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Fusion gene ID: 27844 |
FusionGeneSummary for PNO1_SHROOM3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PNO1_SHROOM3 | Fusion gene ID: 27844 | Hgene | Tgene | Gene symbol | PNO1 | SHROOM3 | Gene ID | 56902 | 57619 |
| Gene name | partner of NOB1 homolog | shroom family member 3 | |
| Synonyms | KHRBP1|RRP20 | APXL3|MSTP013|SHRM|ShrmL | |
| Cytomap | 2p14 | 4q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein PNO1KH-type RNA-binding protein 1RNA binding protein | protein Shroom3F-actin-binding proteinshroom-related protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NRX1 | Q8TF72 | |
| Ensembl transtripts involved in fusion gene | ENST00000263657, | ENST00000296043, ENST00000473602, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 3 X 4=72 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PNO1 [Title/Abstract] AND SHROOM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-85-8072-01A | PNO1 | chr2 | 68385661 | + | SHROOM3 | chr4 | 77476762 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263657 | ENST00000296043 | PNO1 | chr2 | 68385661 | + | SHROOM3 | chr4 | 77476762 | + |
| 5CDS-intron | ENST00000263657 | ENST00000473602 | PNO1 | chr2 | 68385661 | + | SHROOM3 | chr4 | 77476762 | + |
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FusionProtFeatures for PNO1_SHROOM3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PNO1 | SHROOM3 |
| Positively regulates dimethylation of two adjacentadenosines in the loop of a conserved hairpin near the 3'-end of18S rRNA (PubMed:25851604). {ECO:0000269|PubMed:25851604}. | Controls cell shape changes in the neuroepitheliumduring neural tube closure. Induces apical constriction inepithelial cells by promoting the apical accumulation of F-actinand myosin II, and probably by bundling stress fibers. Inducesapicobasal cell elongation by redistributing gamma-tubulin anddirecting the assembly of robust apicobasal microtubule arrays (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SHROOM3 | chr2:68385661 | chr4:77476762 | ENST00000296043 | + | 0 | 11 | 1669_1957 | 56 | 1997 | Domain | ASD2 |
| Tgene | >SHROOM3 | chr2:68385661 | chr4:77476762 | ENST00000296043 | + | 0 | 11 | 928_1030 | 56 | 1997 | Domain | ASD1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PNO1 | chr2:68385661 | chr4:77476762 | ENST00000263657 | + | 2 | 7 | 173_225 | 119 | 253 | Domain | Note=KH |
| Tgene | SHROOM3 | chr2:68385661 | chr4:77476762 | ENST00000296043 | + | 0 | 11 | 25_110 | 56 | 1997 | Domain | PDZ |
