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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2784

FusionGeneSummary for ARNT2_PDLIM5

check button Fusion gene summary
Fusion gene informationFusion gene name: ARNT2_PDLIM5
Fusion gene ID: 2784
HgeneTgene
Gene symbol

ARNT2

PDLIM5

Gene ID

9915

10611

Gene namearyl hydrocarbon receptor nuclear translocator 2PDZ and LIM domain 5
SynonymsWEDAS|bHLHe1ENH|ENH1|L9|LIM
Cytomap

15q25.1

4q22.3

Type of geneprotein-codingprotein-coding
Descriptionaryl hydrocarbon receptor nuclear translocator 2ARNT protein 2class E basic helix-loop-helix protein 1PDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains protein
Modification date2018051920180522
UniProtAcc

Q9HBZ2

Q96HC4

Ensembl transtripts involved in fusion geneENST00000303329, ENST00000533983, 
ENST00000527771, ENST00000531595, 
ENST00000450793, ENST00000538141, 
ENST00000380180, ENST00000318007, 
ENST00000437932, ENST00000317968, 
ENST00000542407, ENST00000508216, 
ENST00000514743, ENST00000380176, 
ENST00000359265, ENST00000512274, 
ENST00000504489, 
Fusion gene scores* DoF score7 X 5 X 5=1759 X 12 X 5=540
# samples 712
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARNT2 [Title/Abstract] AND PDLIM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARNT2

GO:0001666

response to hypoxia

12239177

HgeneARNT2

GO:0006355

regulation of transcription, DNA-templated

11782478

HgeneARNT2

GO:0045944

positive regulation of transcription by RNA polymerase II

24465693


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-EW-A1J2-01AARNT2chr15

80696888

+PDLIM5chr4

95539155

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000303329ENST00000450793ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000538141ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000380180ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000318007ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000437932ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000317968ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000542407ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000508216ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000514743ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-3UTRENST00000303329ENST00000380176ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000359265ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000512274ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
5CDS-intronENST00000303329ENST00000504489ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000450793ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000538141ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000380180ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000318007ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000437932ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000317968ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000542407ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000508216ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000514743ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-3UTRENST00000533983ENST00000380176ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000359265ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000512274ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000533983ENST00000504489ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000450793ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000538141ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000380180ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000318007ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000437932ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000317968ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000542407ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000508216ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000514743ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-3UTRENST00000527771ENST00000380176ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000359265ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000512274ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000527771ENST00000504489ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000450793ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000538141ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000380180ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000318007ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000437932ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000317968ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000542407ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000508216ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000514743ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-3UTRENST00000531595ENST00000380176ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000359265ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000512274ARNT2chr15

80696888

+PDLIM5chr4

95539155

+
intron-intronENST00000531595ENST00000504489ARNT2chr15

80696888

+PDLIM5chr4

95539155

+

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FusionProtFeatures for ARNT2_PDLIM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARNT2

Q9HBZ2

PDLIM5

Q96HC4

Transcription factor that plays a role in thedevelopment of the hypothalamo-pituitary axis, postnatal braingrowth, and visual and renal function (PubMed:24022475).Specifically recognizes the xenobiotic response element (XRE).{ECO:0000269|PubMed:24022475}. May play an important role in the heart development byscaffolding PKC to the Z-disk region. May play a role in theregulation of cardiomyocyte expansion. Overexpression promotes thedevelopment of heart hypertrophy. Contributes to the regulation ofdendritic spine morphogenesis in neurons. May restrainpostsynaptic growth of excitatory synapses (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARNT2_PDLIM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARNT2_PDLIM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARNT2NPAS4, SIM2, EPAS1, BCL6, USP7, APP, SH3GL2, TAX1BP3, BZRAP1, NPAS2, CTBP1, ADAMTSL4, CALCOCO2, CCDC33, CDR2, CEP57L1, CEP63, DTX2, DYDC1, GOLGA2, HIF1A, IKZF3, KIFC3, LZTS2, MAGEA4, MEIS2, MEOX2, MIPOL1, MTUS2, NCOA3, PDE4DIP, PLSCR1, RBCK1, REL, RFX6, RIMBP3, RINT1, SORBS3, SPAG5, SSBP3, SSX2IP, SYCE1, TACC3, TADA2A, TFIP11, TRAF1, TRAF2, TRAF4, TRIM23, TRIM27, TRIM37, TRIM42, TRIP6, USHBP1, VPS52, ZNF341, DGCR6, NDE1, NPAS3, AHR, NPAS1, CLPP, FNTA, FNTBPDLIM5TRIM39, CACNA1B, PRKCB, PRKCE, GFI1B, NDUFA7, SIN3A, ELMSAN1, DSTN, FN1, CALU, EIF4A3, METTL1, NPLOC4, PDE12, ANP32A, CBS, IPO11, PKM, PLIN3, SRP14, UBA2, RAD23B, TPD52, ZYX, COIL, CCDC136, KRT40, KRTAP10-7, SUZ12, RNF2, BMI1, SIRT6, ILK, METTL6, RWDD2B, SYT11, DNAJC8, MAP2K1, MAP2K2, ARFIP2, CAMK2G, NTRK1, BTRC, MED4, SSX2IP, CEP128, CEP19, XPO1, CDH1, PDLIM7, TULP3, PHF19, NFATC2IP, DENR, TPM2, EMILIN1, ATG14, G3BP1, BRCA1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARNT2_PDLIM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARNT2_PDLIM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDLIM5C0005586Bipolar Disorder5PSYGENET
TgenePDLIM5C0036341Schizophrenia4PSYGENET
TgenePDLIM5C0041696Unipolar Depression4PSYGENET
TgenePDLIM5C1269683Major Depressive Disorder4PSYGENET
TgenePDLIM5C0151744Myocardial Ischemia1CTD_human
TgenePDLIM5C0221765Chronic schizophrenia1PSYGENET