|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 27840 |
FusionGeneSummary for PNN_EIF3M |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PNN_EIF3M | Fusion gene ID: 27840 | Hgene | Tgene | Gene symbol | PNN | EIF3M | Gene ID | 5411 | 10480 |
| Gene name | pinin, desmosome associated protein | eukaryotic translation initiation factor 3 subunit M | |
| Synonyms | DRS|DRSP|SDK3|memA | B5|GA17|PCID1|TANGO7|hfl-B5 | |
| Cytomap | 14q21.1 | 11p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pinin140 kDa nuclear and cell adhesion-related phosphoproteinSR-like proteindesmosome-associated proteindomain-rich serine proteinmelanoma metastasis clone A proteinneutrophil proteinnuclear protein SDK3 | eukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H307 | Q7L2H7 | |
| Ensembl transtripts involved in fusion gene | ENST00000553331, ENST00000216832, ENST00000556530, ENST00000557680, | ENST00000531120, ENST00000524896, ENST00000532054, | |
| Fusion gene scores | * DoF score | 4 X 5 X 2=40 | 7 X 5 X 4=140 |
| # samples | 5 | 8 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PNN [Title/Abstract] AND EIF3M [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A573-01A | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000553331 | ENST00000531120 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| In-frame | ENST00000553331 | ENST00000524896 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| 5CDS-intron | ENST00000553331 | ENST00000532054 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| In-frame | ENST00000216832 | ENST00000531120 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| In-frame | ENST00000216832 | ENST00000524896 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| 5CDS-intron | ENST00000216832 | ENST00000532054 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| In-frame | ENST00000556530 | ENST00000531120 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| In-frame | ENST00000556530 | ENST00000524896 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| 5CDS-intron | ENST00000556530 | ENST00000532054 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| intron-3CDS | ENST00000557680 | ENST00000531120 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| intron-3CDS | ENST00000557680 | ENST00000524896 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
| intron-intron | ENST00000557680 | ENST00000532054 | PNN | chr14 | 39645353 | + | EIF3M | chr11 | 32616460 | + |
Top |
FusionProtFeatures for PNN_EIF3M |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PNN | EIF3M |
| Component of the eukaryotic translation initiationfactor 3 (eIF-3) complex, which is required for several steps inthe initiation of protein synthesis (PubMed:17403899,PubMed:25849773, PubMed:27462815). The eIF-3 complex associateswith the 40S ribosome and facilitates the recruitment of eIF-1,eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNArecruitment to the 43S PIC and scanning of the mRNA for AUGrecognition. The eIF-3 complex is also required for disassemblyand recycling of post-termination ribosomal complexes andsubsequently prevents premature joining of the 40S and 60Sribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of asubset of mRNAs involved in cell proliferation, including cellcycling, differentiation and apoptosis, and uses different modesof RNA stem-loop binding