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FusionGeneSequence for PNO1_SHROOM3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PNO1_ENST00000263657_chr2_68385661_+_SHROOM3_ENST00000296043_chr4_77476762_+_2060aa MESEMETQSARAEEGFTQVTRKGGRRAKKRQAEQLSAAGEGGDAGRMDTEEARPAKRPVFPPLCGDGLLSGKEETRKIPVPANRYTPLKE NWMKIFTPIVEHLGLQIRFNLKSRNVEIRVEEGGKADTLSSKLQAGDEVVHINEVTLSSSRKEAVSLVKGSYKTLRLVVRRDVCTDPGHA DTGASNFVSPEHLTSGPQHRKAAWSGGVKLRLKHRRSEPAGRPHSWHTTKSGEKQPDASMMQISQGMIGPPWHQSYHSSSSTSDLSNYDH AYLRRSPDQCSSQGSMESLEPSGAYPPCHLSPAKSTGSIDQLSHFHNKRDSAYSSFSTSSSILEYPHPGISGRERSGSMDNTSARGGLLE GMRQADIRYVKTVYDTRRGVSAEYEVNSSALLLQGREARASANGQGYDKWSNIPRGKGVPPPSWSQQCPSSLETATDNLPPKVGAPLPPA RSDSYAAFRHRERPSSWSSLDQKRLCRPQANSLGSLKSPFIEEQLHTVLEKSPENSPPVKPKHNYTQKAQPGQPLLPTSIYPVPSLEPHF AQVPQPSVSSNGMLYPALAKESGYIAPQGACNKMATIDENGNQNGSGRPGFAFCQPLEHDLLSPVEKKPEATAKYVPSKVHFCSVPENEE DASLKRHLTPPQGNSPHSNERKSTHSNKPSSHPHSLKCPQAQAWQAGEDKRSSRLSEPWEGDFQEDHNANLWRRLEREGLGQSLSGNFGK TKSAFSSLQNIPESLRRHSSLELGRGTQEGYPGGRPTCAVNTKAEDPGRKAAPDLGSHLDRQVSYPRPEGRTGASASFNSTDPSPEEPPA PSHPHTSSLGRRGPGPGSASALQGFQYGKPHCSVLEKVSKFEQREQGSQRPSVGGSGFGHNYRPHRTVSTSSTSGNDFEETKAHIRFSES AEPLGNGEQHFKNGELKLEEASRQPCGQQLSGGASDSGRGPQRPDARLLRSQSTFQLSSEPEREPEWRDRPGSPESPLLDAPFSRAYRNS IKDAQSRVLGATSFRRRDLELGAPVASRSWRPRPSSAHVGLRSPEASASASPHTPRERHSVTPAEGDLARPVPPAARRGARRRLTPEQKK RSYSEPEKMNEVGIVEEAEPAPLGPQRNGMRFPESSVADRRRLFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTSAAGCSLQ EPGPLRERAQSAYLQPGPAALEGSGLASASSLSSLREPSLQPRREATLLPATVAETQQAPRDRSSSFAGGRRLGERRRGDLLSGANGGTR GTQRGDETPREPSSWGARAGKSMSAEDLLERSDVLAGPVHVRSRSSPATADKRQDVLLGQDSGFGLVKDPCYLAGPGSRSLSCSERGQEE MLPLFHHLTPRWGGSGCKAIGDSSVPSECPGTLDHQRQASRTPCPRPPLAGTQGLVTDTRAAPLTPIGTPLPSAIPSGYCSQDGQTGRQP LPPYTPAMMHRSNGHTLTQPPGPRGCEGDGPEHGVEEGTRKRVSLPQWPPPSRAKWAHAAREDSLPEESSAPDFANLKHYQKQQSLPSLC STSDPDTPLGAPSTPGRISLRISESVLRDSPPPHEDYEDEVFVRDPHPKATSSPTFEPLPPPPPPPPSQETPVYSMDDFPPPPPHTVCEA QLDSEDPEGPRPSFNKLSKVTIARERHMPGAAHVVGSQTLASRLQTSIKGSEAESTPPSFMSVHAQLAGSLGGQPAPIQTQSLSHDPVSG TQGLEKKVSPDPQKSSEDIRTEALAKEIVHQDKSLADILDPDSRLKTTMDLMEGLFPRDVNLLKENSVKRKAIQRTVSSSGCEGKRNEDK EAVSMLVNCPAYYSVSAPKAELLNKIKEMPAEVNEEEEQADVNEKKAELIGSLTHKLETLQEAKGSLLTDIKLNNALGEEVEALISELCK PNEFDKYRMFIGDLDKVVNLLLSLSGRLARVENVLSGLGEDASNEERSSLYEKRKILAGQHEDARELKENLDRRERVVLGILANYLSEEQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PNO1_ENST00000263657_chr2_68385661_+_SHROOM3_ENST00000296043_chr4_77476762_+_6180nt ATGGAATCCGAAATGGAAACGCAGAGCGCCAGGGCAGAGGAGGGCTTTACCCAGGTCACCCGCAAGGGTGGCCGACGGGCGAAGAAACGA CAGGCTGAACAGCTGTCCGCAGCAGGAGAGGGCGGGGATGCGGGCCGCATGGACACAGAGGAGGCCAGGCCGGCGAAGAGGCCCGTCTTC CCACCCCTCTGTGGGGACGGGCTCCTGAGTGGGAAAGAAGAAACAAGGAAAATTCCAGTCCCAGCTAACAGATACACACCATTGAAAGAA AACTGGATGAAGATATTTACTCCTATTGTGGAACATTTGGGACTTCAGATACGCTTTAACTTGAAATCAAGGAATGTAGAAATCAGGGTC GAAGAAGGGGGCAAAGCAGACACCCTGAGCTCCAAACTGCAGGCTGGGGATGAGGTTGTGCACATCAATGAGGTGACTCTGAGCAGCTCC AGAAAGGAGGCAGTTTCCCTGGTGAAAGGATCCTACAAGACCCTCAGGCTGGTAGTGCGCAGAGATGTGTGCACAGACCCAGGCCATGCA GATACTGGTGCCTCTAACTTCGTCAGCCCAGAACACCTCACCTCTGGCCCCCAGCACAGGAAAGCAGCGTGGTCAGGAGGGGTTAAACTT CGGCTGAAGCACAGGCGCAGTGAGCCTGCAGGCCGACCTCACTCGTGGCACACAACTAAATCTGGGGAGAAGCAACCCGATGCCAGCATG