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Fusion gene ID: 27913 |
FusionGeneSummary for POLB_UVRAG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLB_UVRAG | Fusion gene ID: 27913 | Hgene | Tgene | Gene symbol | POLB | UVRAG | Gene ID | 11232 | 7405 |
| Gene name | DNA polymerase gamma 2, accessory subunit | UV radiation resistance associated | |
| Synonyms | HP55|MTPOLB|PEOA4|POLB|POLG-BETA|POLGB | DHTX|VPS38|p63 | |
| Cytomap | 17q23.3 | 11q13.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA polymerase subunit gamma-2, mitochondrialDNA polymerase gamma accessory 55 kDa subunitmitochondrial DNA polymerase subunit gamma-2mitochondrial DNA polymerase, accessory subunitp55polymerase (DNA directed), gamma 2, accessory subunitpolymerase ( | UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P06746 | Q9P2Y5 | |
| Ensembl transtripts involved in fusion gene | ENST00000265421, ENST00000538005, ENST00000530566, ENST00000521492, | ENST00000356136, ENST00000528420, ENST00000533454, ENST00000531818, ENST00000532130, ENST00000539288, ENST00000525872, ENST00000538870, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 24 X 13 X 11=3432 |
| # samples | 5 | 25 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(25/3432*10)=-3.77904955283746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POLB [Title/Abstract] AND UVRAG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | UVRAG | GO:0071900 | regulation of protein serine/threonine kinase activity | 22542840 |
| Tgene | UVRAG | GO:0097680 | double-strand break repair via classical nonhomologous end joining | 22542840 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-95-8039-01A | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000265421 | ENST00000356136 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| In-frame | ENST00000265421 | ENST00000528420 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5CDS-5UTR | ENST00000265421 | ENST00000533454 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5CDS-5UTR | ENST00000265421 | ENST00000531818 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5CDS-5UTR | ENST00000265421 | ENST00000532130 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5CDS-5UTR | ENST00000265421 | ENST00000539288 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5CDS-intron | ENST00000265421 | ENST00000525872 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5CDS-intron | ENST00000265421 | ENST00000538870 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5UTR-3CDS | ENST00000538005 | ENST00000356136 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5UTR-3CDS | ENST00000538005 | ENST00000528420 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5UTR-5UTR | ENST00000538005 | ENST00000533454 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5UTR-5UTR | ENST00000538005 | ENST00000531818 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5UTR-5UTR | ENST00000538005 | ENST00000532130 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5UTR-5UTR | ENST00000538005 | ENST00000539288 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5UTR-intron | ENST00000538005 | ENST00000525872 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| 5UTR-intron | ENST00000538005 | ENST00000538870 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-3CDS | ENST00000530566 | ENST00000356136 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-3CDS | ENST00000530566 | ENST00000528420 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-5UTR | ENST00000530566 | ENST00000533454 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-5UTR | ENST00000530566 | ENST00000531818 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-5UTR | ENST00000530566 | ENST00000532130 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-5UTR | ENST00000530566 | ENST00000539288 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-intron | ENST00000530566 | ENST00000525872 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-intron | ENST00000530566 | ENST00000538870 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-3CDS | ENST00000521492 | ENST00000356136 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-3CDS | ENST00000521492 | ENST00000528420 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-5UTR | ENST00000521492 | ENST00000533454 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-5UTR | ENST00000521492 | ENST00000531818 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-5UTR | ENST00000521492 | ENST00000532130 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-5UTR | ENST00000521492 | ENST00000539288 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-intron | ENST00000521492 | ENST00000525872 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
| intron-intron | ENST00000521492 | ENST00000538870 | POLB | chr8 | 42202537 | + | UVRAG | chr11 | 75719851 | + |
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FusionProtFeatures for POLB_UVRAG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLB | UVRAG |
| Repair polymerase that plays a key role in base-excisionrepair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activitythat removes the 5' sugar phosphate and also acts as a DNApolymerase that adds one nucleotide to the 3' end of the arisingsingle-nucleotide gap. Conducts 'gap-filling' DNA synthesis in astepwise distributive fashion rather than in a processive fashionas for other DNA polymerases. {ECO:0000269|PubMed:11805079,ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062,ECO:0000269|PubMed:9572863}. | Versatile protein that is involved in regulation ofdifferent cellular pathways implicated in membrane trafficking.Involved in regulation of the COPI-dependent retrograde transportfrom Golgi and the endoplasmic reticulum by associating with theNRZ complex; the function is dependent on its binding tophosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).During autophagy acts as regulatory subunit of the alternativePI3K complex II (PI3KC3-C2) that mediates formation ofphosphatidylinositol 3-phosphate and is believed to be involved inmaturation of autophagosomes and endocytosis. Activates lipidkinase activity of PIK3C3. Involved in the regulation ofdegradative endocytic trafficking and cytokinesis, and inregulation of ATG9A transport from the Golgi to the autophagosome;the functions seems to implicate its association with PI3KC3-C2(PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved inmaturation of autophagosomes and degradative endocytic traffickingindependently of BECN1 but depending on its association with aclass C Vps complex (possibly the HOPS complex); the associationis also proposed to promote autophagosome recruitment andactivation of Rab7 and endosome-endosome fusion events(PubMed:18552835). Enhances class C Vps complex (possibly HOPScomplex) association with a SNARE complex and promotes fusogenicSNARE complex formation during late endocytic membrane fusion(PubMed:24550300). In case of negative-strand RNA virus infectionis required for efficient virus entry, promotes endocytictransport of virions and is implicated in a VAMP8-specificfusogenic SNARE complex assembly (PubMed:24550300).{ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:24056303, ECO:0000305}. Involved in maintaining chromosomal stability. PromotesDNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required forcentrosome stability and proper chromosome segregation(PubMed:22542840). {ECO:0000269|PubMed:22542840}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >POLB | chr8:42202537 | chr11:75719851 | ENST00000265421 | + | 3 | 14 | 183_192 | 62 | 336 | Region | Note=DNA binding |