to exert either translational activationor repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012,ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815}. (Microbial infection) May favor virus entry in case ofinfection with herpes simplex virus 1 (HSV1) or herpes simplexvirus 2 (HSV2). {ECO:0000269|PubMed:15919898}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 2_32 | 61 | 718 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 163_234 | 61 | 718 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 287_379 | 61 | 718 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 446_467 | 61 | 718 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 172_471 | 61 | 718 | Compositional bias | Note=Glu-rich |
| Hgene | >PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 469_520 | 61 | 718 | Compositional bias | Note=Gln-rich |
| Hgene | >PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 552_704 | 61 | 718 | Compositional bias | Note=Ser-rich |
| Hgene | >PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 632_717 | 61 | 718 | Compositional bias | Note=Arg-rich |
| Hgene | >PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 221_284 | 61 | 718 | Region | Note=Sufficient for PSAP complex assembly |
| Hgene | >PNN | chr14:39645353 | chr11:32616460 | ENST00000216832 | + | 2 | 9 | 2_167 | 61 | 718 | Region | Note=Necessary for mediating alternative 5' splicing |
| Tgene | EIF3M | chr14:39645353 | chr11:32616460 | ENST00000531120 | + | 5 | 11 | 180_339 | 205 | 375 | Domain | PCI |
Top |
FusionGeneSequence for PNN_EIF3M |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PNN_ENST00000553331_chr14_39645353_+_EIF3M_ENST00000531120_chr11_32616460_+_231aa MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK >In-frame_PNN_ENST00000553331_chr14_39645353_+_EIF3M_ENST00000524896_chr11_32616460_+_231aa MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK >In-frame_PNN_ENST00000216832_chr14_39645353_+_EIF3M_ENST00000531120_chr11_32616460_+_231aa MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK >In-frame_PNN_ENST00000216832_chr14_39645353_+_EIF3M_ENST00000524896_chr11_32616460_+_231aa MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK >In-frame_PNN_ENST00000556530_chr14_39645353_+_EIF3M_ENST00000531120_chr11_32616460_+_231aa MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK >In-frame_PNN_ENST00000556530_chr14_39645353_+_EIF3M_ENST00000524896_chr11_32616460_+_231aa MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRCIVRALKDPNAFLFDHLLTLKPVKFLEG ELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PNN_ENST00000553331_chr14_39645353_+_EIF3M_ENST00000531120_chr11_32616460_+_693nt ATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACC GGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTA CTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGC GAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGAT TCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTT GACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAA ATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTT >In-frame_PNN_ENST00000553331_chr14_39645353_+_EIF3M_ENST00000524896_chr11_32616460_+_693nt ATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACC GGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTA CTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGC GAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGAT TCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTT GACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAA ATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTT >In-frame_PNN_ENST00000216832_chr14_39645353_+_EIF3M_ENST00000531120_chr11_32616460_+_693nt ATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACC GGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTA CTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGC GAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGAT TCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTT GACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAA ATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTT >In-frame_PNN_ENST00000216832_chr14_39645353_+_EIF3M_ENST00000524896_chr11_32616460_+_693nt ATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACC GGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTA CTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGC GAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGAT TCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTT GACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAA ATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTT >In-frame_PNN_ENST00000556530_chr14_39645353_+_EIF3M_ENST00000531120_chr11_32616460_+_693nt ATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACC GGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTA CTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGC GAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGAT TCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTT GACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAA ATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTT >In-frame_PNN_ENST00000556530_chr14_39645353_+_EIF3M_ENST00000524896_chr11_32616460_+_693nt ATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACC GGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTA CTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGC GAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGAT TCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTT GACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAA ATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PNN_ENST00000553331_chr14_39645353_+_EIF3M_ENST00000531120_chr11_32616460_+_4653nt ATTGGCTGAGCCCGGCTGTCAGTCCTTTCGCGCCTCGGCGGCGCGGCATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAG GGAGAAGATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAA GCTCACCGGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAG TTTATTACTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTT GGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTT CATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAAT TTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTA CTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGA CACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTT TGTTCTTTGAAAAAAAAGCCCTAAATCATAGTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTAT ACTAAAATCACAAACTCCAGAGGATATGAAGTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAA AAAGGATATTGAAGAAGCAATGAGCACTTTAAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTA GAAAAACTTGGAAAAGCAAAGACAAACTGTAGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTAC ATAATTTCACTACTGAAAGCACTTATCTACATTATTTTAATCTGTTGTTTTTTTCCAACGTCTCTTCTGCTTTTCTTTTCTTTGGCTGGT