ATGCAGATATCTCAGGGTATGATCGGCCCTCCTTGGCACCAAAGCTACCATTCCAGCTCCTCTACTAGTGACCTCTCCAACTATGACCAT GCTTATCTAAGGCGGAGCCCTGACCAGTGCAGCTCCCAGGGGAGCATGGAGAGCCTGGAGCCCAGTGGGGCATACCCACCCTGTCATCTT TCCCCTGCCAAGTCCACCGGCAGCATTGACCAGCTCAGCCACTTCCATAACAAGAGAGACTCGGCTTACAGCTCTTTCTCCACCAGTTCT AGCATCCTAGAGTATCCACACCCTGGCATCTCTGGCCGGGAGCGTTCAGGCTCCATGGACAATACTTCTGCTCGAGGTGGCCTCCTCGAA GGGATGAGGCAGGCAGATATTCGCTATGTCAAGACAGTCTATGACACCCGGAGGGGAGTCTCAGCAGAGTATGAGGTGAACTCTTCAGCC CTGCTGCTTCAAGGTAGGGAGGCCCGAGCCTCAGCAAATGGTCAGGGCTATGATAAATGGTCTAATATTCCTCGGGGCAAGGGAGTGCCA CCCCCATCCTGGAGCCAGCAGTGCCCCAGTTCCTTGGAGACTGCCACGGACAACCTTCCTCCTAAGGTGGGTGCACCCCTGCCTCCAGCT CGGAGTGACAGTTACGCAGCATTTCGGCACCGTGAGCGGCCCAGCTCCTGGTCTAGCCTTGATCAGAAACGGCTCTGCCGGCCTCAGGCA AACTCTTTAGGCTCCCTGAAGTCTCCATTCATAGAGGAGCAGCTGCATACTGTGCTGGAGAAGAGTCCAGAGAACAGCCCCCCAGTGAAG CCCAAGCATAACTATACCCAGAAGGCCCAACCTGGCCAACCTCTGCTGCCGACCAGCATCTACCCGGTACCTTCCCTGGAGCCACACTTT GCCCAGGTGCCTCAGCCTTCTGTGAGTAGCAACGGTATGCTCTACCCTGCACTGGCCAAGGAGAGTGGATACATAGCCCCTCAGGGAGCA TGCAACAAGATGGCTACCATTGATGAGAATGGGAACCAGAATGGATCTGGCAGGCCTGGGTTTGCCTTCTGCCAGCCCTTAGAACATGAC TTGCTGTCCCCAGTGGAGAAGAAACCAGAAGCTACAGCCAAGTATGTCCCCTCCAAAGTCCATTTCTGTTCAGTGCCTGAAAATGAGGAG GATGCCTCCCTGAAGAGACATCTCACACCTCCCCAAGGCAACAGCCCACATTCCAATGAGAGAAAGAGCACCCACAGTAACAAACCATCT TCTCATCCCCACAGCCTCAAATGCCCTCAGGCTCAGGCCTGGCAAGCGGGTGAAGACAAGAGATCTTCCAGGCTCTCAGAGCCCTGGGAG GGCGATTTCCAGGAAGACCACAATGCCAACCTCTGGAGGAGGCTGGAGAGAGAAGGCCTAGGCCAGAGCCTGTCAGGCAACTTTGGCAAG ACCAAGTCAGCCTTCTCATCTCTCCAGAACATTCCTGAGAGTCTGAGAAGACACAGCAGCCTGGAGCTAGGCCGGGGAACCCAGGAGGGT TACCCCGGGGGCAGGCCCACCTGTGCAGTCAACACCAAGGCAGAAGACCCTGGGAGGAAAGCCGCTCCTGACCTCGGGAGCCATCTGGAC CGGCAGGTTTCCTACCCGCGGCCCGAGGGGAGGACCGGTGCCTCGGCTTCTTTCAACAGCACAGACCCAAGTCCCGAAGAGCCGCCTGCC CCCTCGCACCCGCACACATCCAGTCTGGGCCGGAGGGGGCCCGGCCCAGGCAGCGCCTCGGCTCTTCAGGGCTTTCAGTACGGGAAGCCC CACTGCTCGGTGCTGGAGAAGGTCTCCAAATTCGAGCAGCGAGAGCAAGGGAGCCAGAGACCGAGTGTGGGCGGCTCTGGTTTTGGCCAT AACTATAGGCCCCACAGGACCGTCTCAACTTCCAGTACTTCTGGGAATGACTTCGAGGAGACAAAAGCACACATTCGTTTCTCTGAGTCA GCTGAACCCCTAGGCAACGGGGAGCAGCACTTCAAAAACGGGGAGCTGAAGTTGGAAGAGGCTTCCCGGCAGCCCTGCGGTCAGCAGCTG AGCGGAGGAGCGTCGGACAGCGGCCGTGGCCCCCAGAGGCCGGACGCTCGGCTCCTCCGTAGCCAGAGCACCTTCCAGCTCTCCAGCGAG CCAGAGAGGGAGCCCGAGTGGCGGGACAGGCCCGGCTCGCCCGAATCGCCCCTGCTGGATGCCCCCTTCAGCCGCGCCTACCGGAACAGC ATCAAGGACGCACAGTCCCGTGTCTTGGGGGCCACCTCCTTTCGACGTCGAGACCTGGAGCTGGGGGCGCCCGTGGCGTCGAGGTCCTGG CGGCCACGGCCTTCCTCGGCCCACGTGGGGCTGCGGAGCCCCGAGGCGTCGGCCTCCGCCTCCCCGCACACGCCCCGGGAGCGGCACAGC GTGACCCCTGCTGAGGGCGACCTGGCCAGGCCCGTGCCCCCTGCCGCCCGGAGAGGTGCTCGCCGGCGCCTGACTCCCGAGCAGAAGAAG CGCTCCTACTCGGAGCCCGAGAAGATGAACGAGGTGGGGATCGTGGAGGAGGCCGAACCGGCACCCCTGGGCCCGCAGAGAAATGGGATG CGTTTCCCGGAGAGCAGCGTGGCCGACCGGCGCCGTCTCTTCGAGCGCGATGGCAAGGCCTGCTCCACGCTCAGCCTGTCGGGGCCCGAG CTGAAGCAGTTCCAGCAGAGCGCCCTGGCGGACTACATCCAGCGCAAGACCGGCAAGCGGCCTACCTCCGCCGCCGGCTGCAGCCTCCAG