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Fusion gene ID: 27910 |
FusionGeneSummary for POLB_HOOK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLB_HOOK3 | Fusion gene ID: 27910 | Hgene | Tgene | Gene symbol | POLB | HOOK3 | Gene ID | 11232 | 84376 |
| Gene name | DNA polymerase gamma 2, accessory subunit | hook microtubule tethering protein 3 | |
| Synonyms | HP55|MTPOLB|PEOA4|POLB|POLG-BETA|POLGB | HK3 | |
| Cytomap | 17q23.3 | 8p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA polymerase subunit gamma-2, mitochondrialDNA polymerase gamma accessory 55 kDa subunitmitochondrial DNA polymerase subunit gamma-2mitochondrial DNA polymerase, accessory subunitp55polymerase (DNA directed), gamma 2, accessory subunitpolymerase ( | protein Hook homolog 3h-hook3hHK3hook homolog 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P06746 | Q86VS8 | |
| Ensembl transtripts involved in fusion gene | ENST00000265421, ENST00000538005, ENST00000530566, ENST00000521492, | ENST00000307602, ENST00000524839, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 9 X 7 X 7=441 |
| # samples | 5 | 12 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/441*10)=-1.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POLB [Title/Abstract] AND HOOK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | READ | TCGA-DY-A0XA-01A | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000265421 | ENST00000307602 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| 5CDS-intron | ENST00000265421 | ENST00000524839 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| 5UTR-3CDS | ENST00000538005 | ENST00000307602 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| 5UTR-intron | ENST00000538005 | ENST00000524839 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| intron-3CDS | ENST00000530566 | ENST00000307602 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| intron-intron | ENST00000530566 | ENST00000524839 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| intron-3CDS | ENST00000521492 | ENST00000307602 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
| intron-intron | ENST00000521492 | ENST00000524839 | POLB | chr8 | 42202537 | + | HOOK3 | chr8 | 42761316 | + |
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FusionProtFeatures for POLB_HOOK3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLB | HOOK3 |
| Repair polymerase that plays a key role in base-excisionrepair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activitythat removes the 5' sugar phosphate and also acts as a DNApolymerase that adds one nucleotide to the 3' end of the arisingsingle-nucleotide gap. Conducts 'gap-filling' DNA synthesis in astepwise distributive fashion rather than in a processive fashionas for other DNA polymerases. {ECO:0000269|PubMed:11805079,ECO:0000269|PubMed:21362556, ECO:0000269|PubMed:9207062,ECO:0000269|PubMed:9572863}. | Probably serves as a target for the spiC protein fromSalmonella typhimurium, which inactivates it, leading to