TGTCATTTTCTAAACTTAGTAAATTTTCACTTTTATTTAGTTGATTCGTAATGAGGCTCTGCCAGTCATCATCACCAGAAGTATTTTTAG TCGTCTTGATTGCCTGCAAATGGCTTTGTAGTGGAGTTGATATCAGAGGCTTTGTTTTCACCTGGGAAAGATAAACTAATTTTACCTTCG AAATTATTATACAAAAGATTTTAAAGAGTCTGTAAAGCCTCTGCAGTTATGAGTATGTGGTAAAACCACCATCTCTTGGCTGATTTCCAC TACCTTAGTAGTTCTGGCACCAGAAAAGTATACAATGTGAATGTGTAGGCTTATGTAGTAGATCTTCAAAATCTCTAATATATAACTGAA GTAAAGTGTACAAAAACTGCCTTTTACTACTTCATGTTTCCTCCCATGCTTCAGAACACCATTGTTGAAGAAACAGGAAGGGCAGTGAGA TATTTGGAAGTTGGCATGTTTTCAAGACACTGTATTGGGTAATTTTAAAAATAGTGTGTTAAATAACTTTTTCATTTTAAGGTTCTTTTC TGATGTTAAAATACTTACTGGAAATTTAGAAAATAGAGTAAAGTAGAAAGAAACTAAAAATCATTAGTAATCCCTTATCCAGAGAGGCTT GTTGACATTTTGGTATTATTTGCTGCTAGCGTTTTTTTCTATTTTTAGCCTATTTGATCATTCTATAGAATTTTATGTATTTTCCTCTGT GAGCAGTTTCTTAGGTCATTAAAAACAATTGTCTATGGCTGCAAAATACTCCCTTTTATGGATGTTTGATATATCTCCTACTACTGAATG TTTGTTTCCAGTTTATCCCTACCAAAAATTAATTCGAGTTAATTTCATGCAAAACAATCTTTGATGTTTTTGAGAGATTCCCAGATAAAA TTTTCTCTTCAAAAGGAATACTGGGCCAGGCACTGTGACTCATACCTGTAATCCCAGCACTTTGGGAAACTGAGGCGAGTGGATTGCATG AGCTCAGGAGTCGAAAACTAGCCTGAGCAACATGGCAAAACCCCATCTCTACCAAAAATTAGCTGGGCATGGTGGCATGCAACTGTAGTC CCAGCTCCTCGGAGGGCTGAGGTGCAAGGATCATTTGAGCCCAGGAGGTGAAGGTTGCAATGAGCCAAGATCATGCCATTGCACTCCAGC CTGGACAACAGAGTGAGACCCTCTCTCAAAAATAAATAATAGATAAAACAAAAGGAATACTGAATTGTTTTCAAAATAACAATTATGGTG GGCTTTCTTTTAAGATAGGGTCTCACCCTGTCACCTAGGCTGGAGTGCAGTGGCACAATCACAGCTCATTGCAGCCTTGACCTCCCTGGA TTCAGGTGATCCTCCCACCTTCACCTCCTGAGTACCTTGGACTACAGGCATGTGCCACCACACCCAGGTAATTTTTGTATTTTTTGCCAT GTTGCCCAGGCTGGTCTCTCTTAACTCTTGGGCTCAAGTGATCTGACCATCTCGGTCTCCCAAAGTTCTAGGATTACAGGAGTGAGCCAT ACTGTGTTGTGTTTTAGTTGAAAGGGATATACACGTGTATTTTAGAAATATGAAACAGGATAAGAATTACATTAAAATCACCCAAGATCC CAACCACCATTAAAGAGTTTGTGTAAATCTTCTGGTCTCTTTTCTGTATACACTTTTTAAATACTGGGGTCATATTTTTATTGGTTTATA TGCTATGTTAAACATTTTTAGCATTTCCTCCTGTTCTTAAGTCTGTTAAGAGGATAGCTCCATCATATTCTGTGTTCTGCAAATTATTTC TGGACATTTAAATTGTAAGAAAATGGTCACTGTTAACTAGGCTGCAGTGATTATCATTTGTTCATAAATCTTTGTGAAGATCTTTGGGTA CTGCCTTACATTAAAATCTTTTTCAATTTGACCAGTAAAAGTGGCATGTTAGTAACATTGTCATTTTCAGTGTTAGATTATGTAGTACTA AGTTTATTTTATTTTATTTTTGAGACAGAGTCTTGCACTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAACCTCCA CCTCCCAGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCACGATGCCCAGCTAATTTTTTGTAT TTTTAGTAGAGACAGGGTTTCACTATGTTGTCCAGGCTGGTCTCGAACGCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTGTT GGGATTACAGGCATGAGCCACCCTGCCCGACCTAGTAATACTTTTTTTTTTTTTTTTTTTTAATGAACTTAAATGTTTAGAATGGTAAGT TCACGGCTCCCTAAGGAGTGTTCCTTTTGGATTGCTCTGTTTGGCTCCCTCCCTGAAATCCTATAGTCAGCCACTGGTCCCCTCAGAGAG TTTTACCTCTGATCTTTGGGGTGATTCTTTGTTCATATTTATCTGATTGGCTTTGTTCTTCCAAAAGTGTCTGCACAGGACTGCTAAGAG AACCTAGGCAAGTCATTTAATTTTTCTGGGCTTCAGTTTACTCATTAGCTTCTTTTAGTTCCCAGATGCTATTACTGGAAAGAATAACTA GTAATGGATAAAAACCTACATAAATATTTCCTATTTTGCCATCAAAGTGCTGGGTTCATTTTGGTGTATTTGGCATCCAAGTACAAATTA ACAGTTTCCCAAAATCCTGATTCTTTGACTTTTTTATCTTGATGATGGAAAGGAAGGACACGTTTACTTGCTTTAGTTTCTTTCCCCTTA ACTACCCACTTGCTGAGAGGGGTAGGAGCAGGGATTGGCTTTAGAGAAACAAGATACAGTGTAGATTAGCTAATGTTTGCGCTTAACAAA ACTTGTCCTGTTTAACTTACCTGAGGGTTCTGCAGCCTACCGCAGTAATTTTAGTTCTAGCTGTTTTCAGATATATTGCCTTGTATCTTC GTTCTTTCGTCTCCTATCCTTTTTAGAAATTTATCACCTGTTTCTCTTTCAGCCTGACTTACAAAATCTAATTTTTGGCCTAAAAATTTC CCCTAGCTTGGTACTAGTCCTTTTATTTCTGCCTGTGATTATATTTTAAAATTAAACTTAAATGAATCTAATTCATTGGATATATAAAAA AAAAAGTAAGTGGCTTGCTTTGCTTACTCTGGTTTTCCATCCTCATTCCTGGATATAATCAAGATTGCAGTAGGCTAACAATCTAATGCT GAAAACAAGAATGAAAAACATACCATCTTTTCAAGTTACTTTGGACCCATAGAGAGAAAGTGGATTGGTACTTAATACCTTCCCTGAATT >In-frame_PNN_ENST00000553331_chr14_39645353_+_EIF3M_ENST00000524896_chr11_32616460_+_1214nt ATTGGCTGAGCCCGGCTGTCAGTCCTTTCGCGCCTCGGCGGCGCGGCATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAG GGAGAAGATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAA GCTCACCGGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAG TTTATTACTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTT GGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTT CATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAAT TTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTA CTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGA CACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTT TGTTCTTTGAAAAAAAAGCCCTAAATCATAGTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTAT ACTAAAATCACAAACTCCAGAGGATATGAAGTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAA AAAGGATATTGAAGAAGCAATGAGCACTTTAAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTA GAAAAACTTGGAAAAGCAAAGACAAACTGTAGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTAC >In-frame_PNN_ENST00000216832_chr14_39645353_+_EIF3M_ENST00000531120_chr11_32616460_+_4623nt CGCCTCGGCGGCGCGGCATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAGGGAGAAGATGGCGGTCGCCGTGAGAACTTT GCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACCGGGCGGGATCCGAATGACGTGAG GCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTACTGAGGTGTATTGTACGAGCATT GAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAAC CATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACA GAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCA GATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGT AGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAA CAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATA GTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAA GTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTT AAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGT AGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTAC ATTATTTTAATCTGTTGTTTTTTTCCAACGTCTCTTCTGCTTTTCTTTTCTTTGGCTGGTTGTCATTTTCTAAACTTAGTAAATTTTCAC TTTTATTTAGTTGATTCGTAATGAGGCTCTGCCAGTCATCATCACCAGAAGTATTTTTAGTCGTCTTGATTGCCTGCAAATGGCTTTGTA GTGGAGTTGATATCAGAGGCTTTGTTTTCACCTGGGAAAGATAAACTAATTTTACCTTCGAAATTATTATACAAAAGATTTTAAAGAGTC TGTAAAGCCTCTGCAGTTATGAGTATGTGGTAAAACCACCATCTCTTGGCTGATTTCCACTACCTTAGTAGTTCTGGCACCAGAAAAGTA TACAATGTGAATGTGTAGGCTTATGTAGTAGATCTTCAAAATCTCTAATATATAACTGAAGTAAAGTGTACAAAAACTGCCTTTTACTAC TTCATGTTTCCTCCCATGCTTCAGAACACCATTGTTGAAGAAACAGGAAGGGCAGTGAGATATTTGGAAGTTGGCATGTTTTCAAGACAC TGTATTGGGTAATTTTAAAAATAGTGTGTTAAATAACTTTTTCATTTTAAGGTTCTTTTCTGATGTTAAAATACTTACTGGAAATTTAGA AAATAGAGTAAAGTAGAAAGAAACTAAAAATCATTAGTAATCCCTTATCCAGAGAGGCTTGTTGACATTTTGGTATTATTTGCTGCTAGC GTTTTTTTCTATTTTTAGCCTATTTGATCATTCTATAGAATTTTATGTATTTTCCTCTGTGAGCAGTTTCTTAGGTCATTAAAAACAATT GTCTATGGCTGCAAAATACTCCCTTTTATGGATGTTTGATATATCTCCTACTACTGAATGTTTGTTTCCAGTTTATCCCTACCAAAAATT AATTCGAGTTAATTTCATGCAAAACAATCTTTGATGTTTTTGAGAGATTCCCAGATAAAATTTTCTCTTCAAAAGGAATACTGGGCCAGG CACTGTGACTCATACCTGTAATCCCAGCACTTTGGGAAACTGAGGCGAGTGGATTGCATGAGCTCAGGAGTCGAAAACTAGCCTGAGCAA CATGGCAAAACCCCATCTCTACCAAAAATTAGCTGGGCATGGTGGCATGCAACTGTAGTCCCAGCTCCTCGGAGGGCTGAGGTGCAAGGA TCATTTGAGCCCAGGAGGTGAAGGTTGCAATGAGCCAAGATCATGCCATTGCACTCCAGCCTGGACAACAGAGTGAGACCCTCTCTCAAA AATAAATAATAGATAAAACAAAAGGAATACTGAATTGTTTTCAAAATAACAATTATGGTGGGCTTTCTTTTAAGATAGGGTCTCACCCTG