GAGCCCGGGCCACTGCGTGAGCGCGCCCAGAGTGCCTACCTCCAGCCCGGCCCCGCGGCGCTCGAAGGCTCCGGCCTCGCCTCGGCCTCC AGCTTGAGCTCACTGCGGGAGCCCAGCCTGCAGCCCCGCAGGGAGGCCACGCTCCTGCCGGCCACAGTTGCAGAAACCCAGCAGGCTCCC CGAGATCGCAGCAGCTCCTTCGCCGGTGGCCGCCGCCTCGGGGAACGGCGACGCGGGGACCTGCTTAGCGGAGCAAACGGTGGAACAAGG GGCACCCAGAGAGGGGATGAGACCCCCAGGGAGCCATCCTCCTGGGGGGCCAGGGCCGGGAAGTCCATGTCGGCCGAGGACCTGCTGGAA CGCTCGGACGTCCTTGCGGGCCCTGTCCATGTGAGGTCCAGGTCATCTCCCGCCACCGCAGACAAGCGCCAGGATGTGCTTTTGGGGCAA GACAGTGGCTTTGGTCTTGTGAAGGATCCATGTTATTTGGCTGGTCCTGGATCTAGGTCACTCAGTTGTTCAGAAAGAGGCCAAGAAGAG ATGCTGCCGCTCTTCCACCATCTCACCCCTCGTTGGGGTGGTTCAGGCTGCAAAGCCATTGGTGATTCCTCCGTTCCTAGTGAATGTCCT GGAACCCTGGACCATCAGAGGCAAGCCAGTAGGACACCCTGCCCCAGGCCACCACTGGCAGGAACGCAAGGGCTGGTCACAGACACCAGG GCTGCACCCCTGACCCCAATTGGCACCCCTCTGCCTTCAGCCATTCCCTCTGGCTACTGCTCACAGGACGGTCAGACAGGGCGACAGCCT CTCCCGCCCTACACCCCTGCCATGATGCACAGAAGCAATGGTCACACCCTGACCCAGCCTCCCGGTCCAAGAGGCTGTGAGGGCGATGGC CCAGAGCATGGGGTAGAAGAGGGAACGAGGAAGAGGGTCTCGCTGCCTCAGTGGCCACCTCCTTCTCGAGCAAAGTGGGCCCACGCAGCC AGAGAGGACAGCCTTCCTGAGGAATCCTCAGCCCCTGATTTTGCAAACCTGAAGCACTATCAAAAACAGCAGAGTCTTCCAAGTTTATGC AGCACTTCTGACCCAGACACACCTCTTGGGGCCCCGAGCACTCCAGGGAGGATCTCCCTCCGAATATCTGAGTCTGTCCTGCGGGACTCC CCGCCACCTCATGAGGATTATGAAGACGAAGTGTTTGTGAGGGATCCGCACCCCAAGGCCACGTCCAGCCCCACATTTGAACCTCTTCCC CCACCCCCACCTCCTCCACCGAGTCAGGAAACCCCGGTGTATAGCATGGATGACTTCCCTCCACCTCCTCCCCACACTGTATGTGAGGCG CAGCTGGACAGTGAGGATCCCGAGGGGCCACGCCCCAGCTTCAACAAACTTTCTAAAGTGACAATTGCAAGGGAAAGGCACATGCCTGGT GCAGCCCATGTGGTAGGTAGTCAGACACTGGCTTCCAGACTCCAAACTTCTATCAAGGGTTCAGAGGCTGAGTCCACACCACCCTCCTTC ATGAGCGTTCACGCCCAACTTGCTGGGTCTCTTGGTGGGCAGCCAGCACCCATCCAGACTCAAAGCCTCAGCCATGATCCAGTCAGTGGA ACTCAGGGTTTAGAAAAGAAAGTCAGTCCTGATCCTCAGAAGAGTTCAGAAGACATCAGAACAGAGGCTTTGGCCAAGGAAATTGTCCAC CAAGACAAATCTCTAGCAGACATTTTGGATCCAGACTCCAGGCTGAAGACAACAATGGACCTGATGGAAGGTTTGTTTCCCCGAGATGTG AACTTGCTGAAGGAAAACAGTGTAAAGAGGAAGGCCATACAGAGAACTGTCAGCTCTTCAGGATGTGAAGGCAAGAGGAATGAAGACAAG GAAGCAGTGAGCATGTTGGTTAACTGCCCTGCCTACTACAGTGTGTCTGCTCCCAAGGCTGAGCTACTGAACAAAATCAAAGAGATGCCA GCAGAAGTGAATGAGGAAGAGGAACAGGCAGATGTCAATGAAAAGAAGGCTGAGCTCATTGGAAGTCTCACCCACAAGCTGGAGACCCTC CAGGAGGCGAAGGGGAGCCTGCTCACGGACATCAAGCTCAACAACGCCCTGGGAGAAGAGGTGGAGGCTCTGATCAGCGAGCTCTGCAAG CCCAATGAGTTTGACAAGTATAGGATGTTCATAGGGGATTTGGACAAGGTGGTCAACCTGCTGCTCTCCCTCTCGGGGCGTCTAGCCCGT GTTGAGAATGTCCTTAGCGGCCTTGGTGAAGATGCCAGTAATGAAGAAAGGAGCTCTCTTTACGAGAAAAGGAAGATCCTGGCTGGTCAG CATGAGGATGCCCGGGAGCTGAAGGAGAACCTGGATCGCAGGGAGCGAGTAGTGCTGGGCATCTTGGCCAATTACCTTTCAGAGGAGCAG CTCCAGGACTACCAGCACTTCGTGAAAATGAAGTCCACGCTCCTCATTGAGCAACGGAAGCTGGATGACAAGATCAAGCTGGGCCAGGAG CAGGTCAAGTGTCTGCTGGAGAGCCTGCCCTCAGATTTCATTCCCAAGGCTGGGGCCCTGGCTCTGCCCCCAAACCTCACGAGTGAGCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PNO1_ENST00000263657_chr2_68385661_+_SHROOM3_ENST00000296043_chr4_77476762_+_10347nt