a strongalteration in cellular trafficking (By similarity). Component ofthe FTS/Hook/FHIP complex (FHF complex). The FHF complex mayfunction to promote vesicle trafficking and/or fusion via thehomotypic vesicular protein sorting complex (the HOPS complex).May regulate clearance of endocytosed receptors such as MSR1.Participates in defining the architecture and localization of theGolgi complex. Acts as an adapter protein linking the dynein motorcomplex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence ofdynactin. Facilitates the interaction between dynein and dynactinand activates dynein processivity (the ability to move along amicrotubule for a long distance without falling off the track)(PubMed:25035494). {ECO:0000250|UniProtKB:Q8BUK6,ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231,ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >HOOK3 | chr8:42202537 | chr8:42761316 | ENST00000307602 | + | 0 | 22 | 167_433 | 19 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >HOOK3 | chr8:42202537 | chr8:42761316 | ENST00000307602 | + | 0 | 22 | 462_667 | 19 | 719 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >HOOK3 | chr8:42202537 | chr8:42761316 | ENST00000307602 | + | 0 | 22 | 553_718 | 19 | 719 | Region | Note=Required for association with Golgi |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >POLB | chr8:42202537 | chr8:42761316 | ENST00000265421 | + | 3 | 14 | 183_192 | 62 | 336 | Region | Note=DNA binding |
| Tgene | HOOK3 | chr8:42202537 | chr8:42761316 | ENST00000307602 | + | 0 | 22 | 10_126 | 19 | 719 | Domain | Calponin-homology (CH) |
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FusionGeneSequence for POLB_HOOK3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_POLB_ENST00000265421_chr8_42202537_+_HOOK3_ENST00000307602_chr8_42761316_+_762aa MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLIQTFNVDAPCQTVEDLTNGVVMAQVLQK IDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQ AIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERL NQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLE GQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQ KEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLD DANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQ EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_POLB_ENST00000265421_chr8_42202537_+_HOOK3_ENST00000307602_chr8_42761316_+_2286nt ATGAGCAAACGGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGC CAAGCTATCCACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAG AAATTGATCCAGACATTTAATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAG ATAGATCCTGCATATTTTGATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAG AAAATTTTAAAAGGAATCTTGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGG GAGCATTCTGATGCAGCAGAGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGAGTACATCCAA GCCATTATGATGATGGAGGAATCTGTTCAACATGTTGTCATGACAGCCATTCAAGAGCTGATGAGTAAAGAATCTCCTGTCTCTGCTGGA AATGATGCCTATGTTGACCTTGATCGTCAGCTGAAGAAAACTACAGAGGAACTAAATGAAGCTTTGTCAGCAAAGGAAGAAATTGCTCAA