TCACCTAGGCTGGAGTGCAGTGGCACAATCACAGCTCATTGCAGCCTTGACCTCCCTGGATTCAGGTGATCCTCCCACCTTCACCTCCTG AGTACCTTGGACTACAGGCATGTGCCACCACACCCAGGTAATTTTTGTATTTTTTGCCATGTTGCCCAGGCTGGTCTCTCTTAACTCTTG GGCTCAAGTGATCTGACCATCTCGGTCTCCCAAAGTTCTAGGATTACAGGAGTGAGCCATACTGTGTTGTGTTTTAGTTGAAAGGGATAT ACACGTGTATTTTAGAAATATGAAACAGGATAAGAATTACATTAAAATCACCCAAGATCCCAACCACCATTAAAGAGTTTGTGTAAATCT TCTGGTCTCTTTTCTGTATACACTTTTTAAATACTGGGGTCATATTTTTATTGGTTTATATGCTATGTTAAACATTTTTAGCATTTCCTC CTGTTCTTAAGTCTGTTAAGAGGATAGCTCCATCATATTCTGTGTTCTGCAAATTATTTCTGGACATTTAAATTGTAAGAAAATGGTCAC TGTTAACTAGGCTGCAGTGATTATCATTTGTTCATAAATCTTTGTGAAGATCTTTGGGTACTGCCTTACATTAAAATCTTTTTCAATTTG ACCAGTAAAAGTGGCATGTTAGTAACATTGTCATTTTCAGTGTTAGATTATGTAGTACTAAGTTTATTTTATTTTATTTTTGAGACAGAG TCTTGCACTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTTCTGCCTC AGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCACGATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTG TCCAGGCTGGTCTCGAACGCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACCCTGCCCGA CCTAGTAATACTTTTTTTTTTTTTTTTTTTTAATGAACTTAAATGTTTAGAATGGTAAGTTCACGGCTCCCTAAGGAGTGTTCCTTTTGG ATTGCTCTGTTTGGCTCCCTCCCTGAAATCCTATAGTCAGCCACTGGTCCCCTCAGAGAGTTTTACCTCTGATCTTTGGGGTGATTCTTT GTTCATATTTATCTGATTGGCTTTGTTCTTCCAAAAGTGTCTGCACAGGACTGCTAAGAGAACCTAGGCAAGTCATTTAATTTTTCTGGG CTTCAGTTTACTCATTAGCTTCTTTTAGTTCCCAGATGCTATTACTGGAAAGAATAACTAGTAATGGATAAAAACCTACATAAATATTTC CTATTTTGCCATCAAAGTGCTGGGTTCATTTTGGTGTATTTGGCATCCAAGTACAAATTAACAGTTTCCCAAAATCCTGATTCTTTGACT TTTTTATCTTGATGATGGAAAGGAAGGACACGTTTACTTGCTTTAGTTTCTTTCCCCTTAACTACCCACTTGCTGAGAGGGGTAGGAGCA GGGATTGGCTTTAGAGAAACAAGATACAGTGTAGATTAGCTAATGTTTGCGCTTAACAAAACTTGTCCTGTTTAACTTACCTGAGGGTTC TGCAGCCTACCGCAGTAATTTTAGTTCTAGCTGTTTTCAGATATATTGCCTTGTATCTTCGTTCTTTCGTCTCCTATCCTTTTTAGAAAT TTATCACCTGTTTCTCTTTCAGCCTGACTTACAAAATCTAATTTTTGGCCTAAAAATTTCCCCTAGCTTGGTACTAGTCCTTTTATTTCT GCCTGTGATTATATTTTAAAATTAAACTTAAATGAATCTAATTCATTGGATATATAAAAAAAAAAGTAAGTGGCTTGCTTTGCTTACTCT GGTTTTCCATCCTCATTCCTGGATATAATCAAGATTGCAGTAGGCTAACAATCTAATGCTGAAAACAAGAATGAAAAACATACCATCTTT TCAAGTTACTTTGGACCCATAGAGAGAAAGTGGATTGGTACTTAATACCTTCCCTGAATTTAACAGAATTGATGTGGACTGTACATAAAA >In-frame_PNN_ENST00000216832_chr14_39645353_+_EIF3M_ENST00000524896_chr11_32616460_+_1184nt CGCCTCGGCGGCGCGGCATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAGGGAGAAGATGGCGGTCGCCGTGAGAACTTT GCAGGAACAGCTGGAAAAGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACCGGGCGGGATCCGAATGACGTGAG GCCCATCCAAGCCAGATTGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTACTGAGGTGTATTGTACGAGCATT GAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAAC CATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACA GAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCA GATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGT AGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAA CAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATA GTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAA GTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTT AAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGT AGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTAC >In-frame_PNN_ENST00000556530_chr14_39645353_+_EIF3M_ENST00000531120_chr11_32616460_+_4606nt ATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAGGGAGAAGATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAA AGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACCGGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGAT TGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTACTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCAT TTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTA AATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGA GACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATG TTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCA CACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCC TTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATAGTAAAACATTATAAACT AAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAAGTAATAAATTACAAGGG GTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTTAAAGAAAGGATAATATA CAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGTAGAGCTTTAAATACAAC AGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTACATTATTTTAATCTGTTG TTTTTTTCCAACGTCTCTTCTGCTTTTCTTTTCTTTGGCTGGTTGTCATTTTCTAAACTTAGTAAATTTTCACTTTTATTTAGTTGATTC GTAATGAGGCTCTGCCAGTCATCATCACCAGAAGTATTTTTAGTCGTCTTGATTGCCTGCAAATGGCTTTGTAGTGGAGTTGATATCAGA GGCTTTGTTTTCACCTGGGAAAGATAAACTAATTTTACCTTCGAAATTATTATACAAAAGATTTTAAAGAGTCTGTAAAGCCTCTGCAGT TATGAGTATGTGGTAAAACCACCATCTCTTGGCTGATTTCCACTACCTTAGTAGTTCTGGCACCAGAAAAGTATACAATGTGAATGTGTA GGCTTATGTAGTAGATCTTCAAAATCTCTAATATATAACTGAAGTAAAGTGTACAAAAACTGCCTTTTACTACTTCATGTTTCCTCCCAT GCTTCAGAACACCATTGTTGAAGAAACAGGAAGGGCAGTGAGATATTTGGAAGTTGGCATGTTTTCAAGACACTGTATTGGGTAATTTTA AAAATAGTGTGTTAAATAACTTTTTCATTTTAAGGTTCTTTTCTGATGTTAAAATACTTACTGGAAATTTAGAAAATAGAGTAAAGTAGA AAGAAACTAAAAATCATTAGTAATCCCTTATCCAGAGAGGCTTGTTGACATTTTGGTATTATTTGCTGCTAGCGTTTTTTTCTATTTTTA GCCTATTTGATCATTCTATAGAATTTTATGTATTTTCCTCTGTGAGCAGTTTCTTAGGTCATTAAAAACAATTGTCTATGGCTGCAAAAT ACTCCCTTTTATGGATGTTTGATATATCTCCTACTACTGAATGTTTGTTTCCAGTTTATCCCTACCAAAAATTAATTCGAGTTAATTTCA TGCAAAACAATCTTTGATGTTTTTGAGAGATTCCCAGATAAAATTTTCTCTTCAAAAGGAATACTGGGCCAGGCACTGTGACTCATACCT GTAATCCCAGCACTTTGGGAAACTGAGGCGAGTGGATTGCATGAGCTCAGGAGTCGAAAACTAGCCTGAGCAACATGGCAAAACCCCATC TCTACCAAAAATTAGCTGGGCATGGTGGCATGCAACTGTAGTCCCAGCTCCTCGGAGGGCTGAGGTGCAAGGATCATTTGAGCCCAGGAG GTGAAGGTTGCAATGAGCCAAGATCATGCCATTGCACTCCAGCCTGGACAACAGAGTGAGACCCTCTCTCAAAAATAAATAATAGATAAA ACAAAAGGAATACTGAATTGTTTTCAAAATAACAATTATGGTGGGCTTTCTTTTAAGATAGGGTCTCACCCTGTCACCTAGGCTGGAGTG CAGTGGCACAATCACAGCTCATTGCAGCCTTGACCTCCCTGGATTCAGGTGATCCTCCCACCTTCACCTCCTGAGTACCTTGGACTACAG GCATGTGCCACCACACCCAGGTAATTTTTGTATTTTTTGCCATGTTGCCCAGGCTGGTCTCTCTTAACTCTTGGGCTCAAGTGATCTGAC CATCTCGGTCTCCCAAAGTTCTAGGATTACAGGAGTGAGCCATACTGTGTTGTGTTTTAGTTGAAAGGGATATACACGTGTATTTTAGAA ATATGAAACAGGATAAGAATTACATTAAAATCACCCAAGATCCCAACCACCATTAAAGAGTTTGTGTAAATCTTCTGGTCTCTTTTCTGT ATACACTTTTTAAATACTGGGGTCATATTTTTATTGGTTTATATGCTATGTTAAACATTTTTAGCATTTCCTCCTGTTCTTAAGTCTGTT AAGAGGATAGCTCCATCATATTCTGTGTTCTGCAAATTATTTCTGGACATTTAAATTGTAAGAAAATGGTCACTGTTAACTAGGCTGCAG TGATTATCATTTGTTCATAAATCTTTGTGAAGATCTTTGGGTACTGCCTTACATTAAAATCTTTTTCAATTTGACCAGTAAAAGTGGCAT GTTAGTAACATTGTCATTTTCAGTGTTAGATTATGTAGTACTAAGTTTATTTTATTTTATTTTTGAGACAGAGTCTTGCACTGTCGCCCA GGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCTG GGATTACAGGCACCCACCACGATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTGTCCAGGCTGGTCTCGAA CGCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACCCTGCCCGACCTAGTAATACTTTTTT TTTTTTTTTTTTTTAATGAACTTAAATGTTTAGAATGGTAAGTTCACGGCTCCCTAAGGAGTGTTCCTTTTGGATTGCTCTGTTTGGCTC CCTCCCTGAAATCCTATAGTCAGCCACTGGTCCCCTCAGAGAGTTTTACCTCTGATCTTTGGGGTGATTCTTTGTTCATATTTATCTGAT TGGCTTTGTTCTTCCAAAAGTGTCTGCACAGGACTGCTAAGAGAACCTAGGCAAGTCATTTAATTTTTCTGGGCTTCAGTTTACTCATTA