GCGGAGCTGCAGGGGTGGTTGGCTGAGGCTGGCTTCTGCGTGGTGCAGCTGCGCACGTGTTTCAGCCGGCAGCGCTTTAAGATTTCCGGG GATGGAATCCGAAATGGAAACGCAGAGCGCCAGGGCAGAGGAGGGCTTTACCCAGGTCACCCGCAAGGGTGGCCGACGGGCGAAGAAACG ACAGGCTGAACAGCTGTCCGCAGCAGGAGAGGGCGGGGATGCGGGCCGCATGGACACAGAGGAGGCCAGGCCGGCGAAGAGGCCCGTCTT CCCACCCCTCTGTGGGGACGGGCTCCTGAGTGGGAAAGAAGAAACAAGGAAAATTCCAGTCCCAGCTAACAGATACACACCATTGAAAGA AAACTGGATGAAGATATTTACTCCTATTGTGGAACATTTGGGACTTCAGATACGCTTTAACTTGAAATCAAGGAATGTAGAAATCAGGGT CGAAGAAGGGGGCAAAGCAGACACCCTGAGCTCCAAACTGCAGGCTGGGGATGAGGTTGTGCACATCAATGAGGTGACTCTGAGCAGCTC CAGAAAGGAGGCAGTTTCCCTGGTGAAAGGATCCTACAAGACCCTCAGGCTGGTAGTGCGCAGAGATGTGTGCACAGACCCAGGCCATGC AGATACTGGTGCCTCTAACTTCGTCAGCCCAGAACACCTCACCTCTGGCCCCCAGCACAGGAAAGCAGCGTGGTCAGGAGGGGTTAAACT TCGGCTGAAGCACAGGCGCAGTGAGCCTGCAGGCCGACCTCACTCGTGGCACACAACTAAATCTGGGGAGAAGCAACCCGATGCCAGCAT GATGCAGATATCTCAGGGTATGATCGGCCCTCCTTGGCACCAAAGCTACCATTCCAGCTCCTCTACTAGTGACCTCTCCAACTATGACCA TGCTTATCTAAGGCGGAGCCCTGACCAGTGCAGCTCCCAGGGGAGCATGGAGAGCCTGGAGCCCAGTGGGGCATACCCACCCTGTCATCT TTCCCCTGCCAAGTCCACCGGCAGCATTGACCAGCTCAGCCACTTCCATAACAAGAGAGACTCGGCTTACAGCTCTTTCTCCACCAGTTC TAGCATCCTAGAGTATCCACACCCTGGCATCTCTGGCCGGGAGCGTTCAGGCTCCATGGACAATACTTCTGCTCGAGGTGGCCTCCTCGA AGGGATGAGGCAGGCAGATATTCGCTATGTCAAGACAGTCTATGACACCCGGAGGGGAGTCTCAGCAGAGTATGAGGTGAACTCTTCAGC CCTGCTGCTTCAAGGTAGGGAGGCCCGAGCCTCAGCAAATGGTCAGGGCTATGATAAATGGTCTAATATTCCTCGGGGCAAGGGAGTGCC ACCCCCATCCTGGAGCCAGCAGTGCCCCAGTTCCTTGGAGACTGCCACGGACAACCTTCCTCCTAAGGTGGGTGCACCCCTGCCTCCAGC TCGGAGTGACAGTTACGCAGCATTTCGGCACCGTGAGCGGCCCAGCTCCTGGTCTAGCCTTGATCAGAAACGGCTCTGCCGGCCTCAGGC AAACTCTTTAGGCTCCCTGAAGTCTCCATTCATAGAGGAGCAGCTGCATACTGTGCTGGAGAAGAGTCCAGAGAACAGCCCCCCAGTGAA GCCCAAGCATAACTATACCCAGAAGGCCCAACCTGGCCAACCTCTGCTGCCGACCAGCATCTACCCGGTACCTTCCCTGGAGCCACACTT TGCCCAGGTGCCTCAGCCTTCTGTGAGTAGCAACGGTATGCTCTACCCTGCACTGGCCAAGGAGAGTGGATACATAGCCCCTCAGGGAGC ATGCAACAAGATGGCTACCATTGATGAGAATGGGAACCAGAATGGATCTGGCAGGCCTGGGTTTGCCTTCTGCCAGCCCTTAGAACATGA CTTGCTGTCCCCAGTGGAGAAGAAACCAGAAGCTACAGCCAAGTATGTCCCCTCCAAAGTCCATTTCTGTTCAGTGCCTGAAAATGAGGA GGATGCCTCCCTGAAGAGACATCTCACACCTCCCCAAGGCAACAGCCCACATTCCAATGAGAGAAAGAGCACCCACAGTAACAAACCATC TTCTCATCCCCACAGCCTCAAATGCCCTCAGGCTCAGGCCTGGCAAGCGGGTGAAGACAAGAGATCTTCCAGGCTCTCAGAGCCCTGGGA GGGCGATTTCCAGGAAGACCACAATGCCAACCTCTGGAGGAGGCTGGAGAGAGAAGGCCTAGGCCAGAGCCTGTCAGGCAACTTTGGCAA GACCAAGTCAGCCTTCTCATCTCTCCAGAACATTCCTGAGAGTCTGAGAAGACACAGCAGCCTGGAGCTAGGCCGGGGAACCCAGGAGGG TTACCCCGGGGGCAGGCCCACCTGTGCAGTCAACACCAAGGCAGAAGACCCTGGGAGGAAAGCCGCTCCTGACCTCGGGAGCCATCTGGA CCGGCAGGTTTCCTACCCGCGGCCCGAGGGGAGGACCGGTGCCTCGGCTTCTTTCAACAGCACAGACCCAAGTCCCGAAGAGCCGCCTGC CCCCTCGCACCCGCACACATCCAGTCTGGGCCGGAGGGGGCCCGGCCCAGGCAGCGCCTCGGCTCTTCAGGGCTTTCAGTACGGGAAGCC CCACTGCTCGGTGCTGGAGAAGGTCTCCAAATTCGAGCAGCGAGAGCAAGGGAGCCAGAGACCGAGTGTGGGCGGCTCTGGTTTTGGCCA TAACTATAGGCCCCACAGGACCGTCTCAACTTCCAGTACTTCTGGGAATGACTTCGAGGAGACAAAAGCACACATTCGTTTCTCTGAGTC