AGATGCCATGAACTGGATATGCAGGTTGCAGCATTGCAGGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTC AATCAATCTGATTCTATAGAAGACCCTAACAGTCCAGCAGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAA ACATTCAGACTAGAAGCAGCCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGAT GAACTGACCACTTTGGCAGATGAAGCTCAGTCTCTGAAAGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAA GGTCAAGTAGAATCTTATAAAAAGAAGCTAGAAGACCTTGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTAT ATGCAGAATACTGTCAGTCTAGAGGAAGAGTTAAGAAAGGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGTAGTAGAA CTACAAAACAGATTATCCGAAGAATCAAAGAAAGCAGATAAACTAGATTTTGAATATAAGCGGCTAAAAGAAAAAGTTGACAGTCTTCAA AAAGAAAAGGACAGGCTGAGAACAGAAAGGGATTCTCTGAAGGAAACCATTGAAGAGCTTCGTTGTGTACAAGCTCAAGAAGGGCAGCTC ACAACACAAGGGTTAATGCCTCTTGGAAGTCAGGAGTCTTCAGACAGTCTAGCTGCAGAGATTGTTACACCTGAAATCAGGGAGAAACTT ATTCGTCTTCAGCATGAGAATAAGATGTTAAAGCTTAACCAAGAAGGTTCGGACAATGAAAAAATAGCCTTATTGCAGAGCCTTCTAGAT GATGCAAATCTACGCAAGAATGAACTGGAGACAGAGAATAGGCTGGTGAATCAAAGACTTCTGGAAGTACAGTCACAAGTTGAAGAATTA CAAAAATCTTTACAGGATCAAGGCTCAAAAGCAGAAGATTCAGTCCTTCTAAAAAAGAAGCTTGAAGAACATCTAGAGAAGCTGCATGAG GCCAATAATGAACTACAGAAGAAGAGAGCCATTATTGAAGATCTCGAGCCAAGATTTAACAACAGCTCCTTAAAAATTGAAGAATTACAA GAAGCTTTACGAAAGAAAGAGGAAGAAATGAAGCAAATGGAAGAACGATACAAAAAATACTTAGAGAAAGCCAAAAGTGTCATCCGTACT TTAGATCCTAAACAGAATCAAGGAGCAGCACCAGAAATACAAGCTCTTAAAAATCAGCTCCAGGAACGAGACCGACTGTTCCACTCATTA GAGAAAGAATATGAGAAAACAAAGAGTCAGAGAGAGATGGAAGAGAAATATATTGTTAGTGCCTGGTACAATATGGGAATGACCCTGCAT AAAAAGGCAGCTGAAGATAGACTGGCAAGCACAGGCTCAGGGCAGTCATTTCTGGCGAGGCAGAGGCAAGCGACCAGCAGCAGAAGATCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_POLB_ENST00000265421_chr8_42202537_+_HOOK3_ENST00000307602_chr8_42761316_+_14497nt AACAAGCGCCGTGCGCCCCGCCCCCCATCGGGGGCAACCATTGTTCCGCCGGTCGCGCCGGAGCTGGGTTGCTCCTGCTCCCGTCTCCAA GTCCTGGTACCTCCTTCAAGCTGGGAGAGGGCTCTAGTCCCTGGTTCTGAACACTCTGGGGTTCTCGGGTGCAGGCCGCCATGAGCAAAC GGAAGGCGCCGCAGGAGACTCTCAACGGGGGAATCACCGACATGCTCACAGAACTCGCAAACTTTGAGAAGAACGTGAGCCAAGCTATCC ACAAGTACAATGCTTACAGAAAAGCAGCATCTGTTATAGCAAAATACCCACACAAAATAAAGAGTGGAGCTGAAGCTAAGAAATTGATCC AGACATTTAATGTGGATGCACCATGCCAGACCGTGGAAGATTTAACGAATGGGGTTGTGATGGCCCAGGTTCTTCAAAAGATAGATCCTG CATATTTTGATGAAAATTGGCTAAACAGAATCAAAACTGAAGTAGGAGATAATTGGAGGCTAAAGATAAGCAATTTAAAGAAAATTTTAA AAGGAATCTTGGATTATAATCATGAGATTTTAGGACAGCAAATTAATGACTTTACCCTTCCTGATGTGAACCTTATTGGGGAGCATTCTG ATGCAGCAGAGCTTGGAAGGATGCTTCAGCTCATCTTAGGCTGTGCTGTGAACTGTGAACAGAAGCAAGAGTACATCCAAGCCATTATGA TGATGGAGGAATCTGTTCAACATGTTGTCATGACAGCCATTCAAGAGCTGATGAGTAAAGAATCTCCTGTCTCTGCTGGAAATGATGCCT ATGTTGACCTTGATCGTCAGCTGAAGAAAACTACAGAGGAACTAAATGAAGCTTTGTCAGCAAAGGAAGAAATTGCTCAAAGATGCCATG AACTGGATATGCAGGTTGCAGCATTGCAGGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAATCTG ATTCTATAGAAGACCCTAACAGTCCAGCAGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTCAGAC TAGAAGCAGCCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTGACCA CTTTGGCAGATGAAGCTCAGTCTCTGAAAGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAAGTAG AATCTTATAAAAAGAAGCTAGAAGACCTTGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAGAATA CTGTCAGTCTAGAGGAAGAGTTAAGAAAGGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGTAGTAGAACTACAAAACA GATTATCCGAAGAATCAAAGAAAGCAGATAAACTAGATTTTGAATATAAGCGGCTAAAAGAAAAAGTTGACAGTCTTCAAAAAGAAAAGG ACAGGCTGAGAACAGAAAGGGATTCTCTGAAGGAAACCATTGAAGAGCTTCGTTGTGTACAAGCTCAAGAAGGGCAGCTCACAACACAAG GGTTAATGCCTCTTGGAAGTCAGGAGTCTTCAGACAGTCTAGCTGCAGAGATTGTTACACCTGAAATCAGGGAGAAACTTATTCGTCTTC AGCATGAGAATAAGATGTTAAAGCTTAACCAAGAAGGTTCGGACAATGAAAAAATAGCCTTATTGCAGAGCCTTCTAGATGATGCAAATC TACGCAAGAATGAACTGGAGACAGAGAATAGGCTGGTGAATCAAAGACTTCTGGAAGTACAGTCACAAGTTGAAGAATTACAAAAATCTT TACAGGATCAAGGCTCAAAAGCAGAAGATTCAGTCCTTCTAAAAAAGAAGCTTGAAGAACATCTAGAGAAGCTGCATGAGGCCAATAATG AACTACAGAAGAAGAGAGCCATTATTGAAGATCTCGAGCCAAGATTTAACAACAGCTCCTTAAAAATTGAAGAATTACAAGAAGCTTTAC GAAAGAAAGAGGAAGAAATGAAGCAAATGGAAGAACGATACAAAAAATACTTAGAGAAAGCCAAAAGTGTCATCCGTACTTTAGATCCTA AACAGAATCAAGGAGCAGCACCAGAAATACAAGCTCTTAAAAATCAGCTCCAGGAACGAGACCGACTGTTCCACTCATTAGAGAAAGAAT ATGAGAAAACAAAGAGTCAGAGAGAGATGGAAGAGAAATATATTGTTAGTGCCTGGTACAATATGGGAATGACCCTGCATAAAAAGGCAG CTGAAGATAGACTGGCAAGCACAGGCTCAGGGCAGTCATTTCTGGCGAGGCAGAGGCAAGCGACCAGCAGCAGAAGATCATACCCAGGCC ACGTGCAGCCGGCCACAGCAAGGTAGAGAAGTTGTGCCGCTCAATCACAGACACCTGCACCCACAACATACTTCTGTTACACACAAGAAC ATTTCAGGAAACTCAGCCAGCTTATTTTTTGTTTCTCTTCTATGTCAATACTTAGTGTTTCTCATTTTGAGGACTTTTTCTCTCTCCTGT ATCTTTGTTTTAGTTTCTTTGGTTTTTATTTTGTAGTCCTTTCAGTTATTTTTAATGTGCCAAAAATTTGTACATGTTCAATTAAAAATG TTGTATAATAGTGTAATACTTTTCTTTGTATGAAAATGTCCTCTTCTTCAAAGGTATAGGCTTTGTAATGAATTAGATTTTCTGCCAATA ATTGATATACAATTTATATTCTTTATTGTGCCTGTGTGTTACCATGCTAAGAATGTCTTTGTTTAAAGGGAATTAATCTTTTTATGATGT ATTAATCTGTGTTTTCAATTGTTTTCCAAGTACAGTTCAAATAACTTGCATATTTACTATACAAAATGGTTGACAAGTGTTCTTTTTGCA AAGACTTGAATACATTGGCAGAGGTGCTAATCACATCTTCCCTAAGGCACCTGGAAGAATTATTTGAGGAAAAAATGAGTTTTCACATTG TTTTATAGGAAATTAAATTTGTCCAAAGATTTGGAGACTATTTTTAAAACATAAATACATAAAATTTCATTATTTCCTGCTATCTTGTTT GCTGGCAGAAGTGAATGTTTGGTGAGGTTATTTTGGGATAAATTACAAAAGAAAAAAAATTAGACACTGCATTAATTTCTTGTTCTTTTG GAATATCTTAGTAACTGAGGATCATTTTCTAACAATGTGGTTGACATACCTTCAGTTGCTTTCCACATCTAAAAGAGTTATCTTTCATAT ATGTACAAGTTATTGGTAGTCTTATTTTTGGGCTGTTTGTTGACTTATGCCCCATTTGTTTTACTTGTTCTTTAATATAAACCCTTCCAT TTTTTAACAATTCCTAACACTTGATATCTTAATATCAGTCACTAACATTAGTAACTTCTTGTATGTTATATTATGGCAGATCTCTTTACG TTTTTTCTCACATCTATCTGCTAGTCCAGGAATTTGTTACTAAATAGATTTTCTTGGATATTTGGTTGCCTCAAAGTGCTTACATTTGTT AACAGATTGTAAACCACATTTATTTACATTGATGAATGGGCTGTTGAATAATCATTGTAAAGCACTTTGTATATATAAGGTGCTATATAA GTGTGAAATATCATTCATTTATAAATGAAATGCCTTCTAACTTTCCATATTGACTTATGTATTTGGTCCCAAATTATATTTAAGTCTTTT TTCTTGCAACGTAGCCCATTTTTTGAAAGCAAAACATTTCTGAAATTAGGTCATGGTTTTTTTGTTTATTTTTAGGTTAGGTCACTTAAT ATAGGAGGATGTTTTCTCATGTACTTGCTATTTGCAAGTTCAGGTTTCATTTGGTTCTTTATGTTAAATACGAATAAGTAACCTCAAATC AAGCTAAATGTAATTAAGAATTTTCAGCAACTATATTCAAGTGTTTGATTTTTAAATTCTTTCTTTCTTTTTAATAAGAAAGATGACCTA AAAATCAGTGGTATTTGTTTGTCCTCAGAAGCCGTAGTTGAAGAAAGATATTAGAGTATACACAGAACTGGAGCCATACATTGTGCTAAT TTTTTACATTAAGTACAGAAGTCTGAGCACAGCATGAATGCTTCTGCCTGACAGGACCACAAAGCAGCAGAAGTTAGGGATAAATGGAGA