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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 27913

FusionGeneSummary for POLB_UVRAG

check button Fusion gene summary
Fusion gene informationFusion gene name: POLB_UVRAG
Fusion gene ID: 27913
HgeneTgene
Gene symbol

POLB

UVRAG

Gene ID

11232

7405

Gene nameDNA polymerase gamma 2, accessory subunitUV radiation resistance associated
SynonymsHP55|MTPOLB|PEOA4|POLB|POLG-BETA|POLGBDHTX|VPS38|p63
Cytomap

17q23.3

11q13.5

Type of geneprotein-codingprotein-coding
DescriptionDNA polymerase subunit gamma-2, mitochondrialDNA polymerase gamma accessory 55 kDa subunitmitochondrial DNA polymerase subunit gamma-2mitochondrial DNA polymerase, accessory subunitp55polymerase (DNA directed), gamma 2, accessory subunitpolymerase (UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy
Modification date2018052320180523
UniProtAcc

P06746

Q9P2Y5

Ensembl transtripts involved in fusion geneENST00000265421, ENST00000538005, 
ENST00000530566, ENST00000521492, 
ENST00000356136, ENST00000528420, 
ENST00000533454, ENST00000531818, 
ENST00000532130, ENST00000539288, 
ENST00000525872, ENST00000538870, 
Fusion gene scores* DoF score5 X 3 X 4=6024 X 13 X 11=3432
# samples 525
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(25/3432*10)=-3.77904955283746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: POLB [Title/Abstract] AND UVRAG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

TgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-95-8039-01APOLBchr8

42202537

+UVRAGchr11

75719851

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265421ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719851

+
In-frameENST00000265421ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-5UTRENST00000265421ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-5UTRENST00000265421ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-5UTRENST00000265421ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-5UTRENST00000265421ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-intronENST00000265421ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719851

+
5CDS-intronENST00000265421ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-3CDSENST00000538005ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-3CDSENST00000538005ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-5UTRENST00000538005ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-5UTRENST00000538005ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-5UTRENST00000538005ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-5UTRENST00000538005ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-intronENST00000538005ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719851

+
5UTR-intronENST00000538005ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-3CDSENST00000530566ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-3CDSENST00000530566ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000530566ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000530566ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000530566ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000530566ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-intronENST00000530566ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-intronENST00000530566ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-3CDSENST00000521492ENST00000356136POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-3CDSENST00000521492ENST00000528420POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000521492ENST00000533454POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000521492ENST00000531818POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000521492ENST00000532130POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-5UTRENST00000521492ENST00000539288POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-intronENST00000521492ENST00000525872POLBchr8

42202537

+UVRAGchr11

75719851

+
intron-intronENST00000521492ENST00000538870POLBchr8

42202537

+UVRAGchr11

75719851

+

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FusionProtFeatures for POLB_UVRAG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
POLB

P06746

UVRAG

Q9P2Y5

Repair polymerase that plays a key role in base-excisionrepair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activitythat removes the 5' sugar phosphate and also acts as a DNApolymerase that adds one nucleotide to the 3' end of the arisingsingle-nucleotide gap. Conducts 'gap-filling' DNA synthesis in astepwise distributive fashion rather than in a processive fashionas for other DNA polymerases. {ECO:0000269|PubMed:11805079,ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062,ECO:0000269|PubMed:9572863}. Versatile protein that is involved in regulation ofdifferent cellular pathways implicated in membrane trafficking.Involved in regulation of the COPI-dependent retrograde transportfrom Golgi and the endoplasmic reticulum by associating with theNRZ complex; the function is dependent on its binding tophosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:24056303).During autophagy acts as regulatory subunit of the alternativePI3K complex II (PI3KC3-C2) that mediates formation ofphosphatidylinositol 3-phosphate and is believed to be involved inmaturation of autophagosomes and endocytosis. Activates lipidkinase activity of PIK3C3. Involved in the regulation ofdegradative endocytic trafficking and cytokinesis, and inregulation of ATG9A transport from the Golgi to the autophagosome;the functions seems to implicate its association with PI3KC3-C2(PubMed:16799551, PubMed:20643123, PubMed:24056303). Involved inmaturation of autophagosomes and degradative endocytic traffickingindependently of BECN1 but depending on its association with aclass C Vps complex (possibly the HOPS complex); the associationis also proposed to promote autophagosome recruitment andactivation of Rab7 and endosome-endosome fusion events(PubMed:18552835). Enhances class C Vps complex (possibly HOPScomplex) association with a SNARE complex and promotes fusogenicSNARE complex formation during late endocytic membrane fusion(PubMed:24550300). In case of negative-strand RNA virus infectionis required for efficient virus entry, promotes endocytictransport of virions and is implicated in a VAMP8-specificfusogenic SNARE complex assembly (PubMed:24550300).{ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:24056303, ECO:0000305}. Involved in maintaining chromosomal stability. PromotesDNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ) (PubMed:22542840). Required forcentrosome stability and proper chromosome segregation(PubMed:22542840). {ECO:0000269|PubMed:22542840}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOLBchr8:42202537chr11:75719851ENST00000265421+314183_19262336RegionNote=DNA binding
TgeneUVRAGchr8:42202537chr11:75719851ENST00000356136+915224_305333700Coiled coilOntology_term=ECO:0000255
TgeneUVRAGchr8:42202537chr11:75719851ENST00000356136+91544_128333700DomainNote=C2