| Tgene | UVRAG | chr8:42202537 | chr11:75719851 | ENST00000356136 | + | 9 | 15 | 224_305 | 333 | 700 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | UVRAG | chr8:42202537 | chr11:75719851 | ENST00000356136 | + | 9 | 15 | 44_128 | 333 | 700 | Domain | Note=C2 |
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FusionGeneSequence for POLB_UVRAG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000356136_chr11_75719851_+_429aa MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLNEHKDYFVCGVKLPNSEDFQAKDDGSIA VALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL PNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETE RKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQ >In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000528420_chr11_75719851_+_429aa MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLNEHKDYFVCGVKLPNSEDFQAKDDGSIA VALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL PNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETE RKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000356136_chr11_75719851_+_1287nt ATGAGCAAACGGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGC CAAGCTATCCACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAG AAATTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCT GTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCT AGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAG TTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTT CCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAA AGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAAT GAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAG AGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGC TTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTA CCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAA GCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTG GCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGC >In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000528420_chr11_75719851_+_1287nt ATGAGCAAACGGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGC CAAGCTATCCACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAG AAATTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCT GTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCT AGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAG TTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTT CCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAA AGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAAT GAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAG AGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGC TTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTA CCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAA GCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTG GCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000356136_chr11_75719851_+_3239nt AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGAATG AACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTG GTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAA TCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATG GTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGA AAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATAT TTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTC AGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAA CATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAG GCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGC AGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAA TCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGT GTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCA GGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTT GTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGT TATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAG CTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATA ATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGT TTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCC TCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGA CATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTA ATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATC TCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAA AATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGT GTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCAT GAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACAT TGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCCGA CCTGATTTTTTTTTACCAGCTTGGAAATTCCTCTTGAACCTACGTCTCCATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCCAT GTCTATCTAAGCGGAGGCTGTTGACTTCATTCAGTTTGCATATTGTATATAGCAACACAAACACTTGACAGGTATATACTCCAGTCGCCA CATTTGTCCTGCATAACAGCTTCACTCACAGGCCTCACCGTCACTTTATTTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATAGC TACATTGTTGTTTTCCATGTAGAGAACTCACAGGATGACTACATCACAAATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGATC TGCAGAAGCCCATCTTCCTCCACATGAAGAAGTGGGGCTCCTTCACCTAGAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCATTT >In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000528420_chr11_75719851_+_1838nt AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGAATG AACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTG GTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAA TCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATG GTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGA AAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATAT TTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTC AGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAA CATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAG GCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGC AGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAA TCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGT GTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCA GGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTT GTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGT TATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAG CTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATA |
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FusionGenePPI for POLB_UVRAG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| POLB | TAF1D, XRCC1, NEIL1, TLE1, KAT7, PNKP, WRN, NCAPG, PCNA, PARP1, STUB1, HUWE1, UNG, SRPK2, TPP2, APEX1, EP300, XPC, SUPT16H, LIG3, TDP1, PARP2, SSRP1, APLF, HIST1H2AG, HIST2H2AB, BCKDHB, CETN2, APTX, BCKDHA, HSD17B7, HIST1H2BG, XRCC3, EMC2, MMGT1 | UVRAG | BECN1, PIK3C3, VPS33A, VPS18, PIK3R4, PTPRA, KIAA0226, TGFBRAP1, VPS16, VPS11, VPS33B, VPS39, YWHAE, RALB, USP18, XPO1, MYO1C, DDB1, DDB2, CUL4A, RBX1, KIAA0226L |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLB_UVRAG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | POLB | P06746 | DB01592 | Iron | DNA polymerase beta | small molecule | approved |
| Hgene | POLB | P06746 | DB00987 | Cytarabine | DNA polymerase beta | small molecule | approved|investigational |
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RelatedDiseases for POLB_UVRAG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | POLB | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | POLB | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | POLB | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
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