TAGCCATGAGTAGAACTGCTGTAGGGCTTCAGGAGGCTACGCAGACCTGATCAACTGCAAAGTTTCCAAAGTAAAAGATTAAAAACTTTC AGACGGTTCTTACCTCTACCCGTGTTTCACAAATAGCCTGAGGATCCAACTATTTTTAAAGCAAATTGGGGCCAGACGTGGTGCCTCACG CCTGCAATCTCACCATTTGGGAGACCTAGGTGGGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCC CATCTCTACTAAATTACAAAAATTAGCTGGGCATGGTGGCATGTGGCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAGTCACTT GAACTCAGGAGCCAGAGACTGCAGTGAGCTGAGATCGCACCACTGCATTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAATCAGTCA ATCAATCAATCAATCAAATTGGAATATGAGCACTAACCTTGGTAAGTTAAAATTTTGGGAAAATTGTACCTGCAGAATATGATGGATGAA AACAACAGCCAGGTGCAGTGGCTCACGCGTATAATCCCAGCACTTTGGGAGGCCGAGACAGGCACATCATCTGAGGTCAGGACTTCCAGA CCAGCCTGTCCAACATGGTGAAACTCCGTCTCTACTAAAAATACAAACAATTAGCCAGGCATGGTGGTGTGTGCCTGTAGTCCCAGCTAC TTGGGAGGGTGAGGCAGGAGAATTGCTTGAACCTGGGAGACAGAGATTGCAGTGAGCCGAGATGGCGCCATTGCACCCCAGCCTGGCGAC AAGAGCGAAACTCTGTCGCAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAGTCTGTGAACTACTCACTGAATGAATTTTGTTCTGTG AGATGAGAGGTTTTCATTTTCATTTTCTATTTACAGCCCCAGTCCTAATCTCCTACCCATCCACCTACCCAGATATTTTTTCTCTATCTG GGTTGGAAAGGCCCCAGGCTTTTAGAGGGGAGTTTTACTTCTGACTTTTTTTTCCCCCCGAGACGGAGCCTCGTTCCGTCACCCAGGCTG TAGTGCCGTGGCATGATCTCGGCTCACTGCAGCCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATT ACAGGTGCCCACCACCATGGCTGGCTAATTTTTGTAATTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGA CCTCGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGAGATTACAGGCACGAGCCACCGCGCCCAGTCGTACTTCTGACTTTTCTTCAGC ATCTGTTGTATGCTATTATTTTGATGTTTACATTTATAATTTTCTTTCTTTTTTTTTTTTTTGTGAGATGATGTCTCGCTCTGTCACCCA GGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCGG GGACTACAGGCGCCCGCCACTACGCCCGACTAATTTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGA TCTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTACATTTATAATTT TCATTCTCTTTTACCTATAAAATTCAGTGTATTAGTTTCATTACATAGGAGAAATTATATTTCTAAACATTTTATGATGTTTAAAAACAA AACAGGCTGTTGTAAAAAAAAAAAAAAAAAAAACTTCTGAATATACTTTAGGTATCAGAAAGCCAAGAATAAAATTTAGCTCTAACGGTG GCAACTCCATGTCCGGTGTCCAGCTTTGGACAGGGTTTATGACGTTTCTGTTTCTCTAGTAATGATTAATGATTCCTCAGGAGATTCGTG ATGTTGTCTGGTCTATCTGGAAATTTAAAGTCACTAGGAGCTTTGCCTCATCGTGAGTGATGCTGTGCTGTATTTTTACAAACTCTCGCA TACAGCACCTTCCTGGGGCCACGTTGGCTTGTGCAGTGGAGCTTGTCCAGGCACCAGCATGGAGCAAGTACAGGGTTGCTGTGTTGGGTT GGAGCACACTGTCACCACAGTGTCTGAAGTCTTATAAACAGGAAGATCATTTTCTGTTTTCCTTCTAACCAGGGTGAGAAAATACAAAGT AAAGAACTAAAGAATATTAAAACCTAGCATTTATGTTCCACAGTGTGTATTTCAGAAGTTTGTAATCCAGAAAATATAGTAGTGTATAAT ATCTGAAAAGAGAATCAAGTATACAATTGTACATATTTTTAAAGAACTTTGAAAAACTCCGTCATATCTTTTACCATTTGTCTATTTGAT AGTAATGCAGAAAAAAGTCCCTAAAGACCCTGTGTTCCAAAATTTACCAAGATTGACATTTCTATTAGACATCCTTAACCTAAGTGTTTT AATTAGATTATTAGACTATAATAAGGATGAAATTGCTGTCTGTAATTTTGTTGAGGTTTTATTGTTAATATAATAAAAGCTCAACTGTAC AAAATTAAGCTAAATGTTATCCAGTCAGAAACATCAGCCTGTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCC AAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCTAATATGGTGAAACCCCATCTCTACTAAAAATACAGTATTAGCC AGGCATGGTGGCAGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCATGTGAACCCAGGAGGTGGAGGTTGCAGTAAG