AGCTGAACCCCTAGGCAACGGGGAGCAGCACTTCAAAAACGGGGAGCTGAAGTTGGAAGAGGCTTCCCGGCAGCCCTGCGGTCAGCAGCT GAGCGGAGGAGCGTCGGACAGCGGCCGTGGCCCCCAGAGGCCGGACGCTCGGCTCCTCCGTAGCCAGAGCACCTTCCAGCTCTCCAGCGA GCCAGAGAGGGAGCCCGAGTGGCGGGACAGGCCCGGCTCGCCCGAATCGCCCCTGCTGGATGCCCCCTTCAGCCGCGCCTACCGGAACAG CATCAAGGACGCACAGTCCCGTGTCTTGGGGGCCACCTCCTTTCGACGTCGAGACCTGGAGCTGGGGGCGCCCGTGGCGTCGAGGTCCTG GCGGCCACGGCCTTCCTCGGCCCACGTGGGGCTGCGGAGCCCCGAGGCGTCGGCCTCCGCCTCCCCGCACACGCCCCGGGAGCGGCACAG CGTGACCCCTGCTGAGGGCGACCTGGCCAGGCCCGTGCCCCCTGCCGCCCGGAGAGGTGCTCGCCGGCGCCTGACTCCCGAGCAGAAGAA GCGCTCCTACTCGGAGCCCGAGAAGATGAACGAGGTGGGGATCGTGGAGGAGGCCGAACCGGCACCCCTGGGCCCGCAGAGAAATGGGAT GCGTTTCCCGGAGAGCAGCGTGGCCGACCGGCGCCGTCTCTTCGAGCGCGATGGCAAGGCCTGCTCCACGCTCAGCCTGTCGGGGCCCGA GCTGAAGCAGTTCCAGCAGAGCGCCCTGGCGGACTACATCCAGCGCAAGACCGGCAAGCGGCCTACCTCCGCCGCCGGCTGCAGCCTCCA GGAGCCCGGGCCACTGCGTGAGCGCGCCCAGAGTGCCTACCTCCAGCCCGGCCCCGCGGCGCTCGAAGGCTCCGGCCTCGCCTCGGCCTC CAGCTTGAGCTCACTGCGGGAGCCCAGCCTGCAGCCCCGCAGGGAGGCCACGCTCCTGCCGGCCACAGTTGCAGAAACCCAGCAGGCTCC CCGAGATCGCAGCAGCTCCTTCGCCGGTGGCCGCCGCCTCGGGGAACGGCGACGCGGGGACCTGCTTAGCGGAGCAAACGGTGGAACAAG GGGCACCCAGAGAGGGGATGAGACCCCCAGGGAGCCATCCTCCTGGGGGGCCAGGGCCGGGAAGTCCATGTCGGCCGAGGACCTGCTGGA ACGCTCGGACGTCCTTGCGGGCCCTGTCCATGTGAGGTCCAGGTCATCTCCCGCCACCGCAGACAAGCGCCAGGATGTGCTTTTGGGGCA AGACAGTGGCTTTGGTCTTGTGAAGGATCCATGTTATTTGGCTGGTCCTGGATCTAGGTCACTCAGTTGTTCAGAAAGAGGCCAAGAAGA GATGCTGCCGCTCTTCCACCATCTCACCCCTCGTTGGGGTGGTTCAGGCTGCAAAGCCATTGGTGATTCCTCCGTTCCTAGTGAATGTCC TGGAACCCTGGACCATCAGAGGCAAGCCAGTAGGACACCCTGCCCCAGGCCACCACTGGCAGGAACGCAAGGGCTGGTCACAGACACCAG GGCTGCACCCCTGACCCCAATTGGCACCCCTCTGCCTTCAGCCATTCCCTCTGGCTACTGCTCACAGGACGGTCAGACAGGGCGACAGCC TCTCCCGCCCTACACCCCTGCCATGATGCACAGAAGCAATGGTCACACCCTGACCCAGCCTCCCGGTCCAAGAGGCTGTGAGGGCGATGG CCCAGAGCATGGGGTAGAAGAGGGAACGAGGAAGAGGGTCTCGCTGCCTCAGTGGCCACCTCCTTCTCGAGCAAAGTGGGCCCACGCAGC CAGAGAGGACAGCCTTCCTGAGGAATCCTCAGCCCCTGATTTTGCAAACCTGAAGCACTATCAAAAACAGCAGAGTCTTCCAAGTTTATG CAGCACTTCTGACCCAGACACACCTCTTGGGGCCCCGAGCACTCCAGGGAGGATCTCCCTCCGAATATCTGAGTCTGTCCTGCGGGACTC CCCGCCACCTCATGAGGATTATGAAGACGAAGTGTTTGTGAGGGATCCGCACCCCAAGGCCACGTCCAGCCCCACATTTGAACCTCTTCC CCCACCCCCACCTCCTCCACCGAGTCAGGAAACCCCGGTGTATAGCATGGATGACTTCCCTCCACCTCCTCCCCACACTGTATGTGAGGC GCAGCTGGACAGTGAGGATCCCGAGGGGCCACGCCCCAGCTTCAACAAACTTTCTAAAGTGACAATTGCAAGGGAAAGGCACATGCCTGG TGCAGCCCATGTGGTAGGTAGTCAGACACTGGCTTCCAGACTCCAAACTTCTATCAAGGGTTCAGAGGCTGAGTCCACACCACCCTCCTT CATGAGCGTTCACGCCCAACTTGCTGGGTCTCTTGGTGGGCAGCCAGCACCCATCCAGACTCAAAGCCTCAGCCATGATCCAGTCAGTGG AACTCAGGGTTTAGAAAAGAAAGTCAGTCCTGATCCTCAGAAGAGTTCAGAAGACATCAGAACAGAGGCTTTGGCCAAGGAAATTGTCCA CCAAGACAAATCTCTAGCAGACATTTTGGATCCAGACTCCAGGCTGAAGACAACAATGGACCTGATGGAAGGTTTGTTTCCCCGAGATGT GAACTTGCTGAAGGAAAACAGTGTAAAGAGGAAGGCCATACAGAGAACTGTCAGCTCTTCAGGATGTGAAGGCAAGAGGAATGAAGACAA GGAAGCAGTGAGCATGTTGGTTAACTGCCCTGCCTACTACAGTGTGTCTGCTCCCAAGGCTGAGCTACTGAACAAAATCAAAGAGATGCC