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FusionGeneSequence for POLB_UVRAG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000356136_chr11_75719851_+_429aa
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLNEHKDYFVCGVKLPNSEDFQAKDDGSIA
VALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL
PNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETE
RKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQ

>In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000528420_chr11_75719851_+_429aa
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLNEHKDYFVCGVKLPNSEDFQAKDDGSIA
VALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTL
PNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETE
RKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000356136_chr11_75719851_+_1287nt
ATGAGCAAACGGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGC
CAAGCTATCCACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAG
AAATTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCT
GTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCT
AGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAG
TTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTT
CCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAA
AGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAAT
GAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAG
AGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGC
TTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTA
CCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAA
GCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTG
GCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGC

>In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000528420_chr11_75719851_+_1287nt
ATGAGCAAACGGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGC
CAAGCTATCCACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAG
AAATTGAATGAACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCT
GTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCT
AGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAG
TTTGATTATGGTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTT
CCCAACCTGAAAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAA
AGCTCCATATTTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAAT
GAGAGACTTCAGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAG
AGAAAGATAACATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGC
TTAAACGGAGGCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTA
CCCAGCGAGCAGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAA
GCAGAAGAAATCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTG
GCAGTAGAGTGTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000356136_chr11_75719851_+_3239nt
AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA
GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC
GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC
ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGAATG
AACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTG
GTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAA
TCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATG
GTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGA
AAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATAT
TTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTC
AGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAA
CATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAG
GCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGC
AGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAA
TCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGT
GTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCA
GGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTT
GTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGT
TATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAG
CTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATA
ATATAATGAACACACCCTTAGTTTCTCATAAGCATTTGCCCTCACCATGGTTTATAAAACTTTGGGAAAACGGAATATTCAGAAATAGGT
TTCCGCCATGTACTGAAAGGTCTGTGGCCATCTGTGAGGTAGATGAAGAAGCAGCATAGTGGTCTCCTTACATCTAGGCCTAACTGTCCC
TCTTCCTGCCCCCGGGTACCACAGTCCACCTTTAGACCCTACTGTCGCCCCATCTTCTCCGTGGATGGGCCATGCGTCCTGAAAACAGGA
CATCAGATTCACTGGTTCTGTAACCCAGTAGCTGTGACGTTCCATCTCTTCTAACCAGCCATGGCCTTCCCCTCCTCTGCCATACCCTTA
ATGCGGCCCTCAGATTAGATGAAAAACTTGCTCCTGGTGGATCCCAAGGGACCCTCAAGGACCTCGAGGTTACTGCAGTCAGATGCCATC
TCATCCCCTGTGGGGGCCAAAGTTTTTATGTGGGCAGATGCTGTGGTCAGGAACTAGGCATGCTTTCTGGCAATGCACTCACCAGACAAA
AATCCCTTGATGTAAATCCCATGTTAATTTATTAAATTTCAGTCAGAAGGTCAGCATTTACATGACAGAATGTATGTAGAGAGTTGGGGT
GTCTGGTAGGCAAACTGCAAGGCAGTTGAGATAGTTGGATTAAGAGGCTAGACGAGACATAGAATACTATTGGTATGTGTGCAATTTCAT
GAATATTAAATTATGTTTCGAAGTCCAGTTGTCATTCCCGCATTCAGATTTCATTTGCTGTTGCTTTATACGTTACGTACCCAAGGACAT
TGCCTCAGGGTTGCAAACTCTTTAAAGGAAAATTTATCCATATATCCATGTATTATATAGAAGAATAAAAATTGAGTTTACTTCACCCGA
CCTGATTTTTTTTTACCAGCTTGGAAATTCCTCTTGAACCTACGTCTCCATATGTCACATCATGACAGGACTAGCCTGAACAAAAGCCAT
GTCTATCTAAGCGGAGGCTGTTGACTTCATTCAGTTTGCATATTGTATATAGCAACACAAACACTTGACAGGTATATACTCCAGTCGCCA
CATTTGTCCTGCATAACAGCTTCACTCACAGGCCTCACCGTCACTTTATTTTGTGTCCAAGCATTCCTGGGCTCAAGTTTAATGTATAGC
TACATTGTTGTTTTCCATGTAGAGAACTCACAGGATGACTACATCACAAATAAACCCAACTCTCAGGCAGTCGAAAGCTTTAACTGGATC
TGCAGAAGCCCATCTTCCTCCACATGAAGAAGTGGGGCTCCTTCACCTAGAGCAGGAGCTTCTCTGCAGTGTACTGTCTGTCGCTCATTT

