGCTCTCCCTGGACAAATGTTGTATACCCAACCACCACTGAAATTTGTCCGAGCTCCGATG
GTGGTGCAGCAGCCCCCAGTGCAGCCCCAGGTGCAGCAGCAGCAGACAGCAGTACAGACAGCTCAGGCTGCCCAGATGGTGGCTCCCGGA
GTCCAGGTCAGCCAGAGCAGCCTCCCCATGCTGTCCTCGCCGTCACCGGGCCAGCAGGTGCAGACCCCGCAGTCGATGCCCCCTCCCCCC
CAGCCGTCCCCGCAGCCCGGCCAGCCCAGCTCACAGCCCAACTCCAACGTCAGCTCTGGCCCTGCCCCATCTCCCAGTAGCTTCCTGCCC
AGCCCCTCACCGCAGCCCTCCCAGAGCCCAGTGACGGCGCGGACCCCACAGAACTTCAGTGTCCCCTCACCTGGACCTTTAAACACACCT
GTGAACCCCAGCTCTGTCATGAGCCCAGCTGGCTCCAGCCAGGCTGAGGAGCAGCAGTACCTGGACAAGCTGAAGCAGCTGTCGAAGTAC
ATCGAGCCCCTGCGCCGCATGATCAACAAGATCGACAAGAACGAAGACAGAAAAAAGGACCTGAGTAAGATGAAGAGCCTTCTGGACATT
CTGACAGACCCCTCGAAGCGGTGTCCCCTGAAGACCTTGCAAAAGTGTGAGATCGCCCTGGAGAAACTCAAGAATGACATGGCGGTGCCC
ACTCCCCCACCGCCCCCGGTGCCACCGACCAAACAGCAGTACCTATGCCAGCCGCTCCTGGATGCCGTCCTGGCCAACATCCGCTCACCT
GTCTTCAACCATTCCCTGTACCGCACATTCGTTCCAGCCATGACCGCCATTCACGGCCCACCCATCACGGCCCCAGTGGTGTGCACCCGG
AAGCGCAGGCTTGAGGATGATGAGCGGCAGAGCATCCCCAGTGTGCTCCAGGGTGAGGTGGCCAGGCTGGACCCCAAGTTCCTGGTAAAC
CTGGACCCTTCTCACTGCAGCAACAATGGCACTGTCCACCTGATCTGCAAGCTGGATGACAAGGACCTCCCAAGTGTGCCACCACTGGAG
CTCAGTGTGCCCGCTGACTATCCTGCCCAAAGCCCGCTGTGGATAGACCGGCAGTGGCAGTACGACGCCAACCCCTTCCTCCAGTCGGTG
CACCGCTGCATGACCTCCAGGCTGCTGCAGCTCCCGGACAAGCACTCGGTCACCGCCTTGCTCAACACCTGGGCCCAGAGCGTCCACCAG
GCCTGCCTCTCAGCCGCCTAGCCAAGACTGCAGGGATGGCCCGCAGCCTCATCGGGGCCAAGGACACACGCCTCCTGTCAGACACTTCTA
GGTGTTGGCTTCCTTAGAGAGCCTGGGGTTAGGTTAGCTTTCCTGCTTTTATCTTCTGCCTTGGGGACCTGCCAAACGAAATCCCACACC
TGTACAGAACTGGGATAGGCGCAGTGGAGCGGGTTGCTTGGGGGGCGTTGGCCGACTTCTTAGAGAAGGCCCTCCATGTGACTTCCTCCC
AGGAGCCAGATGCGATCCTCAGGCTGCTCTCACCGTGGCCTGTCCACGGTCCAGGTCCATCTCAGCAGCGTGAGGGTGCACTCAGGGTGT
TGTTAGAGCGTCTCGTGTGTGCTAGACGCACCCCTACTCGTTCCTATAGAACACAGAGGACATAGGAAACCCTTAAAACACACATGGGAT
TCTCTGGTCACAGTTTTGGGTTCAGGCTATGCTGCTTTGGGCAGGTGGAGCACCCCCCGAGGAAGCCTGCAAGTCCAGGGCACAGGCTGC
CTTTTGGAGGGAGGGCTGGCCCATAGGTGCTGCTGGCTCCCCGCCACCAGCTGGGCCTCAGCCCTCACGGCATTCCTGCTGAGCACCGTG
GGGCACCCAGGGAGCAGGGGCGTCAGGGATCCTGCTGCCGGCACCCCTGTGCCGCTGGCATGAGGGCCGTGTCCCCACTGTGAAGGATGA
AGAGCAAGGCCCTCAGGACCCGTGTCCTCAGAGCACCACACACTGAGCACCCAGAGACAGCGGGCCTGGCAGCGGGCCGGGCCATGCAGG
GAGCGCCTCCCTATGTTGCCTGCCACTCTGGGCACCGGCCAGCACCCTCTGGTGAGAAGAGGTCCCCCCTTTTTATGTGCACTACCCCAC


Top

FusionGenePPI for POLDIP3_MED15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
POLDIP3RPS6KB1, USP20, TERF2, POT1, HDGF, SIRT7, ERH, NQO1, EIF4G2, EIF4A3, PAN2, NCBP1, EIF4G1, RPS6KA1, GOLGA2, PNMA1, MTUS2, BANP, LZTS2, KRT40, MOV10, NXF1, CUL7, OBSL1, CCDC8, RNF2, LUZP4, KLHL20, KPNA3, TEKT2, YEATS4, RPS6KB2, HNRNPA1, IFI16, SRPK2, PFKFB2, THOC5, BCLAF1, THOC1, RNASEH2A, THOC2, MYH7B, FYCO1, THOC7, FERMT3, U2AF2, ZNF746, CYB5D2, SARNP, UBR1, KLHL22, PDHA1MED15MLLT6, PLSCR1, FHL3, MED10, MED9, MED29, MED19, MED28, MED26, MED25, MED6, ATP5C1, MED1, TRIM11, SMAD1, SMAD2, SMAD3, TRRAP, RELA, SREBF1, MED12, MED18, ZC3H13, TRIP4, QKI, TADA2A, CDK8, MED13, MED14, MED23, MED16, MED17, MED7, CTDP1, ATXN1, IGBP1, UBAP2L, SEC24C, CHEK1, NCOA6, FBXW7, EPAS1, CDK19, CCNC, NR1I3, ALDH8A1, TCL1B, HIF1A, MED11, MED20, MED24, MED27, MED4, MED8, EWSR1, MYO1C, POLR2F, POLR2G, CTDSPL2, MED21, UBE2N, TP73


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMED15chr22:42998776chr22:20905723ENST00000263205+1189_7352789SREBF1
TgeneMED15chr22:42998776chr22:20905723ENST00000292733+1179_7352749SREBF1
TgeneMED15chr22:42998776chr22:20905723ENST00000382974+1169_7352678SREBF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for POLDIP3_MED15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for POLDIP3_MED15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMED15C0036341Schizophrenia2PSYGENET
TgeneMED15C0036337Schizoaffective Disorder1PSYGENET