AGCAGAAGTGAATGAGGAAGAGGAACAGGCAGATGTCAATGAAAAGAAGGCTGAGCTCATTGGAAGTCTCACCCACAAGCTGGAGACCCT CCAGGAGGCGAAGGGGAGCCTGCTCACGGACATCAAGCTCAACAACGCCCTGGGAGAAGAGGTGGAGGCTCTGATCAGCGAGCTCTGCAA GCCCAATGAGTTTGACAAGTATAGGATGTTCATAGGGGATTTGGACAAGGTGGTCAACCTGCTGCTCTCCCTCTCGGGGCGTCTAGCCCG TGTTGAGAATGTCCTTAGCGGCCTTGGTGAAGATGCCAGTAATGAAGAAAGGAGCTCTCTTTACGAGAAAAGGAAGATCCTGGCTGGTCA GCATGAGGATGCCCGGGAGCTGAAGGAGAACCTGGATCGCAGGGAGCGAGTAGTGCTGGGCATCTTGGCCAATTACCTTTCAGAGGAGCA GCTCCAGGACTACCAGCACTTCGTGAAAATGAAGTCCACGCTCCTCATTGAGCAACGGAAGCTGGATGACAAGATCAAGCTGGGCCAGGA GCAGGTCAAGTGTCTGCTGGAGAGCCTGCCCTCAGATTTCATTCCCAAGGCTGGGGCCCTGGCTCTGCCCCCAAACCTCACGAGTGAGCC CATTCCTGCTGGGGGCTGTACTTTCAGTGGTATTTTCCCAACATTAACCTCTCCACTTTAACCTCTTCTAAAATACCCAACCAAAAGATC ACTGTTTCTCTCAACACTATTTAATCTGAAAAATGTTTCAGTACAAACCACTGTTTGAACTATCTGGGTTATTGGTGTTTGTTCCTGATG AAAGGAAAAAAATTCTCTCCAGGAGGAAGCCTTTTTCCTTCTTGCCCTTCCTGATTGATCTTCTGAGAGCTCGAATGCTGCTGGACACGT ACCCCTTTCTATTATTACTTTGTAGTAGAAAGAAAGTTAATGAAACTGAGAACTGATTGGAGGGTGTTTGATCATTTAGTTTTTAACAGG CTGAGGCAACATGGATCAGTGTGTGTCCCCCTCAGGAATGTATCCACAGTGGCCTTCCTTGCTGGTGGGCAGTGTATCCTGATGGCAGGG TACAAGTACCATTAATGAAGGGTCTGCAACATAAAGCCTTAAAAAGACACACACTAAGAAAACTGTAAAACCTTGAACATTGTTATTTAT ATTTTTTAAAATGGAAAAGATCACTATGTTTGTTGTGCTAACCACTTATTTGATTCTGTTTTGTGGTGGACATAGATGATTACGTTTGAG CTTTGTATTTTGTGAAAACCTTAATGAAATGAATTCCAAAGATAGTCACGTTGAGCGTGAAGACTTTTTTTCTTACATTCCTGTCTTATT TTTACCAACACGAGCAGGCATTCTGCGCTTCCACTGGACTGAGTATGGGGGAGTCCTGCTCCCCTCCTGTCTCACACCTTCCCCAGGAGG AAGGCCTCATGCACTGCGGTTATTGCATCATTTCCTAGTGCTTCATGTCATTATCACTGGTGGGGAAACAAAGCTAAATTTTATTAACAA AGACAACTCTCAGACCTATATAATAGGAGGAGGACGTCCAGAATCCAACAAAATTCAAACGGAGCCCATGCTGTTCTCCTGAACAAGATT TGGGCTAAATACGGCCTGTTTATTGAGGCTGTTTTAATGATGCTTTAAAAAAAAAAAATGTTTTCTAAAATGTCAAACCTGTTGACCACA CTTTGATTAAAAACTGCCTCCTTAACCTCTGAAGACTGATTTTGCTTTATCATGTTTCAATAATAACATTTCAGAGGTTACTCTGTAGCC CCAGTTGTAAGCTTATAAAAACAAACTGGAAGGCTGAGGAGGTTATGGGCTGGCAGCCAGGCTATGTTTACAGCTGCTGGAGATGGCAGT AGCCTTATACTTTGAGCAGGTAGTACATCCCAGGCTGTGCTAGAGGTAGATTTGTTTTTTCACGTTTGATCTGTGGCTGGTGGCCACCTT TGTTGATTTGGGCTTACGAGTTTCATAGTAGCCAGTCTTAGAAAATTGGGGGAGTAAAATTTTGAAGTAAAAAAAAAAAAAAAATGACAA GGGAACCAAATGCTCCTTCTCCCCTTAGTACATTTTCATTACTTAATGAAGTTTTATCTCCTATGTAAGAATATCAAAATTGTAGTTTGG GTCTCCAGTAGAGATGTCTTTTGATTAACTTATAAACAACTGGCCACCCAGAAGTTTCCTTTGCATAGTCAACCAAAGCTATGGCTTTGT TCTTTGGAGCTTATATACTGCATGACTCCATTGATACAAATAAGACAGCACCTTGGTTTCCCAGGGATGTTTTCATTCAGAGGTCCTGTC TCCCAGGAAAGCAGTAGAACCAGTGACAGCATTCAACAGCCACACTGCATGGTCATCAGTCTTAGGCCAACATGGGAGCCTGAAATTAAC TCCATCAGTAACTACCTGTGTGTCTTGCTGATACTGAATGAGCCCTCACAAGCCAAGCCAGGTGGAAGACAGCCAGCAAACGTCTACAGT TATTCTTAGTGAAATTCCTCAGAGGAATCCAGGGGGCTCCCAGTTCCCAACACTCTTCGAGATGACCATTTTTCGGGATTTGACTGGGGA ACATTTTACATATTCAGTCTTTCTCAAAAATTTTTATTTATTTTCTTGAGAAAGGGTCTTACTATGTTGCCCAGGCTGGAGTGCAGAGTG