>In-frame_POLB_ENST00000265421_chr8_42202537_+_UVRAG_ENST00000528420_chr11_75719851_+_1838nt
AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA
GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC
GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC
ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGAATG
AACATAAGGATTACTTTGTATGCGGTGTCAAGTTGCCTAATTCTGAGGACTTCCAAGCAAAAGATGATGGAAGCATTGCTGTTGCCCTTG
GTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAA
TCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGAGTTTCCACTGTATCCAAAAGGAGGGGAGAAGTTGCAGTTTGATTATG
GTGTCTATCTTCTGAACAAAAATATAGCACAGCTAAGATATCAACATGGACTAGGGACTCCAGACTTGCGGCAAACCCTTCCCAACCTGA
AAAACTTCATGGAGCATGGACTAATGGTCAGGTGTGACAGACATCACACCTCCAGTGCAATCCCTGTTCCTAAGAGACAAAGCTCCATAT
TTGGGGGTGCAGATGTAGGCTTCTCTGGGGGGATCCCTTCACCAGACAAAGGACATCGAAAACGGGCCAGCTCTGAGAATGAGAGACTTC
AGTACAAAACCCCTCCTCCCAGTTACAACTCAGCATTAGCCCAGCCTGTGACCACCGTCCCCTCCATGGGAGAGACCGAGAGAAAGATAA
CATCTCTATCCTCCTCCTTGGATACCTCCTTGGACTTCTCCAAAGAAAACAAGAAAAAAGGAGAGGATCTAGTTGGCAGCTTAAACGGAG
GCCACGCGAATGTGCACCCTAGCCAAGAACAAGGAGAAGCCCTCTCCGGGCACCGGGCCACAGTCAATGGCACTCTCCTACCCAGCGAGC
AGGCCGGGTCCGCCAGTGTCCAGCTTCCAGGCGAGTTCCACCCAGTCTCAGAAGCTGAGCTCTGCTGTACTGTGGAGCAAGCAGAAGAAA
TCATCGGGCTGGAAGCCACAGGTTTCGCCTCAGGTGATCAGCTAGAAGCATTTAACTGCATCCCAGTGGACAGTGCTGTGGCAGTAGAGT
GTGACGAACAAGTTCTGGGAGAATTTGAAGAGTTCTCCCGAAGGATCTATGCACTGAATGAAAACGTATCCAGCTTCCGCCGGCCGCGCA
GGAGTTCCGATAAGTGAAGTGAGCAGGTCAACAGTAGGACTGGGGCAGAAGCTCTGCCTAAAATGAAGTGAAAGCTGCACTTAACCCTTT
GTGATAATGATGACACAAAATGAATATTAATGGAGGATATTCCTCGGAAAAACAGACTTTGGGAATGAAGGAGGGACTCAGGATCATTGT
TATCAGTGGGCCAAAGTTAGATTTTGCTTTCAAGATTTGCTTTTCGGGCCTGATGATTTTAAAGCAAAAATCACCCTCTAGTTGAAAGAG
CTTACAGCTCGAGTCACCTTTTAGCTATTTGTCTGCTTTTTATTTACCCTTGTATGTTATCCTCAGAGGGAAGATGATAATATATAAATA


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FusionGenePPI for POLB_UVRAG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
POLBTAF1D, XRCC1, NEIL1, TLE1, KAT7, PNKP, WRN, NCAPG, PCNA, PARP1, STUB1, HUWE1, UNG, SRPK2, TPP2, APEX1, EP300, XPC, SUPT16H, LIG3, TDP1, PARP2, SSRP1, APLF, HIST1H2AG, HIST2H2AB, BCKDHB, CETN2, APTX, BCKDHA, HSD17B7, HIST1H2BG, XRCC3, EMC2, MMGT1UVRAGBECN1, PIK3C3, VPS33A, VPS18, PIK3R4, PTPRA, KIAA0226, TGFBRAP1, VPS16, VPS11, VPS33B, VPS39, YWHAE, RALB, USP18, XPO1, MYO1C, DDB1, DDB2, CUL4A, RBX1, KIAA0226L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for POLB_UVRAG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePOLBP06746DB01592IronDNA polymerase betasmall moleculeapproved
HgenePOLBP06746DB00987CytarabineDNA polymerase betasmall moleculeapproved|investigational

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RelatedDiseases for POLB_UVRAG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePOLBC0005695Bladder Neoplasm1CTD_human
HgenePOLBC0009375Colonic Neoplasms1CTD_human
HgenePOLBC0023434Chronic Lymphocytic Leukemia1CTD_human