GCTTCTTTTAGTTCCCAGATGCTATTACTGGAAAGAATAACTAGTAATGGATAAAAACCTACATAAATATTTCCTATTTTGCCATCAAAG TGCTGGGTTCATTTTGGTGTATTTGGCATCCAAGTACAAATTAACAGTTTCCCAAAATCCTGATTCTTTGACTTTTTTATCTTGATGATG GAAAGGAAGGACACGTTTACTTGCTTTAGTTTCTTTCCCCTTAACTACCCACTTGCTGAGAGGGGTAGGAGCAGGGATTGGCTTTAGAGA AACAAGATACAGTGTAGATTAGCTAATGTTTGCGCTTAACAAAACTTGTCCTGTTTAACTTACCTGAGGGTTCTGCAGCCTACCGCAGTA ATTTTAGTTCTAGCTGTTTTCAGATATATTGCCTTGTATCTTCGTTCTTTCGTCTCCTATCCTTTTTAGAAATTTATCACCTGTTTCTCT TTCAGCCTGACTTACAAAATCTAATTTTTGGCCTAAAAATTTCCCCTAGCTTGGTACTAGTCCTTTTATTTCTGCCTGTGATTATATTTT AAAATTAAACTTAAATGAATCTAATTCATTGGATATATAAAAAAAAAAGTAAGTGGCTTGCTTTGCTTACTCTGGTTTTCCATCCTCATT CCTGGATATAATCAAGATTGCAGTAGGCTAACAATCTAATGCTGAAAACAAGAATGAAAAACATACCATCTTTTCAAGTTACTTTGGACC CATAGAGAGAAAGTGGATTGGTACTTAATACCTTCCCTGAATTTAACAGAATTGATGTGGACTGTACATAAAATATGTTGAAAAATAAAA >In-frame_PNN_ENST00000556530_chr14_39645353_+_EIF3M_ENST00000524896_chr11_32616460_+_1167nt ATAGCCCGGCTCGGCCTGTAAAGCAGTCTCAAGCCTGCCGCAGGGAGAAGATGGCGGTCGCCGTGAGAACTTTGCAGGAACAGCTGGAAA AGGCCAAAGAGAGTCTTAAGAACGTGGATGAGAACATTCGCAAGCTCACCGGGCGGGATCCGAATGACGTGAGGCCCATCCAAGCCAGAT TGCTGGCCCTTTCTGGTCCTGGTGGAGGTAGAGGACGTGGTAGTTTATTACTGAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCAT TTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTA AATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGA GACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATG TTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCA CACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCC TTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATAGTAAAACATTATAAACT AAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAAGTAATAAATTACAAGGG GTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTTAAAGAAAGGATAATATA CAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGTAGAGCTTTAAATACAAC |
Top |
FusionGenePPI for PNN_EIF3M |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PNN | SRRM2, RNPS1, NFKBIL1, CTBP1, PPIG, SRSF4, PNISR, ZCCHC17, PRPF4B, KRT19, KRT8, KRT18, TCEA2, SRRM1, RBM39, SF3A2, SIRT7, HNRNPA1, SAP18, CDK2, GRK5, BARD1, EIF4A3, MAGOH, CSNK2A1, KIAA0101, HDAC11, SRPK2, SRPK1, CLK2, CSNK2A2, CUL7, OBSL1, LUZP4, PRPF40A, TRA2A, RALYL, FAM9A, LUC7L, LUC7L2, EDA, SNIP1, PTGER3, PSMC3, C11orf57, DENND2D, SREK1, EPB41L3, ZMYND11, RPL6, ZC3H18, NTRK1, IFI16, NDUFAF1, USP37, SNW1, CDC5L, U2AF2, CCDC9, EPB41L2, ZC3H14, CAMKV, AKAP17A, CLK3, VANGL2, ACIN1, PIP4K2A, CASC3, SCAF1, C17orf85, VANGL1, RSBN1L, THRAP3, PES1, WSB2, DDX41, XAB2, MDK, RBM22, ELAVL2, CDC40, CFAP20, NKTR, FYTTD1, TOPORS, BCLAF1, NOS1AP, PPIE, NKAP, SMOC1, RSBN1, CRNKL1, ISY1, RBBP6, SARNP, GPALPP1, SRSF10, DHX8, AQR, COX15, DLD, DLST, DNM1L, PARK7, PDHA1 | EIF3M | EIF1B, EIF4A2, EIF3A, EIF3F, EIF3H, TADA2A, EIF3B, APP, EIF3C, EIF3E, EIF3D, EIF3I, EIF3K, EIF3L, EIF3G, MMS19, NPM1, EXOSC10, SRPK1, FAM96B, HUWE1, EGFR, EIF3CL, USP34, HSPB1, AHCYL1, COPS4, RPN1, EIF3J, NTRK1, MED4, HERC2, NF2, PTP4A1, PSMD12, EIF4A1, GPBP1L1, UBE2N, CYLD, DLD, TRIM25, G3BP1, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | EIF3M | chr14:39645353 | chr11:32616460 | ENST00000531120 | + | 5 | 11 | 344_374 | 205 | 375 | HSV-1 and HSV-2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for PNN_EIF3M |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for PNN_EIF3M |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|