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Fusion gene ID: 2784 |
FusionGeneSummary for ARNT2_PDLIM5 |
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Fusion gene information | Fusion gene name: ARNT2_PDLIM5 | Fusion gene ID: 2784 | Hgene | Tgene | Gene symbol | ARNT2 | PDLIM5 | Gene ID | 9915 | 10611 |
Gene name | aryl hydrocarbon receptor nuclear translocator 2 | PDZ and LIM domain 5 | |
Synonyms | WEDAS|bHLHe1 | ENH|ENH1|L9|LIM | |
Cytomap | 15q25.1 | 4q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | aryl hydrocarbon receptor nuclear translocator 2ARNT protein 2class E basic helix-loop-helix protein 1 | PDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains protein | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9HBZ2 | Q96HC4 | |
Ensembl transtripts involved in fusion gene | ENST00000303329, ENST00000533983, ENST00000527771, ENST00000531595, | ENST00000450793, ENST00000538141, ENST00000380180, ENST00000318007, ENST00000437932, ENST00000317968, ENST00000542407, ENST00000508216, ENST00000514743, ENST00000380176, ENST00000359265, ENST00000512274, ENST00000504489, | |
Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 9 X 12 X 5=540 |
# samples | 7 | 12 | |
** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/540*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARNT2 [Title/Abstract] AND PDLIM5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ARNT2 | GO:0001666 | response to hypoxia | 12239177 |
Hgene | ARNT2 | GO:0006355 | regulation of transcription, DNA-templated | 11782478 |
Hgene | ARNT2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 24465693 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-EW-A1J2-01A | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000303329 | ENST00000450793 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000538141 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000380180 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000318007 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000437932 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000317968 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000542407 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000508216 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000514743 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-3UTR | ENST00000303329 | ENST00000380176 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000359265 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000512274 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
5CDS-intron | ENST00000303329 | ENST00000504489 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000450793 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000538141 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000380180 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000318007 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000437932 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000317968 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000542407 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000508216 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000514743 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-3UTR | ENST00000533983 | ENST00000380176 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000359265 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000512274 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000533983 | ENST00000504489 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000450793 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000538141 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000380180 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000318007 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000437932 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000317968 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000542407 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000508216 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000514743 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-3UTR | ENST00000527771 | ENST00000380176 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000359265 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000512274 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000527771 | ENST00000504489 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000450793 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000538141 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000380180 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000318007 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000437932 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000317968 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000542407 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000508216 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000514743 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-3UTR | ENST00000531595 | ENST00000380176 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000359265 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000512274 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
intron-intron | ENST00000531595 | ENST00000504489 | ARNT2 | chr15 | 80696888 | + | PDLIM5 | chr4 | 95539155 | + |
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FusionProtFeatures for ARNT2_PDLIM5 |
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Hgene | Tgene |
ARNT2 | PDLIM5 |
Transcription factor that plays a role in thedevelopment of the hypothalamo-pituitary axis, postnatal braingrowth, and visual and renal function (PubMed:24022475).Specifically recognizes the xenobiotic response element (XRE).{ECO:0000269|PubMed:24022475}. | May play an important role in the heart development byscaffolding PKC to the Z-disk region. May play a role in theregulation of cardiomyocyte expansion. Overexpression promotes thedevelopment of heart hypertrophy. Contributes to the regulation ofdendritic spine morphogenesis in neurons. May restrainpostsynaptic growth of excitatory synapses (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ARNT2_PDLIM5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ARNT2_PDLIM5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ARNT2 | NPAS4, SIM2, EPAS1, BCL6, USP7, APP, SH3GL2, TAX1BP3, BZRAP1, NPAS2, CTBP1, ADAMTSL4, CALCOCO2, CCDC33, CDR2, CEP57L1, CEP63, DTX2, DYDC1, GOLGA2, HIF1A, IKZF3, KIFC3, LZTS2, MAGEA4, MEIS2, MEOX2, MIPOL1, MTUS2, NCOA3, PDE4DIP, PLSCR1, RBCK1, REL, RFX6, RIMBP3, RINT1, SORBS3, SPAG5, SSBP3, SSX2IP, SYCE1, TACC3, TADA2A, TFIP11, TRAF1, TRAF2, TRAF4, TRIM23, TRIM27, TRIM37, TRIM42, TRIP6, USHBP1, VPS52, ZNF341, DGCR6, NDE1, NPAS3, AHR, NPAS1, CLPP, FNTA, FNTB | PDLIM5 | TRIM39, CACNA1B, PRKCB, PRKCE, GFI1B, NDUFA7, SIN3A, ELMSAN1, DSTN, FN1, CALU, EIF4A3, METTL1, NPLOC4, PDE12, ANP32A, CBS, IPO11, PKM, PLIN3, SRP14, UBA2, RAD23B, TPD52, ZYX, COIL, CCDC136, KRT40, KRTAP10-7, SUZ12, RNF2, BMI1, SIRT6, ILK, METTL6, RWDD2B, SYT11, DNAJC8, MAP2K1, MAP2K2, ARFIP2, CAMK2G, NTRK1, BTRC, MED4, SSX2IP, CEP128, CEP19, XPO1, CDH1, PDLIM7, TULP3, PHF19, NFATC2IP, DENR, TPM2, EMILIN1, ATG14, G3BP1, BRCA1, TES |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARNT2_PDLIM5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARNT2_PDLIM5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PDLIM5 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Tgene | PDLIM5 | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | PDLIM5 | C0041696 | Unipolar Depression | 4 | PSYGENET |
Tgene | PDLIM5 | C1269683 | Major Depressive Disorder | 4 | PSYGENET |
Tgene | PDLIM5 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | PDLIM5 | C0221765 | Chronic schizophrenia | 1 | PSYGENET |