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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2777

FusionGeneSummary for ARMCX2_ARMCX2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARMCX2_ARMCX2
Fusion gene ID: 2777
HgeneTgene
Gene symbol

ARMCX2

ARMCX2

Gene ID

9823

9823

Gene namearmadillo repeat containing X-linked 2armadillo repeat containing X-linked 2
SynonymsALEX2|GASP9ALEX2|GASP9
Cytomap

Xq22.1

Xq22.1

Type of geneprotein-codingprotein-coding
Descriptionarmadillo repeat-containing X-linked protein 2ARM protein lost in epithelial cancers on chromosome X 2armadillo repeat protein ALEX2armadillo repeat-containing X-linked protein 2ARM protein lost in epithelial cancers on chromosome X 2armadillo repeat protein ALEX2
Modification date2018051920180519
UniProtAcc

Q7L311

Q7L311

Ensembl transtripts involved in fusion geneENST00000330154, ENST00000328766, 
ENST00000356824, ENST00000467416, 
ENST00000330154, ENST00000328766, 
ENST00000356824, ENST00000467416, 
Fusion gene scores* DoF score1 X 2 X 1=21 X 2 X 1=2
# samples 22
** MAII scorelog2(2/2*10)=3.32192809488736log2(2/2*10)=3.32192809488736
Context

PubMed: ARMCX2 [Title/Abstract] AND ARMCX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE843388ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
ChiTaRS3.1BI044858ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000330154ENST00000330154ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000330154ENST00000328766ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000330154ENST00000356824ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-intronENST00000330154ENST00000467416ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000328766ENST00000330154ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000328766ENST00000328766ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000328766ENST00000356824ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-intronENST00000328766ENST00000467416ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000356824ENST00000330154ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000356824ENST00000328766ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000356824ENST00000356824ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-intronENST00000356824ENST00000467416ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000467416ENST00000330154ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000467416ENST00000328766ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-3CDSENST00000467416ENST00000356824ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-intronENST00000467416ENST00000467416ARMCX2chrX

100910575

+ARMCX2chrX

100910798

-
intron-5UTRENST00000330154ENST00000330154ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000330154ENST00000328766ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000330154ENST00000356824ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000330154ENST00000467416ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000328766ENST00000330154ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000328766ENST00000328766ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000328766ENST00000356824ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000328766ENST00000467416ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000356824ENST00000330154ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000356824ENST00000328766ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000356824ENST00000356824ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000356824ENST00000467416ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000467416ENST00000330154ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000467416ENST00000328766ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000467416ENST00000356824ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-
intron-5UTRENST00000467416ENST00000467416ARMCX2chrX

100912660

+ARMCX2chrX

100913494

-

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FusionProtFeatures for ARMCX2_ARMCX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARMCX2

Q7L311

ARMCX2

Q7L311

May regulate the dynamics and distribution ofmitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}. May regulate the dynamics and distribution ofmitochondria in neural cells. {ECO:0000250|UniProtKB:Q6A058}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARMCX2_ARMCX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARMCX2_ARMCX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARMCX2_ARMCX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARMCX2_ARMCX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource