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Fusion gene ID: 27788 |
FusionGeneSummary for PMF1_SYT11 |
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Fusion gene information | Fusion gene name: PMF1_SYT11 | Fusion gene ID: 27788 | Hgene | Tgene | Gene symbol | PMF1 | SYT11 | Gene ID | 100527963 | 91683 |
Gene name | PMF1-BGLAP readthrough | synaptotagmin 12 | |
Synonyms | PMF1 | SYT11|sytXII | |
Cytomap | 1q22 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | PMF1-BGLAP proteinpolyamine-modulated factor 1 | synaptotagmin-12synaptotagmin-XII | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6P1K2 | Q9BT88 | |
Ensembl transtripts involved in fusion gene | ENST00000368279, ENST00000368273, ENST00000368277, ENST00000565805, ENST00000567140, | ENST00000368324, ENST00000539162, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 4 X 1 X 4=16 |
# samples | 2 | 4 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PMF1 [Title/Abstract] AND SYT11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-8590-01A | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000368279 | ENST00000368324 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
5CDS-5UTR | ENST00000368279 | ENST00000539162 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
Frame-shift | ENST00000368273 | ENST00000368324 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
5CDS-5UTR | ENST00000368273 | ENST00000539162 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
Frame-shift | ENST00000368277 | ENST00000368324 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
5CDS-5UTR | ENST00000368277 | ENST00000539162 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
Frame-shift | ENST00000565805 | ENST00000368324 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
5CDS-5UTR | ENST00000565805 | ENST00000539162 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
Frame-shift | ENST00000567140 | ENST00000368324 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
5CDS-5UTR | ENST00000567140 | ENST00000539162 | PMF1 | chr1 | 156182967 | + | SYT11 | chr1 | 155850291 | + |
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FusionProtFeatures for PMF1_SYT11 |
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Hgene | Tgene |
PMF1 | SYT11 |
May be involved in Ca(2+)-dependent exocytosis ofsecretory vesicles through Ca(2+) and phospholipid binding to theC2 domain or may serve as Ca(2+) sensors in the process ofvesicular trafficking and exocytosis. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PMF1_SYT11 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PMF1_SYT11 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PMF1 | NFE2L2, MIS12, DSN1, GDF9, KIAA1377, MED31, CRMP1, PTN, COPS6, GIT1, COPS7A, SUGT1, HSP90AA1, TCP10L, KDM1A, USHBP1, BUB1B, NSMCE1, NSL1, ZWINT, SGTB, SEC63, PGRMC2, ZRANB1, WDR45B, GNPAT, PPP1CC, ZMPSTE24, CMTM6, GFER, TALDO1, SPC24, SPC25, CASC5, NUF2, KIF21B, BICD2, RUFY2, GCC2, NDC80, ZC4H2, CEP89, FBXO28, RUFY1, TSNAX, ATG16L1, NRBF2, ALOX5, MLLT10, CENPC, RGPD8, STXBP4, MLF1, TRIM25, UBE2S | SYT11 | APPBP2, PARK2, ATP13A2, SGTA, TTC1, UBE2O, PDLIM7, PRKAR1B, PDLIM5, NTRK1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PMF1_SYT11 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PMF1_SYT11 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SYT11 | C0036341 | Schizophrenia | 1 | PSYGENET |