CCGAGATTGTGCCACTGCACTCCAGCCTGGGCCACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAGAAACATCAGCCTG TATATTCCAGTAGTTCTCACAGAAGAATGAAAATCCGTGCTGTGCAAATAGATCAGTAGTGAGTGAGTGTTAAGTGAAAGATGAGCTAGG TTGAAGAAAATATACATTTTATTGATGAGCCACTTTGCTATCTCTCCTTCCTTCCTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC CTTCTTTTCTTTTTTCTTTTCTTTTCTTTTCTCCCTCCTTTCTTCCTTCCCTTCCCTTCCCCTCCCCTCCCCCAGGCTGGAGTGCAGAGG CACGATCCTGGCTGACTGCAAACTCTGCCTACCAGGTTCAAGCGATTCTCCTGCCTCATCCTCCCTAGTAGCTAGGATTACAGGCATCTG CCACCACGCCCAGCTAATTTTTGTATTTTTACAAAATACAAAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAACTCCTGACC TCAGGTGATCCGTCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGTGTTACTGCCCCAGCCTCCTATTTCCTTTTCGAAAGTAG CAGTTTGGTTTATTCTCGTTTGCTAAGTAATTGTTTGAAATATTTTTCAGCCTCTCCTGCTCCCTCACAAAAATTCACCTGTCATTTTAA TGATAACAGCATGTTAAAAACTTGGAAGTCTTTATCCCAATATAAGAATTATCTTGAAACAAAAATCTAAATTACTTTTAAAAATTCTCT TAACTCTGCATTTAGTCTCCTATTATCTAGATCTCTGAGTCCAGGATAACTCCAGTTATCCCCAGTTGGATCATGTGTGATTTATCTGAG AAAGCATCCACAACCCACAGCTAGTGGAAACCGAGCTAGTTTACAGCCACGTGGATAAGAACATCTTTGTTTCTAAAGTGAGAGGAAAGT GCTTGGTATCTTGCTTTTTGCTGAGGGCAAAATAACAACATGAAGACAAAGTGCTTTTTGTTGTCTATTCATGAAACTGTAGAAGAATAT TTTGAGTTTTTATTCTTATATTATGAAGGGATTCTTTGCCTAGCAGTGGCCGTCAAACTGATGTAGCATTGTACTTCTCAACAGTGAAGC CTGTGTAATACCATACAGTAGGATGAAAGACTATTCTGAGCAAAATCAAATGGGATGTCAGAATCTTTGAAAATTATTTTATCATTTTTT CTATTTTTTCATTTTTATAAATTAGAAGGATTTTCCATTCAATAAGGATAATCTCTCTTCCTATCATTCTGTCAAAATGGCAGTTTCTTT TGGTAATTATCCAACCTAGTTTCATTACATTTAGAAGGAGGTTTCAGAGCTTATTCTTGATAACTATAATAATGATTTGAATGTTTTATA TCATGAAGTTTTTTCTATGAGGAAGGCTATTCTCAATGTATCTGTCGTCTAATTTTTTATTTTCTATCTATAAAGAATATTTAAATAATA ATTGGTGTATGTTCCTTTTGTTGAAAATGTTTTATTGTCCAGTTTTAACACAGAAGTGGTCTAAAGTTTTGCAGCAAATGCTGTTCAGTT CCCAGAAGCCTAAAAAACATAACATAATATGCTAACAGAGCTAATTTCCACCCAATCCCTCAAATTACCGAAGTATTAATATTTAGCTTC CTTTCTAGAAAACAAGGGGCAGCACAAATGGGGTGGCATCCATCTCTTTTAAATCACTGATGATTTTCTGGGGAAGTATATATAGATGAT TTTATTTTTTAAATAGCCTTTTATCAAACCATTTCACATGTATTATCTATATGACTATAGAAACTTATAAAACATTTAATTCATGTTGAC TTAAAACATGGGCATCCTTGGATTCTCCACATTGACTGAAATGATAGAGAAAGGGACATTTGTTTGAGAAACAAGAGACCTGTACCTAAT TATGGCAAGTATATGAGTTTTGGTGATTGTGGGGGGTTATAAATGTTTTCCTATGATAGATAAATATATAGATATAGATCAGGAATTACT TGATGTCTCTTCAGAAGTTTTCTGTTTTCTTATAATTTCCAGTAATACTCTGTAAGACTCGGTTTGCATGCTGTGTGTGTTTGCATGAGT ATAGAAACCTAAGAACATAATGGAAGGCTATTAAGGCAAATTCATTCCTAGAAAGTGGAGTGGATCATTGGGATAAGAAATAGCCTAATT ATAAACAAATATGCAGGCAGAGGGAAGTCCTAATACAATGAAAACTTGCATTATCTAAACAGATGTTCCCAAAGCAATAGTTTGCCTAAA ATCCTCTGTATTACATGATTATTCAGTAAAAGAGTAAACAAATATCTAATTTATTTTCTAATTGTCCTTCCCTTCATTGAGTATTAACTA GGTGCATAATGTAGTTGTATATGTTTACTAGTAAAGGGAAAAACACTTATTTTCATTTTGAGACTGTTTGGCTATTACTAAAGCTGAGAA AGTGATTTTAGGTCGCCAAGGATACTATGATTTGATGAGATGAGAAGAAATCTGCGGTGGCTGAAAATCGTGACCAACTTGGTGTTATCT AGATCTGCTTTATCTAGTTTGCAAGCCATAGGCTCAATTTTATGTCCTTCTTACTTACACACAGTAGCCCCACACAGTTTTGTTTTAAAT GAAGGCAAAAGTAGACATTTTTAAAGTATATTCAACATTGTGCCATTATTTACCTGATAAAGGTGAAATCAGAGGTGTCCACGGCCTCAA AGTTTGGGCCCATGGGACTATCAAATCCGAATTATATCTACTTAGAGCTTAGAGGAAGAATTAGGTATCATGAGAAAAGCAACTCCTACT TGAGAGAAAGAAGACTACCAAAGCATGTTGAGGCTTTAACATGGGAGACTTCCAGGTAGGCGTTAACACTTGAGTGGTAACTAGCTTGAT GAAGGAAAATAATTACTTTAGCAGTTATGTTGTAAAATTAATAAAAAGGACTCATGTTTATTCTGGTGTATTTGTCAACCCATGGGTAGT GATTACTCCGTGTACATTCTATAGTGTGTGTATTTTATTTAGTGTCTTAATATATAGTCTTTATATAGTATCTTAATATTATTTACTGTT ACTTCTAGTCATTTATGTAGTATATTTTACTGCAAAATTTGTAGCACTTTACTAATATTAGATCATTATTTTCCCTCTTCCCCTCTACCT TTCTGGCATTTTCTGTTATCTTAGAGTCAGGAATCTAAAGGTCTAAGTCTAGAAATCTGTTGGAAGCTGGGTTGGAGCTACTGGATATGA GTTACTTTTTACATGTCTCCTTAAGAAGACTCTTTTATAATGTAATACTTAGAAGCCAAATCCTTTCAAACGCAAACACCCTTGAAACTT GATGCTTTCTGAAGTTGTATTCATAAAAATTATCCCATCTTACAGTTAATCAGAAGATGTTCTTACCTTTGGTTTGCCTGCCTCCTGAAA CACAAACCTGCAGATTGCCCCTAACTTCAGCAGTGCCTCCGTCACTGCATGTACCTAAAAGACAGGAAAGCCAAGTTCTGGGAGCTGTCA AGTCGGAGGATCAGGAAAATGGTGGGGAAGAGGTGACTGGAAAGGCAGGCACTAAAGATGGCAGGCTGCAAAAGCATTCTGAGTTCCCCT GTAACAGATAGGTTTTATGAACTCAGCTGTTTTCTTTTTTCTTTTTTTTTCTTTTGAGATGGAGTCTCACTCTGAGTCTCACTCTGTTGC CCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAGCCTCCACCTCCCGGTTTCAAGTGATTCTCCCACCTCAGCCTCCCGAGTAG TTAGGATTACAGGTGCCCACCACCACGCCCAACTAATTTTTGTATTTTTAGTAAAGACAGGGTGTCGCCATATTGGCTAGGCTGGTTTTG AACTCCTGACCTCAGGTAATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTATTATAGGCGTGAGCCACCATGCCCAGTGAACTTGGC CATTTTCTTACATTCATATATAGCAAAGTTTTCAACTTGTCTACCGAGAGACTTTCTTTAGGAGCCAGGACTTCTACATTTGTAACTTGA GTATATTAATATTCAAATCATAGTTCAAAAATACTGAAATACTTGTTTATTATGTTACATAAATATGGACACAATTACTGCCAAAGAATA GAGAGATTTGCTTATGAGAACATTCTGTCATTTGTTCTGTTTGTAGATGAGAGACATGCTTTTAAAGTACAAAACGTTTCTCTTCTACCT TACCCCCTGTTCTACTGACGTGCTTTGCATGAGAAGCTCATCTAGAAGAGAGCAACGCTGGAATAGAGAAGTCTAGACCCTGGCCTTTGA GGGAAAGGACTGCTTTTTTTCTCTCCCAAATTAGAAAATTAAAAGTGAAACATAACACATAAGGACGAAATACAATGTTCTGAATATCTT CCACTAATTAATTGTTGAATGATTAAGTCTCTAAGTATCTTAACTTCCATTGTCTTCTTGTTAACCTAGACAAGAGTAGATTATTCAGTA GCCACATGTGACAGTTAAAATTAAGTAAAATTAAAACTATAGTTTCTCAGTGGCCTAGCCACATTTCAAGTGTTCCACAGTCACATGTGG ATAGTAGTTACCTATCAGACAGTACAGGTATAGAACATTTCCAGTATTGCCAAAAATGCTATTCAACAGCACTTTTATTGCCCAGAGAGA AAATAAGGACAAAATAAAGGCAGTGAAGTAACTTAAGACAACTCTGAGATTTTACCACCATACTTAGAGAAAGTTTTTCTGTTATAAAAA TTAATACTAATCCTTTTTAAAGACCTTGGAAAAAATCAAAACCCCATTCCTTTAAGCTAGTCTTCAGTATATATTTTTCTAAGAACAGAT TCTCAATACTTTATTTTTCAAGTGATAAAATCATTTTATAAATCATTTCTTAATATCTTCAGTGTTTTTTCCCTTTTTATGTAAACTCTT TTAAAATTGATATTAGCTGGGCATGGTAGCTCATGCCTGTAGTCCCAGCTACTCCAGAGGTCGAGGCAGGAGCATCGCTTAAGCCCAGGA GGTTCAGGCTGCAGTAAGGTCTGATCACACCTGACTGCACTCCAGCCTGGGTGGCAAAGCAAGACCCCTGTCTCTAAAAAAAAATAATAT AAATTGATGTTATATAGTTAACATTTATCAGGCAAATTCATATGAATGCTTATTTCAAATAAAGATTGATAGATTTAATGATATCCTTCC TTTTAAATTTATATAGATCTAATGAACATTGCCAACAGTTTTTTTTGTTTCTGTCCCTTAAACATTTCCCCTGAAAGTCCACCTCAAAGG TACATCAAGATGCAAACAATTTTTTTATCTTCATAACTTCCTGCTCTTATTAACTTGTATTATGAATCAAATTAAGTTTTATGTATAAGG CATTTACTATTCCAGTGACTTAGCTAATGAAAACATTTAAAAATATGTATTAATTTACTTGGCCTGCTACTAAAGTGCTTAACATAACTA AATGGATCTATAGTAACATGTCTAAATTTTTTAATGGAAATAAGGGACTAACCATAATCCTTTTGAGTCAGCTTGGTGCTTACAATTATT TTGTTAGGAAATCTTGATGCTTTCTTCTTTCTCTTTAAATTTTTGTAATCAAGCAACAGACTTGATCCAGCAGTGTCGAATTCCAAGCAA GTTATGATGATTCTTATTGTAGTTCAAGTACAGATGAGTAAGTGGTGTGACTTCAGTTTATTATCTTCTTGGTGACCTACTTTAGTATGT