GTGCGATAACAGCTCATTGCAGTCTGAACCTCTGAGGCTCAAGCCATCCTCCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGGTGTGC ACCACTATGCTTGGCTAATTTTTTGATTTTTTATAGAGACGGGGGTCTCGCTATGTTGCCCAGGCTGGTTTCAAACTCCTGGGCTCAAGG GATCCTTCCGCTTTGGTCCCAGAAGTGCTGGGATTACAGGCATGAGCCACTTCACCCAGCCACTTTTCTAATTTATAGACATAAAAGTAA TTGACTCCCACAGCACAGTAACAGGCAATGCTGCTTGGCATGCCACAAACATCTGAAAGCTTGTGACACTCCTAGGATTGTGTCCATTCT TTCATTATGTGGAAACTTTGTTCTGTTATGTGAAATGGGTAAGGCACCAAGTGAGACTTTGAAATCTAATTTTTAGGTGGATGTGATATT TATTGTAATAGGACTTGACCTCTGTACTTTAAAGAAATCACTAACCAAATTTTCAAAGTTTCCTTTTAAATGCGTTTAGCTAGAAATCTA TGTATTTATCCCTTTCCTATTTTGCATTCTTCTCCCACTATTTTTAAAAACTCATTTACAGTAGAAACCATTCTTCTTTCTCCCAACAGT ATCCTTTGCCAAGACCATGAGAACAGTAAGGAGCATGTTGTTGGTCAGGGTTTCAGAATACGCGTGATGTCACTGAGAATGTTTGCTCAC AGTCAATAATTGTCTTTGTGGATGTGATAATTTTGGAGATACACTTCTGGTCAGAACTCAGGTGAGATAATCTTGCAATACTCCAAATGC AGATACTCCAGCCACCCGCAAGGTTCCAGGAAAGGACAATGTCCTGCGAGAAAATCAGGAGGCCTCCACTTCCTGGGCCACTTGAGAAGT TCCTGGGCATGTCACTACATGTTGGTTGACTCAGCCATTTCTCATGCTGTTTTGTTTCTTGCGGTGGCCACTTAACCCCAAAGAATGAAG GGAGGATCCACAGTGAAAGTGCCTGAGTTTCTCTATGAGACCAGATGCTGTCGAAACCAAACATCTTTTCCTTTGCTCTATGGGAACATT TTAGGGTTTGTTTTGCACAGCTGGTTTCCAGACTAGAAGATTAACAAGTTTGGGTCCACCCCTAAGAATCAGTGGCTGTCTTTTAAGGTG AGGAGTGTGGGCTTAACTGAGGTCCTTTGAGGGAGCTATAAAGGAGAAACAACCTGGGACATCCCAGTTTTCCTATTCCTCCACTGTTAA TATCTCATCTAAAATAATTCATGAGTTTAAATGGTAAATATATGCTTTAAGCTCTACCTTTAAACTTGTATGTTATTCAGGCATCTCTTA TTAAGATACTGGGTCTCTGGATACCCAAGGAAATGTTGGCTTTTTATTCTTATGTGGTTCCAAATTTACTTCTCTTCAGTTTAATTGTCC ATGGTAGTGCTGGCTTCATTGTTAGGTTGGAGTTATTATTTTCCTTTTAGAACAACATGAATTTTATTCACCTTACTATTAGAAAAAGGA ATAACTACAGCCAGAAATAACTTCATTTCCTACAAGGTATAAAAAGTGGTCAAGTGAATGTGAAGGGGCTTTTCTACACAGGAATATATT ATCGGGAACAAAGTATTTCCTGCTGCCTTAACTCTTTGGGATGCATAGGATAAAATGATAAAGACCATTTTAATATCAGAAAGGGTTGTC TTATTAATTTTTAAATAAAACTTCACATTTCTTAATGGGGAGCTCATTCAGAAACTAAATAATGGTTTCTCAAAGTGTGGTCAGGATACG ATCTGCATCAGAATCCTTGGAATGCTTGTTAAAAATACCAATTGCTATGACAAAACCAAGTCTGCTGGAAACTGCATTTCAGCAGGTTTC CCATGTTATTCTGATGTATTTTAACATTTGAGAGCCACTACCAATCATCTGTACAGTTCCTACTGTTATGATCACAATAAGACTAACATG |
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FusionGenePPI for PNO1_SHROOM3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PNO1 | KLF6, GSTP1, ATP5C1, SGSM2, CSNK1E, PDPK1, FRZB, CAND1, BYSL, WDR3, DDX49, RB1, FBL, VCP, FAU, KCMF1, RPS12, RPS13, RPS26, RPS20, RPS23, RPS24, RPS27, RPS5, RPS7, RPS9, WDR26, WIBG, RPS15A, RPS3, RPS6, TSR1, EED, RNF2, EGFR, COMTD1, UTP14A, UTP14C, MTMR3, NOB1, HNRNPA1, LRRC47, NOC3L, NSUN2, RPSA, XPO1, HNRNPU, MYC, NPM1, RPL10, C17orf85, PTPN2, FOXA1 | SHROOM3 | SFN, SAAL1, YWHAB, UBTD1, CDK2, ILK, RPS6KA2, SIK2, RPS6KB2, MYH9, RAB32, SNW1, CDC5L, CDH1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PNO1_SHROOM3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PNO1_SHROOM3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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