GTTCTGTAGCGATTCATATTAGTTAAGGGACGTTTTCAATATGCTTGAAATAAGAAATAGCATTTTACTCTAAATACAAGAAATGACTGT ACACAAATGCTAATCAGTGATTTGGGGCCTTTTAATGTCTTTAACAGCAATCTTTTATTTATTTATTTATTTATTTTTGAGACGGAGTCT TGCTGTGTCACCAGGCTGGAGCAGTGGCACGATCTCGCCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCTATTCTCCTGCCTCAGCCTC CCAAGTAACTGGGACTGCAGGCACATGCCACCACATCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTGGCCAGGA TGATCTCGATCTCTTGATCTCGTGATCTGCCCGCATTGGCCTCCTGAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCAAAT CTTTTATTTTTTAACAGCCTTAGTTATTTATAATTCAAATGCACTAAAATATCATCGCTGTCATGAACTTTGCTGTTTACAGGTTCTGTG TAATTCAGAATGCTTTGTACTTAGAAAATAATTTCTAGGCTTATCTTGTTTTGCAGTTTTCATGTTTTGACAATTGCCCACCATTTACAA TACTCAATTTTTGATTATGAAATGAATAGTAAAATTCAAACATATCTAATAATAATTTGCCTTAGTTTGATTAATAAATTATATCAAAAA ACTTGGGGATAGAAAGAGGCTTTTTTTTCCCCCTGTAGTATTTTTAAAACTTTTTAGATGAGCTGGATGAAACCTTAGTACATTGGAGCT GGAGTTGTATTGAGTACAGCCCCAACTCTGAAGCCTTATATTCATGTCTTAAGTACCATTGATTGTTCTGTGAATTGTTGTTAGTTTCAT ATTTGACATTGTAGTAATCCACCTTGCATTTTAGTCTTTGCAAAAAGGATATTGCTAGGTATATTCTTATTTCTGATTGAGTATTGAATT TACATTTTTCAGAATTTCATTCTTTGTCATTATAATCCAAAAACAATGTCCACATCAGACTTGGAACTTCTCACTTCAAAAATGAAATAC AGATTTAGCAGTGTTGTACATAATGATGTCCAAGCATTTTTCCACCTGTTTACTGAGTTTTCCAACCATTTACTATGTGTTGAGATTGGT GGGTTTTCTGGCTGTTTTTCTGAGGTGAATGACTTGTTACAGAGCCTCAGTAAGAAATTTCAACTAAAATCACAAAAACATAAAGTCCAG GAAACCACCAGAAGATGGATTTTTAGTGTTTTTGAAATCTTGTATTTCCTTTTGATATCATTTACTCATTTTAATTTTACGACTGCCAAC TTGTTACGGTATTAATTATATGTATGTGTTTATATGTATGCATATAATATATGTATATGTATATGAAGAATAAAGTTAAGATTTGGTCAA ACTATATTTTCCCATTCAAGTACAAAAATGTTTTCAAGGCTGCAAAAAGTGTACAGTTGTTAAACAAGTTGTAAATAAAGACTTGTATAA |
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FusionGenePPI for POLB_HOOK3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| POLB | TAF1D, XRCC1, NEIL1, TLE1, KAT7, PNKP, WRN, NCAPG, PCNA, PARP1, STUB1, HUWE1, UNG, SRPK2, TPP2, APEX1, EP300, XPC, SUPT16H, LIG3, TDP1, PARP2, SSRP1, APLF, HIST1H2AG, HIST2H2AB, BCKDHB, CETN2, APTX, BCKDHA, HSD17B7, HIST1H2BG, XRCC3, EMC2, MMGT1 | HOOK3 | CUL3, AKTIP, HOOK1, HOOK2, HOOK3, FAM160A2, VPS16, VPS41, SCFD1, CCDC8, ZC4H2, COMTD1, TNFSF13B, IFT57, FNTB, MRE11A, NTRK1, SSX2IP, CEP63, DUSP3, FAM160A1, MTMR4, SYCE3, RALBP1, CDC16, NCAPH2, KLHL10, KLHL20 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for POLB_HOOK3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | POLB | P06746 | DB01592 | Iron | DNA polymerase beta | small molecule | approved |
| Hgene | POLB | P06746 | DB00987 | Cytarabine | DNA polymerase beta | small molecule | approved|investigational |
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RelatedDiseases for POLB_HOOK3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | POLB | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | POLB | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | POLB | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
| Tgene | HOOK3 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
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